If you RSVP "no" to a party you were never invited to, are you really making a stand?

Like...Dude. Nobody cares how you feel about trans people. Nobody (cis or trans) wants to fuck you in the first place.

Truly disturbing

ah. polyestradiol phosphate. Ouch, the pharmacokinetics of that...

You do understand that word, right?

Pharmacokinetics See also: Pharmacokinetics of estradiol PEP has a very long duration and is given by intramuscular injection once every 4 weeks.[35] In men, an initial intramuscular injection of PEP results in a rapid rise in estradiol levels measured at 24 hours followed by a slow and gradual further increase in levels up until at least day 28 (the time of the next injection).[35] Subsequent injections result in a progressive and considerable accumulation in estradiol levels up to at least 6 months.[35] The mean elimination half-life of PEP has been found to be 70 days (10 weeks) with a single 320 mg intramuscular dose of the medication.[7] The tmax (time to maximal concentrations) for estradiol was about 16 days.[7] PEP has a duration of approximately 1 month with a single dose of 40 mg, 2 months with 80 mg, and 4 months with 160 mg.[60][61][62][63][39]

PEP reaches the bloodstream within hours after an injection (90% after 24 hours), where it circulates, and is accumulated in the reticuloendothelial system.[52] Estradiol is then cleaved from the polymer by phosphatases, although very slowly.[64] Levels of estradiol in men with intramuscular injections of PEP once every 4 weeks were about 350 pg/mL with 160 mg, 450 pg/mL with 240 mg, and almost 700 pg/mL with 320 mg, all measured after 6 months of treatment.[35] With monthly injections, steady-state estradiol concentrations are reached after 6 to 12 months.[52] Estradiol is metabolized primarily in the liver by CYP3A4 and other cytochrome P450 enzymes, and is metabolized to a lesser extent in extrahepatic tissues.[20][1] The metabolites are mainly excreted in urine via the kidneys.[1]

Early studies found that a dosage of 80 mg PEP every 4 weeks rapidly produced relatively high mean estradiol levels of about 400 to 800 pg/mL.[65] These levels are similar to those of 100 mg estradiol undecylate every month, which has been found to produce estradiol levels of around 500 to 600 pg/mL.[66][67] As a result, it has previously been said that 80 mg PEP per month and 100 mg estradiol undecylate per month are roughly equivalent.[68][69][7] However, subsequent studies showed that this dosage of PEP actually achieves much lower estradiol levels than originally demonstrated.[35]

source: https://en.wikipedia.org/wiki/Polyestradiol_phosphate#:~:text=The%20mean%20elimination%20half%2Dlife,estradiol%20was%20about%2016%20days.

hmm. nice for the bubs. that good long term build up of female sex hormones with a half life 100x times that of the 17h of estradiol itself. must be why its use is contraindicated in..... breastfeeding