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[–]Kai_Decadence[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (1 child)

Thank you for this explanation. I will admit that there's a lot I didn't quite understand, namely the more scientific jargon but I think I'm understanding the main point which is essentially a perfectly health baby (in this case a male baby), if he does have any intervention of feminized neurons that can corrupt the brain, the testosterone will block and counter it. Is that correct?

[–]MarkTwainiac 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

Actually, I reject the idea of "feminized" neurons - I was just using the terminology of the theory we're discussing.

The general points I was trying to make are:

1) Pregnant women's bodies don't manufacture hormones in haphazard and unpredictable ways wholly unrelated to and independent of the embryos/fetuses they are gestating at the time.

2) The hormones that pregnant women's bodies make do not get dumped in undiluted, unchanged form directly into the circulatory systems of fetuses - which is a key part of what would have to happen according to the theory that says some male and female fetuses end up developing all the anatomy and physiology customary for their sex yet somehow also develop brains/neurons/nervous systems of the opposite sex.

3) The idea that males might end up with a "feminized" brain because of exposure to too much estrogen during gestation in utero assumes that male brains are not accustomed to, and built to handle, estrogen and therefore when exposed to "excess" estrogen in utero, they end up "feminized." When in fact, male brain development and activity in utero - and throughout the rest of life - seem to be heavily dependent on and shaped by estrogen - a hormone that males naturally make in various parts of their bodies (testes, adrenals, fat and the brain). The main way that males make estrogen is by turning some of the testosterone originally produced in their testes into estrogen through aromatization (the same process that takes place in the placenta during pregnancy with a female fetus to turn the mother's elevated testosterone into estrogen).

There is a complex interplay between the blood chemistry, and the hormones, of pregnant women and fetuses; but each fetus makes its own endogenous sex hormones from its own gonads (ovaries or testes) and its own adrenal glands and those internally-made hormones (and the fetuses own genetics) are the dominant drivers of sex development. In other words, fetuses are not mere repositories that maternal hormones are poured into. In fact, fetuses are not mainly repositories for maternal hormones at all.

How a fetus develops in terms of sex appears to be primarily and most strongly affected and determined by the endogenous hormones that each fetus makes by and for itself - along with the other aspects inherent to the fetus itself, such as whether it has male or female DNA in each cell, whether it has male or female hormone receptors and physiology, and the fetus's own genetic profile/DNA, which is different to the genetic profile/DNA of the mother.

There is no evidence that if/when the ovaries, adrenals and fat of pregnant women's bodies make hormones that are atypical for pregnant women carrying a fetus of either sex that this leads to atypical physical or psychological development in the fetus.

A maternal hormone "imbalance" such as low progesterone might lead a pregnant woman to have a miscarriage. Higher than usual maternally-generated testosterone has been shown to be linked to premature birth and smaller-than-usual, low birthweight babies - this is because high testosterone (especially chronically as in PCOS) diminishes the elasticity of the uterus, reducing its ability expand to typical full-size in the latest weeks of pregnancy. But there is no evidence whatsoever that maternal hormones that are atypical, imbalanced, or go up in down in various combinations during fetal development somehow end up inside fetuses where they cause "surges," "spikes" and "washes" of opposite-sex hormones to rain down on the fetal brain cells, leading the fetus to develop a brain-body mismatch that will evince many years later.

But assuming just for the sake of argument that a male baby could be born with a "feminized" brain because his mother had hinky hormones when he was developing in utero, then yes I would think the impact of what happened to that child in utero would definitely be largely or entirely counteracted by the fact that in the first year of life all male babies go through male mini puberty of infancy, a 4-7 months-long period when their testes pump out huge amount of testosterone and their entire bodies including their brains are bathed/steeped in all that T. As anyone who has ever been around babies knows, the development that they undergo week by week after birth is really dramatic - and post-natal development in infancy and early childhood is at least as important as pre-natal development, in fact probably more so.