A question for the community.

submitted by [deleted] from self.GenderCritical

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[–]lefterfield 9 insightful - 1 fun9 insightful - 0 fun10 insightful - 1 fun -  (3 children)

...Are you serious right now? Hormones do not work the same in male bodies as they do in female bodies, REGARDLESS of what type of hormones they are or if you are taking them at a comparable rate. TIMs interactions with estrogen can only tell us how males respond to estrogen. It tells us NOTHING about post-menopausal women.

Site your evidence that hormones literally remake physiology, and I'll dig up some studies that say that men remain men and have male symptoms - even after taking estrogen.

[–]RationalNeutral 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (2 children)

Something that might be useful for your search would be cross-sex heart transplants: https://www.reuters.com/article/us-heart-transplant-idUKTRE4AB7FK20081112

I would suspect that if your claim holds as much as you propose, that a cross-sex heart transplant would fail 100% of the time, but the above article is showing a 15% failure rate for men-only. Which, suggests there is something more complicated going on.

Transgender medical research MIGHT help shed light on the nuances that can decrease that kind of risk.

The article points out that Male hearts vary in size from Women's hearts, which, could be exactly influenced by sex hormones (and not genetic makeup) during puberty.

So then the question might get posed do we see the same kind of rate of failures for pre-puberty heart transplants?

That's your rabbit hole to go down though, seeing as at the moment I'm attempting to prove your point for you on the suspicion you aren't going to put in the effort.

[–]MarkTwainiac 3 insightful - 1 fun3 insightful - 0 fun4 insightful - 1 fun -  (1 child)

Most of the marked sex differences in human heart size - and thus differences in such factors as how hard & fast the heart has to work to pump the same amount of blood - occur as a result of the changes each sex goes through in the puberty of adolescence. In/after puberty, the left ventricle - the muscled chamber that pumps blood to the rest of the body - in males is 25-38% larger than in females. Prior to puberty, the difference is much smaller - males only have a 6% advantage prior to age 12 - but 6% is still not nothing.

https://pubmed.ncbi.nlm.nih.gov/7490158/

In pediatric heart transplants

Organ-recipient gender mismatch did not affect mortality for either male or female recipients, though gender-mismatched females had the worst survival compared to gender-matched males, who had the best survival (unadjusted HR 1.26, CI 1.07-1.49; p = 0.005). After adjustment for other risk factors affecting transplant mortality, female recipients had decreased survival compared to male recipients (HR 1.27, CI 1.12-1.44; p = 0.020) and gender matching had no effect. In conclusion, gender mismatch alone did not increase long-term mortality for pediatric heart transplant recipients. However, there may be additive effects of gender and gender matching affecting survival. There are insufficient data at this time

https://pubmed.ncbi.nlm.nih.gov/24119046/

[–]RationalNeutral 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

This is pretty consistent with my current understanding of the development of the human body at various ages. I don't have any issue with what you've presented here, other than I really wanted /u/lefterfield to show they are capable of doing the work or if they'd rather opine away.