I recall a talk by a researcher who claimed that prior to the introduction of seed oil products in the very early 1900s (or maybe it was the late 1800s) western medicine didn't even have a category called Heart Disease. There were, of course, congenital circulatory system issues and other diseases of the heart but they were relatively rare. Somebody dying of a heart attack due to clogged arteries was literally unheard of.

In the space of about 10 years Heart Disease became a major killer and since then everyone has just accepted it as a fact of life. But it was Crisco that killed them.