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[–]weavilsatemyface 3 insightful - 1 fun3 insightful - 0 fun4 insightful - 1 fun -  (0 children)

The natives of South America, e.g. the Inca and Aztec empires, and dozens of other nations and tribes.

[–]Jiminy 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

Inca empire

[–]UncleWillard56 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

Everybody.

[–]Hematomato 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

Well, mostly it wasn't the Spanish personally. It was the smallpox the Spanish brought with them. Within a few years, 90% of everyone who had lived in South America was dead. Which left plenty of room for colonization.