"Furin Cleavage Site" by JasonCarswell in Coronavirus
[–]EddieC 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 0 fun2 insightful - 1 fun - 1 day ago (0 children)
Check out these:
1) The Patents:
US7223390B2 - Insertion of furin protease cleavage sites in membrane proteins and uses thereof
WO 03/083095 A1 - Viral Mutants, manipulated in the furin cleavage sites of glycoproteins
2) The Math:
3 days ago * by EddieC to /s/conspiracy from self.conspiracy
Distract. Divide & Rule
3 days ago * by EddieC to /s/LateStageCapitalism from self.LateStageCapitalism
3 days ago * by EddieC to /s/environment from self.environment
Our Only Way Out Is To Be United In Truth by EddieC in Coronavirus
[–]EddieC[S] 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 1 fun3 insightful - 2 fun - 14 days ago (0 children)
Thanks. Indeed, there is much noise & cacophony going on right now - all leading to nowhere, all part of the divide and rule.
I hope people will quickly realize that all they need to do is turn off the noise and just focus on this.
There's work to be done for sure.
Little Susie Knows How to Destroy the Globalists' Chokehold on Humanity by hennaojichan in conspiracy
[–]EddieC 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 1 fun3 insightful - 2 fun - 14 days ago (0 children)
The Battle Is In The Narrative, Let's Seize The Narrative!
Writings On The Wall
14 days ago * by EddieC to /s/Coronavirus from self.Coronavirus
Our Only Way Out Is To Be United In Truth
15 days ago * by EddieC to /s/Coronavirus from self.Coronavirus
The Wall by EddieC in Coronavirus
[–]EddieC[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 0 fun3 insightful - 1 fun - 20 days ago (0 children)
Thanks very much indeed. Greatly appreciated!
There Are Over 40 Ways Voting Is A Rigged Joke. by JasonCarswell in politics
[–]EddieC 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 1 fun3 insightful - 2 fun - 25 days ago (0 children)
I am going to post this to the Yang Gang on Twitter
[–]EddieC[S] 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 1 fun3 insightful - 2 fun - 29 days ago (0 children)
Thanks very much indeed again. Jason!
I believe I do not have permission to create/edit wiki pages as these are what I can view on my end:
https://saidit.net/s/SaidIt/wiki/create/eddiec --> https://postimg.cc/VJdCBJc2
https://saidit.net/s/SaidIt/wiki/eddiec/page1 --> https://postimg.cc/HVSSk82N
As such, I would grateful if /u/d3rr you would allow access to do so.
[–]EddieC[S] 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 1 fun3 insightful - 2 fun - 1 month ago (0 children)
Thanks very much indeed. Jason!
However, the link says "Page Not Found". Maybe it needs to be activated on the back-end?
How does one create a personal wiki page on SaidIt?
I tried searching but could not find anything.
The ruling groups really killed a whole lot of people's perspective intellectually by fooling people into thinking that conspiracies are something rare. Most people aren't ethically capable of defending a decent society anymore. by HibikiBlack in C_S_T
[–]EddieC 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 1 fun3 insightful - 2 fun - 1 month ago (0 children)
How about something in between:
Let's Co-opefy The Economy to Decenter Corporatocracy
[–]EddieC[S] 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 1 fun3 insightful - 2 fun - 2 months ago (0 children)
Thank you for the tips. Let me mull over them.
On Vaccines by EddieC in Coronavirus
[–]EddieC[S] 3 insightful - 1 fun3 insightful - 0 fun4 insightful - 0 fun4 insightful - 1 fun - 2 months ago (0 children)
I had hidden it - not sure why anyone else could view it.
Please have another look at it now. Thanks!
I have hidden the post as I am working on it - not sure why anyone else can view it.
2 months ago * by EddieC to /s/Coronavirus from self.Coronavirus
Some people think Covid19 happened without advance planning & that it will be over soon.
The World Bank had a huge report on COVID ready by April 2020.
it indicates the first phase of the Covid-19 project will last until 2025.
Bioenergetic Homeostasis by EddieC in Coronavirus
[–]EddieC[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 0 fun2 insightful - 1 fun - 2 months ago* (0 children)
Niacin @ Nicotonic Acid (NA)
Anti-inflammatory effects of nicotinic acid in adipocytes (aka fat cells) demonstrated by
"NA suppresses pro-atherogenic chemokines and upregulates the atheroprotective adiponectin through a G-protein-coupled pathway. Since adipose tissue has the potential to contribute to both systemic and local (perivascular) inflammation associated with atherosclerosis our results suggest a new “pleiotropic” role for NA."
Melatonin is highly efficient at reducing oxidative stress and seems to prevent the conversion of mitochondrial OXPHOS of normal cells to aerobic glycolysis (the Warburg effect) of cancer cells.
Melatonin synthesis does not occur in cancer cell mitochondria because of acetyl-CoA deficiency.
When cells assume a Warburg-type metabolism, the cells
upregulate PDK the gatekeeper enzyme
downregulate/inhibit PDC, the enzyme that metabolizes pyruvate to acetyl-CoA,
causing a depletion of acetyl-CoA
and, in turn, the deprivation of melatonin
If, however, nocturnal circulating melatonin levels are sufficiently elevated, it does enter mitochondria to inhibit PDK, allowing for nocturnal switch away from Warburg effect
Niacin fine-tunes energy homeostasis through canonical GPR109A signaling
Niacin, "acting on GPR109A, shows the potential to maintain energy homeostasis through multi pathways, representing a potential approach to the treatment of obesity, diabetes and cardiovascular disease."
“Niacin exhibited inhibitory effects on:
These findings were verified by real-time qRT-PCR.”
"The true power of flush niacin isn’t fully harnessed without sufficient melatonin"
"Repleting melatonin will make the GPR109A aka ACE2 receptors fully expressed across the body for the flush to bind to and induce autophagy / clear inflammasome / reset health"
"High dose melatonin (like 10 to even up to 50 mg for some)
+ flush niacin (500 mg up to even 2 g)
a few times a day within a week should do it for everyone"
Significantly elevated levels of blood plasma galectin-9 protein linked to cytokine storm in COVID-19 patients:
"Niacin & Melatonin will directly affect galectin-9
NAC would marginally affect it, but there might be underlying mechanisms with NAC."
Sodium Bicarbonate (NaHCO3) and COVID
Co_opefy The Economy to Decenter Corporatocracy
2 months ago * by EddieC to /s/DecentralizeAllThings from self.DecentralizeAllThings
Let's Co-opefy The Economy, Decenter The Corporatocracy by EddieC in LateStageCapitalism
It is status quo to the extent that there are no institutional changes - because we are not in a real position to do them, but more importantly, we can make real changes without them - by simply focusing on the inalienable power we have collectively - economic power.
With each individual deciding to buy from co-ops and to form co-ops, each individual will inoculate her/him self from being exploited by Corporations ie the 0.01%. "Herd Immunity" is reached when the very idea of corporations having any material impact on our lives is looked down upon & shunned by the majority as it would represent a return to enslavement by the minority.
Things That Stop The Virus
3 months ago * by EddieC to /s/Coronavirus from self.Coronavirus
Emergency Use Authorization (EUA) of COVID Vaccines: The Rules
[–]EddieC[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 0 fun2 insightful - 1 fun - 3 months ago (0 children)
Thanks for the great insight on Syndicalism!
The Emergency Use Authorized (EUA) COVID Vaccines: Pre-EUA Criteria & Conditions Post-EUA Monitoring, Reporting, Review, Revision & Revocation
Essentially, the aim is for everyone to get used to the idea of a Co-op-dominated economy instead of a Corporation-dominated economy because of the economic benefits & leverage it would provide to the working class.
However, it does not mean pushing out small business owners. They will continue as before and would even flourish when income is better retained within the community through co-ops, circulates & grows.
I put "Unionize" in quotes i.e. to mean that the existing Workers of Corporations should organize into Co-ops that compete with the Corporations. Unionizing would only continue to put the power with the Corporations.
The classes could cooperate through the funding of the Co-ops i.e. the investor class can provide loans to Co-ops directly or indirectly through Credit Unions, but they will not have a say in the running of the Co-ops.
Looking at the features of syndicalism listed in this video, most of the features/boxes listed would left unticked under this idea. So,...
Yes, I think in lists. LOL
[–]EddieC[S] 3 insightful - 1 fun3 insightful - 0 fun4 insightful - 0 fun4 insightful - 1 fun - 3 months ago* (0 children)
a) "Soviet"=an elected governmental council in a Communist country
b) Kibbutz =a communal farm or settlement in Israel, a socialist economic organization based on the principle of state ownership of land
Co-ops are private, economic organizations, not public, political organizations.
Anyone can set up co-op right now - no changes to the political system or laws are necessary.
A community, depending on its size, may have multiple co-ops for a given activity as well as different co-ops for different activities.
"Co-opefy The Economy" would be a value shift for the entire population (not just a community) away from 0.01%-owned Corporations to build economic power for political leverage.
[–]EddieC[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 0 fun3 insightful - 1 fun - 3 months ago* (0 children)
Not everyone will choose to start a co-op. But everyone will get to decide whether to buy from Co-ops or Oligarch-owned corporations.
It is fine if co-ops fail. New, better ones can be built from failed experiences.
It is entirely up to the people who are interested to discuss, negotiate & decide amongst themselves how they want their coops to be.
Co-ops can be big or they can be small. There can be many co-ops in any one locale, not just one.
Let the people (ie the market) decide whichever they support.
The objectives are to enable us:
(1) To Organize ourselves into something bigger
(2) To Decenter The Corporatocracy
(3) To Make the shift away from Corporations
All We Have To Do... (Before It Is Too Late) by EddieC in LateStageCapitalism
[–]EddieC[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 0 fun3 insightful - 1 fun - 3 months ago (0 children)
I really appreciate your comment.
Hope you will have a look at this post which further elaborates on how real change is within our reach.
[–]EddieC[S] 4 insightful - 1 fun4 insightful - 0 fun5 insightful - 0 fun5 insightful - 1 fun - 3 months ago (0 children)
"Co-opefy The Economy, Decenter The Corporatocracy" is an idea to put economic (& thus political) leverage in the hands of the people, increasing voters' power (vs the 0.01%'s) to push for such referendums for Direct Democracy to happen.
Q: How do we get to a direct democracy political system?
Bear in mind this 2014 Princeton University study which concluded that:
- "the opinion of the average citizen has near zero impact on (US) public policy", whilst
- "economic elites have a quite substantial, highly significant impact on policy"
ie the US Govt works for the 0.01%
Let's Co-opefy The Economy, Decenter The Corporatocracy
3 months ago * by EddieC to /s/LateStageCapitalism from self.LateStageCapitalism
All We Have To Do... (Before It Is Too Late)
3 months ago by EddieC to /s/Coronavirus from self.Coronavirus
3 months ago by EddieC to /s/LateStageCapitalism from self.LateStageCapitalism
3 months ago by EddieC to /s/LateStageCapitalism from i.postimg.cc
Getting Our Priorities In Order...
Blanket Vaccination for COVID is Unnecessary
4 months ago * by EddieC to /s/Coronavirus from self.Coronavirus
Niacin and Covid by EddieC in Coronavirus
[–]EddieC[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 0 fun2 insightful - 1 fun - 5 months ago* (0 children)
[Niacin increases cellular free & decreases ester cholesterol] https://www.jlr.org/article/S0022-2275(20)39224-5/fulltext
HDL-C-mediated cholesterol efflux & selective cholesterol transport become dysfunctional in chronic metabolic diseases such as obesity or atherosclerosis, consistent with the increased mortality observed in elderly patients & patients w/obesity or diabetes
Niacin increases serum total and HMW adiponectin concentrations and decreases lipolysis within minutes following GPR109A receptor activation. Because adiponectin concentrations are generally low and adipose tissue lipolytic activity high in obese individuals with the metabolic syndrome, niacin may be an ideal pharmacological approach to reduce CVD in this population.
Protection against/risk of #SARS_CoV_2 infection (& similarly for progression of #COVID19 severity as shown in another report) is (independently) associated with only HDL-C (/ApoA-I) and not LDL-C, ApoB, triglycerides, or anything else.
a 10 mg/dl increase in serum HDL-cholesterol or apolipoprotein A1 levels was associated with ∼10% reduced risk of SARS-CoV-2 infection, after adjustment for age, sex, obesity, hypertension, type 2 diabetes, and coronary artery disease. https://www.jlr.org/article/S0022-2275(21)00043-2/fulltext
a 0.2 mmol/L increase in HDL-C was associated with a corresponding 9% reduction in risk for COVID hospitalization. A very similar pattern of association was apparent when COVID-19 mortality was the outcome of interest.
[–]EddieC[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 0 fun2 insightful - 1 fun - 5 months ago (0 children)
Nicotinic acid modulates intracellular calcium concentration and disassembles the cytoskeleton:
"In conclusion, the present study indicated that NA disassembles F-actin and microtubule systems, thereby blocking cytoskeleton-dependent intracellular transport."
[–]EddieC[S] 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 1 fun3 insightful - 2 fun - 5 months ago (0 children)
Niacin and its metabolites as master regulators of macrophage activation
"This study reveals for the first time that niacin and its metabolites possess antioxidant, reprogramming and antiinflammatory properties on human primary monocytes and monocyte-derived macrophages
Our findings imply a new understanding of the mechanisms by which niacin and its metabolites favor a continuous and gradual plasticity process in the human monocyte/macrophage system."
Niacin promotes cardiac healing after myocardial infarction through activation of the myeloid prostaglandin D2 receptor subtype 1:
"niacin increased PGD2 release in macrophages and shifted macrophages to M2 polarization both in vitro and in vivo by activation of DP1 and accelerated inflammation resolution in zymosan-induced peritonitis in mice.
Moreover, niacin treatment facilitated wound healing and improved cardiac function after MI through DP1-mediated M2 bias and timely resolution of inflammation in infarcted hearts. In addition, we found that niacin intake also stimulated M2 polarization of peripheral monocytes in humans. Collectively, niacin promoted cardiac functional recovery after ischemic myocardial infarction through DP1-mediated M2 polarization and timely resolution of inflammation in hearts."
[–]EddieC[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 0 fun3 insightful - 1 fun - 5 months ago* (0 children)
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system:
"These results identify niacin as a novel stimulator of macrophage/microglia phagocytosis in culture that acts through Hcar2 to upregulate CD36 culminating in myelin engulfment.
We conclude that niacin is not affecting circulating monocytes or the recruitment of macrophages/microglia into lesions in middle-aged animals, but that it promotes the intralesional phagocytic clearance of inhibitory myelin debris.
These results demonstrate that systemic treatment with niacin improves remyelination in the aging CNS, specifically in larger caliber axons that otherwise would not be remyelinated in aging after lysolecithin-induced demyelination.
Recently, it was shown that the ability for macrophages/microglia to export phagocytosed cholesterol is important for preventing the formation of cholesterol crystals and lysosomal rupture within macrophages/microglia in demyelinated lesions, and that this is reduced in aging.
As niacin has an extensive clinical history when used in dyslipidemia and is well tolerated, we examined whether systemic niacin treatment would be effective in improving the deficient remyelination observed in middle-aged mice.
Indeed, daily treatment with niacin enhanced myelin debris clearance, promoted OPC recruitment, as well as enhanced remyelination in lesions.
Altogether, these results identify a novel clinically approved medication that is able to significantly stimulate the innate immune system to enhance remyelination in the aging central nervous system.
These cells have also been shown to be detrimental through the secretion of free radicals and reactive oxygen species in addition to the release of potentially harmful pro-inflammatory cytokines .
As we found that niacin was able to significantly upregulate the secretion of several pro-inflammatory cytokines in vitro, including TNF-α which has been shown to be toxic in its soluble form through TNFR1 on oligodendrocytes , we were concerned that niacin treatment in middle-aged mice may exacerbate neurotoxicity. We do not think that this is the case, however, as we found no difference in axonal density with niacin treatment.
Furthermore, niacin treatment of mice induced with experimental autoimmune encephalomyelitis, an inflammatory model of MS, improved disease score and minimized the degree of inflammatory infiltrates in the CNS .
As pro-inflammatory macrophages/microglia have been previously shown to be important for remyelination [1, 26, 30], we may be harnessing the beneficial aspects of these cells without causing significant cell death or neurotoxicity.
It is also reassuring that we did not find elevation of pro-inflammatory monocytes in the circulation of niacin-treated mice, suggesting its safety in patients with inflammatory demyelinating diseases including MS.
Altogether, these results further emphasize the potential clinical utility of using niacin for remyelination.
We have identified niacin as a novel clinically approved medication that enhances macrophage/microglia phagocytosis of inhibitory debris, resulting in increased OPC recruitment and ultimately remyelination in the aging CNS."
Niacin and Covid
5 months ago * by EddieC to /s/Coronavirus from self.Coronavirus
The Covid Wall by EddieC in Coronavirus
Nature (Nov 2020): Post-lockdown SARS-CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China:
"All city residents aged six years or older were eligible and 9,899,828 (92.9%) participated. No new symptomatic cases and 300 asymptomatic cases (detection rate 0.303/10,000, 95% CI 0.270–0.339/10,000) were identified. There were no positive tests amongst 1,174 close contacts of asymptomatic cases. 107 of 34,424 previously recovered COVID-19 patients tested positive again (re-positive rate 0.31%, 95% CI 0.423–0.574%). The prevalence of SARS-CoV-2 infection in Wuhan was therefore very low five to eight weeks after the end of lockdown."
2003: An influenza pandemic occurs when a new influenza virus appears against which the human population has no immunity, resulting in several simultaneous epidemics worldwide with enormous numbers of deaths and illness.
2009: An influenza pandemic may occur when a new influenza virus appears against which the human population has no immunity
Feb 2010: A pandemic is the worldwide spread of a new disease.
An influenza pandemic occurs when a new influenza virus emerges and spreads around the world, and most people do not have immunity.
18 Reasons i Won't Be Getting A Covid Vaccine
Genetic vaccines, are they the new thalidomide?
Pfizer's 94% efficacy = Relative Risk Reduction
It's Absolute Risk Reduction = 0.7%
The Illusion of Evidence-based Medicine
The Nose is an excellent filter compared to the Mouth
Mask wearing could have the effect of increasing mouth breathing and lowering nose breathing, thereby bypassing the mucosal system.
Prof Sucharit Bhakdi -Blood Clots and Beyond
C.2.3 Reports / References
The Best Enemies Money Can Buy: An Interview with Prof Antony C Sutton by Dr Stanley Monteith (1980)
Italy: Early treatments for Covid has been approved by the Italian Senate
(Watch the interview (in English) with Dr. Stramezzi within the article)
The report presents the scientific basis, which the Italian Senate based on in their decision to authorize hydroxychloroquine for the early treatment of Covid-19.
Global Report 2019-nCov Summary of Facts https://online.anyflip.com/inblw/ufbs/mobile/index.html
Plandemic2: Indoctornation https://www.bitchute.com/video/4u7rt61YeGox/
Prof Sucharit Bhakdi: https://odysee.com/@TruthVault:0/Sucharit-Bhakdi---Full-Interview---Planet-Lockdown-:b
B.3.6. Reports / Findings:
Laboratories in US can’t find Covid-19 in one of 1,500 positive tests
B.3.5 On PCR test using High CTs (Cycle Thresholds or Amplification Cycles)
B.3.4 On PCR test as a Disease Diagnostic Tool for a Pandemic: Mass Test Contamination Risk for a sensitive molecule amplification & detection tool
B.3.3 On PCR test as a Disease Diagnostic Tool for Covid: The Test Assays
Independent peer review found major scientific flaws including no peer review and conflicts of interest
B.3.2 On PCR test as a Disease Diagnostic Tool:
a. Kary Mullis, its Inventor rejected the notion
b. Doctors were misled before - back in 2007
B.3.1 "Asymptomatic Spread"
A large JAMA meta-analysis of 54 studies with close to 80,000 participants found that the risk of virus transmission in households is 18% for symptomatic individuals but only 0.7% for truly asymptomatic individuals.
B.2.3 Masks Pollute
B.2.2. Masks for Mucosal Bypass and MORE Disease
B.2.1 Masks: For Compliance
Lockdowns had little or no efficacy (despite unconscionable harms)
30 published papers https://threadreaderapp.com/thread/1349478824606502912.html
Video: What Went Wrong in Canada's Pandemic Response? https://youtu.be/cKGr5Ks-euM
Lieutenant Colonel David Redman, former head of emergency management in Alberta, Canada presents a detailed explanation of where Canada went wrong in dealing with the pandemic:
E.3. Our Solutions: Decentering The Oligarchs: Co-opefy The Economy!
E.2. Our Solutions: Decenter the Jabs: Prophylaxis
E.1. Decenter the Fear Narrative: The Great Debate. End Lockdowns, End their Leverage,
C.2.2 The Jabs - Risks
C.2.1 The Jabs - "Benefits"
C.2. The Jabs
C.1 Jabs4All -> JabID -> ePanopticon / Surveillance Capitalism
Alison McDowell https://youtu.be/tMMlU4I_INs?t=425
B.4. Withhold Cures: For More Deaths
Multifaceted highly targeted sequential Multi-Drug Treatment of Early Ambulatory High Risk SARS-CoV2 Infection by Peter McCollough et al. https://rcm.imrpress.com/article/2020/2153-8174/RCM2020264.shtml
B.3. Mass Test Asymptomatics: For More Cases
B.2. Masks: For Compliance, Mucosal Bypass, Pollution
B.1. Discard Emergency Plan. Lockdown: To Crush Economy + Lives & Use as Their Leverage
A.2. "Reinfection" & "Asymptomatic Spread"
A.1. "Novel"+"No Immunity/Cure"= "PANDEMIC"
F. Other Resources & References
E. Our Solutions
D. The Perpetrators & Their Past
C. "The Solution"
A. "The Problem" - The Fear Narrative
The Covid Wall
The Great Debate on Covid-19
6 months ago * by EddieC to /s/Coronavirus from self.Coronavirus
**The Great Debate** by EddieC in Coronavirus
[–]EddieC[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 0 fun3 insightful - 1 fun - 6 months ago* (0 children)
The Solution: Make Direct Change Ourselves
All We Have To Do:
Affirm that We the 99.99% do not need the 0.01%
Unshackle ourselves & just walk away from them
Do our own Direct Change: ➡ Co-opefy The Economy
Appeal to the humanity of the Order Executors: Please side with the Truth. Be Human, Be Humane.