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[–]MoutonelectriqueBland Straight ♀ 6 insightful - 2 fun6 insightful - 1 fun7 insightful - 2 fun -  (2 children)

Wait, a line of women? As in the mother was the carrier of the gene and the daughter developed CAIS?

Regardless, DSDs should not be used as a gotcha by men in party wigs and programmer socks.

[–]PenseePansyBio-Sex or Bust 6 insightful - 1 fun6 insightful - 0 fun7 insightful - 1 fun -  (0 children)

Well, those with CAIS can't be female. By definition. Even though you'd never know it without doing their karyotype, or giving them an X-ray.

CAIS = Complete Androgen Insensitivity Syndrome. Males whose bodies don't respond at all to masculinizing hormones (like testosterone) develop, from the time they're in utero, to appear female. But the key word is appear. Internally, their gonads are male-- instead of a uterus and ovaries, they have testes-- and their chromosomes are XY.

[–]spanishprofanity 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

We report herein a remarkable family in which the mother of a woman with 46,XY complete gonadal dysgenesis

A 46,XY mother who developed as a normal woman underwent spontaneous puberty, reached menarche, menstruated regularly, experienced two unassisted pregnancies, and gave birth to a 46,XY daughter with complete gonadal dysgenesis.

link