WIKI TOOLS

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cancer

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Review, 2019: Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action https://doi.org/10.1080/10408398.2018.1555789

Review, 2018: Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy https://doi.org/10.3389/fmicb.2018.02020 "overview of how the bacterial signals and signatures may influence epithelial homeostasis and delineate mechanisms, which might be potential targets for therapy"

Review, 2018: Microbiota in cancer development and treatment https://link.springer.com/article/10.1007/s00432-018-2816-0 "In this review, the role of microbiota is explained in carcinogenesis, mechanisms of microbiota-mediated carcinogenesis, and role of gut microbiota in modulation of cancer therapy"

Researchers discover that a bacterial protein promotes cancer (Dec 2018, mice) https://medicalxpress.com/news/2018-12-bacterial-protein-cancer.html - Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperon protein, has broad oncogenic properties https://doi.org/10.1073/pnas.1815660115

A gut punch fights cancer and infection. Microorganisms in the human gut can affect immune-system cells. Gut bacterial strains have been discovered that boost immune cells that have cell-killing capacity and that can target cancer and protect against infection. (2019): https://www.nature.com/articles/d41586-019-00133-w

Brain:

New study finds Zika vaccine can treat brain tumors. The virus infection triggered a strong antiviral response, which elicited inflammation that killed GBM stem cells. Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143740/

Bile:

Cancer is not directly caused by the bile, but by the dysbiosis the bile (secondary bile acids) causes: http://onlinelibrary.wiley.com/doi/10.1002/ijc.30643/abstract - Secondary bile acid‐induced dysbiosis promotes intestinal carcinogenesis (2017).

Colorectal:

Review, 2018: Colorectal carcinogenesis: an archetype of gut microbiota–host interaction https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145524/

Review, 2018: Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer https://www.karger.com/Article/FullText/494052

Single probiotic supplement (Lactobacillus helveticus NS8) suppresses colitis‐associated colorectal tumourigenesis by modulating inflammatory development and microbial homeostasis (mice, 2018): https://doi.org/10.1111/jgh.14516

Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin (2018): http://dx.doi.org/10.1136/gutjnl-2018-317200

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice (2018): https://doi.org/10.1053/j.gastro.2018.12.003

In conclusion, this study suggests that local microbiome dysbiosis may contribute to functional changes at the cancer sites. Results from the current study also contributed to the list of metabolites that are found to differ between normal and tumor sites in CRC (2018): https://doi.org/10.1371/journal.pone.0208584 Metabolomics and 16S rRNA sequencing of human colorectal cancers and adjacent mucosa.

Drugs:

Gut microbiome affects efficacy of cancer drugs: http://www.nature.com/nrgastro/journal/vaop/ncurrent/full/nrgastro.2017.20.html - http://www.umassmed.edu/news/news-archives/2017/04/examining-the-role-of-the-microbiome-in-the-effectiveness-of-colorectal-cancer-treatment/

Researchers found certain bacteria hiding out among cancer cells, gobbling up chemotherapy drugs intended to demolish tumors. https://arstechnica.com/science/2017/09/see-jerkface-bacteria-hiding-in-tumors-and-gobbling-chemotherapy-drugs/

Chemotherapy-driven dysbiosis in the intestinal microbiome. (2015): https://www.ncbi.nlm.nih.gov/pubmed/26147207 - https://www.drperlmutter.com/chemotherapy-microbiome/

Gastric:

Review, 2018: Microbial community reshaped in gastric cancer https://www.europeanreview.org/article/16260 "Currently, it appears disrupted homeostasis and inter-individual variations of gastric microbiota are involved in cancer development"

Genitourinary:

Review, 2019: The Microbiome and Genitourinary Cancer: A Collaborative Review https://doi.org/10.1016/j.eururo.2018.12.043 "There is preliminary evidence to implicate the members of the genitourinary microbiota as causative factors or cofactors in genitourinary malignancy. Clinical trials, such as fecal microbiota transplant to increase the efficacy of immunotherapy, are currently underway"

Liver:

Review, 2017: The gut microbiome and liver cancer: mechanisms and clinical translation: /r/HumanMicrobiome/comments/6m0rms

Bile Acids, the Microbiome, Immunity, and Liver Tumors (2018): https://www.nejm.org/doi/10.1056/NEJMcibr1807106 Bile acids affect the expression of a chemokine ligand by liver sinusoidal endothelial cells, which in turn affects the extent to which a type of natural killer cell is present in and diminishes the burden of hepatocellular carcinomas in a mouse model of the disease.

Study finds gut microbiome can control antitumor immune function in liver. "if you treat mice with antibiotics and thereby deplete certain bacteria, you can change the composition of immune cells of the liver [due to bile acid changes], affecting tumor growth in the liver" (2018): /r/HumanMicrobiome/comments/8m4fh4

Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma (2019): https://doi.org/10.1186/s13099-018-0281-6

Lung:

Bacteria promote lung tumor development, study suggests. https://news.mit.edu/2019/bacteria-promote-lung-tumor-development-0131 Commensal Microbiota Promote Lung Cancer Development via γδ T Cells (Jan 2019). https://doi.org/10.1016/j.cell.2018.12.040 "were able to greatly reduce the number and size of the lung tumors by treating the mice with antibiotics or blocking the immune cells stimulated by the bacteria"

Modulation of Pulmonary Microbiota by Antibiotic or Probiotic Aerosol Therapy: A Strategy to Promote Immunosurveillance against Lung Metastases (mice, 2018): https://doi.org/10.1016/j.celrep.2018.08.090 "Aerosolized Lactobacillus rhamnosus strongly promoted immunity against B16 lung metastases as well. Furthermore, probiotics or antibiotics improved chemotherapy activity against advanced B16 metastases"

Alterations of fecal bacterial communities in patients with lung cancer (2018): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220220/ "To our knowledge, this is the first study to evaluate the correlations between certain specific bacteria and inflammatory indicators"

Oral:

"Our current theory is that your gut bacteria determine whether your oral bacteria cause cancer" (2017): https://www.irishtimes.com/news/science/bugging-cancer-gut-bacteria-and-the-big-c-1.3096035

Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus (2019): https://doi.org/10.1002/ijc.32152

Pancreas:

Gut bacteria determine speed of tumor growth in pancreatic cancer. The population of bacteria in the pancreas increases more than a thousand fold in patients with pancreatic cancer, and becomes dominated by species that prevent the immune system from attacking tumor cells. (2018): /r/HumanMicrobiome/comments/86btcd

Tongue microbiome could help identify patients with early-stage pancreatic cancer (2019): https://www.eurekalert.org/pub_releases/2019-01/tfg-tmc012519.php - Tongue coating microbiome data distinguish patients with pancreatic head cancer from healthy controls: https://tandfonline.com/doi/full/10.1080/20002297.2018.1563409

Fecal Microbiota Transplant:

Mayo Clinic study shows FMT is safe in cancer patients: https://www.youtube.com/watch?v=8_RWsL_2Foo

Fecal Transplant Heals Colitis [in 2 cancer patients] Caused by Immunotherapy (2018): https://www.the-scientist.com/news-opinion/fecal-transplant-heals-colitis-caused-by-immuno-65074

Replacing laboratory mice's gut microbiomes with the microbial communities of their wild counterparts alters the lab animals' immune systems and boosts their resistance to colorectal cancer development and influenza http://cancerdiscovery.aacrjournals.org/content/early/2017/11/14/2159-8290.CD-NB2017-162

Immunotherapy:

Review, 2018: Roles of intestinal microbiota in response to cancer immunotherapy https://doi.org/10.1007/s10096-018-3374-8

Review, 2018: The intimate relationship between gut microbiota and cancer immunotherapy https://doi.org/10.1080/19490976.2018.1527167


revision by MaximilianKohlerreads microbiomedigest.com daily— view source