At my worst drinking I was going through 3 handles of vodka a week, 120 standard drinks. I think I could keep up with Archer's drinking, but definitely not be the world's best spy. I developed a fatty liver from that, the precursor to cirrhosis, and had to dry out for a year (mostly) so it could heal. It's important for drunks to not only get regular liver enzyme tests but also an liver ultrasound since you can have stage 4 cirrhosis and normal enzymes.

I'm not supposed to drink vodka anymore but it's hard getting drunk on beer. The enzyme CYP2E1 is induced by chronic alcohol consumption and allows metabolizing ethanol to acetaldehyde at elevated ethanol concentrations pdf. Once it turns on it doesn't turn off again unfortunately.

Women are shockingly vulnerable to liver damage because they don't metabolize alcohol nearly as well as men. Mallory would almost certainly have died long, long ago.