Testosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline (Jan 2019) "Early-life exposure to doxycycline shows negative outcomes of testis health in later-life. Early-life exposure to low-dose of doxycycline associates with increased risk of obesity." by MaximilianKohler in HumanMicrobiome

[–]MaximilianKohler[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

I'm not sure. I'm not knowledgeable enough on that to comment.

But I am very knowledgeable on antibiotics and the microbiome, and to me antibiotics seem like a much bigger threat/harm.

Testosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline (Jan 2019) "Early-life exposure to doxycycline shows negative outcomes of testis health in later-life. Early-life exposure to low-dose of doxycycline associates with increased risk of obesity." by MaximilianKohler in HumanMicrobiome

[–]MaximilianKohler[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

That's a misleading statement on your part.

You have to look at the rates of vaccine injury vs rates of injury from the diseases the vaccines protect against. You also have to look at the severity of the injuries.

I think the science backing the gut microbiome as the causative factor is the strongest: https://old.reddit.com/r/HumanMicrobiome/wiki/intro#wiki_autism.3A

Though the gut microbiome also impacts vaccine efficacy & immune system: https://old.reddit.com/r/HumanMicrobiome/wiki/immunesystem

Testosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline (Jan 2019) "Early-life exposure to doxycycline shows negative outcomes of testis health in later-life. Early-life exposure to low-dose of doxycycline associates with increased risk of obesity." by MaximilianKohler in HumanMicrobiome

[–]MaximilianKohler[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

You're misinformed about vaccines. You have a tremendous amount of information at your fingertips via a simple web search. Use that instead of making ignorant guesses.

There are some knowledge resources in these comments: https://archive.fo/MpwmK#selection-2331.8-2335.0

Testosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline (Jan 2019) "Early-life exposure to doxycycline shows negative outcomes of testis health in later-life. Early-life exposure to low-dose of doxycycline associates with increased risk of obesity." by MaximilianKohler in HumanMicrobiome

[–]MaximilianKohler[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

EDC = endocrine disrupting chemical. https://www.who.int/ceh/risks/cehemerging2/en/

Highlights

• Doxycycline may be EDCs through mitochondrial dysfunction mechanism cause endocrine disruption.

• Early-life exposure to doxycycline shows negative outcomes of testis health in later-life.

• Early-life exposure to low-dose of doxycycline associates with increased risk of obesity.

Abstract

Veterinary tetracyclines drugs are emerging organic pollutants detected at high concentrations in the urine of school children and a potential public health risk. However, the implications of early-life exposure to tetracyclines on testosterone production, being new endocrine disruptors, remain unknown. We investigated whether the early-life exposure to low-doxycycline, a widely used tetracycline, on mitochondria dysfunction and testosterone disruption in Leydig cells in vitro and in vivo. Next, we determined the mRNA levels of testis cells markers for early-life exposure to low-doxycycline outcomes of testis health in later-life. Finally, we compared the weight gain performance exposed to low- and therapeutic-doses through 15 weeks and examined the role of the microbiota during development. Our results showed doxycycline disturbed steroidogenesis process by mitochondrial dysfunction in mouse Leydig tumor cell line (MLTC-1) cells in vitro. Leydig cells mitochondrial function was disrupted by early-life exposure to low-doxycycline from birth to 49 days, causing testosterone deficiency and decreased quality of the sperm in mice. Early-life exposure to low-doxycycline significantly altered the mRNA levels of key genes in Leydig cells (Cyp11a1, Cyp17a1 and 17β-HSD) and spermatogenic cells (Grfal, Plzf, and Stra8) in later-life in mice. Subchronic low- and therapeutic-doses doxycycline changed gut microbiota differences in diversity reduction and compositional alteration. Moreover, the weight gain effects of doxycycline were only observed in low-dose in male mice. Overall, these results provide insight into the effects of doxycycline on both testis and gut microbiota health. The results provide insight that environmental antibiotics are needed additional research to classify as ECDs.

Welcome to Saidit.net! by magnora7 in SaidIt

[–]MaximilianKohler 4 insightful - 1 fun4 insightful - 0 fun5 insightful - 1 fun -  (0 children)

Subs dominating topics is part and parcel of the sub system, it's how it works, for better or worse.

We have the random sub button, that can help people discover stuff. Also the /all page. What do you imagine other than that?

I think what I quoted Darto doing seems pretty easy and great.

For example, instead of subscribing people to all subs, have a page of categories, so when they choose "science" they get a page full of science-related subs to choose from. Probably with the name of each sub should be a short description that can be used to differentiate them.

Subs dominating topics is part and parcel of the sub system, it's how it works, for better or worse.

I think this is a pretty major flaw of reddit that can and should be addressed.

RES for saidit - supports Chrome, Opera, Firefox, and Edge by magnora7 in SaidIt

[–]MaximilianKohler 3 insightful - 1 fun3 insightful - 0 fun4 insightful - 1 fun -  (0 children)

What do you want to use the most from RES?

I guess mostly the tags and vote tallies on individual users. I use the macros a lot on reddit.

I don't really notice stuff till it's gone, but looking through the settings the formatting links is another. New comment count + highlighting of new comments.

/r/toolbox addon is just as important as RES IMO.

Guide to probiotics. by MaximilianKohler in HumanMicrobiome

[–]MaximilianKohler[S] 3 insightful - 1 fun3 insightful - 0 fun4 insightful - 1 fun -  (0 children)

Fixed now.

Welcome to Saidit.net! by magnora7 in SaidIt

[–]MaximilianKohler 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

On this page https://saidit.net/subs it would be nice to have a "1-50 of 226". As is, there's only a "next" button with no indication of how many pages or total subs.

Also, any plans on preventing one sub from dominating a topic? Such as /s/science vs /s/sciences? On reddit, the latter one would virtually never be able to compete.

Darto for example is trying to address this via:

through a Discover page where users can find new and trending communities, a global tag system so one community doesn't own a specific topic

Also, I think somewhere else you linked to a page of your "to do" list, but maybe add that link to this OP?

RES for saidit - supports Chrome, Opera, Firefox, and Edge by magnora7 in SaidIt

[–]MaximilianKohler 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

For firefox, you have to do it every time you restart your browser huh? It does seem to be temporary. /u/d3rr

Guide to probiotics. by MaximilianKohler in HumanMicrobiome

[–]MaximilianKohler[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

Thanks :)

I've been following the microbiome literature very closely, and the wiki here is very extensive as well.

Guide to probiotics. by MaximilianKohler in HumanMicrobiome

[–]MaximilianKohler[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

I copied over the css from the reddit sub. I've changed that line. Did it fix it?

Gut feeling: study links depression to digestive bacteria by useless_aether in HumanMicrobiome

[–]MaximilianKohler[M] [score hidden] stickied comment (0 children)

Someone reported this as spam. I don't think it's spam, but it's better to use sites that directly link to the study, or share the study in the comments.

Saidit.net — Feb 13, 2019 — New Rule: Sub moderator logs are now publicly available by magnora7 in SaidIt

[–]MaximilianKohler 6 insightful - 1 fun6 insightful - 0 fun7 insightful - 1 fun -  (0 children)

Great, thanks!

Guide to probiotics. by MaximilianKohler in HumanMicrobiome

[–]MaximilianKohler[S,M] [score hidden] stickied comment (0 children)

List of source of strains:

EDIT: here's a project with a list of strains that /u/markus_naslund has started: https://old.reddit.com/r/HumanMicrobiome/comments/aceyab/commercially_available_probiotic_strain_database/

You can PM me for additions so I can keep this updated. If google will not tell you the source you'll have to contact the company and ask. The vast majority are food-sourced so it might be easier to just keep a list of human-sourced.

We have to keep in mind that there is a difference between strains sourced from human stool (which may be transient environmental microbes) and strains sourced from the intestinal wall (which are more likely to be host native). Then we have to keep in mind that not every human-sourced probiotic will be beneficial, or significantly so. Which is why I primarily focus on FMT, and wait till there are proven benefits for new/old strains and simply list the main ones here.

Human-sourced:

Food-sourced:

Unknown source:

Reuteri pearls: https://archive.is/luQNi