I stand by my earlier comments. You have provided ZERO evidence or substantiation for your preposterous claim that

Some cells do fundamentally alter their function in response to exogenous hormones

Or for your other claims, such as that studying old men who take exogenous estrogen will provide valuable insight into female health and medical care. Coz there is no evidence or substantiation for the pie-in-the-sky malarkey you've made up out of whole cloth.

I did not say that transgender people are "misogynistic, male-centrist, male-supremacist." Nor would I, coz I know a number who aren't. I didn't say you are that way either. I said simply that the views you are espousing are "misogynistic, male-centrist, male-supremacist tosh." Look, see here:

you seem to be suggesting that post-menopausal women are physically the same as men. That's misogynistic, male-centrist, male-supremacist tosh.

You're the only one on this thread that has come out with ad hominems to cast aspersions on me as a person. And tellingly, you've used sexist ad hominems specifically meant to deride me and dismiss everything I say simply because I am a woman:

the level of contempt apparent in your comment makes it seem like your hatred of trangender people is really an outlet for a greater overarching hatred of men as a whole.

LOL, why don't you call me a frigid man hater & ball buster while you're all it!

BTW, whilst I was typing this one of my adult sons phoned. He had a good laugh at the idea that because I disagree with you and called you out on the misogynistic tosh you're spouting, it means I am full of "contempt" and "hatred" for everyone in an entire population group, and he wants you to know that you are absolutely brilliant in sussing out that my supposed contempt and hatred of all "transgender people"

is really an outlet for a greater overarching hatred of men as a whole.

As for your query,

To that end though, why do you apply that same hatred to TIFs? Lumping all transgender people together?

I don't understand. My comment didn't mention TIFs at all. The idea that I "apply that same hatred to TIFs" seems to come from the same place that you got your belief that when males take estrogen in hopes it will make them resemble women it causes their cells to "fundamentally alter their function." Which in polite circles is sometimes referred to as where the sun don't shine.

Finally, I don't get why in response to my statement that

HRT stands for "hormone replacement therapy." The HRT you are talking about was designed to replace the hormones that women's bodies naturally make, have the correct kind & amount of receptors for, and which female bodies have evolved to utilize in female-specific ways. When males take these hormones it's not "HRT"!

You would respond by saying

It's also not called Hormone Replenishment Therapy, but that is never the less what it does for post-menopausal women.

As if this is some gotcha. Comes across as mansplaining to me. Or maybe it's TIM transplaining; after all, replenish and replace have slightly different meanings.

But the real issue here is that, as you yourself say,

My current understanding is that the only major difference between each sex are cumulative changes as a function of time and certain life changes that are influenced by sex hormones.

Which is an admission that you are very poorly informed and have not kept up with the scientific literature on sex differences and development in human zygotes, embryos, fetuses, children and adults that's come out since the 1990s - and all that's been learned in the era of stem cell research.