Would recommend Life is Strange! It's not perfect on the TQ front but is pretty good-- no trans characters, but it does kinda gives off the message at points, implicitly, that "everyone is bisexual," which is more than a little weird and I remember wondering about even back when I was more of a TRA and still in denial of my own same-sex attraction. But, for me it was a huge thing to play that game because it normalized being same-sex-attracted, and I'd never even thought about it as being a "normal" thing before. I also love the layout of the game, where you get to make choices about the plot and stuff. I need to play more games like that.

I keep hearing recommendations about Mass Effect and Dragon Age so those might be good to try, I see a few people here mentioning them as well.