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Ivermectin Table of Contents

Ivermectin Table of Contents

Template for reddit wiki editing copied from: https://gist.github.com/anonymous/5928646

About this Wiki

Changes

Dec 20, 2022 - added some links to papers to "Ivermectin for Multiple Sclerosis (MS), Lyme disease and for nerve remyelination" section

Oct 5, 2023 - added anosmia reversal anecdote from reddit user u/007_jmp

Oct 3, 2023 - added "Ivermectin and post-covid19 Anosmia reversal - long term anosmia reversal - months to years"

Aug 25, 2023 - added "Sodium butyrate topical application and Psoriasis"

Aug 14, 2023 - added "Ivermectin - taking on empty stomach - or taken with fatty meal - and the impact on anti-IVM trials"

Aug 14, 2023 - added "Ivermectin - dosing at 0.2mg/kg bodyweight - or 0.4mg/kg bodyweight - and the impact on anti-IVM trials"

Aug 14, 2023 - added "Ivermectin - dosing by weight - or dosing non-linearly - and the impact on anti-IVM trials"

Aug 14, 2023 - added "Ivermectin - beyond dosing by weight - dosing by body mass index (BMI) - and the impact on plasma levels"

July 18, 2023 - added "Ivermectin - availability in various countries"

May 18, 2023 - added "Ivermectin and gum disease"

May 7, 2023 - added Ivmmeta.com - and c19ivermectin.com censorship - reddit-wide blacklisting" - split into separate topic

May 4, 2023 - added the reddit comment text directly to the section "Ivermectin and mold toxicity" for easier reading

May 2, 2023 - added Dr Dave Cartland - Gettr url

Apr 22, 2023 - added additional descriptions of Ivermectin and visual disturbances in the section "Ivermectin - Dizziness, visual disturbances" - by u/SchlauFuchs on reddit

Mar 25, 2023 - added "Some more info on diagnosing DKA"

Feb 23, 2023 - added additional descriptions of Ivermectin and visual disturbances in the section "Ivermectin - Dizziness, visual disturbances" - by Dr Jackie Stone (Zimbabwe)

Feb 7, 2023 - added additional descriptions of Ivermectin and visual disturbances in the section "Ivermectin - Dizziness, visual disturbances" - by u/RestingLogo on reddit

Jan 14, 2023 - added "Ivermectin and Fatty Liver Disease"

Jan 14, 2023 - added to "Early Treatment situation in UK"

Jan 11, 2023 - added Dr Tess Lawrie Twitter account

Jan 10, 2023 - added "Ivermectin and Herpes Simplex Virus type 1 (HSV-1)"

Jan 10, 2023 - added "Ivermectin and Herpes zoster virus (shingles)"

Jan 10, 2023 - added "Ivermectin and Epstein-Barr Virus (EBV)"

Jan 10, 2023 - added anecdote to "Ivermectin and mold toxicity"

Jan 7, 2023 - added Dr Mollie James jamesclinic.com website

Dec 31, 2022 - added Peter Pham anecdote on Ivermectin reversing post-covid19 anosmia in 6 people

October 5, 2022 - added "Fluvoxamine - treatment for covid19 - early history"

October 5, 2022 - corrected "Dr Angela Rieirsen" to "Dr Angela Reiersen"

September 16, 2022 - added "Long Haulers Treatments - Survey of Anosmia treatments - on Reddit"

September 16, 2022 - added "Long Haulers Treatments - React19 survey of treatments for long haulers and vaccine long haulers"

September 16, 2022 - added "Long Haulers Treatments - LongCovidPharmD (organichemusic on Twitter) survey of treatments for long haulers"

September 16, 2022 - added "Long Haulers Treatments - Nattokinase, Serrapeptase, Lumbrokinase"

September 16, 2022 - added "Ivermectin and migraines"

September 16, 2022 - for "Ivermectin - Dizziness, visual disturbances" - added additional explanation for what "visual disturbances" look like

August 4, 2022 - added "Early Treatment Protocols - my simplified protocol for early treatment and preventing long haulers"

July 31, 2022 - added "Twitter and LinkedIn censorship - Dr Darrell DeMello (Mumbai, India)"

July 31, 2022 - added "Twitter and LinkedIn censorship - Dr Robert Malone"

July 27, 2022 - added "Ivermectin - assessing the quality of tablets ordered online from other countries"

July 24, 2022 - added "NAC for COVID-19 patients with cancer"

July 24, 2022 - added "Ivermectin and Dengue - antiviral activity"

July 24, 2022 - added "Ivermectin and Dengue - early treatment for Dengue"

June 17, 2022 - added "Dr Paul Marik invaluable advice in appearances on Dr Been show"

June 17, 2022 - added "Dr Paul Marik (FLCCC co-founder)"

June 17, 2022 - added "NAC for Tylenol (Acetaminophen, Paracetamol) overdose - preventing and reversing organ damage (liver, kidneys)"

June 17, 2022 - added "NAC for MRI Contrast Agent Injury - reversing organ damage"

June 17, 2022 - added "NAC for Heat Stroke - reversing organ damage in heatstroke"

June 17, 2022 - added "NAC for Fatty Liver Disease - reversing organ damage"

June 17, 2022 - added "NAC impact on stomach "spare tire" and systemic inflammation"

May 13, 2022 - added to "Ivermectin - regions offering over the counter (OTC)" section

May 13, 2022 - added to "Pharmacies which fulfil Ivermectin prescriptions" section

Apr 29, 2022 - added Dr Syed Haider's new YouTube and Odysee channels

Apr 26, 2022 - added new Famotidine paper reference

Apr 24, 2022 - added to pinned posts

Apr 15, 2022 - added some links to papers to "Ivermectin for Multiple Sclerosis (MS), Lyme disease and for nerve remyelination" section

Apr 15, 2022 - added "Dr Steven Phillips (author of bestseller 'Chronic')" section

Mar 26, 2022 - cleaned up/reorganized "Links to Wiki", "Corrections and Feedback", "Archives of .." sections

Mar 20, 2022 - added "Canadian Covid Care Alliance" section

Mar 20, 2022 - added to meta-analysis websites: c19ivermectin.com, c19vitamind.com, c19hcq.com

Mar 20, 2022 - added website and twitter info to "Dr Tina Peers (UK)" section

Mar 20, 2022 - added "Early Treatment situation in UK" section

Mar 20, 2022 - added "Early Treatment situation in Canada" section

Mar 19, 2022 - added "YouTube censorship - Sky News Australia" section

Mar 19, 2022 - added "YouTube censorship - Sen Ron Johnson" section

Mar 19, 2022 - added "YouTube censorship - Kim Iversen (journalist - The Hill)" section

Mar 19, 2022 - added to "Early Treatment discussion - censorship by YouTube" section - YouTube Terms of Service mentions Ivermectin and HCQ by name

Mar 19, 2022 - added Dr Been (Dr Mobeen Syed) section - that mentions his substack etc.

Mar 19, 2022 - added "Ivermectin - regions offering over the counter (OTC)" section

Mar 16, 2022 - added "Ivermectin and post-covid19 Anosmia/Fatigue reversal" section

Mar 16, 2022 - added Ivermectin and post-vaccine hearing loss (in one ear) section

Mar 6, 2022 - added Ivermectin and Vitiligo section

Mar 6, 2022 - added Ivermectin and Scabies section

Mar 6, 2022 - updated Ivermectin and Rosacea section

Mar 3, 2022 - added to pinned posts

Mar 1, 2022 - added Dr Darrell DeMello Twitter link and contact info to Early Treatment Doctors section

Mar 1, 2022 - added Dr Syed Haider Twitter links

Mar 1, 2022 - added Dr AK Chaurasia info

Feb 28, 2022 - added Alternatives to TNI-signatory Media Platforms section

Feb 20, 2022 - added Books section

Nov 23, 2021 - replaced www.reddit.com links by old.reddit.com links

The reddit quarantine on r/ivermectin has placed some roadblocks to easy viewing of content on r/ivermectin. One is that the wiki is no longer easily visible. And users not logged into reddit are asked to log in before viewing the sub-reddit.

However, if an old.reddit.com version of the url is used, then non-logged-in viewers don't have to log in - but just have to click on the "Continue" button.

Dec 20, 2022 - one other restriction due to quarantine seems to be that if you tag (i.e. mention a user) in a comment - they don't seem to get a ntification about it.

https://old.reddit.com/r/ivermectin/comments/zqffvi/quarantine_disadvantages_you_cant_tag_users_they/

Links to Wiki

To mention this wiki to others, use this mirror link:

https://saidit.net/s/Ivermectin2/wiki/index

The reddit link for this wiki is no longer visible (one of the negatives of being quarantined by reddit - see below).

The direct link to this wiki on Reddit is:

https://old.reddit.com/r/ivermectin/wiki

https://old.reddit.com/r/ivermectin/about/wiki/index

NOTE: after decision by reddit to quarantine r/ivermectin (under pressure from PowerMod attack), the wiki for r/ivermectin became inaccessible (even though it exists and is being updated).

For this reason, the mirror on saidit.net should be used when suggesting wiki to others.

Mirror of wiki on Saidit.net - s/Ivermectin2:

https://saidit.net/s/Ivermectin2/wiki/index

Historical note: a copy of the wiki was placed on the Saidit.net - s/Ivermectin forum initially - but since it may have been controversial for that forum (we are not top mods there, but secondary mods), it was removed from there, and placed in the s/Ivermectin2 forum (where we are top mods).

Corrections and Feedback

Message the moderators for r/ivermectin on reddit.

If you are on Twitter, send a tweet to:

https://www.twitter.com/stereomatch2

Instructions for Moderators

Historical note: the wiki was announced on r/ivermectin here:

https://old.reddit.com/r/ivermectin/comments/oh7xfw/added_a_wiki_for_rivermectin_for_organizing_the

Asked for viewer review of wiki content (July 27, 2021):

https://old.reddit.com/r/ivermectin/comments/oswmfb/factchecking_the_wiki_updated_the_wiki_still

Moderators: this wiki was enabled for this sub-reddit using Mod Tools - Community Settings - change "Disabled" to "Mods only" for now - then Mod Tools - Community Appearance - Menu Links - Wiki - turn this On - now shows Wiki button at top.

TODO: search for TODO below for the areas still needing clarification.

Moderators and editors: please keep multiple copies of your edits as text files on your computer/phone, since content here may be inadvertently deleted by another editor - so keep your own copies for later reconcilation/merging.

History of pinned (stickied) posts on r/ivermectin

You can only have 2 stickied posts on reddit - so sometimes it is used to highlight Dr Tess Lawrie's GoFundMe page, but then switches to highlight some new podcast, and then switches back.

https://old.reddit.com/r/ivermectin/comments/k4824u/where_to_find_the_results_of_ivermectin_trials/ Where to find the results of ivermectin trials quickly and easily Posted by u/TrumpLyftAlle

https://old.reddit.com/r/ivermectin/comments/lk54ix Anybody know a doctor who I can get a prescription from in STL Posted by u/Jolly_Difficulty3617

https://old.reddit.com/r/ivermectin/comments/mg00ag Petition: Provide Access and Information on Ivermectin; Stop the COVID-19 Deaths Now Posted by u/Inner_G84

https://old.reddit.com/r/ivermectin/comments/mq1ima Help us get life-saving drug (ivermectin) approved for covid-19... Dr.Tess Lawrie & E-BMC GoFundMe Posted by u/Inner_G84

2021-05-14 (?):

https://old.reddit.com/r/ivermectin/comments/nbez5n Goa (India) residents mass administration of Ivermectin - Frequently Asked Questions Posted by u/stereomatch

Archive of above webpage:

https://archive.md/J8ybq

2021-05-31 (?):

https://old.reddit.com/r/ivermectin/comments/nofm87 Indian Bar Association serves legal notice upon Dr. Soumya Swaminathan, the Chief Scientist, WHO Posted by u/Inner_G84

Archive of above webpage:

https://archive.md/htW4w

Also see:

Background on legal notice in Indian court against WHO Chief Scientist Dr. Soumya Swaminathan:

https://old.reddit.com/r/ivermectin/comments/nofm87/indian_bar_association_serves_legal_notice_upon/h00ej70

Archive of above webpage:

https://archive.is/GTjq9

2021-06-02:

https://old.reddit.com/r/ivermectin/comments/npyafw Dr. Pierre Kory LIVE NOW at the Dark Horse Podcast: COVID, Ivermectin, and the Crime of the Century: DarkHorse Podcast with Pierre Kory & Bret Weinstein Posted by u/giddyrobin

2021-06-07:

https://old.reddit.com/r/ivermectin/comments/nscleb/gavi_the_vaccine_alliance_is_paying_for_adwords Gavi, the Vaccine Alliance, is paying for AdWords against Ivermectin Posted by u/HeeeeeyNow

Archive of above webpage:

https://archive.ph/liXxi

2021-06-26:

https://old.reddit.com/r/ivermectin/comments/o67v62 Joe Rogan Experience #1671 - Bret Weinstein & Dr. Pierre Kory Posted by u/AlrightyAlmighty

2021-07-09:

https://old.reddit.com/r/ivermectin/comments/ogij5u/another_fascinating_effect_of_ivermectin_faster/h4mcviv Announcing World Ivermectin Day! Posted by u/EbMCsquared

2021-08-25:

https://old.reddit.com/r/ivermectin/comments/pb9h1s/time_to_tighten_comment_mod_rules/ Time to tighten comment mod rules? Posted by u/akaariai

2021-08-29:

https://old.reddit.com/r/ivermectin/comments/pdnodz/anatomy_of_a_powermod_hit_august_25_2021_5pm_est/ Anatomy of a Powermod Hit (August 25, 2021 - 5pm EST) - Powermods at Reddit, Brigading, the revolving door at the FDA/NIH vs. on the ground clinicians/ICU specialists like the FLCCC - IVM use up 10-20x but poison center calls up 5x - why the hue and cry - is Merck's Molnupiravir approval imminent? Posted by u/stereomatch

Archive of above webpage:

https://archive.ph/35blb

NOTE: this story was featured in Forbes as Editor's Pick (though still had some inaccuracies):

https://www.forbes.com/sites/roberthart/2021/09/02/internet-vigilantes-are-fighting-ivermectin-misinformation-with-memes-and-explicit-horse-cartoons/ Internet Vigilantes Are Fighting Ivermectin Misinformation With Memes And Explicit Horse Cartoons Sep 2, 2021

Archive:

https://archive.is/VdQur

2021-08-31:

https://old.reddit.com/r/ivermectin/comments/pfa1lt/newsweek_has_4_articles_on_ivermectin_august_31/ Newsweek has 4 articles on Ivermectin (August 31, 2021) - if there was ever a sign that we are reaching a tipping point this is it Posted by u/stereomatch

2021-09-14:

https://old.reddit.com/r/ivermectin/comments/podm0e/international_covid_summit_2021_rome_italy/ International Covid Summit 2021 - Rome, Italy - ongoing 3 day event (Sept 12-14, 2021) - Dr Robert Malone, Dr George Fareed, Dr Bruce Patterson and others from FLCCC, AAPS, and independent researchers and physicians - Day 2 includes a presentation to Italian government officials

2021-10-21:

https://old.reddit.com/r/ivermectin/comments/qca4ho/reddit_admins_require_that_we_limit_discussion_on/ Reddit admins require that we limit discussion on veterinary forms of ivermectin - this is also a good signal of further restrictions to come - so a good time to start posting new content to saidit forums

Mar 3, 2022:

https://old.reddit.com/r/ivermectin/comments/t4x3w6/large_study_retrospectively_comparing_outcomes Large study retrospectively comparing outcomes data for Remdesivir vs Ivermectin - finds Ivermectin had 1/3 the mortality vs those given Remdesivir, after propensity score matching (Feb 28, 2022)

Mar 26, 2022:

https://old.reddit.com/r/ivermectin/comments/tnw90n/is_the_rivermectin_wiki_gone/ Is the r/ivermectin wiki gone?

Apr 24, 2022:

https://old.reddit.com/r/ivermectin/comments/u90dje/survey_of_anosmia_treatments_ivm_or_other/ Survey of Anosmia treatments - IVM or other treatments - share your experiences reversing covid19 anosmia (taste/smell loss) esp. if reversal was immediately after treatment start (i.e. looks like treatment helped immediately) (April 21, 2022)

Archive of above webpage:

https://archive.ph/ZB9qV

About r/Ivermectin and r/gettingIvermectin

Archives of r/Ivermectin

u/ivm_archive has archived the content in r/ivermectin:

https://old.reddit.com/r/ivermectin/comments/n03x8m/a_complete_archive_of_this_community_including

A complete archive of this community. Including every single comment, post and link that has ever been posted here. Just in case this community ever disappears.

April 28, 2021

The entire archive can viewed online here: https://ivm.netlify.app.

The download link to save the archive to your computer can be downloaded here: https://disk.yandex.com/d/hTXiAeObkoBNDw

If you decide to download the archive to your computer, here is how it works:

Download the zip file.
Double click on the zip file and extract it. If you don't extract it and just start clicking the files, it won't work.
In the extracted folder (called Ivermectin) click on index.html.
It should now open the archive in your browser. If it doesn't try right clicking on index.html and search for something along the lines of "Open With" and then select your browser.

Update: August 25, 2021

https://old.reddit.com/r/ivermectin/comments/pbe9o5/updated_a_full_downloadable_archive_of_this

[Updated] A full downloadable archive of this subreddit, including every submission and comment ever posted.

August 25, 2021

Download zip file: https://www.swisstransfer.com/d/d496dbb1-36a2-4936-a5fd-d4e3473face9

Here's how you can use the archive:

Download the zip file.
Double click on the zip file and extract it. If you don't extract it and just start clicking the files, it won't work.
In the extracted folder (called Ivermectin) click on the folder Index and then on ivermectin_date.html.
It should now open the archive in your browser. If it doesn't try right clicking on ivermectin_date.html and search for something along the lines of "Open With" and then select your internet browser.

u/ivm_archive reports also:

I will be providing a copy that is viewable online too, and different mirrors. Please give me an hour or so to update this post.

For the nerds like me: there is also a database called ivermectin.db file in the archive, feel free to use it however you'd like.

Archives of r/gettingIvermectin

u/ivm_archive has recovered the information in r/gettingIvermectin (which was removed by reddit, after reddit banned u/TrumpLyftAlles - another casualty of the Trusted News Initiative (TNI) impact on censorship rules at social media companies):

https://old.reddit.com/r/ivermectin/comments/n1zh13/hi_team_ivermectin_im_back_this_time_with_an

Hi team ivermectin! I'm back. This time with an archive of the blocked community "gettingIvermectin

April 30, 2021

If the above link doesn't work, here is the direct link to the archive - from where it can be downloaded as a zip file:

https://disk.yandex.com/d/Ff0u0mjyUJ5tkA

It is also available online - viewable as a webpage at:

https://ivm.netlify.app/gettingivermectin/

Alternative to Reddit - start posting on Saidit

Reddit quarantine

Reddit has quarantined the r/ivermectin subreddit, which will lead to eventual ban:

Start posting on Saidit: https://saidit.net/s/Ivermectin2

The wiki is already there at: https://saidit.net/s/Ivermectin2/wiki/index

More information on Saidit.net:

August 29, 2021: In case we are banned from Reddit, the mods were invited by the top mod for the saidit subreddit s/Ivermectin to become moderators (which we accepted): https://saidit.net/s/Ivermectin

September 26, 2021: In order to house a copy of the Wiki (which contains controversial and opinionated material), we created a new subreddit s/Ivermectin2 (2 suggesting it is a successor forum): https://saidit.net/s/Ivermectin2 - a copy of the Wiki is now placed there as well at: https://saidit.net/s/Ivermectin2/wiki

NOTE: Saidit.net is a fork of the Reddit open source code, and the look and feel of the site is similar to the old Reddit. Just some minor changes in the naming - for example s/subreddit is used instead of r/subreddit.

Making a Saidit account

Creating an account on saidit is easy - just go to the link below (use a desktop browser), choose a username and password (e-mail is optional) - fill in the captcha to verify you are human and click "Sign Up":

https://saidit.net/login

NOTE: e-mail is optional - useful for security or to recover an account in case forget password etc.

You can also create an account using the Saidit app on Android as well (see below).

Saidit Android app

The saidit app for Android is available on F-Droid (open source, reliable app):

https://github.com/libertysoft3/RedReader

Direct link to APK:

https://f-droid.org/packages/org.saiditnet.redreader/

Saidit iOS app

For iOS there is no app currently, but you can use a browser to do the same thing.

Alternatives to Media Platforms (that are Trusted News Initiative (TNI) signatories)

Most of the big media and social media outlets are signatories to the Trusted News Initiative (TNI) - see elsewhere here for more information.

These platforms decide if content is diversionary - if in their view, it contributes to "vaccine hesitancy" - if so they feel it is justifiable to censor that information.

Oftentimes that judgement is made by fact-checking organizations who go overboard in censoring early treatments, questions about vaccine side-effects, and reports of rare vaccine-related events.

This deprives oxygen from ideas that would drive innovation and improvements in treatment strategies etc.

For example, early treatment is seen by some fact-checkers as some fantasy.

This perpetuates the perception in the public and many doctors that there is no early treatment.

The reason for hostility - that if early treatment was acknowledged, it would lead to vaccine hesitancy.

However, early treatment is complementary to vaccination - if vaccinated folks get a breakthrough infection, early treatment could save their lives.

TNI-inspired censorship includes suppression of early treatment, questions about vaccine side effects, and questions about vaccine severe side effects.

This censorship has contributed to:

the lack of awareness of early treatment
lack of awareness of viral timeline
lack of awareness of treatment strategies for severe cases, such as for long haulers - and especially for post-vax side effects

Google search results routinely suppress content - that same content is more easily found on DuckDuckGo.com - which has less harsh filter.

Are there any alternative platforms where such censorship is not happening?

Yes - but these are mostly smaller companies which were not signatories to TNI, and thus can offer censorship-free participation.

In an environment where users are banned or face censure on the mainstream platforms, these smaller companies see opportunity to grow and attract new users, by offering less censorship.

Reddit alternative

saidit.net (r/ivermectin wiki which is now not visible because of quarantine - is mirrored on saidit)

Twitter alternative

Gettr.com (Dr Robert Malone moved there when banned on Twitter)

YouTube alternatives

Bitchute.com (bitchute links can't be posted on Reddit from pre-covid19 times)
Rumble.com (famously offered Joe Rogan to move off Spotify to Rumble for $100M)
Odysee.com (this is an interesting new outlet - where automatic mirroring of YouTube videos to Odysee is one of the features) - Dr Bret Weinstein, FLCCC and Dr Been are also on Odysee. Ivory Hecker is on Bitchute.

Medium alternative

Substack.com - FLCCC, and many others have blogs on Substack

Discord alternative

Google alternative

Google often censors results that fall awry of the TNI.

In such cases, use DuckDuckGo:

duckduckgo.com

Another option may be:

search.brave.com

COVID-19 - Timeline of Events (Mika Turkia)

Mika Turkia has an excellent timeline of events related to Ivermectin and covid19.

New parts are added over time - these are the parts created so far:

Part 1: https://doi.org/10.13140/RG.2.2.13705.36966

Part 2: https://doi.org/10.13140/RG.2.2.16973.36326

Part 3: https://doi.org/10.13140/RG.2.2.23081.72805

Part 4: https://doi.org/10.13140/RG.2.2.26000.53767

Part 5: https://doi.org/10.13140/RG.2.2.35015.16807

More details are given below.

April 04, 2021:

https://twitter.com/Covid19Crusher/status/1379899467504173056?s=19

The Ivermectin Chronicles

"A Timeline of Ivermectin-Related Events in the COVID-19 Pandemic"

57 pages and growing...

https://www.researchgate.net/publication/350610718_A_Timeline_of_Ivermectin-Related_Events_in_the_COVID-19_Pandemic_April_3_2021

Part 1:

https://www.researchgate.net/publication/350610718_A_Timeline_of_Ivermectin-Related_Events_in_the_COVID-19_Pandemic_April_3_2021

A Timeline of Ivermectin-Related Events in the COVID-19 Pandemic [April 3, 2021]

April 2021

DOI:10.13140/RG.2.2.13705.36966

Project: COVID-19

Authors: Mika Turkia

Part 2:

https://www.researchgate.net/publication/352853743_A_Continuation_of_a_Timeline_of_Ivermectin-Related_Events_in_the_COVID-19_Pandemic_June_30_2021

A Continuation of a Timeline of Ivermectin-Related Events in the COVID-19 Pandemic [June 30, 2021]

June 2021

DOI:10.13140/RG.2.2.16973.36326

Project: COVID-19

Mika Turkia

Part 3:

https://www.researchgate.net/publication/354967795_Third_part_of_a_timeline_of_ivermectin-related_events_in_the_COVID-19_pandemic_September_30_2021

Third part of a timeline of ivermectin-related events in the COVID-19 pandemic [September 30, 2021]

September 2021

DOI:10.13140/RG.2.2.23081.72805

Project: COVID-19

Authors: Mika Turkia

EDIT: January 7, 2022:

Part 4:

https://www.researchgate.net/publication/357469228_Fourth_parth_of_a_timeline_of_ivermectin-related_events_in_the_COVID-19_pandemic_December_31_2021

Fourth parth of a timeline of ivermectin-related events in the COVID-19 pandemic [December 31, 2021]

December 2021

DOI:10.13140/RG.2.2.26000.53767

Project: COVID-19

Authors:

Mika Turkia

EDIT: February 12, 2022:

Part 5:

https://www.researchgate.net/publication/358248142_Fifth_part_of_a_timeline_of_ivermectin-related_events_in_the_COVID-19_pandemic_January_31_2022

Fifth part of a timeline of ivermectin-related events in the COVID-19 pandemic [January 31, 2022]

January 2022

DOI:10.13140/RG.2.2.35015.16807

Project: COVID-19

Authors: Mika Turkia

Caution - Veterinary Ivermectin

We generally avoid discussing the veterinary version of Ivermectin. However you can try some of these venues:

Discord channel created by u/foggynotion:

https://discord.gg/bajet7GDfw

EDIT: August 27, 2021 - u/foggynotion reports that his discord server has been removed as a consequence of the current crackdown on ivermectin on social media. This happened coincidentally at the same time that supermods of reddit (those who moderate multiple sub-reddits) joined together to protest the existence of sub-reddits like r/NoNewNormal (which is seen as anti-mask and right-of-center) - and r/ivermectin (which they were perceiving as forum advocating horse dewormer).

Dr Been's Discord server:

https://discord.com/invite/bkmg3rk3sQ

There are some websites also dedicated to sources of ivermectin - via prescription and internationally from places (it is also available over the counter in many countries):

https://www.getivermectin.com/

Users should be cautioned about the risks and cautions regarding use of veterinary ivermectin - there is a risk of inadvertent overdosing - see these posts for warning and cautionary information:

https://old.reddit.com/r/ivermectin/comments/ocbmly/how_to_get_ivm_new_resource_page How to get IVM - new resource page

2021-09-27:

Another website examining dosing issues around veterinary ivermectin:

https://nonvenipacem.com/2021/02/04/ivermectin-whats-good-for-the-horse-is-good-for-the-handler/ Ivermectin… what’s good for the horse is good for the handler February 4, 2021

2021-09-27:

This webpage also examines measurement and dosing issues associated with veterinary ivermectin:

https://www.barnhardt.biz/ivermectin/

Some of the information needs to be updated to match the newer FLCCC recommendations for treatment (which are now higher than 0.2mg/kg bodyweight).

The webpage also talks about monthly dosing for prophylaxis - which may not be sufficient, as weekly dosing was recommended for a long time, and now more recently with Delta variant and increased virulence, a twice a week dosing is recommended to avoid breakthrough cases (prophylaxis).

2021-09-27:

This video and webpage from 2014, explains some of the details regarding dosing - with fatty meal for 2.5x bioavailability for systemic use and on empty stomach if want for worms. It also explains half-life, as well as the issues around use of veterinary ivermectin and understanding of dosing:

https://www.maximpulse.com/permethrin/ivermectin-calculating-a-dose.html Calculating a dose of ivermectin for scabies

However the use of odd mathematics on this webpage is confusing:

Take your weight in pounds, divide by 33 and that’s how many 3 mg ivermectin pills you get.

It would be much simpler to say 0.2mg/kg bodyweight weekly or twice a week for prophylaxis, and 0.4-0.6mg/kg bodyweight per day for treatment (once someone has shown symptoms i.e. is past day1 of symptoms). This mg/kg dosing is how dosing is presented on the FLCCC protocols.

Ivermectin - availability in various countries

If your pharmacy is not giving you Ivermectin - you can get it from a compounding pharmacy who are more cooperative (though may be more expensive).

Finding early treatment doctors - getting prescription and medicines:

https://saidit.net/s/Ivermectin2/wiki/index#wikiearly_treatment_and_long_haulers.2Fpost-vaccine_treatment-_finding_doctors_and_obtaining_a_prescription

Glenn Chan - LongHaulWiki section on getting Ivermectin in various countries of the world:

https://www.longhaulwiki.com/index.php/Ivermectin#How_to_get_ivermectin

Ivermectin - assessing the quality of tablets ordered online from other countries

Many people order direct from Indian online pharmacy websites like Indiamart dot com.

Many in the US and UK have reported ordering from such websites.

However there also have been reports from UK etc. that such orders are sometimes not delivered - as they are stopped by customs.

So the situation may vary - you will have to consult on online forums to gauge what the situation currently is regarding the practicality of online delivery of Ivermectin to your country.

Do the Ivermectin drugs from India have the right dose? Are they adulterated with filler material?

Adam Gaertner (a prominent and early Ivermectin researcher and proponent) has conducted a study of the tablets available online - and the overall conclusion was that most of the tablets being sold as Ivermectin are pretty good quality (i.e. sometimes the doses may be slightly less - but since there is a wide dosage range which is tolerable - such a small difference doesn't make much difference in practical terms).

So Ivermectin tablets imported from India are probably ok - especially since Ivermectin, as a generic drug, is not expensive (and given the media negativity against Ivermectin, there is not such a huge demand for Ivermectin as would have been otherwise). So there is little incentive to cut corners on Ivermectin, when the real drug is available relatively cheaply in less developed countries of the world (where it is used more commonly as an anti-parasitic drug).

Ivermectin - Guides, Methods of Action

Here is a google doc i use to organize links for myself. Maybe there is something useful in there for you.

https://docs.google.com/document/d/1UIPA1nIwZL6gEIywraAZVpWzHHirB7PGmWjlWnaJFIs/edit?usp=drivesdk

Dr Been

These two videos by Dr Been were removed by YouTube (the Trusted News Initiative (TNI) at work) - and are now available here:

https://odysee.com/@DrMobeenSyed:1/Ivermectin:7 Ivermectin Mechanism of Action
https://odysee.com/@DrMobeenSyed:1/Ivermectin-Dosage:7 Ivermectin Dose

See:

https://old.reddit.com/r/ivermectin/comments/ohlti4/youtubegoogle_book_burning_during_pandemic_two YouTube/Google book burning during pandemic - two more of Dr Been videos removed (July 10, 2021)

Here is Dr Been announcing the removal of 2 videos by YouTube:

https://twitter.com/drbeen_medical/status/1413536962091184132?s=19

Behold the work of modern era book burners - our ushers to dark ages. @YouTube censorship.

Two books burned!

https://twitter.com/drbeen_medical/status/1413567511795101696?s=19

Yes. Moving to odysee and bitchute.

Whiteboard Doctor

Whiteboard Doctor has covered many Ivermectin studies - like Dr Been, MedCram, Dr John Campbell, and others, he has had his videos on Ivermectin demonetized - the Trusted News Initiative (TNI) at work.

Video:

https://www.youtube.com/watch?v=VlP3rIAw6rw Ivermectin Binding SARS-CoV-2 Spike Protein In COVID-19: A Possible Mechanism Of Action? Mar 24, 2021 Whiteboard Doctor

also see:

https://www.youtube.com/watch?v=9bgcgiutrw8&t=0s Ivermectin And COVID-19: How Is It Proposed To Work? Review Of All Theorized Mechanisms Of Action. Nov 2, 2020

https://www.youtube.com/watch?v=cJHPMIRMjPY Ivermectin, STAT3, And COVID-19: A Possible New Mechanism To Explain Efficacy Against SARS-CoV-2! Oct 26, 2020

Some other sources

https://old.reddit.com/r/ivermectin/comments/l2rkvz Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents - study highlights why ivermectin may be effective vs COVID-19

https://www.nature.com/articles/s42003-020-01577-x Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents 20 January 2021

Guidelines for Companies

Guidelines for Companies - risk management

Companies can take certain steps to reduce incidence of covid19 among their employees.

While social distancing, ensuring there is no stagnant air inside buildings and such measures are already being used, more direct, safe and cost-effect methods are available as well.

One direct step is relatively safe (short term use of Ivermectin), and cost-effective - the administration of Ivermectin to all close contacts of an index case.

If employees are tested regularly using rapid tests, or PCR tests, or even if employees are just monitored for symptoms like fever, bodyache, headache, minor cough, runny nose - their close contacts can be administered Ivermectin for 2-3 days to ensure covid19 is not spread beyond the index case.

Because in adults there is a 4-5 day gestation period before symptoms appear (day1 of symptoms - which coincides with live viral peak) - it is possible to identify all close contacts of an index case, and administer Ivermectin for 2 or 3 days in order to ensure all exposed personnel receive Ivermectin well before day1 of symptoms (before live viral peak).

One complication is the presence of asymptomatic covid19 cases who may be spreading the live virus, while being asymptomatic.

With increased intramuscular vaccination (which produces humoral immunity but not mucosal immunity in the respiratory airways), it becomes possible for vaccinated individuals to be infected in their respiratory airways and to spread live virus to others from their respiratory airways.

Guidelines for Companies - Diabetes, Vitamin D3

Companies around the world that are worried about employee sickness due to covid19 or sickness in their families can consider some actions:

ask employees that are diabetic to maintain their blood glucose levels - many employees may have stopped visiting their doctors and may have under-managed blood glucose levels. Since out of control diabetes can affect outcomes negatively, restoring to normal levels will improve outcomes.
have employees maintain a Vitamin D level above 30ng/mL (Vitamin D levels closer to 40ng/mL may be desirable for protective effect against covid19) - such a level is achievable if Vitamin D3 5000 IU is taken daily for an adult - test after 2-3 months if a level above 30ng/mL is achieved - reduce dosage slightly if needed

Guidelines for Companies - Prevent Household Spread

You can also adopt more aggressive guidelines regarding treatment to ensure there are near zero deaths, and zero long haulers. A single death in a family will impact employee health and productivity for months from an employer viewpoint.

The following guidelines may be more difficult as long as there is regulatory hostility towards Ivermectin specifically, and Early Treatment generally.

if an employee or family member gets sick, all family members should start the weight-specific pre-exposure prophylaxis I-MASK+ FLCCC protocol (pregnant, breastfeeding and children under 15kg weight should avoid Ivermectin). This will ensure that no one (beyond the index case) progresses to symptomatic disease, or if they do that it is mild. The index case can be treated with the outpatient treatment in the I-MASK+ or MATH+ FLCCC treatment protocols.

Guidelines for Companies - Critical Employees

For employees who are critical to the functioning of an organization, an even more aggressive prophylaxis approach can be adopted:

have the crucial employees take Ivermectin weekly according to the pre-exposure prophylaxis FLCCC protocols - for both vaccinated and un-vaccinated employees
this will ensure nearly zero employees have symptomatic disease
the reason a weekly prophylaxis dose works is that Ivermectin has a half-life of 18 hours, which means it's levels in blood fall by half within 18 hours, and to a quarter in a further 18 hours. Monthly doses reduce incidence, and every two weekly also reduces cases, but not perfectly. Weekly dosing is effective because covid19 has a 5 day gestation period - from exposure to live viral peak (at day 1 of first symptoms). This means **regardless of which day of the week you get exposed, during the gestation period the live virus will get exposed to an Ivermectin peak before viral peak, or very soon after.
if exposures to virus are likely to happen over the weekend, then a weekly dose of Ivermectin every Sunday may be a good strategy
if exposure to virus is likely to happen at the workplace (Monday to Friday), then a weekly dose of Ivermectin every Wednesday may be better. It will arrest exposures that happened on Monday, Tuesday (which will have only had 2-3 days to grow), as well as Thurday and Friday (Ivermectin impact will still be strong for some days after dosing).
additionally, for obvious exposure events, a critically important employee can take a one day additional dose of Ivermectin (in addition to the weekly doses of Ivermectin they are taking). For example if they took a long airline flight, and feel they were exposed, or took a crowded bus or train, they can come home and take an additional Ivermectin dose that day, or within the next 2 days (well before the live viral load has had a time to peak in 5 days).

Understanding COVID-19 Timelines - for physicians

NOTE: please consult the FLCCC MATH+ extended protocol document, and the earlier MATH+ versions from Dr Paul Marik for explanations of viral timeline

The timeline of COVID-19 symptoms appearance, and deterioration follows a predictable pattern.

After exposure, it typically takes (gestation period) 4-5 days for first symptoms to appear ("day 1 of symptoms").

The live viral load peaks on day 1.

After exposure, the virus is replicating exponentially, and within 4-5 days achieves peak (at day1), and then starts going down.

By day 5-6, the live viral load is near zero in many people.

By day 8, for nearly all people the live viral load is near zero.

Viral timeline - a blind spot for regulators and in media coverage

This pattern was examined in the FLCCC MATH+ protocol old documents first, and were the only location where this information was discussed and disseminated.

For months after that regulators, and media have failed to highlight the pattern and timeline of infection.

This "confusion" has allowed for the rampant use of drugs like Remdesivir - under the guise that "the virus is still alive". And that has been repeated all over the world, most recently around May 1, 2021. During that wave there was a rush by patients, desperate appeals, and campaigns to increase the supply of Remdesivir. Even state governments pledged to increase supply. However, Remdesivir is not helpful esp. in late stages of the disease. This has been known from the time the pre-print study was revealed.

The lack of understanding shown by regulators and the media (around day 8 and the likelihood that live virus is near zero) has continued to this day (July 2021) - however, in the last few months some officials have mentioned (usually in videoconference calls released to the public) that the virus is nearly zero by day 8.

The FLCCC has from very early in 2020 been showing that the live virus is deady by day 8 in most people.

This has been the reason they have argued that steroids CAN and should be used by day 8 if you want to stop the hyperinflammatory stage (post-day-8) from happening.

This is also why the FLCCC (Dr Pierre Kory) testified in front of the US Senate in 2020 that steroids should be used to save lives - this was at the time that NHS, CDC, WHO had all guided for non-use of steroids - bringing the use of steroids to a halt around the world (that doctors were already using according to their judgement).

It is unclear how many lives were lost due to this hiccup in the use of steroids. For a time, the use of steroids became associated with bad behavior because of the pronouncements of the WHO.

It was only after the RECOVERY UK trial some time later, that NHS, CDC, WHO and then regulators around the world relaxed their guidelines around non-use of steroids.

Foundational work by FLCCC MATH+ protocol

From the early days of the disease, the FLCCC MATH+ protocol document has remained the pre-eminent document for understanding the timeline and the reasoning for that timeline.

I (u/stereomatch) have observed a number of covid19 cases, and have found the FLCCC timeline to be spot on.

Once exposed it takes 4-5 days for live virus to peak (this coincides with "day 1 of symptoms).

Understanding timeline for diagnosing day 1

This gestation period can be used to rationalize the timeline stories you collect from members of an infected household - it can sometimes allow you discover the actual day1 for a patient based on who and when he infected someone.

From the live virus graphs from Dr Michael Mina, it becomes clear that the live virus goes from what seems nearly zero to max peak from 4th day (after exposure) to the 5th day.

Probably a person is infectious at day 1 (and from one day before day1) - and remains infectious for some days after that, until the live viral load achieves near zero by day 5-6 in some and by day 8 in nearly all patients.

This is why after day 8, it becomes hard for a person to infect another.

For safety, quarantining may continue until day 10 or so or day 14, depending on the policy adopted.

Hyperinflammatory stage - post-day-8

While the virus expands after exposure within 4-5 days to achieve peak (day 1), and then starts going down (probably because ACE2 receptor targets on cells get exhausted and growth slows, and meanwhile the immune response catches up).

By day 8 it is near zero in nearly all patients.

However (as Dr Paul Marik explains in his appearances on Dr Been YouTube channel) the viral debris is huge - and this continues to trigger an immune reaction.

This hyperinflammatory reaction grows exponentially.

If it is not arrested early, it can get out of control - to the point where even steroids are unable to reign in the immune response. As Dr Paul Marik explains at that point, plasma exchange (not to be confused with convalescent plasma) has been shown to help - as it removes the viral debris irritants. Dr Paul Marik reported there have only a very few cases where plasma exchange was used.

Timing the steroids dose - day 1 and oximeter observations

For this reason, we can rougly split the timeline into a day1-7 stage (so-called "viral stage"), and a day8-onwards stage (hyperinflammatory stage).

While Ivermectin, Famotidine, Vitamin D, Vitamin C, NAC (N-acetyl cysteine) and other supplements can be given at any time, it is the timing of the steroids which is the real crucial decision for anyone treating a covid19 patient.

The timing of steroids depends on having a firm grasp on when "day 1" was.

This means interviewing the patient comprehensively to establish when they first had symptoms.

With earlier patients it was a very clear fever, or cough, or backache or bodyache.

But now with new variants, early symptoms can sometimes be very mild - that combined with imprecise recollections by patients (usually won't remember mild symptoms) - can lead to difficulty in ascertaining "day 1" for some patients.

This used to be a problem with earlier variants as well, but with newer variants this seems to have become a bit more common.

Newer variants with milder early symptoms - deciding day 1

It is possible that this change may be behind the perception among some Indian doctors on Twitter that the May 1, 2021 wave in India had patients becoming severe "within a few days". There were suggestions that this was more common in vaccinated individuals, and that this behavior may be an outcome of ADE (antibody dependent enhancement).

ADE may be familiar because it happens with dengue, where a second infection by a variant leads to the earlier antibodies in a patients binding imprecisely in a non-neutralizing way to the variant dengue virus - and it can lead to a situation where the antibody fast-tracks the entry of the varient into the cell.

It is not clear if ADE was responsible for this perception.

But I (u/stereomatch) proposed that one possibility is that the new milder symptoms at day 1 may be missed by patients.

And I quote the example of a case I (u/stereomatch) observed, where a 74 year old diabetic (pre-covid19 blood sugar of 280), obese, patient was reported as having "had fever for 3 days". Yet his oximeter was 90, pulse rate 98, and looked like a day 10 or a day 14 case.

On further query, it appeared he may have had earlier symptoms a week earlier, and then on matching "who infected whom" it became apparent that the patient was at day 14 from first symptoms - which matched his condition - he couldn't speak, couldn't get out of bed, oximeter would drop to mid-80s on going t o the bathroom or on effort.

This case may naively have been reported by patient's caregivers as day 3-4, if they are only seeing fever as a symptoms, and are ignoring the very mild cough he had 2 weeks ago.

Lacking day 1 precision - aiming for middle ground

Once day 1 is confidently ascertained, it becomes earlier to watch for oximeter declines (or pulse rate increases) around day 8.

In the absence of a clear handle on when day1 was, the treating physician has to balance his approximate estimate for day 8, with the observational oximeter/pulse changes - if there is a steady drop of oximeter below 97 (i.e. patient is not able to reach 97 even with breathing deeply), then this may be a sign that hyperinflammatory stage is starting.

Steroids timing - not too early, not too late

Steroids are used to reduce the rising inflammation starting with day7-8.

You cannot start steroids too early (while live virus is still dominant and is growing) - since suppressing the immune system with steroids will allow the live virus an advantage.

For this reason steroids are started, but not too much earlier than day 8.

And steroids are not delayed too much longer after day 8. Otherwise the inflammation has had a chance to reach high levels (becomes harder to quell), and in the meantime has started to damage organs.

The oximeter declines visible at day7-8 onwards, are evidence of vascular changes - inflammation leading to leaky blood vessel walls, leading to leakage (and potentially spread any remaining small amounts of live virus to new virgin territory for infection and growth).

In addition the inflammatory damage to blood vessel walls (endothelial damage) can lead to clotting factors being released.

Other ways in which the virus can wind up coalescing RBCs (red blood cells) via CD147 receptor, can also lead to coagulation, hindering blood flow.

What is Inflammation?

Inflammation as a regular part of machinery in the body - for repair and responses to infection etc.

But then if gets out of hand (as with covid19 post-day7-8) or when become never-ending (chronic or auto-immune disease - and in covid19 long haulers).

For a general discussion on inflammation with Dr Roger Seheult (MedCram on YouTube):

https://youtu.be/63synatP-D4

The MAIN CAUSES Of Inflammation & How To REDUCE IT TODAY! - Roger Seheult

Dec 16, 2021

PCR testing

PCR testing - understanding positive and negative results

PCR tests are a useful way of identifying whether parts of the virus are present in the test sample - usually taken with a nasal swab from nasal area.

PCR positive is thus reliable in terms of detection of viral debris (excepting rare case of contamination while testing).

If a PCR test is positive, it indicates that the virus has touched you at some point in the recent past.

However, a positive PCR test is NOT indicative of infectivity.

The reason is that the PCR test is not a test for presence of live virus alone - but it can also be triggered by the presence of viral debris.

This is relevant because the viral timeline for covid19 has the virus grow after exposure - within 4-5 days it leads to a live viral peak (usually day 1 of first symptoms as well) - after which the live viral load starts going down. By day 5-6 it is near zero in many, and for nearly all patients it is near zero by day 8.

However there is a lot of viral debris - which continues to trigger the body's immune system.

By day 7-8, this hyperinflammatory response is becoming evident.

A PCR test can show positive results well beyond day 8 (when the live virus is near zero) - and can be PCR positive for a month or longer.

So while a PCR positive test does show that virus was there at some point, it is not diagnostic for infectivity.

That being said, there is probably a slighly higher probability someone is infective if they have tested PCR positive.

A PCR negative test result is not diagnostic at all (except for some statistical or demographic sense).

The reason is that a lot of infective people can show up as PCR negative.

In fact a person can test PCR negative one day, then PCR positive the next, and PCR negative the next day, and so on.

By my (u/stereomatch) estimate testing active cases will lead to nearly half testing PCR negative (seen for a family - a mother and 3 daughters - who all had symptoms but half tested negative).

PCR negative is a dangerous thing as many patients and doctors who may otherwise have treated for covid19 can be lulled into being complacent, and assume it is "only pneumonia" (as happened with the husband of above family - he wound up in ICU).

Nowadays PCR lab results have a disclaimer that PCR negative is not diagnostic.

Live viral persistence

After day 8 live virus is dead in most people.

However a large amount of viral debris is still present.

The PCR test can continue to be triggered by this viral debris for a month or more in some patients.

In some immuno-compromised patients, the live virus been found to persist for 100+ days (rare).

The live virus may also persist in some immuno-privileged sites in the body.

Live virus has also been found to reside in some parts of the gut in some patients.

PCR testing - should one wait for PCR testing before starting Ivermectin for suspected covid19 case?

The current FLCCC suggestion is to start Ivermectin at the first signs of flu-like or symptoms that look like they could be covid19 - see reference below.

That is don't wait for test results.

The reason is that even if it is not covid19, the downside to taking ivermectin is minimal. The downside of waiting a day for a PCR test, is time you are not going to get back.

In any case, if PCR test comes back negative, it is not diagnostic (as explained in the PCR section). That is, you could have covid19, and it can still give a PCR negative test result.

Some people have wasted time this way thinking they have "pneumonia" just because their PCR test came back negative. It later turned out to be covid19.

See this section in the wiki on PCR positive and PCR negative test results:

https://old.reddit.com/r/ivermectin/wiki/index#wiki_pcr_testing_-_understanding_positive_and_negative_results

References:

https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/flccc-weekly-update%E2%80%948-11-21%E2%80%94dr.:1? FLCCC WEEKLY UPDATE—8/11/21—Dr. Pierre Kory & Dr. Paul Marik on the Delta Variant & Protocol Changes

August 12th, 2021

at the 29:10 minute mark:

https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/flccc-weekly-update%E2%80%948-11-21%E2%80%94dr.:1?r=A87JUB8GGGxTjvnFWiLEfU7fVGtj7LH5

due to safety of ivermectin

Totally reasonable to do treat then test

Rather than waiting for test

Time matters, early treatment is key

at the 30:05 minute mark:

Dr Paul Marik

If you have flu like symptoms

Likelihood is it is covid19

If it is not have no downside to taking ivermectin

PCR testing - for airline travel and at work

Fallibility of the PCR negative test

Despite it's unreliability as a screening tool (PCR negative does not guarantee you are not currently infective), a negative PCR test is often used for airline travel or by human resources departments - for lack of any other tool for testing.

While a negative PCR test does not GUARANTEE you are disease-free/non-infective, as a demographic tool it MAY have some efficacy.

That is, if you took out all the PCR positive people, the people you are left with (who are testing PCR negative) are more likely to have fewer actual non-infective people.

So you can use a PCR negative as a ROUGH screening tool.

But it will not guarantee that every infective person has been screened out.

Fallibility of the PCR positive test

The PCR positive test result is more reliable (barring contamination during testing or processing).

However, it is only reliable in the sense that it will indicate that:

either you have the disease currently
or you had it sometime in the past month or two

Yet many human resource departments in companies use a PCR positive test to prevent the return of an employee to work.

Since the live virus is near zero by day 8 from first symptoms, after that there is little culturable live virus present.

That is, a person is USUALLY non-infective after day 8 from first symptoms.

Exceptions are those who are immune-compromised (were taking immuno-suppressants for an organ transplant or for some other disease).

And there can be occasion for viral persistence in immuno-privileged sites in the body. Live virus has been found to persist in some parts of the gut as well in some people.

However the bulk of people are not infective much beyond day 8 from first symptoms.

Yet their PCR tests can continue to test positive due to viral debris.

These people will be excluded from returning to work by human resources departments - even though they are not actually infective.

A far better way to screen may be to expect a robust recovery and 10 days (14 days for even more safety) or more having passed from day 1 of first symptoms.

PCR testing - Dr Michael Mina (Harvard) comments on PCR testing

Michael Mina has been an advocate for testing for high viral load as a proxy for active infection - since testing for any low viral load is not diagnostic (since in some, while they may stop being infectious, the PCR test may continue to test positive for a month because of viral debris).

Dr Michael Mina is a strong advocate of rapid testing.

He argues that a rapid test does not have to be extremely sensitive - but that one which is only triggered by high viral loads may be a sufficient tool to screen for infectivity in individuals.

While it may not be an accurate tools for the individual - as there can be variation, he argues that on a demographic scale, it will on average (statistically) reduce the community spread of disease.

As someone testing positive on it in the morning, will know he has a very high viral load, and should not go to work.

August 9, 2021:

Michael Mina (Harvard) graphs for live viral load

Michael Mina's graphs for live viral load suggest that the bulk of the viral expansion occurs in the last day of the 4-5 day gestation period (which is expected for exponential growth).

For this reason, a person is expected to be infectious from one day before their "day1" and onwards - by day5-6 the live viral loads is very low:

https://www.hsph.harvard.edu/news/features/coronavirus-covid-19-press-conference-with-michael-mina-01-22-21/

Coronavirus (COVID-19): Press Conference with Michael Mina, 01/22/21

It’s really hard to appreciate, but if you put that on a linear scale, something that our minds can really understand, the peak viral titers on that same graph, if you put it on a linear scale, will be extremely narrow. It’s not this broad kind of curve like that. 95 percent of that curve is essentially really, really low viral load compared to the peak.

that PCR stays positive for a long time. So if you’re asymptomatic and you just happen to go get a PCR test through surveillance, it’s more likely than not that if it’s a very low viral load, very high CT value, that you probably already were infectious and you maybe don’t need to be isolated in your recent contacts yesterday.

And this is one of the reasons I feel very strongly that we should not try to scale up PCR any more than we have, because when you try to scale PCR, you’re playing with fire. It’s an extremely easy technology to get wrong, it’s easy to get false negatives, it’s easy to get false positives. If used appropriately, and all the steps are put in place and designed and everyone’s following every rule perfectly, then the tests can be amazing and amazingly sensitive. But when you’re scaling up testing for one of the highest complexity tests, we could do, which is manual PCR, where if you drop one specimen that has already been amplified with PCR and it splashes, you could contaminate your entire lab because the PCR can detect one molecule and one specimen post amplification makes literally trillions of trillions of molecules. So if it crystallizes and goes airborne, not the virus, just the molecules, then all of a sudden you can get whole plates for a week that are false positive, you could misstep and lead to a lot of false negatives.

Early Treatment

Early Treatment - ivermectin is one part of the wider need for Early Treatment

Better medicines may emerge later, and Ivermectin may or may not remain an issue.

However, Early Treatment and the widespread denial of Early Treatment is the actual crime of the century.

Despite a year of experience, there still is no official recognition of early treatment as a strategic necessity in order to reduce mortality to near zero, and long haulers to near zero.

US guidelines as of July 2021 still predominantly favor supportive care - giving Tylenol and waiting for patient to become hypoxic at home. This is an unnecessary and cruel imposition.

The public has been conditioned to also not seek out early treatment - which creates a vicious cycle. Once hypoxic, the patient will come to hospital out of desperation, however in the period prior to that, they feel they are doing the right thing by staying at home and not seeking help.

By telegraphing that there is no treatment available, regulators are criminally negligent for misdirecting public thinking away from mitigation strategies that are known to reduce mortality and incidence of long haulers syndrome.

While mortality is a low risk per individual, long haulers is a very palpable risk, because nearly 25-30 percent of covid19 patients (not receiving early treatment) experience long hauler syndrome.

Early Treatment - denial of early treatment

Widespread denial of early treatment is contributing to unnecessary deaths and disability as long hauler syndrome seems to be affecting 25-30% of covid19 patients when they are given Paracetamol and sent home from hospital.

There is slow mobilization to address long haulers syndrome - the NIH has allocated funds for the study of long hauler syndrome.

However there still is no examination of Early Treatment - perhaps because it is seen as a "distraction" from vaccination strategy. Reduction of threat of the disease (down to near zero mortality) may dissuade people away from vaccination.

Early Treatment (ivermectin + steroids at day 8, or anti-histamines + steroids by day 8 or such variants of early treatment) are capable of achieving near zero mortality, and zero long haulers.

Yet it is not universally recognized as an option by regulators, hospitals, and even by patients themselves. The Trusted News Initiative (TNI) further cements the silence around this topic.

The Denial of Early Treatment by both the public and the hospitals, has led to a toxic situation:

Hospitals turn away the mild cases of this week with just Paracetamol (a policy that was adopted due to early triage conditions) - these mild cases then become the severe cases of next week. We are witnessing a case of triage protocols gone wrong.
Patients have been made to believe there is nothing they can do to improve outcomes - they have been told to stay at home and wait for hypoxia to appear. As a result, patients ignore advice from those who argue for early treatment - but when day 8 arrives, their hypoxia then forces them to seek oxygen. As a result, an unnecessarily large portion of patients arrive at hospitals at day 10 or day 14 when it becomes much more difficult to save them.

Early Treatment - understanding early treatment denial

A possible explanation for why early triage protocols at hospitals may have led to entrenchment of denial of early treatment:

https://old.reddit.com/r/ivermectin/comments/n0y2uj/the_concerned_citizens_guide_to_proselytizing_to/ The Concerned Citizen's guide to proselytizing to Early Treatment deniers

April 29, 2021

An introduction to denial of treatment - in response to Dr Jordan Peterson's question about Ivermectin:

https://old.reddit.com/r/ivermectin/comments/no8jty/how_would_you_explain_the_psychological/ How would you explain the psychological denial-of-treatment phenomenon around Ivermectin? Dr Jordan Peterson (renowned psychologist) would like to know!

Ivory Hecker - whistleblower - formerly of Fox News - examines media censorship of Early Treatment she experienced when reporting on FLCCC affiliated hospital - with mortality of 6 percent compared to 18 percent at area hospitals. She explains how mention of the treatments that accomplished that was forbidden at Fox News:

https://old.reddit.com/r/ivermectin/comments/o6su0t Reporter/whistleblower Ivory Hecker covers censorship of Ivermectin use at Houston hospital

Dr Bret Weinstein interviews Dr Pierre Kory of the FLCCC (authors of MATH+ protocol) - this podcast was removed from YouTube (the Trusted News Initiative (TNI) at work):

https://odysee.com/@BretWeinstein:f/COVID-Ivermectin-and-the-Crime-of-the-Century-DarkHorse-Podcast-with-Pierre-Kory-Bret-Weinstein:f COVID, Ivermectin, and the Crime of the Century: DarkHorse Podcast with Pierre Kory & Bret Weinstein Bret Weinstein June 1, 2021

Transcript:

https://www.betterskeptics.com/transcript-covid-ivermectin-and-the-crime-of-the-century-darkhorse-podcast-with-pierre-kory-bret-weinstein/ Transcript: COVID, Ivermectin, and the Crime of the Century July 14, 2021

Bret Weinstein talks with Dr Robert Malone pioneer of mRNA vaccine technology, and Steven Kirsch entrepreneur and funder of trials for Fluvoxamine, another promising generic drug - this podcast was also removed by YouTube (the Trusted News Inititive (TNI) at work):

https://odysee.com/@BretWeinstein:f/how-to-save-the-world,-in-three-easy:0?t=3391 How to save the world, in three easy steps. Bret Weinstein June 10, 2021

This shorter segment covers some of the denial of early treatment, ivermectin and other such issues:

https://odysee.com/@ivermort:4/Tucker-Carlson-Today---Bret-Weinstein---July-9,-2021:9 Tucker Carlson Today - Bret Weinstein - July 9, 2021 July 13th, 2021

Early Treatment - is early treatment denial heartfelt or feigned?

EDIT: November 13, 2021 - taken from: https://old.reddit.com/r/ivermectin/comments/qsup2b/comment/hkhi76h/

We don't know if all this incredulity by skeptics of early treatment is real or feigned.

But they have mired themselves so severely into an impossibility universe, that it will be a real internal reckoning for them to justify why they delayed early treatment and the attendant deaths.

That is, if their skepticism was heartfelt.

If their skepticism was feigned, in service of an agenda, they will not do too badly, since plenty of camoflage available with all the other people they have convinced.

Fortunately for the feigned skeptics, they have convinced so many people to be skeptics, that skeptics of early treatment are a majority.

So nothing will happen to those who played a part in delaying early treatment, and the attendant deaths.

Those skeptics who are feigning are also likely to speak in absolutes, to be brash, callous even. As they have nothing to lose - can't be more wrong than being party to a killing.

No wonder they act not curious, but keep quiet about real world reporting by early treatment practitioners ("oh we only look at RCTs" is the refrain - and certainty of paper reports is what they are looking for - they don't need alerts from the battlefield).

Unrelenting shift

But the tide is only going one way - the list of early practitioners is growing.

While the US is bedeviled by hijinks (medical license threats, removal of ability to prescribe MATH+ and denial of prescriptions by pharmacists), the rest of the world is not so constrained and early treatment is the norm in all the unregulated countries.

Recognition of early treatment is not ebbing but growing.

Not one, but every early treatment practitioner, is saying early treatment is leading to near zero deaths, and zero long haulers.

What were a few emerging early treatment physicians with their protocols, are now more numerous.

Public display of abuse-by-RCT

All the shenanigans with the ivermectin RCTs (Lopez-Medina) - done right in front of a mainstream audience this time (since pandemic is everybody's business) - has made it completely plausible that a similar fate may have befallen Dr Paul Marik's vitamin c-thiamine protocol for sepsis (used often as a preamble to belittle him).

If Dr Paul Marik is SO right in what he has said about covid19 - viral timeline, justification for steroids (and has been pilloried at every stage for that) - could his sepsis protocol also have had similar authenticity?

That sepsis protocol was shot down as standard industry practice with no outsiders looking.

This pandemic is different - all this is playing out with many interested viewers from outside the industry.

And it is not looking good - when industry insiders/authority figures lack common sense, common tools of science like curiosity are absent (zero interest in interviewing the early treatment doctors).

And zero interest in learning anything that distracts away from the research THEY currently are doing in their department.

From the outside, all this is not looking so good - more like turf wars than science, curiosity and exploration.

The entrenched mores in pharmaceutical and medical industry look less like science than high dogma.

Early Treatment - labelling of early treatments as "Right Wing"

Currently in the U.S., the standard of care for covid19 is paracetamol, isolation, and to come to hospital only when hypoxic. This means organ damage has already started before a patient feels he can get back to the hospital.

As a result patients often delay going - feeling they have to comply with hospital orders - and thus wind up going several days too late, when the hyperinflammatory post-day8 stage has taken it's toll, not only on their lungs, but also on other organs. Often tachycardia due to pericarditis is present and ignored by the patient, because they feel they would be a burden going to the hospital with such a minor ailment.

The result is, not only are hospitals remiss in not treating early, they have convinced the patients that they too should not seek out help unless they are hypoxic.

The mild patient of this week is being turned back - to become the severe patient of next week.

Triage conditions may have allowed such practices to prevail earlier - though even then separate teams of volunteers should have handed out medicine packs in the car park. Medicine packets could have included Ivermectin (or even HCQ) - but most importantly steroids like prednisolone at 30mg per day - to be taken on day7-8 from first symptoms, or if oximeter was not able to reach 97 persistently, or if pulse rate was elevated in 90s or 100+ at rest. Patients should have been advised over phone to take steroids in that situation, and then report daily via phone.

Continuation of triage conditions at hospitals - and failure of govt agencies to institute parallel support for outpatients is burdening hospitals unnecessarily, and also failing to deliver treatment to outpatients in time.

There are two major groups of doctors in the US which are lobbying for early treatment to become standard of care.

FLCCC - which is generally leaning towards Democrats
AAPS - which is right-leaning and generally pro-Trump

BOTH organizations say the same thing:

Ivermectin should be part of the multi-drug protocol for early treatment

AAPS differs in that it also includes HCQ in the multi-drug protocol, while the FLCCC feels HCQ, while beneficial, is not beneficial enough, and is not included because more effective drugs are available - like Ivermectin.

Thus there is little difference between left-leaning and right-leaning doctors in the U.S. regarding the necessity for early treatment.

Trump was given Famotidine and HCQ - and Ivermectin?

There has been an effort to politicize Ivermectin - in the same way that Hydroxychloroquine (HCQ) was during the Trump administration.

Thankfully, Trump did not mention Ivermectin.

This article, however, by journalist Michael Capuzzo suggests Trump got not only HCQ (as is usually reported), but also Ivermectin at Walter Reed Hospital:

https://covid19criticalcare.com/wp-content/uploads/2021/05/The-Drug-that-Cracked-Covid-by-Michael-Capuzzo.pdf The Drug that Cracked Covid Michael Capuzzo

In addition, Kory, Marik, et. al published the first comprehensive COVID-19 prevention and early treatment protocol (which they would eventually call I-MASK). It is centered around the drug Ivermectin, which President Trump used at Walter Reed hospital, unreported by the press, though it may well have saved the president’s life while he was instead touting new big pharma drugs.

For HCQ, a campaign was launched which leveraged the hatred for Trump to turn off the anti-Trump voter from HCQ, and any possibility that it may just help a bit.

Although some of the better studies from that time did suggest some benefit for HCQ - for example one NYU Langone study showed that HCQ was lowering IL-6, and had some benefit.

Recent studies - like this large Iranian study suggest HCQ has some benefit as well:

https://old.reddit.com/r/ivermectin/comments/njwm60/large_28759_patient_study_iran_suggests/ Large 28,759 patient study (Iran) suggests Hydroxychloroquine beneficial for early treatment - results match those seen in earlier smaller studies of HCQ - hospitalizations reduced by 38% and deaths by 73% (April 6, 2021) - how long before pundits stop using HCQ as argument against ivermectin?

A Right Wing Drug

Whether HCQ has benefit, that pales in comparison to the benefit Ivermectin seems to be showing in the numerous trials.

And meta-analyses have been published showing a signal in favor of Ivermectin.

Yet, even though Trump is not around to use as a prop, there still is an ongoing effort to paint Ivermectin as a "Right Wing" drug.

The Hill discusses Matt Taibbi's article on how Early Treatments for covid19 are labelled as "Right Wing" in order to make them distasteful to half the population.

This is ironic, since the effort to counter "fake news" was motivated by the evidence on Cambridge Analytica where politically divisive fault lines were exploited to divide people.

Yet the same Trusted News Initiative (TNI) is engaging in similar practices - labelling Early Treatment as a right wing effort - essentially polarizing public perceptions on Ivermectin along political lines.

The opponents of Early Treatment are doing exactly the same thing as Cambridge Analytica did - they are seeking to label Early Treatments as somehow antithetical to the left-of-center voters, and trying to gain followers for the anti-ivermectin view by proxy.

https://old.reddit.com/r/ivermectin/comments/obslza (The Hill) The Rising show converses with Journalist Matt Taibbi about unfounded censorship & Right-wing designation of Ivermectin

Video:

https://www.youtube.com/watch?v=MJQBK1L9tu0 Matt Taibbi: Silicon Valley Makes Ivermectin ‘Right-Wing,’ Medical Community Held HOSTAGE By MSM The Hill Jul 1, 2021

Journalist, Matt Taibbi, details his reporting on the controversy surrounding the Covid-19 treatment Ivermectin.

The Hill article accompanying above video:

https://thehill.com/hilltv/rising/561153-matt-taibbi-reporting-on-potential-covid-19-treatments-like-ivermectin-shouldnt Matt Taibbi: Reporting on potential COVID-19 treatments like ivermectin shouldn't be taken as an endorsement July 01, 2021

Matt Taibbi article:

https://old.reddit.com/r/ivermectin/comments/o8s3cs (Matt Taibbi) Ivermectin: Can a Drug Be "Right-Wing"?

https://taibbi.substack.com/p/ivermectin-can-a-drug-be-right-wing Ivermectin: Can a Drug Be "Right-Wing"? A potential Covid-19 treatment has become hostage to a larger global fight between populists and anti-populists Matt Taibbi June 26, 2021

When does social media censorship become State Censorship?

In this article Matt Taibbi argues that when social media platforms censor while following governmental guidelines, that may be equated with state censorship (which goes against the First Amendment of the US).

YouTube explicitly forbids (as of July 2021) any mention of Ivermectin or HCQ as possible treatments for covid19.

Article:

https://taibbi.substack.com/p/a-case-of-intellectual-capture-on If Private Platforms Use Government Guidelines to Police Content, is that State Censorship? Matt Taibbi Jul 3, 2021

YouTube's decision to demonetize podcaster Bret Weinstein raises serious questions, both about the First Amendment and regulatory capture

Early treatment - understanding Trusted News Initiative (TNI) and regulatory capture

The Trusted News Initiative (TNI) was launched to coordinate media censorship of "fake news" - but seems to have wound up censoring discussions about early treatment as well.

While this censorship by private companies is harder to prosecute, an argument under development is that if private companies are censoring according to some government guidelines, then it may fall awry of the First Amendment i.e. right to free speech in the US:

https://taibbi.substack.com/p/a-case-of-intellectual-capture-on If Private Platforms Use Government Guidelines to Police Content, is that State Censorship? Matt Taibbi Jul 3, 2021

YouTube's decision to demonetize podcaster Bret Weinstein raises serious questions, both about the First Amendment and regulatory capture

Also see:

https://old.reddit.com/r/ivermectin/comments/obslza (The Hill) The Rising show converses with Journalist Matt Taibbi about unfounded censorship & Right-wing designation of Ivermectin

This comment has a summary of the video:

https://old.reddit.com/r/ivermectin/comments/obslza/the_hill_the_rising_show_converses_with/h3rw7uk

Archive of above webpage:

https://archive.ph/MjgPA

Dr Edmund Fordham (BIRD Group UK) analysis of the early treatment denial syndrome plaguing most countries:

https://www.conservativewoman.co.uk/scandal-of-the-suppressed-case-for-ivermectin/ Scandal of the suppressed case for ivermectin By Edmund Fordham June 29, 2021

Early Treatment Protocols

Early Treatment Protocols - my simplified protocol for early treatment and preventing long haulers

This is roughly the protocol I have used on 75+ cases - with zero long haulers.

With some who were on oxygen at home and quickly reversed.

As explained elsewhere - the lifesaver is steroids-at-day8 (Prednisolone) in sufficient quantity to show reversal of post-day8 hyperinflammatory signals.

Other standouts are that Ivermectin works very obviously (once you have seen enough cases) for:

pre/post-exposure prophylaxis
post-day8 residual anosmia/fatigue reversal

Famotidine is very effective in reducing symptoms during day1-7 period.

Cyproheptadine and Inhaled Budesonide is effective post-day8 for severe cases.

These are all on the FLCCC I-MASK+ outpatient/at-home and MATH+ for-hospitalized protocols.

In this series of substack posts, I take the example of Queen Elizabeth to outline the treatment options available for a person of that age and susceptibility:

https://stereomatch.substack.com/p/queen-elizabeth-tests-positive-for?utm_source=url&s=w

Queen Elizabeth tests positive for covid19 - what early treatments will she be getting - will those be advertised to the public? (Feb 20, 2022) Will it include Ivermectin, or at the very least steroids-at-day8 to avoid risk of death, and avoid risk of long haulers?

Feb 21, 2022

Also covered here:

https://old.reddit.com/r/ivermectin/comments/sxcl34/queen_elizabeth_tests_positive_for_covid19_what/

Queen Elizabeth tests positive for covid19 - what early treatments will she be getting - will those be advertised to the public? (Feb 20, 2022) - will it include Ivermectin, or at the very least steroids-at-day8 to avoid risk of death, and avoid risk of long haulers?

Update on preventing long haulers in the post-covid19 period - again using the case of Queen Elizabeth who had started showing some residual long hauler type symptoms in the post-covid19 period:

https://stereomatch.substack.com/p/update-to-queen-elizabeth-post-evidently

Update to Queen Elizabeth post - evidently she now has some mild long covid19 (which should not have had if treated correctly) (April 12, 2022) Here are some suggestions for what she could be given in her current condition (post-covid19 residual fatigue)

Apr 12, 2022

https://old.reddit.com/r/ivermectin/comments/u1u3rr/update_to_queen_elizabeth_post_evidently_she_now/

Update to Queen Elizabeth post - evidently she now has some mild long covid19 (which should not have had if treated correctly) (April 12, 2022) - here are some suggestions for what she could be given in her current condition (post-covid19 residual fatigue)

April 12, 2022

FLCCC Prophylaxis and Treatment protocols (MATH+, I-MASK+, I-MASS, I-RECOVER)

Check out:

https://www.flccc.net

it takes you to:

https://covid19criticalcare.com

Check out the I-MASK+ protocol for prophylaxis and early outpatient/home: https://covid19criticalcare.com/covid-19-protocols/i-mask-plus-protocol/

I-MASS protocol for mass administration: https://covid19criticalcare.com/covid-19-protocols/i-mass-protocol/

MATH+ hospital: https://covid19criticalcare.com/covid-19-protocols/math-plus-protocol/

I-RECOVER long haulers: https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/

And the longer MATH+ extended PDF - which has more explanations (61 pages):

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf

Also of interest is their webpage for optional medicines (Inhaled Budesonide, Nitazoxanide, Colchicine):

https://covid19criticalcare.com/covid-19-protocols/medical-evidence-and-optional-medicines/optional-medicines/

Original MATH+ protocol

Earlier MATH+ protocol as it was published by Dr Paul Marik (now been updated by the protocols above) - but the original one had some good commentary - here dated Dec 27, 2020:

Summary PDF:

https://www.evms.edu/media/evms_public/departments/internal_medicine/Marik-Covid-Protocol-Summary.pdf

Extended PDF:

https://www.evms.edu/media/evms_public/departments/internal_medicine/Marik_Critical_Care_COVID-19_Protocol.pdf

EDIT: Jan 7, 2022 - here is a very early review of the MATH+ protocol (June 8, 2020) - provided here for historical purposes:

https://www.youtube.com/watch?v=zeUhYixexHk

MATH+ Treatment Protocol for COVID-19 Explained!

Jun 8, 2020

ICU Advantage

322K subscribers

In this lesson we take a look at the MATH+ treatment protocol for COVID-19, put together by the Frontline COVID-19 Critical Care work group. This protocol was designed in a time when people were desperately looking for something to use to treat these patients, and this work group of critical care and emergency medicine clinical scholars combined the best available evidence and best practices in to a protocol to treat COVID-19.

The most important take away with this protocol is that timing is imperative and that this is meant for early intervention. The goal by utilizing this protocol and these medications aggressively is that we can prevent the 2 major complications of COVID-19; the hyper-inflammatory state, or cytokine storm, as well as the hyper coagulable state that we see in these patients. By doing this and doing this early, we can try to prevent ICU admission, ventilator usage, and ultimately save lives.

The name MATH+ is an acronym for the medications. Methylprednisolone, Ascorbic Acid, Thiamine, low molecular weight Heparin, and PLUS additional options, such as zinc, vitamin D and other treatments the provide may determine. I go through each of these talking about why we use them as well as the recommended dosing.

Finally we finishing up covering a few points that they make regarding hypoxemia in COVID patients. Hopefully at the end of this lesson, you will have a much better understanding of what is involved in this treatment protocol, how to use it, and more importantly, why.

0:00 Intro 1:42 What is MATH+? 5:46 The Protocol 11:15 Hypoxemia 13:20 Conclusion

A few comments in the above video are interesting - for how some doctors agreed with the protocol and strategies:

https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgxKNuegEFxTAlImTdx4AaABAg

Hannibal EnemyofRome 1 year ago

Have used this, plus Ivermectin since June. Clearly mortality is down. One key point vs Recovery decadron, is that you adjust the methylprednisolone to the patient and the CRP. You do not just plop them on decadron 6 mg daily. Have used as much as 125 mg every 6 hours. Thanks for doing this....it is largely considered witch doctoring and homeopathy in my State by organized medicine types. The politicizing of Medicine is the biggest CoVid tragedy.

https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgxKNuegEFxTAlImTdx4AaABAg.9GqfIDQ56lu9Gz6JlMN6dJ

ICU Advantage 1 year ago

I couldn't agree more with the politicizing. It is sad. As for your dosing to CRP, how are you determining the dose/frequency? Sounds like you are also weighing other factors such as the patients presentation I imagine.

https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgxKNuegEFxTAlImTdx4AaABAg.9GqfIDQ56lu9GzKnCskD6I

Hannibal EnemyofRome 1 year ago (edited)

@ICU Advantage if they are at less than 4 lt/mn nasal cannula, I will often use decadron 6 mg orally. But sick patients, I bolus 80 mg Solumedrol and start 40 mg IV BiD. I follow CRP daily; if CRP and patient better, I can consider going down in steroid dose, but if either is worse, you go up. A common feature is that the CRP will fall, but the patient is needing more oxygen. Then you must increase steroids till the patients oxygen requirements also fall. That is where I have used up to 125 mg every 6 hours. Use high flow up to FI02 of 60 %, but not beyond. That is the point to use your BiPAP machine in CPAP ( PEEP ) mode. Too many lungs have been fried by days of high flow or BiPAP above 70%! Have been experimenting with hyperoxia in some patients stuck at high oxygen levels, ( the home concentrators that can be used on discharge are maxed a 5 lt/ min flow ). I take them to a tight fitting mask with rebreather that can go to about 80% for four hours, then back to their previous oxygen. Their sats go from 88 to 98% on the mask and then back to 88% on their previous. Trying to use the relative hypoxia to engender Hypoxia Inducing Factor - 1 alpha and furins to transcribe more ACE 2 for their lungs and restore the RAAS system from inflammation and fibrosis to goodness and anti- inflammatory niceness. Cheers!

https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgzQGOQ9Wod0_gr--qh4AaABAg

Dawood Azeemy 1 year ago

Enjoyed this and helped a lot of my patients. Thank you

https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgzQGOQ9Wod0_gr--qh4AaABAg.9AP_E7L1nWS9RCx3xahark

Thom Zydervelt 4 months ago

I find it fascinating that suddenly directly after big pharma “donates” 4.5 million dollars to Vietnam the highly profitable but ineffective Remdesivir suddenly appears. While ivermectin cheap, overwhelmingly shown to be effective, generic, readily available is never mentioned. A bit suspect?

Mika Turkia - review of FLCCC MATH+ protocol

Mika Turkia has also reviewed the FLCCC and MATH+ protocol in this report:

https://old.reddit.com/r/ivermectin/comments/kt7lg9 A brief review of FLCCC Alliance's MATH+ protocol and I-MASK+ ivermectin protocol

Report:

https://www.cureus.com/articles/47669-the-history-of-methylprednisolone-ascorbic-acid-thiamine-and-heparin-protocol-and-i-mask-ivermectin-protocol-for-covid-19

TECHNICAL REPORT

PEER-REVIEWED

The History of Methylprednisolone, Ascorbic Acid, Thiamine, and Heparin Protocol and I-MASK+ Ivermectin Protocol for COVID-19

Mika Turkia

Published: December 31, 2020 (see history)

DOI: 10.7759/cureus.12403

Alternate links:

https://www.researchgate.net/publication/348077948_The_History_of_Methylprednisolone_Ascorbic_Acid_Thiamine_and_Heparin_Protocol_and_I-MASK_Ivermectin_Protocol_for_COVID-19

https://ssrn.com/abstract=3762097

Dr George Fareed & Dr Brian Tyson - protocol

Dr George Fareed & Dr Brian Tyson (AAPS affiliated) have also reported great success with early treatment (reduced mortality, and lower incidence of long haulers syndrome).

https://www.thedesertreview.com/news/dr-george-fareed-and-dr-brian-tyson-share-early-treatment-protocol/article_7728815e-3ca2-11eb-8a08-7b4b0156c181.html Dr. George Fareed and Dr. Brian Tyson share early treatment protocol Dec 12, 2020 Updated Apr 16, 2021

Their protocol includes moderate amounts of Ivermectin, Hydroxychloroquine (HCQ) and other supplements.

Dr George Fareed and Dr Brian Tyson protocol for Imperial Valley, California is covered in this news article:

https://www.thedesertreview.com/health/local-frontline-doctors-modify-covid-treatment-based-on-results/article_9cdded9e-962f-11eb-a59a-f3e1151e98c3.html

Local frontline doctors modify COVID treatment based on results

Apr 5, 2021

Dr Dirk Koekemoer (South Africa) protocol

Dr Dirk Koekemoer (South Africa) - well written protocol that is similar to FLCCC, and includes elements of Dr Shankara Chetty protocol - ie includes H1/H2 blocker antihistamines.

And steroids at day 8 (just as in FLCCC protocol).

u/JosephTheManJohnson brought this protocol to our attention here:

https://old.reddit.com/r/ivermectin/comments/okj4jw A 26 page continuously updated Google Docs document on Ivermectin

Protocol:

https://docs.google.com/document/d/1aLWOUC7Z1VD60Fbm0rxvkOYl92LAEP0G6BSaNiDRD24/edit?fbclid=IwAR1vTQrVZkJNSRYbIscnFwCLy7xPY9W2NSPqiyDqV2SizENMTMvsHGCk8v4

Taking Ivermectin for COVID-19

Dr Dirk Koekemoer

MBChB (South Africa)

Last updated (26 June 2021)

See my (u/stereomatch) review of it here:

https://old.reddit.com/r/ivermectin/comments/okj4jw/_/h58nzqc

Dr Peter McCullough protocol

Dr Peter McCullough is one of the most published cardiologists in the U.S.

He has been active in early treatment and his group has published a paper on treatment strategies:

https://rcm.imrpress.com/EN/10.31083/j.rcm.2020.04.264

Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)

Peter A. McCullough1,*, Paul E. Alexander2, Robin Armstrong3, Cristian Arvinte4, Alan F. Bain5, Richard P. Bartlett6, Robert L. Berkowitz7, Andrew C. Berry8, Thomas J. Borody9, Joseph H. Brewer10, Adam M. Brufsky11, Teryn Clarke12, Roland Derwand13, Alieta Eck14, John Eck14, Richard A. Eisner15, George C. Fareed16, Angelina Farella17, Silvia N. S. Fonseca18, Charles E. Geyer, Jr.19, Russell S. Gonnering20, Karladine E. Graves21, Kenneth B. V. Gross22, Sabine Hazan23, Kristin S. Held24, H. Thomas Hight25, Stella Immanuel26, Michael M. Jacobs27, Joseph A. Ladapo28, Lionel H. Lee29, John Littell30, Ivette Lozano31, Harpal S. Mangat32, Ben Marble33, John E. McKinnon34, Lee D. Merritt35, Jane M. Orient36, Ramin Oskoui37, Donald C. Pompan38, Brian C. Procter39, Chad Prodromos40, Juliana Cepelowicz Rajter41, Jean-Jacques Rajter41, C. Venkata S. Ram42, Salete S. Rios43 , Harvey A. Risch44, Michael J. A. Robb45, Molly Rutherford46, Martin Scholz47, Marilyn M. Singleton48, James A. Tumlin49, Brian M. Tyson50, Richard G. Urso51, Kelly Victory52, Elizabeth Lee Vliet53, Craig M. Wax54, Alexandre G. Wolkoff55, Vicki Wooll56, Vladimir Zelenko571Baylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, 75226, TX, USA

2 Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, L8S 4L8, Ontario, Canada

3 Armstrong Medical Group, Texas City, 75510, TX, USA

4 North Suburban Medical Center and Vibra Hospital, Thornton, 80229, Colorado, USA

5 Chicago Health and Wellness Alliance, Chicago, 60603, IL, USA

6 Recipient of the Texas HHS Meritorious Service Award, 78751, Texas, USA

7 PianoPsych, LLC, Natick, 01760, MA, USA

8 Division of Gastroenterology, Department of Medicine, Larkin Community Hospital, S. Miami, 33143, FL, USA

9 Centre for Digestive Diseases, Five Dock, 2046, NSW, Australia

10 Infectious Diseases, St. Luke's Hospital, Kansas City, 64111, MO, USA

11 University of Pittsburgh, Department of Medicine, Pittsburgh, 15213, PA, USA

12 Clarke Neurology, Newport Beach, 92660, CA, USA

13 Alexion Pharma Germany GmbH, 80687, Munich, Germany

14 Affordable Health, Inc., Piscataway, 08854, NJ, USA

15 Eisner Laser Center, Macon, 31210, GA, USA

16 Pioneers Medical Center, Brawley, 92227, CA, USA

17 Privia Medical Group, Webster, 24510, TX, USA

18 Hapvida HMO, Ribeirão Preto,14015-130, SP, Brazil

19 Houston Methodist Cancer Center, Houston, 77030, TX, USA

20 The Medical College Of Wisconsin, Milwaukee, 53226, WI, USA

21 Personal Healthcare Network, Kansas City, 64116, MO, USA

22 Fusion Clinical Multimedia, Inc., Philadelphia, 19019, PA, USA

23 Ventura Clinical Trials, PROGENABIOME, Malibu Specialty Center, Ventura, 93003, CA, USA

24 Stone Oak Ophthalmology, Immediate Past President, Association of American Physicians and Surgeons, San Antonio, 78258, TX , USA

25 Cardiosound, Atlanta, 30342, GA, USA

26 Rehoboth Medical Center, Houston, 77083, TX, USA

27 Complex Primary Care Medicine, Pensacola, 32507, FL, USA

28 University of California Los Angeles, Los Angeles, 90095, CA, USA

29 Emergency Medicine, Phoenix, 85016, AZ, USA

30 Family Medicine, Kissimmee, 34741, FL, USA

31 Lozano Medical Clinic, Dallas, 75218, TX, USA

32 Howard University College of Medicine, Mangat and Kaur, Inc., Germantown, 20876, MD, USA

33 President, MyFreeDoctor.com Pensacola Beach, 3256, FL, USA

34 Department of Medicine, Henry Ford Hospital, Wayne State University School of Medicine, Detroit, 48202, MI, USA

35 Orthopaedic and Spinal Surgery, Private Practice, Omaha, 68135, NE, USA

36 Internal Medicine, Executive Director, Association of American Physicians and Surgeons, Tucson, 85716, AZ, USA

37 Foxhall Cardiology, PC, Washington, 20016, DC, USA

38 Orthopedic Surgery, Salinas, 93907, CA, USA

39 McKinney Family Medicine, McKinney, 75070, TX, USA

40 Illinois Sports Medicine and Orthopaedic Center, Glenville, 60025, IL, USA

41 Pulmonary and Sleep Consultants, Ft. Lauderdale, 33316, FL, USA

42 MediCiti Medical College, 500005, Hyderabad, India

43 University of Brasília, Brasilia , 70910-900, DF, Brazil

44 Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, 06510, CT, USA

45 Robb Oto-Neurology Clinic, Phoenix, 85012, AZ, USA

46 Bluegrass Family Wellness, Crestwood, 40014, KY, USA

47 Heinrich Heine University, Düsseldorf, 40225, Germany

48 Past Pres. Association of American Physicians and Surgeons, Tucson, 85716, AZ, USA

49 NephroNet Clinical Trials Consortium, Buford, 30518, GA, USA

50 All Valley Urgent Care, El Centro, 92243, CA, USA

51 Houston Eye Associates, Houston, 77025, TX, USA

52 Victory Health, LLC., 80487, Colorado, USA

53 Vive Life Center, 85728, Arizona & Texas, USA

54 Family Medicine, Mullica Hill, 08062, NJ, USA

55 CMO Emergency Hapvida Saude, HMO, Fortaleza, 60140-061, CE, Brazil

56 National Healthcare Coalition, Family Medicine, Eagle, 83616, ID, USA

57 Affiliate Physician, Columbia University Irving Medical Center, New York City, 10032, NY, USA

30 December 2020

Also available on the AAPS website:

https://aapsonline.org/stem-the-tide-of-covid-hospitalizations-deaths/

Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)

December 30, 2020

Their main points:

early treatment is essential
early treatment is not being done currently in large hospitals (instead it is "wait at home until you turn hypoxic")
multi-drug therapy is essential to cover all bases and reduce risk of breakthrough to severe disease

Their multipronged therapeutic approach includes:

adjuvant nutraceuticals
combination intracellular anti-infective therapy
inhaled/oral corticosteroids
antiplatelet agents/anticoagulants
supportive care including supplemental oxygen, monitoring, and telemedicine

They emphasize that relying on RCTs (randomized clinical trials) do not provide the nuanced treatment protocols that doctors develop from practice:

"Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed .."

Steven Kirsch protocol

Steven Kirsch, a tech entrepreneur (inventor of the optical mouse), has spent his own money for trials for repurposed drugs (where the NIH has been notably absent - as they have been busy with big pharma drug candidates, and have neglected the old drugs with well established safety results).

He had funded a trial of Fluvoxamine - which has allowed it to be included in further trials. It has yielded positive results in the TOGETHER trial as well.

Fluvoxamine is in the FLCCC I-MASK+ and MATH+ protocols as well.

Here Steven Kirsch discusses various early treatment options:

https://www.quora.com/Is-there-any-cure-for-COVID-19/answer/Steve-Kirsch Is there any cure for COVID-19?

Steve Kirsch, High tech serial entrepreneur based in Silicon Valley

April 16, 2021

His website has a tutorial on early treatments, finding early treatment telemedicine doctors who will prescribe the necessary medicines (including ivermectin for prophylaxis), and for long haulers syndrome, and post-vax side-effects (see the section Post-Vaccine Inflammatory Syndrome PVIS):

https://www.skirsch.io/how-to-treat-covid

How to treat COVID, long-haul, and COVID vaccine side-effects

Steven Kirsch

4 MAY 2021

AIMMS, New Delhi, India protocol

Recent AIIMS, New Delhi, India guidelines for at home treatment:

https://pbs.twimg.com/media/EzHEzagUYAQKHEu?format=jpg&name=900x900 AIIMS, New Delhi

INTERIM CLINICAL GUIDANCE FOR MANAGEMENT OF COVID-19 (Version 1.6)

7th April 2021

https://medicaldialogues.in/news/coronavirus/aiims-releases-interim-clinic-guidance-for-management-of-covid-19-76799

AIIMS releases Interim Clinic Guidance for Management of COVID-19

Early Treatment Deniers

Early Treatment cases

Long Haulers Syndrome (long COVID-19)

Synonyms for long haulers:

long haulers
long covid or long covid19
post-acute sequelae of covid (PASC)
post-acute covid-19 syndrome (PACS)

While SARS-CoV-2 virus infection is called COVID-19.

Long haulers syndrome refers to those who have evidently "recovered" from covid19 i.e. 2-3 weeks since day1 of first symptoms, and yet are still suffering from some symptoms.

Some of these symptoms can be due to continuing inflammation (usually recoverable with ivermectin, famotidine, short course of prednisolone (steroids), or other drugs).

And some of these symptoms can be due to organ damage (usually for cases who were in hospital or needed oxygen for a long time and had some lung damage. These symptoms can take time to slowly recover from - for example if there is structural damage in the lung, it may take a longer time to recover.

Long Haulers Treatment cases

Long Haulers Treatment protocols

Long Haulers Treatment Deniers

Long Haulers Treatments - React19 survey of treatments for long haulers and vaccine long haulers

Results: https://react19.org/treatment-outcomes/

or (newer results):

https://longhaulwiki.com/treatment-outcomes/

EDIT: May 16, 2023 - react19 survey is now not being updated - but is being continued by Glenn Chan (@LongHaulWiki on Twitter)

Glenn Chan:

React19 stopped publishing the survey of treatments - which Glenn Chan was involved with).

So now Glenn Chan has continued that effort with his LongHaulWiki website and treatment surveys.

LongHaulWiki Treatment Survey (long haulers and post-vax): https://longhaulwiki.com/treatment-outcomes/

Blog post - guide to treatment results: https://forum.sickandabandoned.com/t/has-anybody-tried-heres-how-you-can-get-answers-to-that-question-fast/228

Video - guide to treatment results: https://odysee.com/@LongHaulWiki:2/What-worked-for-those-who-recovered-Feb-2023:d

Presentation slides: https://longhaulwiki.com/resources/assets/What-worked-Feb-16-2023.pdf

Survey results data dump: https://longhaulwiki.com/treatment-outcomes/2022-11-26-living-survey-b.html

Pharma access to treatment drugs:

https://odysee.com/@LongHaulWiki:2/Dallas-Buyers-Club:c Dallas Buyers Club - How To Get Access To Healthcare January 23, 2023

Presentation slides: https://longhaulwiki.com/resources/assets/Dallas-Buyers-Club.pdf

ME/CFS forum thread on finding reliable online pharmacies: https://forums.phoenixrising.me/threads/tips-for-finding-reliable-and-trustworthy-prescription-free-online-pharmacies.8113/

LongHaulWiki section on getting Ivermectin in various countries of the world:

https://www.longhaulwiki.com/index.php/Ivermectin#How_to_get_ivermectin

Website: https://www.LongHaulWiki.com

Blog posts and forum: https://forum.sickandabandoned.com

Reddit: https://www.reddit.com/u/glennchan

Twitter: https://www.twitter.com/LongHaulWiki

Twitter: https://www.twitter.com/glennchanWordpr

Twitter list - Chronic illness support - For people suffering from chronic illness: https://twitter.com/i/lists/1623781364330889219

Twitter list - COVIDVax/Injured /Adv. - VACCINE INJURED- ADVOCATES - DR/MED PROFESSIONALS https://twitter.com/i/lists/1612610684868775937

Glenn Chan is also the moderator of these sub-reddits:

https://www.reddit.com/r/VaxRecoveryGroup/

https://www.reddit.com/r/longcovidhaulers/

React19:

Twitter: https://twitter.com/React19org

Facebook: https://www.facebook.com/react19org/

Instagram: https://www.instagram.com/react19org/

Website:

https://react19.org/

https://react19.org/symptoms-and-solutions/

https://react19.org/for-patients/

https://react19.org/stories/

References:

https://old.reddit.com/r/vaccinelonghaulers/comments/wwzod0/the_react19_treatment_outcomes_survey_needs_your/ The React19 Treatment Outcomes survey needs your experiences with treatments, good or bad

The survey takes 3-9 minutes and can be completed through this link:

https://docs.google.com/forms/d/e/1FAIpQLSdUdMgkWSUswVl7wQbltbVGLIE572IPYUl6vP18DlwQKIwKww/viewform?usp=pp_url&entry.1840324711=r/VaccineLongHaulers

Once you're done the survey, you can take a sneak peak at the results here:

https://react19.org/treatment-outcomes/

or (newer results):

https://longhaulwiki.com/treatment-outcomes/

Results for other vax injury surveys from React19 and others can be found here:

https://www.longhaulwiki.com/index.php/Vax_injury_research_surveys Vax injury research surveys

Video:

NOTE: Glenn Chan (LongHaulWiki) has reported benefit using Ivermectin for his post-vaccination issues (neurological - twitching of fingers etc.).

https://odysee.com/@LongHaulWiki:2/data-driven-long-haul-treatment:9 A data-driven approach to Long COVID and COVID vaccine injury treatment (July 2022) July 30th, 2022 Long Haul Wiki

Presentation slides are here:

https://longhaulwiki.com/resources/assets/Long-Haul-Treatment-2022-07-29.pdf

Please fill out the Treatment Outcomes survey if you haven't already:

https://forms.gle/ryc6gcJLpUmbjNZ77

Survey results are here (and are constantly being updated):

https://react19.org/treatment-outcomes/

COVID early treatment and prevention info:

https://www.longhaulwiki.com/index.php/COVID_prevention_and_treatment

My (u/stereomatch) comments on the survey:

https://old.reddit.com/r/vaccinelonghaulers/comments/wwzod0/comment/ilunfd9/

Long Haulers Treatments - LongCovidPharmD (organichemusic on Twitter) survey of treatments for long haulers

https://twitter.com/organichemusic/status/1566364020709462016?t=AMrhGtztxJeodBm-41PyvQ&s=19

LongCovid Prescription Survey RESULTS‼️

Lots of charts & data - don't miss anything:

1) comparison charts 2) individual drug pie charts 3) Observations on data

Let's get started!

Twitter: https://twitter.com/organichemusic (LongCovidPharmD)

Website: https://pharmd.substack.com

My (u/stereomatch) comments on the survey (where I suggested that Ivermectin should also be included):

https://twitter.com/stereomatch2/status/1566529233207558145?t=6F18RbDNo6WpyFeJs94WHg&s=19

IVM makes a reasonable showing in react19 survey

But seems to be missing in @organichemusic -perhaps same peer-pressure in academia issue

Here my (u/stereomatch) requrest for chart for Paxlovid:

https://twitter.com/stereomatch2/status/1570398248451424256?t=OXzN5chpGY4t8hhqAwE_cQ&s=19

Do you have a similar chart for Paxlovid?

Long Haulers Treatments - Nattokinase, Serrapeptase, Lumbrokinase

Keywords: Nattokinase, Serrapeptase, Lumbrokinase, fibrinolytics, micro-clots, amyloid, fibrin

After other treatments have reached a plateau (FLCCC I-RECOVER protocol for long haulers and similar protocols - using Ivermectin, Famotidine, steroids, NAC and so on) - and the patient is not improving further - it is now clearer that that last bit of long haulers may be due to micro-clots and amyloid fibrils (and similar buildup of protein complexes).

While some have resorted to more complicated measures like HELP apheresis (Dr Resia Pretorius and others), those groups have also used triple anti-coagulant therapy.

And use of Nattokinase and similar drugs (fibrinolytics).

Nattokinase has been used more - and thus has a stronger anecdotal base than Serrapeptase, Lumbrokinase etc.

Anecdotally in a good percentage of chronic long haulers, Nattokinase seems to help.

Although as with other drugs that nearly always help some (like Ivermectin, Famotidine) - there can be a plateau associated with this as well.

However, more information has become available about Nattokinase dosing - and a recent study suggests that Nattokinase 8000-12000 FU seems to be effective - taking lower doses does not seem to give visible effects.

See this Twitter thread by @organichemusic (LongCovidPharmD) for explanation of the paper:

https://twitter.com/organichemusic/status/1572885502457704453

NEW STUDY on NATTOKINASE!

With further evidence of microclots in #LongCovid emerging, this NK study is timely.

Typical NK dose is 2,000 FU qd, but is that high enough in Long Covid? And is NK safe w/ aspirin? Read ahead for answers, details and Q&A.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441630/

Nattokinase seems to be promising (because it is one of the drugs - along with Ivermectin, Famotidine etc.which seems to help long haulers to some extent) - and will be in FLCCC protocols soon (is mentioned already)

FAQ by @organichemusic - Frequently Asked Questions

For more on Nattokinase follow @organichemusic (LongCovidPharmD) on Twitter - or check out the FAQ website they have recently made:

https://twitter.com/organichemusic/status/1595184415717707776?t=heMPZhYMqwmLKjFJ3rhPsQ&s=19

I get a lot of DMs inquiring about nattokinase dosing, brands, benefits, etc. Please check out my new FAQ section here for all your questions on nattokinase, lumbrokinase and serrapeptase!

https://pharmd.substack.com/p/frequency-asked-questions-nattokinase?utm_source=twitter&sd=pf

Long Haulers Treatments - Survey of Anosmia treatments - on Reddit

Archive of above webpage:

https://archive.ph/ZB9qV

Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs

NOTE: also see the section Ivermectin and post-covid19 Anosmia/Fatigue reversal

Post-covid19 anosmia is linked to inflammation of the area around or surrounding the olfactory bulb (and not necessarily the nerves or olfactory bulb itself).

Also see the section Ivermectin and post-covid19 Anosmia reversal - Dr Been testimony.

The olfactory bulb is the area that covid19 can enter the brain - and the anosmia seems to be an outcome of the inflammatory efforts to block that passage.

In studies on brain MRI scans, there has been evidence of impact on brain - and is via the olfactory bulb:

Generally post-covid19 anosmia seems to reverse without issue with Ivermectin.

And even in some anosmia cases that persisted 5 months or more, there has been near complete reversal of anosmia with Ivermectin.

Thus the clinical anecdotal evidence also suggests that for most post-covid19 anosmia cases that persist for long, there is likely to be near 100% reversal of anosmia.

Since the damage is to the lining and not the nerves/olfactory bulb itself.

That is the sense in that Dr Been video on olfactory bulb - see the wiki:

https://saidit.net/s/Ivermectin2/wiki/index#wiki_ivermectin_and_post-covid19_anosmia.2Ffatigue_reversal

However, the longer the anosmia, I (u/stereomatch) suspect the more refresher doses may be required.

And it is not clear if 99-100pct anosmia reversal is always possible for those with many months old post-covid19 anosmia - though anecdotally nearly everyone who takes Ivermectin is able to recover a large part of their taste/smell (anosmia reversal).

https://www.youtube.com/watch?v=rgeP5lQiajc Brain Shrinking after Mild COVID (Oxford Study)

https://odysee.com/@DrMobeenSyed:1/brain-size-reduction-after-mild-covid:a Brain Size Reduction after Mild COVID (and Potential Solutions)

Mar 15, 2022

Drbeen Medical Lectures

In this followup companion discussions video, Dr Been uses an anatomy program - and does a walkthrough showing brain anatomy and the location of the olfactory bulb:

https://www.youtube.com/watch?v=X6Nwj2-YVRs Discussion for Brain Shrinking After Mild COVID

https://odysee.com/@DrMobeenSyed:1/discussion-for-brain-size-reduction:0 Discussion for Brain Size Reduction After Mild COVID

Mar 15, 2022

Drbeen Medical Lectures

So it could be argued that complete anosmia reversal is a good sign, or that early intervention using Ivermectin may avoid larger issues.

Long haulers and vagus nerve inflammation

Some long haulers suggest that Vagus Nerve inflammation may explain many of the typical long hauler symptoms.

Vagus nerve inflammation as possible factor in long haulers symptoms like POTS:

https://www.reddit.com/r/covidlonghaulers/comments/ushr47/recovery_after_2_years_with_stellate_ganglion/ Recovery after 2 years with stellate ganglion block

Archive of above webpage:

https://archive.ph/012Nv

Post-vax - pre-vaccine protocols for reducing vaccine injury

Rationale for pre-vaccine protocols for reducing vaccine injury

While risk of vaccine injury is low, it is not zero.

There are protocols which can be used to reduce that risk.

Most of these protocols are based on treatment protocols that have been effective in reversing post-vaccine injury/severe side effects either in 1-2 hours, or in severe cases within 3-4 days.

In order to be completely sure these protocols are preventing side effects, one would need to do a trial using a large number of vaccinated cases.

However, it can be reasonably assumed that what works for post-vax injury should also work in a protective way if used early enough (soon after vaccination, or just before).

The reality of mandated vaccinations in a post-Omicron vaccine-hesitant world

Some folks are not comfortable with mRNA vaccines, have already gotten covid19, or feel they have already been exposed to Omicron by now (given it's high transmissability and ubiquity).

A person may already have gotten covid19 (which has superior immunity compared to vaccination according to some studies).

Or a person may be unvaccinated, but is reasonably sure they have been exposed to the ubiquitous and highly transmissable Omicron variant.

They may feel they have little to gain from an mRNA vaccination.

In addition, in a post-Omicron world, there may be less urgency overall for mandated vaccination.

However not all organizations have understood this.

As a result, some employees are stuck between a rock and a hard place - with their workplace-imposed mandated vaccination requirements at odds with their vaccine hesitancy.

Or they may have to travel, and some airline or some country is still requiring mandated vaccinations.

Protocol

See:

https://old.reddit.com/r/ivermectin/comments/retnve/interested_in_a_discussion_on_taking_ivermectin/ Interested in a discussion on taking Ivermectin post vaccine

And the answer there by u/stereomatch:

https://old.reddit.com/r/ivermectin/comments/retnve/interested_in_a_discussion_on_taking_ivermectin/ho9t929

Archive of above webpage:

https://archive.ph/v54k5

Post-vax - side-effects or injury and treatments

This is just a preliminary entry.

Discuss the following with your doctor:

See this case and my (u/stereomatch) comments there too - if you want you can contact the author of that post by replying there with a link to your post here so you don't have to retype.

They also reported benefit with the proposed treatment protocol:

https://old.reddit.com/r/ivermectin/comments/o5g09s IVR After Pfizer Vaccine [Neurological Side Effects].

Update:

https://old.reddit.com/r/ivermectin/comments/osx45y/ivermectin_pepcid_liposomal_glutathione_cured_me Ivermectin + Pepcid + Liposomal Glutathione Cured Me. 90% Better After Vaccine Nerve Problems.

Check out Dr Syed Haider (who has a lot of experience with Ivermectin + Fluvoxamine - and is current with FLCCC protocols and Dr Bruce Patterson/Dr Yo efforts for long haulers).

In this 2nd interview with Dr Been, he says he is now getting 2/3 cases who are long haulers, vaccine injury etc. and 1/3 covid19 patients.

You can get consultation with him as well if you want:

https://www.youtube.com/watch?v=Md-y01JdxvE

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid-2:8

Dr. Syed Haider Discusses COVID Management (July 2021) Drbeen Medical Lectures July 9, 2021

Post-vax - treatment cases

Post-vax - treatment protocols

Post-vax - treatment deniers

Early Treatment and Long Haulers/Post-vaccine treatment - finding doctors and obtaining a prescription

Early Treatment Doctors

The FLCCC dot net maintains a list of doctors that do early treatment.

However currently there are few doctors there for Canada and the UK.

Canada has even prosecuted doctors doing early treatment, and seems to have a toxic atmosphere for doctors.

Early treatment doctors lists

FLCCC maintains a list of early treatment doctors - who will prescribe medicines for prophylaxis, treatment, long haulers, and post-vaccine side effects:

https://covid19criticalcare.com/i-mask-prophylaxis-treatment-protocol/how-to-get-ivermectin/ How to Get Ivermectin

Usually a doctor who is capable of prescribing for covid19 treatment, also will have built up the toolset for treating long haulers and post-vaccine side effects to some degree.

May 13, 2022 - here is another FLCCC webpage with a list of covid19 care providers:

https://covid19criticalcare.com/ivermectin-in-covid-19/covid-19-care-providers/

Here is another list of early treatment doctors:

https://www.exstnc.com/ Directory of Doctors Prescribing
Effective Outpatient COVID-19 Therapy Updated: 21 March 2021

Many of the doctors in this list are also in the FLCCC list above.

Jan 14, 2023: Here is a crowd-sourced list of long covid19 (long haulers) doctors. The public can add doctors they know of who they have found helpful for treatment of long haulers:

https://longcoviddoctors.org

Most of the additions are for the US, but by searching one can see many in the UK as well.

Reference:

https://www.reddit.com/r/LongCovid/comments/xytydp/website_for_long_covid_doctors/

Website for Long Covid doctors

ginger_turmeric

Hi Everyone,

I've made a website where you can add useful long covid doctors. Here's the link: https://longcoviddoctors.org/

Please add any doctors that have helped you. Thanks! Also (if you can) I'd appreciate if you could share the link on social media to spread the word.

https://www.reddit.com/r/LongCovid/comments/xytydp/website_for_long_covid_doctors/irkiqqt

ginger_turmeric

All the doctors here are submitted by long haulers (not me). I checked each doctor's website to make sure they are real/not a scammer, then I approved the submission. So we are relying on each long hauler's opinion here.

https://www.reddit.com/r/LongCovid/comments/xytydp/comment/irmcgia/

ginger_turmeric

Most of the submissions have come from the US, but this website is for the whole world. Just I'm not getting many submissions from outside the US.

Early Treatment situation in UK

The early treatment doctors lists above have very few or zero doctors listed from the UK.

Here are a few in the UK:

Dr Tina Peers - is one early treatment doctor - who is active in treatment of long haulers (search this document for Dr Tina Peers).

But may be hard to get appointment with her - heard that from someone many months ago.

She co-authored the FLCCC I-RECOVER protocol for long haulers - along with Dr Mobeen Syed

https://www.twitter.com/DrTinaPeers

Jan 14, 2023:

Dr Dave Cartland - has started telehealth services in the UK

Twitter: https://www.twitter.com/dr_cartland

Gettr: https://gettr.com/user/drcartland

YouTube channel: https://www.youtube.com/@drcartland2439

Remote telemedicine service: https://drcartland.com/

Dr Philip A McMillan - has been active from the start on early treatment and has interviewed many of the prominent early treatment doctors on his YouTube channel - Vejon Health.

Twitter: https://www.twitter.com/philamillan

Substack 1: https://philipmcmillan.substack.com/

Substack 2: https://drphilipmcmillan.substack.com/

YouTube channel: https://www.youtube.com/@VejonHealth

Dr Claire Taylor - is a doctor specializing in long covid19/long haulers - and is also active on Twitter.

Not as much early treatment aware maybe (and not experienced in Ivermectin) - but is specializing in micro-clots - and may be running a long haul clinic.

Twitter: https://twitter.com/drclairetaylor

Early Treatment situation in Canada

The early treatment doctors lists above have very few or zero doctors listed from Canada.

EDIT: but now we can see one doctor listed at:

https://www.exstnc.com/

CANADA

Dr. Umbrine Fatima (Ontario only)

+1 (716) 407-3250

admin@myhealth360wellness.com

myhealth360wellness.com

Prophylaxis, Active, Long COVID (appointments only ... no walk ins)

Dr Ira Bernstein based in Toronto, is an active early treatment campaigner who is active on Twitter (search this document for Dr Ira Bernstein).

But he may not be taking new patients.

The early treatment situation in Canada is worse than in the US.

In the US there is a push to censure early treatment doctors with the American Medial Association (AMA) writing to state medical boards to penalize doctors, and to pharmacist associations to deny delivery of early treatment drugs.

However, there is also pushback by early treatment doctors and those in support of early treatment.

In Canada the situation is much worse than the US - with the few who have tried to treat early having been debarred or censured.

Very few doctors in Canada are listed in the list of early treatment doctors.

While one can get a consult with an early treatment doctor in the US or India, they will find it harder to get their prescription respected by a pharmacy in Canada.

It will be difficult to get a pharmacy in Canada to fill a prescription for Ivermectin.

However Ivermectin is not the only drug to use.

Far more important is the availability of steroids-at-day8 - which can be a lifesaver (to quell the post-day8 hyperinflammatory stage).

So even though a Canadian doctor may be afraid to prescribe Ivermectin (for fear of being debarred by his medical accreditation board), they should still be able to prescribe other drugs suggested by the FLCCC MATH+ protocol.

For example Famotidine, and steroids-at-day8 (Prednisolone) - or Cyproheptadine and Inhaled Budesonide (inhaled steroids) for serious patients post-day8.

So even if Ivermectin is not available, there are plenty of other non-controversial drugs that an early treatment doctor can use to ensure there are zero deaths and zero long haulers (notably the availability of steroids-at-day8 protocol).

Reference:

https://old.reddit.com/r/ivermectin/comments/nkibab/someone_close_to_me_is_sick_with_covid_i_would/gzdc54x

https://old.reddit.com/r/ivermectin/comments/nmbuab/seriously_how_do_i_get_this_in_canada/

Dr Been (Dr Mobeen Syed)

Dr Been is a licensed doctor and engineer.

Dr Been is only licensed to practice in Pakistan.

Dr Been is an educator with a long list of important videos esp on the covid19 pandemic.

He has also interviewed a number of early treatment doctors about treatment strategies.

Dr Been has also contributed to the FLCCC I-RECOVER protocol for long haulers.

And has hosted some of the FLCCC conferences.

From: https://covid19criticalcare.com/drbeen/

A medical doctor and software engineer, Dr. Mobeen Syed (known to his fans as Dr. Been) has been teaching medicine since 1994. He collaborated with the FLCCC Alliance to create the I-RECOVER protocol to treat long COVID.

Dr Been's YouTube channel:

https://www.youtube.com/c/USMLEOnline Drbeen Medical Lectures

Dr Been's newer YouTube channel - for discussion (created March 2022):

https://www.youtube.com/channel/UCKt2yqtcxJtqjJujr93yX4A KoolBeens Cafe Live

YouTube has been censoring some of his videos on Ivermectin.

YouTube is a signatory to the Trusted News Initiative (TNI).

Dr Been often has to use other names for the drug in his discussions:

Loofymectin (Loofy is one of his cats)

Dr Been now has a presence on Odysee:

https://odysee.com/@DrMobeenSyed:1

And Bitchute as well. There is a reddit-wide ban on bitchute links, but you can use a tinyurl or bit dot ly url shortener instead:

https://www dot bitchute dot com/channel/bbZOpTZkmPY0

https://tinyurl.com/v3x8yx53

And on Rumble:

https://rumble.com/user/drmobeensyed

Website:

https://www.drbeen.com

Twitter:

https://twitter.com/drbeen_medical

Dr Been's substack:

https://mobeensyedmd.substack.com

Dr Been on reddit:

https://www.reddit.com/u/mastcell

Dr Syed Haider

Dr Syed Haider is a pioneer in the use of Fluvoxamine (along with Ivermectin).

Dr Syed Haider has a lot of experience with Ivermectin + Fluvoxamine - and is current with FLCCC protocols and Dr Bruce Patterson/Dr Yo (IncellDx and covidlonghaulers.com) efforts for long haulers.

In this 2nd interview with Dr Been (from July 9, 2021), he says he is now getting 2/3 cases who are long haulers, vaccine injury etc. and 1/3 covid19 patients.

You can get consultation with him as well if you want via his website (see below).

In his 2nd interview with Dr Been, he said his website is free for signup, and the chat feature there is free for asking him questions:

https://www.youtube.com/watch?v=Md-y01JdxvE

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid-2:8

Dr. Syed Haider Discusses COVID Management (July 2021) Drbeen Medical Lectures July 9, 2021

The above interviews are examples of how responsive doctors have been thinking about the management of covid19 disease, long haulers and post-vax side effects.

Compare this to how doctors at large US hospitals are following rigid hospital-mandated protocols (6mg dexamethasone + Remdesivir) - protocols which have remained unchanged for 1.5 years - despite the excessive mortality seen at these hospitals (when compared to hospitals which use FLCCC MATH+ protocol for example) - or as compared to the early treatment doctors (who have near zero deaths, and near zero long haulers).

Here is his 1st appearance on Dr Been:

https://www.youtube.com/watch?v=v8-J1ES86os

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid:9

Dr. Syed Haider Discusses COVID Management Drbeen Medical Lectures May 2, 2021

As one of the moderators of r/ivermectin I (u/stereomatch) had been hearing a lot of feedback on patient experiences with Dr Syed Haider. In this post on r/ivermectin, I discussing the telemedicine doctors available that have been vetted by the FLCCC, as well as Dr Syed Haider:

https://old.reddit.com/r/ivermectin/comments/malbqw/telemedicine_doctors_dr_syed_haider_an/ Telemedicine doctors - Dr Syed Haider - an interesting telemedicine doctor and emerging resource for Ivermectin and Fluvoxamine

Dr Syed Haider mentions in the video above that signup is free on his website - and he mentions that asking questions via chat is free.

Website: https://www.drsyedhaider.com

Dr Syed Haider lists these websites in his video descriptions:

https://mygotodoc.com - prepper antibiotics and med refills.

https://drsyedhaider.com - COVID protocols

Twitter: https://twitter.com/DrSyedHaider (Twitter banned this account - reinstated after Elon Musk acquisition of Twitter)

Twitter: https://twitter.com/DrSyedHaider2 (however this account is not used that much)

Facebook: https://www.facebook.com/docsyedhaider

Facebook: https://www.facebook.com/syedhaidermd

April 29, 2022 - Dr Syed Haider now has his own YouTube channel as well (mirrored to Odysee as well):

YouTube: https://www.youtube.com/channel/UCUTZ04QJ1OF24lfhGjof33A

Odysee: https://odysee.com/@drsyedhaider:e

Rumble: https://rumble.com/c/DrSyedHaider

2021-12-30

Some users had reported that Dr Syed Haider is focusing more on delivering medicines ahead of time to the patient.

FLCCC also recommends having the protocol drugs available at home ahead of time because of the delays in getting drugs delivered to patients, pharmacies that are refusing to fill generic drugs for covid19 (like Ivermectin). Thus having these medicines at home in the medicine cabinet ahead of time is preferred.

Dr Miguel Antonatos (Text2MD.com)

Dr Miguel Antonatos is also one of the pioneers in the use of Ivermectin + Fluvoxamine:

https://www.youtube.com/watch?v=0G2nBJT_xUk Dr. Antonatos Discusses COVID management May 11, 2021 Drbeen Medical Lectures

He also has made a 2nd appearance on Dr Been:

https://youtu.be/gfskyH8pXlM Dr. Antonatos Discusses COVID management (7/14/2021) Drbeen Medical Lectures July 14, 2021

He is also listed on the early treatment doctor's list:

https://www.exstnc.com/

Dr. Miguel Antonatos

(855) 767-8559

https://text2md.com

(States: AL, AZ, CO, FL, GA, IA, ID, IL, KS, KY, MD, ME, MI, MN, MS, ND, NE, NJ, NV, NY, OK, SC, SD, TN, UT, VT, WA, WI, WV)

Dr Miguel Antonatos also treats long haulers.

You may want to check out some of the comments for this Dr Been video - similar symptoms - neurological etc.

And the one comment below has mention of Dr Miguel Antonatos (Text2MD.com):

https://youtu.be/rGCgc1mX4cg

Post COVID Long Haul Syndrome (PCLHS) Management Drbeen Medical Lectures Jun 17, 2021

Post COVID Long Haul Syndrome (PCLHS) Management Let’s discuss the first release of the post COVID long-haul syndrome management.

Comments:

Lisa Tipton

My husband and I have just completed the entire FLCCC I-recover protocol and happy to report all of our symptoms have resolved. We are patients of Dr. Antonatos/text2MD and we are happy he gave us this protocol even before it was published on the FLCCC site. We did take IVM + protocol during COVID but 2 months later found some of the symptoms returned after we resumed exercise, or a few had just not completely gone away. This protocol works!!!

Dr Ben Marble (myfreedoctor.com)

Aug 4, 2023: Dr Ben Marble founded myfreedoctor.com - donation based and free telemedicine in 50 states of US.

Dr Ben Marble created the service myfreedoctor.com keeping in mind that there were a large number of patients in the US suffering from covid19 and allied conditions - who may not be able to afford early treatment.

So he adopted a donation model - those who could pay would pay, while those who could not would be able to get a free consult (though would still have to pay for the medicines).

Twitter: https://twitter.com/BenMarble_MD (suspended then reinstated)

Twitter: https://twitter.com/MarbleBenjamin (Account suspended)

Dr Syed Haider interviews Dr Ben Marble of myfreedoctor.com:

https://www.youtube.com/watch?v=NU9nCGdZids

This video has been removed for violating YouTube's Community Guidelines

Mirror:

https://odysee.com/@drsyedhaider:e/dr-ben-marble-free-online-healthcare:3 DR BEN MARBLE: FREE ONLINE HEALTHCARE Dr Syed Haider June 20, 2022

at 5:30 minute mark:

250,000 patients treated - only lost 6 patients

Covexit interview of Dr Ben Marble:

https://youtu.be/W-HFRuII6W4 Let's Talk Telemedicine with Dr. Ben Marble Covexit News and Analysis Jun 28, 2021

Mirror:

https://rumble.com/vj42yd-interview-of-dr-ben-marble-from-myfreedoctor.com.html

Interview of Dr Ben Marble, from MyFreeDoctor.com June 27, 2021

With over 20,000 consultations, MyFreeDoctor.com has become a leading telemedicine service for the early treatment of COVID-19 in the USA. Learn about how this initiative came to birth, how it evolved, and what are the plans for Dr Marble has for further expanding the initiative, both nationally and internationally.

Dr Ben Marble at the US Senate roundtable:

https://rumble.com/vth9i3-dr.-ben-marble-md-founder-of-myfreedoctor.com-has-99.99-survival-rate.html

Dr. Ben Marble MD, Founder of MyFreeDoctor.com, Has 99.99% Survival Rate Jan 28, 2022

References:

u/Full_Food6568 has a walkthrough for getting a prescription from myfreedoctor.com (founded by Dr Ben Marble) - they ask for a donation from those who can pay, free for others:

https://old.reddit.com/r/ivermectin/comments/oihckh IVM prescriptions from myfreedoctor.com (see captions for how to)

u/botfantasies has another walkthrough for getting a doctor's consult and prescription for ivermectin from myfreedoctor.com:

https://old.reddit.com/r/ivermectin/comments/ojulud CONFIRMED: FASTEST, CHEAPEST, SAFEST WAY TO GET IVERMECTIN IN THE USA

Dr Mollie James (Telemedicine - US)

Dr Mollie James is familiar with the FLCCC protocols and was one of the panel members on stage at the Global Covid Summit.

Twitter: https://twitter.com/molsjames/

Website:

https://www.ivermectincan.com

https://www.ivermectincan.com/about

adding Jan 7, 2023: https://www.jamesclinic.com/about

References:

https://twitter.com/molsjames/status/1612089014802169856

Dr Mollie James

Here’s how to:

Become a patient: http://jamesclinic.com

or 636-751-9440

Request speaking: hello@jamesclinic.com

Follow more:

IG: @molsjames @james_clinic

Facebook: same

Listen: http://realtalk933.com or thru app @RealTalk933FM - T-Th-Fri 9-11 central

adding Sept 9, 2023: Twitter thread on Dr Mollie James' podcast:

https://twitter.com/molsjames/status/1699030308681658464

Todays the day!

My podcast drops! Episodes linked below:

Dr Mary Talley Bowden (Florida, US)

For Florida residents, Dr Mary Talley Bowden offers monoclonal antibody treatments and early treatment protocols (is familiar with FLCCC).

Twitter:

https://twitter.com/MdBreathe

Dr Mary Talley Bowden

Dr. Bowden’s practice Breathe MD is here - website:

https://breathemd.org/

Dr Darrell DeMello (Mumbai, India)

Mumbai based Dr Darrell DeMello favors use of Colchicine (which has not done so well in studies - but perhaps they are using it incorrectly).

Currently has incorporated Ivermectin - but still used Colchicine (anti-oxidant/anti-inflammatory) and steroids.

https://old.reddit.com/r/ivermectin/comments/nri2mz/dr_darrell_demello_discusses_covid_outpatient Dr. Darrell DeMello Discusses COVID Outpatient (June 3, 2021) - Dr DeMello shares his experiences treating in Mumbai, India with Dr Been

Colchicine is used for pericarditis - it's use for covid19 may prevent the heart rate issues that are common in long haulers.

Twitter: https://twitter.com/DarrellMello

COVID Telemedicine. Treated over 10,000 cases of Acute Covid Infection successfully. Treat Post/Long COVID. Vaccine Prophylaxis.

Mumbai

Call/WhatsApp: +918097249586

Website: https://www.darrelldemello.in/

Dr Darrell DeMello offers telemedicine services in India and in some countries outside India as well - possibly the UK (?)

For the US - although he may be able to consult in the US, if he is not registered to practice there, his prescription may not be filled by a pharmacist.

He also offers consultation to corporations:

https://www.darrelldemello.in/faq

Dr AK Chaurasia (UP, India)

Dr AK Chaurasia (Anil Kumar Chaurasia) is located in Uttar Pradesh, India.

He is well regarded among early treatment-aware users on Twitter for his insights into covid19 treatment.

He is quite accessible, and answers questions, and may be contacted for consultations as well:

Twitter: https://twitter.com/drakchaurasia

Dr Shankara Chetty (South Africa)

Dr Shankara Chetty has had to work without access to Ivermectin (South Africa initially jailed doctors for prescribing Ivermectin - has now relented in the face of legal action by doctors).

https://old.reddit.com/r/ivermectin/comments/o6kw7t/covid_management_with_dr_shankara_chetty_june_23 COVID Management With Dr. Shankara Chetty (June 23, 2021) - Dr Been interviews Dr Chetty from South Africa who has been treating covid19 with an H1/H2 anti-histamine protocol (and steroids at day 8 - similar to MATH+ protocol)

He has crafted a protocol that uses H1/H2 blocker anti-histamines initially - and then steroids at day 8 (similar to FLCCC protocol).

Now he argues that using anti-histamines usually shows recovery within 4 hours.

If patient is not showing recovery within 4 hours, he sees that as a sign that this is post-day-8 hyperinflammatory stage which will require steroids.

And then he treats them aggressively with steroids.

Essentially he is treating with steroids by day 8 - however since with newer variants it can be difficult to pinpoint day 1 (because of mild initial symptoms) - one needs to be independently assessing patient state for day 8 hyperinflammatory stage. Declines in oximeter settings is another.

Dr Ira Bernstein (Canada)

Dr Ira Bernstein is an active early treatment campaigner who is also active on Twitter in support of early treatment strategies for covid19.

Twitter: https://twitter.com/search?q=ira%20bernstein

Website: https://doctorirabernstein.ourmd.ca/our-team

Dr Ira Bernstein in based in Toronto.

However does not take many new patients last we heard (from comments on reddit from some time ago).

Dr Tina Peers (UK)

UK based doctor specializing in Mast Cell Activation Syndrome (MCAS).

Active in treatment of long haulers - which may also have MCAS involvement.

Treatment includes H1/H2 blocker antihistamines.

Twitter: https://twitter.com/DrTinaPeers

Website: https://www.drtinapeers.com/

Dr Steven Phillips (author of bestseller 'Chronic')

Dr Steven Phillips is the bestselling author of "Chronic" and has been interviewed by Dr Been many times:

https://www.youtube.com/watch?v=xwMwR6IJC3o Chronic Diseases Talk with Dr. Steven Phillips (Lyme, COVID Long Haul and More) March 19, 2021 Drbeen Medical Lectures

He has some interesting insights into Lyme disease, Multiple Sclerosis.

And auto-immune disease, dementia and chronic pain.

And is aware of Ivermectin use for nerve remyelination in Multiple Sclerosis (see the section Ivermectin for Multiple Sclerosis (MS), Lyme disease and for nerve remyelination).

He has expertise in covid19 treatment, long haulers (long covid19) as well.

Twitter: https://twitter.com/StevePhillipsMD

Substack: https://zerospin.substack.com

Website: https://stevenphillipsmd.com/

Consult: https://stevenphillipsmd.com/our-practice/

Dr Steven Phillips substack article on Ivermectin - anti-cancer, nerve remyelination potential, and use against chronic viral infections:

https://zerospin.substack.com/p/ivermectin-upon-neutral-ground Ivermectin--Upon Neutral Ground The truth will set you free. But first it will piss you off. Mar 1, 2022

Dr Pierre Kory (President - FLCCC)

Dr Pierre Kory is one of the founding members of the FLCCC, and has been very active in his advocacy for early treatment protocols.

He is well known for his testimony at the US Senate, first in favor of steroids-at-day8 (at a time when WHO/NIH/CDC had campaigned to dissuade doctors from using it), and then for Ivermectin for prophylaxis and treatment.

Prior to his advocacy for early treatment, Dr Pierre Kory was an Associate Professor and Medical Director of the Trauma and Life Support Center, and Chief of the Critical Care Service at the University of Wisconsin, in the US.

Advocacy for early treatment cost jobs

Dr Pierre Kory recounts how his advocacy for early treatment landed him in hot water at his job:

https://pierrekory.substack.com/p/how-i-lost-three-icu-jobs-during?r=iutjw&utm_campaign=post&utm_medium=web

How I Lost Three ICU Jobs During the COVID-19 Pandemic - Job 1

Prior to COVID, I was a nationally known expert in Pulmonary & Critical Care Medicine. Despite the massive need for specialists like me across the US, I had to leave 3 different US medical centers.

Pierre Kory, MD, MPA

January 19, 2022

Dr Pierre Kory's substack blog:

https://pierrekory.substack.com/

Dr Pierre Kory now has a website (April 2022) - for telemedicine appointments for covid19, long haulers (long covid19), and post-vax injury for most states in the US:

https://drpierrekory.com/

https://drpierrekory.com/contact/

https://twitter.com/PierreKory/status/1510992408854601729?t=7weqhH8JrZH5_pUSiZNi3A&s=19

Pierre Kory, MD MPA

Me and my http://drpierrekory.com team are happily learning more and more about the treatment of long haul and post-vax syndromes..and our patients are even happier. Check out our reviews, let us know if we can help anyone, we are seeing most states now!

https://drpierrekory.com/reviews/

Dr Pierre Kory is active on Twitter: https://twitter.com/PierreKory

Instagram: https://www.instagram.com/pierrekorymd/?hl=en

LinkedIn: https://www.linkedin.com/in/pierre-kory-md-mpa-8021731b6

Facebook: https://www.facebook.com/Dr-Pierre-Kory-105970911953636

Gab: https://gab.com/PierreKoryofficial

Telegram: https://t.me/PierreKoryFLCCCofficial

Dr Paul Marik (FLCCC co-founder)

Dr Paul Marik is the co-founder of FLCCC, and the author of the original MATH+ protocol which:

first (early to mid-2020) clearly laid out the viral timeline (that live virus is near zero by day5 for many, and near zero by day8 for nearly all) - which justifies the use of steroids-at-day8
outlined a plan of treatment - that was updated over time
Ivermectin originally appeared as optional, and steadily was elevated as more evidence became apparent

Dr Paul Marik invaluable advice in appearances on Dr Been show

Dr Paul Marik has appeared a few times on Dr Been show - where he has outlined invaluable advice about covid19 patient management - often nuances that are not evident from reading MATH+ protocol:

outlining the need for ESCALATING steroids if hypoxia (inflammatory signals) are not reversing immediately - as reversing the hyperinflammatory explosion early is crucial and to use however much steroids it takes to achieve that (they can later be tapered down to levels while keeping them high enough so there is no rebound of hyperinflammatory signals)
outlining the problem with large US hospital protocols which oddly CAP the dosage of Dexamethasone at 6mg (equivalent to Prednisolone 40mg) which is sometimes not enough for the most severe patients or those who arrive late - and their use of Remdesivir at day8 which is seen negatively by the WHO, yet continues to be practiced widely in the US and overseas - Dr Paul Marik says these hospitals are using "homeopathic doses of steroids"

Here is the list of appearances of Dr Paul Marik on Dr Been's YouTube show:

https://www.youtube.com/watch?v=xZJixjgu3tk

COVID-19 Patient Management with Dr. Paul Marik (Author of MATH+ Protocol)

Jul 16, 2020

https://www.youtube.com/watch?v=cy1kdZhXsP8

COVID-19 Management With Dr. Paul Marik - Author Of MATH+ Protocol

Sep 16, 2020

https://www.youtube.com/watch?v=DOWEPqHtt-0

Dr. Paul Marik Discusses Vitamin D, COVID Prophylaxis (IMASK+ Protocol)

Mar 8, 2021

https://www.youtube.com/watch?v=O4gkLn-z4II

Dr. Paul Marik Discusses Latest Trends In COVID Management

Jun 30, 2021

https://www.youtube.com/watch?v=bXiDpMBvsO8

A Talk With Prof. Dr. Paul Marik (11/17/2021)

Nov 18, 2021

Dr Joe Varon - co-founder FLCCC

Dr Joe Varon is one of the most interviewed doctors in the US on covid19.

See Ivory Hecker's interview with Dr Joe Varon - where he mentions the media interviews have steered clear of mentioning Ivermectin:

https://www.bitchute.com/video/rvccR4Tg6fRS

https://odysee.com/@ChristopherKennethBowser:6/Ivory-Hecker-Sends-A-Message-Of-Courage:3

Pursuing Truth in COVID Drug Treatment Amid a Censored Media Landscape

Ivoryhecker

June 25, 2021

Early Treatment discussions - censorship by YouTube, Facebook and others

YouTube along with other Big Tech media (that are signatories of the Trusted News Initiative (TNI)) have been censoring discussion of early treatment.

The FLCCC and other groups of ICU doctors who have been trying to get the word out (and have been right in their advice than the WHO/NIH/CDC/FDA) - have been banned.

For example, the FLCCC YouTube channel got banned a long time ago:

FLCCC Press: https://www.youtube.com/channel/UC5rJlf5jdr_I6qiozbQdx-g

"This account has been terminated for violating YouTube's Community Guidelines.")

YouTube Terms of Service explicitly prohibits Ivermectin and Hydroxychloroquine as drugs that should NOT be suggested as treatments for covid19:

https://support.google.com/youtube/answer/9891785?hl=en COVID-19 medical misinformation policy

Or archive.org snapshot (May 24, 2021):

https://web.archive.org/web/20210524215029/https://support.google.com/youtube/answer/9891785?hl=en

YouTube doesn't allow content that spreads medical misinformation that contradicts local health authorities’ or the World Health Organization’s (WHO) medical information about COVID-19. This is limited to content that contradicts WHO or local health authorities’ guidance on:

NOTE: are they aware that WHO's own meta-analysis (based on Dr Andrew Hill for UNITAID) found 81 percent mortality benefit, and yet a recommendation to use in clinical trials only?

NOTE: WHO decision seems to be a political decision - as Dr Andrew Hill suggested in a video presentation earlier, EU and other countries without a strategic stockpile of ivermectin need time to acquire such stocks

Note: YouTube’s policies on COVID-19 are subject to change in response to changes to global or local health authorities’ guidance on the virus. This policy was published on May 20, 2020.

If you're posting content

Don’t post content on YouTube if it includes any of the following:

Treatment misinformation:

Content that recommends use of Ivermectin or Hydroxychloroquine for the treatment of COVID-19

Claims that Ivermectin or Hydroxychloroquine are effective treatments for COVID-19

Prevention misinformation: Content that promotes prevention methods that contradict local health authorities or WHO.

Content that recommends use of Ivermectin or Hydroxychloroquine for the prevention of COVID-19

NOTE: text below is taken from: https://old.reddit.com/r/ivermectin/comments/mrdisk/comment/guli1wm/

Mary Beth Pfeiffer reports on YouTube's warning to content creators about mentioning ivermectin:

https://twitter.com/marybethpf/status/1382362064170156040?s=19

The folks at YouTube, who think they know best, have updated their medical misinformation policy. IVM & HCQ are off the menu. Step out of line, censor cops strike. Legit medical debate is being squelched. Free speech is being stomped on by this monopoly.

The tweet above is not visible because it's author Mary Beth Pfeiffer has been banned from Twitter (!)

However the rest of the thread can still be viewed using the above link.

YouTube censorship - Sen Ron Johnson

Sen Ron Johnson (Wisconsin) - has played a strong role in advocacy for early treatment in covid19.

He led the Senate hearings on early treatment - which highlighted Dr Pierre Kory testimony favoring use of steroids for covid19.

This was at a time when WHO/NIH/CDC had started dissuading doctors from using steroids for covid19 (a wrong move - since steroids-at-day8 is THE way to prevent progression to death and to get zero long haulers).

His second set of hearings at end of 2020 led to Dr Pierre Kory's famous plea for inclusion of Ivermectin in early treatment protocols - especially their use for prophylaxis.

Listen to the tone of this piece from Forbes - written by a Professor of Health Policy and Management at CUNY (previous research has been funded by Gates Foundation as well):

https://www.forbes.com/sites/brucelee/2021/06/12/youtube-suspends-republican-senator-ron-johnsons-account-for-violating-covid-19-policy/?sh=14a010f946eb YouTube Suspends Republican Senator Ron Johnson’s Account For Violating Covid-19 Policy Bruce Y. Lee June 12, 2021

Senator Ron Johnson (R-Wisconsin) is neither a medical doctor nor a scientific researcher. And he isn’t the Johnson in Johnson & Johnson. But that didn’t keep him from talking about the use of hydroxychloroquine and ivermectin against Covid-19 and his YouTube account from posting a video featuring his comments. And now surprise, surprise this video has gotten his account banned from YouTube for seven days.

According to Bill Glauber reporting for Milwaukee Journal Sentinel, a YouTube spokesperson said the following about the Johnson video: “We removed the video in accordance with our Covid-19 medical misinformation policies, which don’t allow content that encourages people to use Hydroxychloroquine or Ivermectin to treat or prevent the virus.” Per Glauber, Johnson apparently stood up and made the comments at the Milwaukee Press Club on June 3. Glauber also quoted Johnson criticizing the U.S. government for “not only ignoring but working against robust research [on] the use of cheap, generic drugs to be repurposed for early treatment of Covid.”

So these journalists and their outlets were instrumental in the suppression and generation of derision for early treatment options.

YouTube’s policy about ivermectin and hydroxychloroquine is pretty clear. It says, “Don’t post content on YouTube if it includes any of the following:

Content that recommends use of Ivermectin or Hydroxychloroquine for the treatment of Covid-19

Claims that Ivermectin or Hydroxychloroquine are effective treatments for Covid-19

Content that recommends use of Ivermectin or Hydroxychloroquine for the prevention of Covid-19”

This is completely in line with what’s indicated by the National Institutes of Health (NIH) Covid-19 Treatment Guidelines about hydroxychloroquine and ivermectin.

Note how these draconian measures against Ivermectin are an overreaction - compared to NIH's own ambivalence about Ivermectin - don't recommend for OR AGAINST Ivermectin:

And here’s what the guidelines say about ivermectin: “There are insufficient data for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.”

This statement about the number killed by vaccines may be not far from the mark - from new disclosures about Pfizer clinical trial (as of March 19, 2022 today):

And in May, Joy Reid on her MSNBC show Joy Reid called Johnson a “dangerous disinformation peddler” after Johnson inaccurately claimed that Covid-19 vaccines had killed over 3,000 people:

YouTube censorship - Sky News Australia

https://www.bbc.com/news/world-australia-58045787 Sky News Australia barred for week by YouTube over Covid misinformation 1 August 2021

Archive of above webpage:

https://archive.ph/56P80

YouTube has barred Sky News Australia from uploading new content for a week, saying it had breached rules on spreading Covid-19 misinformation.

YouTube did not point to specific items but said it opposed material that "could cause real-world harm".

A YouTube statement said it had "clear and established Covid-19 medical misinformation policies based on local and global health authority guidance".

A spokesperson told the Guardian it "did not allow content that denies the existence of Covid-19" or which encouraged people "to use hydroxychloroquine or ivermectin to treat or prevent the virus". Neither has been proven to be effective against Covid.

https://www.skynews.com.au/business/media/youtubes-sky-news-australia-suspension-disturbing-assault-on-freedom-of-thought/news-story/cc2ce1cad0dd5ec9693e2192759eab8b#top YouTube’s Sky News Australia suspension ‘disturbing’ assault on freedom of thought

Digital Editor Jack Houghton argues YouTube’s decision to suspend Sky News Australia is a disturbing attack on the ability to think freely. Jack Houghton Digital Editor August 1, 2021

Archive of above webpage:

https://archive.ph/prUmk

YouTube censorship - Kim Iversen (journalist - The Hill)

Kim Iversen's YouTube channel was suspended (removed) from YouTube after she covered a study on efficacy of Ivermectin.

Another example of the Trusted News Initiative (TNI) at work.

Here she discusses her suspension on a segment of The Rising show on The Hill in which she appears:

https://old.reddit.com/r/ivermectin/comments/th8vtx/kim_iversen_is_suspended_from_youtube_over/ Kim Iversen Is SUSPENDED from YouTube Over Segment On Covid Therapeutic Study and IVM prosperouslife

Video:

https://www.youtube.com/watch?v=lnsByps85gE

Kim Iversen Is SUSPENDED From YouTube Over Segment On Covid Therapeutic Study

Mar 14, 2022

The Hill

Kim Iversen details the suspension of The Kim Iversen Show's YouTube channel.

According to the CDC: Ivermectin is not authorized or approved by FDA for prevention or treatment of COVID-19. The National Institutes of Health’s (NIH) COVID-19 Treatment Guidelines Panel has also determined that there are currently insufficient data to recommend ivermectin for treatment of COVID-19.

YouTube censorship - Dr Been (Dr Mobeen Syed)

Dr Been now has a presence on Odysee and Bitchute as well:

https://odysee.com/@DrMobeenSyed:1

There is a reddit-wide ban on bitchute links, but you can use a tinyurl or bit dot ly url shortener instead:

https://www dot bitchute dot com/channel/bbZOpTZkmPY0

https://tinyurl.com/v3x8yx53

At one point, Dr Been had 54 of his videos demonetized by YouTube - the Trusted News Initiative (TNI) at work:

https://old.reddit.com/r/ivermectin/comments/mm3ju6 Dr. Been mentions at 5:20 that all of his past videos mentioning ivermectin have been demonetized and he won't be speaking that word going forward.

In Dr Been's own words:

https://twitter.com/drbeen_medical/status/1379575228670435332?s=19

54 videos demonetized in one day by @YouTube.

All are medical concept videos for education. No conspiracy. Just medical concepts.

YouTube censorship - MedCram (Dr Roger Seheult)

Has also reported videos removed by YouTube for discussing academic papers about Ivermectin - the Trusted News Initiative (TNI) at work.

YouTube censorship - WhiteBoard Doctor

Has also reported videos removed by YouTube for discussing academic papers about Ivermectin - the Trusted News Initiative (TNI) at work.

Very active YouTube doctor who has analyzed papers on Ivermectin and other treatment options very actively.

YouTube censorship - Dr Yo

Has also reported videos removed by YouTube for discussing academic papers about Ivermectin - the Trusted News Initiative (TNI) at work.

Dr Yo is a prominent YouTube doctor. Joined Dr Bruce Patterson (IncelDX) work on characterizing long haulers syndrome, and is active in their outreach effort to collate blood samples so a test could be fine-tuned for long haulers (a test will go a long way to dispelling the notion among many doctors who don't know how to treat it - that it is a psycho-somatic disease):

https://www.covidlonghaulers.com

He also has had YouTube videos fall victim to the Trusted News Initiative (TNI).

YouTube censorship - Dr John Campbell

Has also reported videos removed by YouTube for discussing academic papers about Ivermectin - the Trusted News Initiative (TNI) at work.

Mainstream YouTuber - frequent guest on Deutsche Welle TV (DW TV).

Has always maintained Vitamin D deficiency needs to be addressed for improved outcomes in covid19.

Has also been repeatedly disappointed by WHO and NIH/CDC guidelines and how far off the mark they are or always late to the game.

Has invited Dr Tess Lawrie on his YouTube channel (see Dr Tess Lawrie section above for videos).

Slow convert to Ivermectin.

Now urges UK govt to strongly consider ivermectin for further investigation:

https://old.reddit.com/r/ivermectin/comments/o0xzp9/_/ Dr. John Campbell reviews Egyptian nasal spray study and re-issues an urgent call to all health authorities and ministers to immediately address the evidence on ivermectin!

Video:

https://youtu.be/R0-90kvoQac Vaccination and ivermectin

Dr. John Campbell

994K subscribers

Jun 16, 2021

Dr John Campbell discusses how there is money and support for patented antivirals still in development (with no safety profiles).

Yet generic drugs with excellent safety records that are promising (like Ivermectin) remain unfunded and unsupported - the NIH has (as of July 2021) not funded a single trial of Ivermectin (despite pleas by Dr Rajter author of the first Ivermectin study in the US - at the Broward County Hospital system):

https://www.youtube.com/watch?v=Of5_oiuqDp8 Money for antivirals

160,834 views

Jun 20, 2021

Dr. John Campbell

1.05M subscribers

Dr John Campbell - social media:

Twitter: https://twitter.com/Johnincarlisle

Substack: https://substack.com/@johninengland

YouTube: https://www.youtube.com/channel/UCF9IOB2TExg3QIBupFtBDxg

Website: https://drjohncampbell.co.uk/

Twitter and LinkedIn censorship - Dr Darrell DeMello (Mumbai, India)

Dr Darrell DeMello has been censored on Twitter and LinkedIn for talking about early treatment for covid19 and for dengue:

https://twitter.com/DarrellMello/status/1551100539790061568?t=pu3i07YE879C8SEadD7Smw&s=19

DrDarrellDeMello

I have successfully treated patients with Dengue Fever using a combination of Colchicine and Ivermectin. Reversal of platelet count occurs 24-48 hours. Covid-19 has helped me learn a lot!

NOTE: the above tweet has now been deleted by the author (possibly related to his recent temporary ban on Twitter):

https://twitter.com/drakchaurasia/status/1552362119101759488?t=cYDiIzDddhIdaaNjyILwxg&s=09

dr a k chaurasia

Dr D, were you blocked recently by twitter?

https://twitter.com/DarrellMello/status/1552368167476817920?t=v5OUDaLZxvILCy_6FrL-Hw&s=09

DrDarrellDeMello

Yes...for a week

https://twitter.com/DarrellMello/status/1552369945551327235?t=6Uo4pbyI8TAjswbMYjleEw&s=09

DrDarrellDeMello

Worst is LinkedIn.

Deleted my 20+ year account with all my Corporate history, and contacts. For what reason ..don't know. Pathetic Customer Service.

https://twitter.com/DarrellMello/status/1555816797550419968?t=b7vPo5PnjJoyKtpWhVIW-w&s=19

DrDarrellDeMello

I am not a big account!

Suspended by Twitter 3 times, for 7 days each

By Facebook ....stopped counting.. and shadow banned.

LinkedIn: permanent deletion of my 20+ year old account, with no access to my old contacts.

Reason has never been communicated to me.

Twitter and LinkedIn censorship - Dr Robert Malone

Dr Robert Malone - an early contributor to the technology that led to the mRNA vaccine - and a critic of the mRNA vaccine's choice of the spike protein (which is toxic in it's own right) as a target.

He has had his Twitter and LinkedIn accounts blocked.

He has been forced to move to other platforms like Gettr.

Pharmacies which fulfil Ivermectin prescriptions

August 15, 2021:

The FLCCC has a list of pharmacies that will fill ivermectin prescriptions:

https://covid19criticalcare.com/pharmacies/

May 13, 2022 - this list of pharmacies is now quite large.

From the above webpage, this Sept 2021 pdf document is "to help guide you in how to effectively push back with any pharmacists that deny filling your prescription":

https://covid19criticalcare.com/wp-content/uploads/2021/09/Overcoming-Pharmacy-Barriers.pdf Overcoming the Barriers to Access Ivermectin Prescriptions

It has been reported by patients that some pharmacists (see reddit.com/r/pharmacy) have decided they will not fulfil prescriptions for Ivermectin.

The reason for this is the signaling coming out of Merck - which has reneged on it's 2003 opinion on the safety of Ivermectin, and now suggests it is not safe - a change which may have to do with Merck's rollout of the drug Molnupiravir which aims to do some of the same functions as Ivermectin - except at much higher price.

August 28, 2021:

Dr Fauci has recently started to dream of a pill - he is probably dreaming of Molnupiravir and the drug coming out of Pfizer - since the NIH has been a laggard in their support for Repurposed Drugs.

Dr Fauci dream pill:

https://old.reddit.com/r/ivermectin/comments/oy03fk/faucis_great_pivot_toward_oral_drug_therapies_to/h7qdcml

September 19, 2021:

The FLCCC had a discussion video on the difficulties posed by pharmacists who are refusing to fill prescriptions from doctors for Ivermectin:

https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/FLCCC-WEBINAR-091521_Pharmagedon:7?t=810

FLCCC Weekly Update September 15, 2021: Pharmageddon Unleashed on Ivermectin

September 16th, 2021

This week's FLCCC Weekly Update hosted by Betsy Ashton features Dr. Paul Marik, Dr. Pierre Kory, and attorney Alan Dumhoff.

This episode discusses the issues that doctors and nurses are facing writing prescriptions for their patients and how pharmacies are blocking needed prescriptions from being filled. Alan Dumhoff discusses the legal implications of all of this for healthcare providers and patients.

at the 44:00 minute mark:

Attorney Alan Dumhoff has some suggestion for doctors worried about medical boards coming after them

Should have ivermectin consent form (patient recognizes was informed vaccines as top recommendation but still wants IVM) filled by patient not at front desk, but signed after discussion with doctor

October 22, 2021:

Dr Syed Haider provides a list of pharmacies that will fill and ship ivermectin to the 40 states in the US that he is licensed to practice in.

https://twitter.com/DrSyedHaider/status/1451345062839963653?t=OHkSDl1TtAd3EQqblrEfkA&s=19

Dr. Syed Haider

My staff has spent months scouring the country for pharmacies that will fill and ship ivermectin to each of the 40 states I'm licensed in. Here's the master list.

https://docs.google.com/spreadsheets/d/1S4X0PAx1BA1zI_KxulHjVZnWdcmrIv4b-RYSm9zmuys/edit#gid=101247289&fvid=278659903

https://tinyurl.com/3h89a4de

Dr Syed Haider also outlines the difficulties he has had with pharmacies:

https://twitter.com/DrSyedHaider/status/1451285955743207427?t=H-DoX2y3vKuIB-mRYZ3Tcg&s=19

Dr. Syed Haider

My experience using ivermectin and fluvoxamine in 4000 acute COVID-19 patients: 5 hospitalized. 0 dead. 4000 recovered. 5 pharmacist threats. 1 medical board complaint. 1 lawyer retained. Hundreds of medication transfers for pharmacist refusals.

Ivermectin

Ivermectin is considered a safer drug than Tylenol or Aspirin according to the adverse events data collected over 40 years and 3.7 billion doses administered.

(TODO: add reference)

NOTE: Ivermectin should generally only be given to those above 15kg in weight, and those who are not pregnant and not breastfeeding a baby. Since Ivermectin is neuro-toxic but does not cross the blood-brain barrier in humans, care should still be taken for those who have weakened blood-brain barrier - small children and those who have an active ongoing meningitis infection.

About 1 in 20 people may show signs of dizziness or visual disturbance - for these patients the dosage can be halved and often the issues go away. If issues remain, then consider discontinuing ivermectin - or switching to a spread out dosing strategy (for example instead of 12mg every Sunday, you may consider giving 3mg morning + 3mg evening on Sunday, and then 3mg morning + 3mg on Thursday).

Usually Ivermectin at the 0.2mg/kg bodyweight every Sunday (pre-exposure prophylaxis) dosing - does not give any side effects.

However at the 0.4mg/kg bodyweight every day for 3 days (post-exposure prophylaxis) or for 5 days or longer (for treatment) - some patients may experience dizziness or visual disturbance (sensation is similar to when you are sleep deprived and start seeing visual artifacts).

In some people, ivermectin (esp at the 0.4mg/kg dose) may be causing lower blood pressure (which may lead to dizziness).

See the section Ivermectin - Dizziness, visual disturbances.

Genetic variation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929173

Rarely, some people may have a genetic variation which weakens the blood-brain barrier. In these folks, Ivermectin may trigger the dizziness etc. side-effects mentioned above.

The 1 in 20 people mentioned above who have side-effects, may have these issues, or may be suffering from parasites.

Ivermectin - taking on empty stomach - or taken with fatty meal - and the impact on anti-IVM trials

When Ivermectin is being given for worms (or parasitic infections) - it is usually given on an empty stomach.

The idea is to increase concentrations of Ivermectin in the gastro-intestinal tract.

The perception that Ivermectin should be taken on an empty stomach - comes from this history of use.

However for covid19 - or wherever Ivermectin needs to be systemically available i.e. throughout the body - there it should be given with a fatty meal.

Since Ivermectin with a fatty meal - increases bioavailability by 2.5 times (2.5x).

This higher bioavailability is mentioned in the specification sheet for Ivermectin.

The reason is that Ivermectin is a fat soluble drug (not as water soluble) - and is better absorbed when it is taken with a fatty meal.

Impact of anti-IVM trials' use of Ivermectin-on-empty-stomach

The anti-IVM trials on "mortality benefit" (Lopez-Medina, TOGETHER, ACTIV-6) seem to share a quirk in their dosing protocols (possibly attributable to the input of trial designers that were common to these trials).

That quirk is that they all chose to give Ivermectin on an empty stomach.

This despite calls from early treatment doctors to administer with a fatty meal (or with a meal) - and NOT on an empty stomach.

However, these appeals were consistently refused.

So there was a degree of hostility in the TOGETHER trial - first on advocacy from early treatment doctors that a higher 0.4mg/kg dose was required (this was acceded to).

But the advocacy for use with a fatty meal - was refused.

The reason given by them - is that the FDA already has a convention for use of Ivermectin on empty stomach - and it was easier to go with that.

(TODO - add reference)

(TODO - check this if this is correct).

References:

https://www.reddit.com/r/gettingivermectin/comments/kn4v3n/_/ghikixj

bikes4paul

I was confused about this too. Dr. Carvallo answered it very clearly in a recent interview with WhiteBoard Doctor. For antiparasitic uses take on empty stomach. This maximized the concentration in the GI tract to kill the parasites. If taking for C19 take with a fatty meal. This increases the systemic absorption by 250% (i.e. lungs) which is what's desired in C19.

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3714649

Antiviral Effect of High-Dose Ivermectin in Adults with COVID-19: A Pilot Randomised, Controlled, Open Label, Multicentre Trial

11 Nov 2020

Alejandro Krolewiecki et al.

Diet is a key variable affecting the oral bioavailability of IVM, with increased plasma concentrations achieved with fed state, mostly related to the fat content of the meal

https://twitter.com/sudokuvariante/status/1690296205123690497

Fred Stalder

The most obvious point is the administration on an empty stomach in almost all RCTs published in high IF journals while experts (@SabinehazanMD and @Covid19Critical group) recommended from the beginning to administer with food based on published data.

https://twitter.com/sudokuvariante/status/1658153669190205440

Fred Stalder

People don't understand how much Guzzo et al. is devastating to all ivermectin "empty stomach" trials.

https://accp1.onlinelibrary.wiley.com/doi/abs/10.1177/009127002237994

Max. concentration and AUC with 347-541 μg/kg in a fed state are similar than those with 1404-2000 μg/kg in a fasted state.

https://twitter.com/Aguirre1Gustavo/status/1482418466900647940

Dr. Gustavo Aguirre-Chang

There are at least 3 studies indicating that the bioavailability of IVM is better when taken with high-fat meals

In the link is the study of February2020 in which it was obtained as a result that the effect of IVM was 18% better when it was given with food

https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkz466/5613771?login=false

https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkz466/5613771?login=false The effect of food on the pharmacokinetics of oral ivermectin Urs Duthaler, Rory Leisegang, Mats O Karlsson, Stephan Krähenbühl, Felix Hammann February 2020

For this analysis, we investigated the influence of fasted versus fed dosing on the oral PK of ivermectin as published data so far have been ambiguous.

Guzzo et al. reported a 2.6-fold increase in AUC with high-fat meals for fixed doses of 30 mg ivermectin in healthy volunteers (fasted: n=12, fed: n=11).

Miyajima et al. reported a more modest increase (1.25%) in AUC in 13 Japanese patients with scabies.

Homeida et al. reported no effect of either food or alcohol intake on bioavailability.

...

Our findings are similar to the recent publication by Miyajima et al., who also administered a dose of 12 mg, but much lower than the value of 2.6 reported by Guzzo and colleagues.

A possible reason for this discrepancy may be the high doses (30 mg) given in the latter trial.

This could be due to ivermectin being a good substrate for active efflux pumps such as P-glycoprotein (P-gp, MDR1, ABCB1). P-gp is prominently expressed in the gastrointestinal tract, and at higher doses, along with an exposure increased by meals, concentrations could saturate the active efflux process. This in turn would lead to greater systemic concentrations.

Alexandros Marinos and Fred Stalder have examined issues with the anti-IVM trials on "mortality benefit" (Lopez-Medina, TOGETHER, ACTIV-6):

https://doyourownresearch.substack.com/p/the-problem-with-the-together-trial The Problem with the TOGETHER Trial The most sophisticated trial of early treatments for COVID-19 doesn't quite add up. Alexandros Marinos Apr 13, 2022

https://doyourownresearch.substack.com/p/activ-6-trial-ivermectin-scientists ACTIV-6 Trial on Ivermectin: NIH Scientists Behaving Badly Alexandros Marinos Oct 28, 2022

https://www.youtube.com/watch?v=kLXiQEihg8s Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret Bret Weinstein May 2, 2022 Bret speaks with Alexandros Marinos, who has analyzed the TOGETHER trial, which aims to identify effective repurposed therapies to prevent the disease progression of COVID-19.

Mirror: https://odysee.com/@BretWeinstein:f/cold-confusion-alexandros-marinos:7 Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret Bret Weinstein May 2, 2022

https://odysee.com/@DarkHorsePodcastClips:b/dosing-and-weight-limit-anomaly-on:3 Dosing and weight limit anomaly on ivermectin TOGETHER trial (Alexandros Marinos & Bret Weinstein) DarkHorse Podcast Clips May 17, 2022

Ivermectin - dosing at 0.2mg/kg bodyweight - or 0.4mg/kg bodyweight - and the impact on anti-IVM trials

As Omicron arrived, the FLCCC and other early treatment doctors started noticing that the 0.2mg/kg bodyweight per week dosing was not 100% preventing appearance of symptoms during day1-7.

For this reason the FLCCC issued an update and the dosing for prophylaxis was increased to 0.2mg/kg - taken twice a week.

Similarly the doses using during treatment were increased (by this time early treatment doctors had also become more comfortable with using higher doses of Ivermectin - having seen how the lower doses worked, and having seen how some of the severe patients performed when they had to use higher doses).

So after Omicron, the Ivermectin 0.4mg/kg bodyweight dosing became more common.

Impact of anti-IVM trials' use of 0.2mg/kg vs 0.4mg/kg bodyweight dosing

The anti-IVM trials on "mortality benefit" (Lopez-Medina, TOGETHER, ACTIV-6) did increase the dosing from 0.2mg/kg as Omicron appeared.

But this was after much lobbying by early treatment doctors - that they need to use at least a 0.4mg/kg dose for TOGETHER trial.

TOGETHER trial did however refuse to give Ivermectin with fatty meal - and instead advocated for using on empty stomach.

TOGETHER trial also used non-linear dosing - so the most obese did not get the full 0.4mg/kg (see below).

Ivermectin - dosing by weight - or dosing non-linearly - and the impact on anti-IVM trials

Most trials of Ivermectin use a 0.2mg/kg dosing - later trials may use a 0.4mg/kg bodyweight dosing. Some have used 0.6mg/kg bodyweight.

However, some of the anti-IVM trials seem to share a quirk - that they said they were using a 0.4mg/kg dosing - but then capped the maximum dose arbitrarily.

The result was that the highest bodyweight individuals did not receive the full 0.4mg/kg bodyweight dosing.

The impact of this quirky choice was that obese patients (overrepresented in the high bodyweight subset) - would be getting lower than optimal Ivermectin dosing.

Yet the obese patients are usually the higher risk group in covid19 trials on mortality benefit.

Thus these trials may have (deliberately or inadvertently - by choice of predetermined protocol) - have ensured that the treatment arm could not turn around the patient subset which would contribute the most deaths.

Thus the protocol could have led to a higher than expected death rate in the treatment arm (if the treatment arm is not allowed to work using the optimal dose).

Impact of anti-IVM trials' use of non-linear dosing

The quirk is that if they said Ivermectin dosing was 0.4mg/kg bodyweight - in actual practice the dosing was lower for higher bodyweight patients.

(specifically the TOGETHER and ACTIV-6 trials)

(the reason why most of these trials had this bias - may be attributable to some trial designers being common to all these trials)

(TODO check this - Dr Boulware was common to TOGETHER and ACTIV-6 trials)

Since the trials used 0.4mg/kg - but then also capped the total dose to an absolute maximum milligram dose for all patients.

Meaning higher dosing subset did not get the full 0.4mg/kg dose.

The impact of this quirky choice was that obese patients (overrepresented in the high bodyweight subset) - would be getting lower than optimal Ivermectin dosing.

Yet the obese patients are usually the higher risk group in covid19 trials on mortality benefit.

Thus these trials may have (deliberately or inadvertently - by choice of protocol) - have ensured that the treatment arm could not turn around the patient subset which would contribute the most deaths.

Thus the protocol could have led to an unnecessarily high death rate in the treatment arm.

References:

(TODO: See Alexandros Marinos substack articles on the Ivermectin dosing cap in TOGETHER and ACTIV-6 trials - and Fred Stalder discussion - and the link to possible common trial designers (Dr Boulware))

Ivermectin - beyond dosing by weight - dosing by body mass index (BMI) - and the impact on plasma levels

Does the same Ivermectin 0.4mg/kg bodyweight dosing have different impact for a lean vs an obese patient - on blood plasma levels of Ivermectin ?

Ivermectin tends to accumulate in fatty tissue - so if a person has higher percentage fat - the concentration in blood plasma is likely to be lower in the obese vs the lean person.

If all patients are given the same 0.4mg/kg bodyweight dosing of Ivermectin - the obese patients may not reach the same plasma levels of Ivermectin as the lean patients.

So the highest risk patients may not have gotten the dose they needed for optimal benefit.

However, most Ivermectin trials - not just the anti-IVM trials - but even the positive ones - generally do not use dosing by BMI - but usually just adopt a dosing-by-weight protocol (0.2mg/kg bodyweight or 0.4mg/kg bodyweight - for example).

However, some earlier trials - have shown that at the same 0.2mg/kg or 0.4mg/kg dosing - the patients had widely different blood plasma levels of Ivermectin.

(TODO - provide references - is it Krolewiecki paper?)

And in those trials - according to a separate analysis - the death rates were lower in the patients who achieved high Ivermectin levels in blood plasma.

(TODO - add reference - is it Krolewiecki paper? - see Fred Stalder tweets mentioning reference)

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524481/

Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2–12 years

Ivermectin is a lipophilic drug and therefore accumulates in fat tissue. When ivermectin is administered to patients with higher BMI, it is likely that a larger proportion of ivermectin accumulates in fat tissue, leading to smaller amounts available in the blood and thus to lower AUC values.

Ivermectin - regions offering over the counter (OTC)

https://old.reddit.com/r/ivermectin/comments/tgkjlo/list_of_country_where_ivermectin_is_available/ List of country where Ivermectin is available over the counter

Tennessee, USA (April 22, 2022):

https://old.reddit.com/r/ivermectin/comments/ucmf29/ivermectin_may_be_sold_or_purchased_as_an/ Ivermectin may be sold or purchased as an over-the-counter medication in Tennessee without a prescription or consultation with a pharmacist or other healthcare professional (signed by Governor - April 22, 2022) - IVM becomes available OTC in Tennessee

New Hampshire, USA (May 10, 2022):

https://old.reddit.com/r/ivermectin/comments/uodvjx/ivermectin_gets_approval_for_over_the_counter_otc/ Ivermectin gets approval for over the counter (OTC) use in New Hampshire (May 10, 2022) - earlier IVM was approved for OTC use in Tennessee (USA)

Ivermectin - Meta-analyses of studies

Ivmmeta.com - informal meta-analysis/study aggregation

https://www.ivmmeta.com

Ivmmeta.com by @CovidAnalysis is an informal website that collects references for studies and their results, and presents a near real-time meta-analysis of studies.

As another example of clampdown (see Trusted News Initiative (TNI)), evidently @CovidAnalysis twitter account was suspended by twitter:

https://ivmmeta.com/twitter.html

Ivmmeta.com has come under attack by pro-vaccine or pro-Trusted News Initiative (TNI) employees for pushing an imprecise meta-analysis.

The reason for their ire is the frequent quotation of the ivmmeta.com website by pro-ivermectin personalities like Craig Kelly MP (Australia).

As a result the ire falls on the website for a free service this website has been providing for months - pointing researchers to new studies.

Ivmmeta.com does not make claims of being a rigorous meta-analysis, but is a best-effort service provided free to the world.

But that is not all. Ivmmeta.com has tabs at the top that point to other meta-analyses for researchers to get a birds-eye view of potential generic drug candidates for covid19.

https://c19early.com/

https://c19ivermectin.com/

https://c19vitamind.com/

https://vdmeta.com/ (calcifediol (fast acting) and Vitamin D3)

https://c19proxalutamide.com/

https://c19fluvoxamine.com/

https://c19pvpi.com/ (povidine-iodine nasal flush/spray)

https://c19budesonide.com/

https://c19bromhexine.com/

https://c19ly.com/ (bamlanivimab)

https://c19regn.com/ (casirivimab/indevimab)

https://c19hcq.com/

https://hcqmeta.com/ (hydroxychloroquine)

https://c19nitazoxanide.com/

https://c19colchicine.com/

https://c19curcumin.com/

Ivmmeta.com - and c19ivermectin.com censorship - reddit-wide blacklisting

EDIT: 2021-11-17 - it has become apparent that on reddit as well, the ivmmeta.com and c19ivermectin.com type websites are blacklisted (reddit-wide blacklisting). That is, the default reddit behavior is to remove the comment that includes that url - if moderators see it and approve it - only then does that comment become visible (so default behavior is to censor). The ostensible reason given by fact-checkers/critics for hating these websites is that they are not legitimate meta-analyses (which some users tend to categorize them as). However these websites are important because they remain as clearinghouses for early treatment candidate drugs (even if you don't recognize them as meta-analysis websites).

Dr Tess Lawrie/BIRD Group UK

Dr Tess Lawrie and the BIRD Group UK meta-analysis final peer-reviewed meta-analysis:

https://old.reddit.com/r/ivermectin/comments/ny528m/dr_tess_lawrie_metaanalysis_now_available_as/ Dr Tess Lawrie meta-analysis now available as peer-reviewed paper (June 12, 2021) - in the American Journal of Therapeutics (same journal that the FLCCC paper was published in)

Paper:

https://journals.lww.com/americantherapeutics/abstract/9000/ivermectin_for_prevention_and_treatment_of.98040.aspx Ivermectin for Prevention and Treatment of COVID-19 Infection

Video:

https://odysee.com/@The_BiRD_Group:3/Thank-You_June2021_2k_titleA:9 Dr. Tess Lawrie thanks her team and supporters from around the globe for the publication of the BiRD group meta-analysis on ivermectin.

Dr John Campbell reviews the meta-analysis by Dr Tess Lawrie group:

https://youtu.be/3j7am9kjMrk

Best ivermectin meta analysis

Dr. John Campbell

Jun 25, 2021

Dr John Campbell discussion with Dr Tess Lawrie:

https://youtu.be/D2ju5v4TAaQ Ivermectin discussion with Dr Tess Lawrie

Dr. John Campbell

Published on Apr 7, 2021

Dr John Campbell earlier interview of Dr Tess Lawrie:

https://old.reddit.com/r/ivermectin/comments/lza64t/dr_john_campbell_interviews_dr_tess_lawrie/ Dr John Campbell interviews Dr Tess Lawrie (meta-analysis and BIRD panel) - interesting because Campbell has a large viewership, and appears on Deutsche Welle TV as well (March 7, 2021)

Video - 1st part:

https://www.youtube.com/watch?v=UY92vb-9vEw Evidence based practice, Dr Tess Lawrie Mar 6, 2021 Dr. John Campbell

Video - 2st part:

https://www.youtube.com/watch?v=vYF8bnmdQfY Ivermectin Evidence with Dr Tess Lawrie Mar 7, 2021

FLCCC meta-analysis

The FLCCC peer-reviewed meta-analysis paper on Ivermectin and early treatment:

https://old.reddit.com/r/ivermectin/comments/n1v3gm FLCCC paper was published by American Journal of Therapeutics: Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

Paper:

https://journals.lww.com/americantherapeutics/Fulltext/2021/06000/Review_of_the_Emerging_Evidence_Demonstrating_the.4.aspx Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

Dr Andrew Hill meta-analysis for Unitaid (which informed WHO decision-making)

Peer-reviewed final paper by Dr Andrew Hill while sponsored by Unitaid. His conclusions in the pre-print were found to have been influenced by Unitaid (his sponsors). This research informed the WHO as well, which chose to wait for more studies.

Unlike the earlier pre-prints, this final paper no longer recommends further trials (i.e. evidence is sufficient). It shows a clear signal for early treatment, and a dose-dependent effect, which an important factor in judging efficacy:

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab358/6316214?guestAccessKey=16d25c42-5820-456b-b8e9-b5e289b0188a Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection 06 July 2021

Bayesian analysis of studies

https://old.reddit.com/r/ivermectin/comments/ok6l1e Bayesian Meta Analysis of Ivermectin Effectiveness in Treating Covid-19 Disease

Paper:

https://www.researchgate.net/publication/353195913_Bayesian_Meta_Analysis_of_Ivermectin_Effectiveness_in_Treating_Covid-19_Disease Bayesian Meta Analysis of Ivermectin Effectiveness in Treating Covid-19 Disease July 2021

Dr Andrew Hill - the controversy and the opportunity lost

Dr Andrew Hill was the right person in the right place - who could single-handedly have changed the direction of the once-in-a-century pandemic. But failed to do so.

His critics claim it was because he remained indebted to his sponsor (Unitaid - and an influential French bureaucrat there) - and to the constraints of his university employer (Univ of Liverpool which was to receive a large grant from the Gates Foundation later).

For many this many be a much smaller goal than the saving of human lives - and for this reason many fail to understand Dr Andrew Hill's actions fully.

Dr Andrew Hill was in a unique position in early 2021 - he was examining Ivermectin benefit for covid19. The sponsor of his report was Unitaid and was to inform WHO policy later.

Prior to the release of the report he was very positive - his preliminary report was positive as well - and he made presentations to South African audiences and others that suggested Ivermectin should be adopted and stockpiled by governments.

That is, he suggested that governments should be stockpiling Ivermectin - and that the longer they wait (and as word gets out of it's efficacy) - it will be harder to procure stockpiles of Ivermectin.

When the meta-analysis report was finally revealed the body of the report was generally positive to Ivermectin - but the Conclusion section was confusingly skeptical and proposed waiting for more studies.

This was a shock to many who had been expecting Dr Andrew Hill to not wait any further - and to deliver to the WHO an endorsement of Ivermectin (for prophylaxis and treatment).

Dr Tess Lawrie - an advocate of early treatment and of Ivermectin as one of the remedies - was in talks with Dr Andrew Hill, according to her account, to work on a Cochrane review of Ivermectin (Dr Tess Lawrie has prior experience writing Cochrane reviews and in advising the WHO).

She was also surprised by the conclusions presented by Dr Andrew Hill.

She reported that she had confronted him about this decision - and had been told that the "sponsors" (Unitaid - and specifically an influential French cancer researcher) had ghost-written the Conclusion part to downplay the immediate use of Ivermectin.

She chose to part ways with Dr Andrew Hill on the Cochrane review - and do the review herself.

Later, Cochrane chose another group to do the evaluation - and turned in a negative review of Ivermectin - as they hand-picked the studies that were included in the meta-analysis.

An audio recording later emerged - confirming Dr Tess Lawrie's narration of events.

It was a video recording of a zoom call between Dr Andrew Hill and Dr Tess Lawrie - which corroborated the earlier accounts of the discussion by Dr Tess Lawrie (see links below for a video excerpt).

Other audio also emerged where Dr Andrew Hill seemed to be downplaying the delay's impact on the UK arguing tha since the UK didn't have Ivermectin stockpiles anway, a delay would have little impact on the UK.

It is possible that the delay of confirmation may have had a strategic reason - to provide time for the UK to secure strategic reserves of Ivermectin.

However we don't have compelling evidence to suggest that Ivermectin was used at all in the highest echelons of power in the UK either. So even if it was stockpiled - it was never used. Or was not even stockpiled.

Critics of Dr Andrew Hill say that his concession to UNITAID ("the sponsors") was an unattributed change to his paper - where Conclusion was written by a third party (and not one of the authors).

To his credit, Dr Andrew Hill did contribute to the promotion of Ivermectin - with his talks and presentations on video to various audiences.

His failing was that he did not go against his sponsors - and did not play the hero that people had expected him to be.

For a person to be in a crucial position at an opportune time - and to fail to leverage that position - was a tragic opportunity missed in the eyes of early treatment advocates.

That is - they were hoping Dr Andrew Hill would stick to his guns - and become a whistleblower of sorts at a time when all attention was on him.

My defence of him has been that not everyone can be a hero. We also do not know what compulsions Dr Andrew Hill was at that time.

This case however highlights the weakness of the public as well - where such policy and power is abdicated to 3 letter organizations - who in turn are under government and private influence (like the Gates Foundation has excessive influence over the WHO - being large funder - and over the field of epidemiology - being primary funder).

It is a major weakness for the world to depend on the bravery and fortitude of a single scientist - to set things right.

And signals the lack of preparedness of the public for such events.

When the Gates Foundation is prepared - he gets a place at the table ahead of the public.

Gates Foundation - as the sugar daddy of epidemiology - has built up an influence networks within the army of epidemiologists (to the point that it would be dangerous to their career to go against what GAVI is advocating - when GAVI was advertising against Ivermectin, which epidemiologist would buck that signal?).

This article has portions of the zoom video call between Dr Andrew Hill and Dr Tess Lawrie - where they argue over the need for releasing the results to the public (Dr Tess Lawrie) - and Dr Andrew Hill arguing for more time - and that there is pressure from his sponsors (Unitaid).

https://bird-group.org/watch-dr-tess-lawrie-sends-a-video-letter-to-dr-andrew-hill-one-year-on-from-his-u-turn-on-ivermectin/

Watch. Dr Tess Lawrie sends a video letter to Dr Andrew Hill one year on from his U-turn on ivermectin

March 7, 2022

Video:

https://odysee.com/@OracleFilms:1/2022.03.04-A-Letter-to-Andrew-Hill-V8_HD:3

A Letter to Dr Andrew Hill | Dr Tess Lawrie | Oracle Films

March 4th, 2022

Oracle Films

TrialSite News coverage of the controversy:

https://www.trialsitenews.com/a/the-case-of-dr-andrew-hill-was-their-unethical-activity-associated-with-his-ivermectin-meta-analysis-or-just-another-drug-dev-day

The Case of Dr. Andrew Hill: Was there Unethical Activity Associated with his Ivermectin Meta-Analysis or Just Another Drug Dev Day?

TrialSite Staff

Dec. 13, 2021

See this reddit comment - for Dr Pierre Kory response to Dr Andrew Hill's change of posture regarding Ivermectin:

https://old.reddit.com/r/ivermectin/comments/ov3z28/pierre_kory_md_replying_to_dr_andrew_hill/h77wbhw

Archive of above webpage:

https://archive.ph/GE8bO

See this reddit comment - for Dr Robert Malone's defense of Dr Andrew Hill (this was when there was hope of positive news eventually from Dr Andrew Hill):

https://old.reddit.com/r/ivermectin/comments/o6oclg/andrew_hill_finally_tweets_about_ivermectin_again/h2x1v33

Archive of above webpage:

https://archive.ph/AnoEy

Discussions on whether Dr Andrew Hill or his university (Univ of Liverpool) benefitted somehow by complying to pressure in the report on Ivermectin to Unitaid/WHO:

https://twitter.com/carriepricecox3/status/1558121047483899905?t=Z9bFFkI-MsEOSX7Y-8daQw&s=19

How much grant money did Andrew Hill’s department at University of Liverpool receive from the Bill & Melinda Gates Foundation in the mist of his..shifting of position? Sizable. We see how this works.

https://www.healtheconomics.com/industry-news/researcher-andrew-hills-conflict-a-40-million-grant-from-bill-and-melinda-gates-vs-a-half-million-human-lives

Researcher Andrew Hill’s conflict: A $40 million grant from Bill and Melinda Gates vs a half million human lives

by WorldTribune Staff

December 9, 2021

https://twitter.com/alexandrosM/status/1558146599678750720?t=RQaGpcX4zdXBGh2qpW-Dnw&s=19

Alexandros Marinos

I think the precise details of that grant are not correct there, though I do think the grant was a big factor in what happened.

Other coverage:

https://gettr.com/post/pyj4qa87b1

In this video, the single most influential person in the anti-Ivermectin narrative, Dr. Andrew Hill, admits to knowingly shaping his findings based on institutional influence and withholding information about the efficacy of Ivermectin while millions of people were dying.

This video is absolutely stunning.

WATCH:

https://theconservativetreehouse.com/blog/2022/03/04/dr-andrew-hill-the-man-who-killed-millions/

https://theconservativetreehouse.com/blog/2022/03/04/dr-andrew-hill-the-man-who-killed-millions/

Dr. Andrew Hill, The Man Who Killed Millions?

March 4, 2022

Example of the type of reactions:

https://twitter.com/LizEarleMe/status/1500345790526636032?t=09IjAkSTAIIp3RBelioxpg&s=19

Andrew Hill seemed so very pro ivermectin and the studies looked as tho extremely helpful. I contacted many times for an interview/comment - then he dropped off the face of the earth, went silent. Always wondered why. Devastating if this is as true as it seems.

Ivermectin - Proposed mechanisms of action

https://www.nature.com/articles/s41429-021-00430-5 The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article 15 June 2021

This video by Dr Been was removed by YouTube - and is now available here:

https://odysee.com/@DrMobeenSyed:1/Ivermectin:7 Ivermectin Mechanism of Action

u/Haitchpeasauce analysis of mechanisms of action:

https://old.reddit.com/r/ivermectin/comments/ooncz9/3_existing_drugs_fight_coronavirus_with_almost/h604qi8

Ivermectin and cancer

https://old.reddit.com/r/ivermectin/comments/l3keqr/ivermectin_and_cancer/

Ivermectin and cancer

Archive of above webpage:

https://archive.ph/Ter6B

Ivermectin and Scabies

Ivermectin is NOT approved by the FDA for treatment of Scabies - yet is widely considered the treatment of choice for Scabies:

https://ijdvl.com/wonder-drug-for-worms-a-review-of-three-decades-of-ivermectin-use-in-dermatology/ Wonder drug for worms: A review of three decades of ivermectin use in dermatology 2019

Scabies

Ivermectin is the only recommended oral medication for scabies. Two doses of oral ivermectin are given 7 days apart, to act on newly hatched scabietic nymph. In severe or resistant cases, it is often combined with topical medications like permethrin. Two doses of topical ivermectin were also found to be as effective as two applications of permethrin. In case of crusted scabies, multiple doses of oral ivermectin are given as shown in [Table - 2].

Papers:

https://pubmed.ncbi.nlm.nih.gov/25911032/ The efficacy of topical and oral ivermectin in the treatment of human scabies 2015

https://pubmed.ncbi.nlm.nih.gov/22960817/ Comparative efficacy and safety of topical permethrin, topical ivermectin, and oral ivermectin in patients of uncomplicated scabies 2012

https://pubmed.ncbi.nlm.nih.gov/19584457/ Crusted scabies 2009

Ivermectin and Rosacea

Ivermectin is approved by the FDA for treatment of Rosacea:

https://ijdvl.com/wonder-drug-for-worms-a-review-of-three-decades-of-ivermectin-use-in-dermatology/ Wonder drug for worms: A review of three decades of ivermectin use in dermatology 2019

Rosacea

Ivermectin 1% cream is now approved by US FDA for inflammatory rosacea. Ivermectin not only targets Demodex folliculorum, but also reduces the inflammation associated with the condition.[16]

Papers:

https://pubmed.ncbi.nlm.nih.gov/27504249/ The efficacy, safety, and tolerability of ivermectin compared with current topical treatments for the inflammatory lesions of rosacea: a network meta-analysis 2016

Ivermectin and Psoriasis

I (u/stereomatch) could not find much evidence for Ivermectin benefit for Psoriasis.

However, this article suggests some interesting treatment possibilities:

https://www.aad.org/public/diseases/psoriasis/treatment/medications/off-label Psoriasis treatment: “Off-label” medicines that work throughout the body

6-thioguanine

Azathioprine

Fumaric acid esters

Hydroxyurea

Leflunomide

Mycophenolate mofeti

Sulfasalazine

Tacrolimus

Some cases of Psoriasis may be due to Crusted Scabies - in which case Ivermectin may be beneficial:

https://pubmed.ncbi.nlm.nih.gov/18257840/ Psoriasis or crusted scabies 2008

We describe a case of a 67-year-old woman with a 1-year history of nail thickening and a non-itchy erythematous scaly eruption on the fingertips. She was diagnosed with psoriasis and started on methotrexate after having had no response to topical calcipotriol. The diagnosis was reviewed after it was revealed by another consultant that the patient's husband had been attending dermatology clinics for several years with chronic pruritus, which had been repeatedly thought to be due to scabies. Our patient was found to have crusted scabies after a positive skin scraping showed numerous mites. She was treated with topical permethrin, keratolytics and oral ivermectin. We also review the literature on crusted scabies and its management, with recommendations.

And:

https://pubmed.ncbi.nlm.nih.gov/33781644/ Crusted scabies mimicking psoriasis in a patient with type 1 diabetes mellitus 2021

Sodium butyrate topical application and Psoriasis

This section is speculative - however it covers the potential benefit of butyrate topical application on skin to alleviate the symptoms of psoriasis.

See this section in this paper on topical butyrate applications for skin conditions:

https://www.mdpi.com/1420-3049/27/6/1849/htm

Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases

Serena Coppola, Carmen Avagliano, Antonia Sacchi, Sonia Laneri, Antonio Calignano, Luana Voto, Anna Luzzetti and Roberto Berni Canan

12 March 2022

3. Butyrate in Psoriasis Disease

Psoriasis is a chronic immune-mediated inflammatory skin disease, affecting more than 125 million people globally [30 ]. This condition is typified by enhanced tumor necrosis factor-α (TNF-α)/interleukin-23 (IL-23)/IL-17 axis, with hyperproliferating epidermal ker- atinocytes, and with anomalous differentiation [ 31 , 32]. Dendritic cells (DCs) secrete TNF-α, which acts on themselves and induces the secretion of IL-23, which in turn induces the conversion of Tregs into type 17 helper T (Th17) cells, which proliferate and overproduce IL-17A. IL-17A reduces forkhead box protein 3 (Foxp3) expression, suppressing Tregs functional activity and stability [31 ]. Indeed, functional defects in CD4+CD25+ Foxp3 Tregs affect patients with psoriasis, the main suppressors of the excess immune response and mediators of homeostasis. Defects in Tregs may contribute to psoriasis disease development and exacerbation [ 33 ].

The metabolites SCFAs of specific gut microbic populations (e.g., Bacteroides fragilis, Faecalibacterium prausnitzii, Clostridium cluster VI and XIVa) influence Tregs activity and number [ 34, 35], and several pieces of evidence reported that psoriatic patients show a decrease in the GM abundance of protective taxa producing butyrate, which may contribute to the defects in Tregs, such as Parabacteroides and Coprobacillus [36 ], Prevotella and Ruminococcus [37 ], Akkermansia muciniphila [ 38], and Faecalibacterium prausnitzii [ 39 ].

Furthermore, it has been shown that the gut microbial genes encoding the enzymes involved in butyrate synthesis, butyrate kinase, and phosphate butyryltransferase are less abundant in psoriatic patients compared to matched non-psoriatic controls [40].

Acetylation of H3 histones is associated with the activity of Tregs, and it has been described that H3 acetylation is significantly decreased in Tregs of patients with psoriasis, compared to healthy controls [ 41].

Since butyrate acts on DCs to promote Foxp3 expression in Tregs, and it has a well-known role as an HDAC inhibitor, it has been demonstrated that it induces on Foxp3 intronic enhancer the histone H3 acetylation, allowing the expression of Foxp3 in naïve CD4+ T cells, inducing their differentiation into Tregs [42].

The impaired number and activity of Tregs in psoriasis determine deleterious effects on the ability to control the inflammatory response [ 43 ,44 ]. It has been shown that Tregs isolated from the blood of psoriatic patients have an altered suppressive activity, which was normalized through the topical application of sodium butyrate on human biopsies of psoriatic lesions [41 ].

Sodium butyrate topically applied normalizes the enhanced expression of IL-17 and IL-6 and restores IL-10 and FOXP3-expression levels [ 41 ].

Moreover, in the same study it has been demonstrated that sodium butyrate, though only topically applied, reduced also systemic inflammation response, since it was able to reduce splenomegaly and IL-17 expression and to induce IL-10 and Foxp3 in the spleen [41].

A more decreased expression of keratinocytes in psoriatic patients than in healthy controls of the butyrate binding receptors GPR43 and GPR109a [45 ] has been described.

The topical appliance of sodium butyrate was able to increase the reduced expression of both receptors and was able to restore the altered cytokine balance in psoriasis via GPRs. Butyrate topical application caused an increase in IL-10 and IL-18 production, and a reduction in the cytokines, which block the suppressive activation of Tregs, IL-17, and IL-6 [45].

Altogether, this evidence indicates that the restoration of defective Tregs represents a promising therapeutic target for psoriasis disease. As stated, butyrate restores the defected Tregs, and it may represent a promising tool in the management of psoriasis.

Improving the production of butyric acid in the gut

If topical application of sodium butyrate helps - then one could potentially address butyrate production by improving the gut synthesis of butyrate.

A probiotic which contains bifidobacteria - plus some dietary fiber like psyllium husk in water - maybe given over some period could alleviate the psoriasis (?).

Dietary butyric acid from food sources

One can get butyric acid from dietary sources - for example from butter - but it seems dietary butyric acid is at low levels in food sources (compared to what can be produced in the gut - by bifidobacteria digestion of dietary fiber):

https://www.healthline.com/health/butyric-acid What Is Butyric Acid, and Does It Have Health Benefits?

The amount of butyric acid in food is small compared to the amount your gut bacteria produce. ... Butter is one of the best dietary sources of butyric acid. About 11 percent of the saturated fat in butter comes from SCFAs. Butyric acid makes up about half of these SCFAs.

Oral sodium butyrate supplementation - caution for pregnant women

NOTE: some caution also, as this section suggests (this applies to sodium butyrate oral supplementation - not topical use for skin - which would lead to much less systemic dosage):

https://www.healthline.com/health/butyric-acid What Is Butyric Acid, and Does It Have Health Benefits?

However, if you’re pregnant or breastfeeding, you may want to avoid butyric acid supplementation.

One animal study found that giving pregnant and breastfeeding rats sodium butyrate led to insulin resistance and increased fat storage in their offspring.

Ivermectin and Vitiligo (Leucoderma)

Some anecdotal cases of Ivermectin helping Vitiligo:

https://old.reddit.com/r/ivermectin/comments/t1umwi/ivermectin_and_vitiligo_leucoderma/ Ivermectin and Vitiligo (Leucoderma)

Archive of above webpage:

https://archive.ph/2EyDB

Also see u/realopticsguy confirmation of similar results in his case:

https://old.reddit.com/r/ivermectin/comments/t1umwi/comment/hzb2i65/

Archive of above webpage:

https://archive.ph/sqmQA

Ivermectin and gum disease

Just a single anecdote on Ivermectin impact on gum disease from u/realopticsguy:

https://www.reddit.com/r/ivermectin/comments/t1umwi/ivermectin_and_vitiligo_leucoderma/hzb2i65

Archive of above webpage:

https://archive.ph/sqmQA

u/realopticsguy says there:

I have vitiligo. My spots stopped growing after I took ivm for covid last summer. Some have filled in. I was going to post here about it but I'm more impressed with how my gum disease has gone away.

I found several papers about parasitic origins of gum disease, and toxoplasmosis and an amoeba were mentioned. Ivermectin treats both.

Ivermectin and Asthma

https://old.reddit.com/r/ivermectin/comments/l3fbgb Ivermectin and asthma

Archive of above webpage:

https://archive.ph/4Z3LC

Ivermectin and seasonal allergies

Ivermectin seems to reduce seasonal allergies for some - which may or may not have a link to strongyloides exposure:

https://old.reddit.com/r/ivermectin/comments/mzet2x/allergy_cures/ Allergy Cures

Archive of above webpage:

https://archive.ph/1Qjgr

Ivermectin and mold toxicity

Dr Syed Haider in his 2nd appearance on Dr Been YouTube channel, mentions that he has seen phenomenal benefit of ivermectin with mold toxicity patients. Normally they have to change residences etc.

https://youtu.be/Md-y01JdxvE Dr. Syed Haider Discusses COVID Management (July 2021) Drbeen Medical Lectures July 9, 2021

at the 5:15 minute mark:

https://youtu.be/Md-y01JdxvE&t=315

Dr Syed Haider:

Like I've seen a few mold toxicity patients who responded very very well to Ivermectin - I mean it was shocking - I mean I told the lady you have mold toxicity - you don't have long covid19 - you don't have covid19 - you need to leave your house you know - you're not going to get better unless you leave your house.

She was almost normal after starting Ivermectin - I mean it was just incredible - I mean I don't treat mold toxicity but i've read about it and you know the people who do treat it, they tell you you basically have to leave the mold - you know there's no other solution.

You know you can you know detox all you want but as long as you're in the house with the mold there's you're just not going to get better - but um that was one of the most remarkable things - mold toxicity.

Reference:

https://old.reddit.com/r/ivermectin/comments/ohtmt3/topical_calcineurin_inhibitors_are_an_effective/h4stj9t

Archive of above webpage:

https://archive.ph/bjUjP

Jan 10, 2023: additional anecdote on mold toxicity (unfortunately that account seems to have been deleted):

https://twitter.com/LacosseVee/status/1409495091497013248?s=19

repeated exposure to black mold tanked my immune system and allowed the dormant EBV to reactivate. A year and a half of every treatment published had little effect, until i tried IVM.

Ivermectin and migraines

Found this interesting comment for a YouTube video:

https://www.youtube.com/watch?v=Gz4adJXLHgA&lc=UgxzRme9wI8GLqEX9WF4AaABAg

Gold Country Russ

Vindication is within sight, finally! I started prophylaxis with the FLCCC I-Mask+ protocol including Ivermectin on 12-23-20.

Was infected in Jan-21 but that was only 1 night with head congestion, felt perfect the next day.

So far, I have taken 70 doses at .2mg/kg, mostly on a once weekly basis.

The Ivermectin's only side effect has been to eliminate my migraine, what's not to love about that?

Ivermectin for Multiple Sclerosis (MS), Lyme disease and for nerve remyelination

See:

https://old.reddit.com/r/ivermectin/comments/oxc4x8/taking_ivermectin_for_the_first_time_12mg/h7wxsde

If you plan to start ivermectin for Lyme or Multiple Sclerosis (MS), you may want to start with a low dose so you can assess any side-effects for your case.

Some Lyme disease patients, and Multiple Sclerosis (MS) patients may experience herxheimer reactions to the killing of parasites (Lyme), or to reaction with demyelinated nerves (MS) - since ivermectin is neuro-toxic but in humans does not cross blood-brain barrier.

So as Dr Steven Phillips bestselling author of "Chronic" explains it is best to start with a low dose and build up - since ivermectin seems to help in the long run even with MS, because of it's nerve remyelination potential.

Keep us updated.

For more info on Lyme, MS and nerve remyelination potential, check out:

https://old.reddit.com/r/covidlonghaulers/comments/ma4zal/pruned_fingers/gructg7

See:

https://old.reddit.com/r/covidlonghaulers/comments/ma4zal/pruned_fingers/gructg7

Regarding neuropathy mention in other comments - in the recent interview by Dr Been of recent bestselling book "Chronic" author Dr Steven Phillips, Dr Phillips said ivermectin may have remyelination impact.

Since ivermectin helps with covid19 treatment, and anecdotally some subset of long haulers, I don't know if this is relevant.

https://old.reddit.com/r/ivermectin/comments/mavt6e/ivermectin_and_multiple_sclerosis_ms_ivermectin/

Ivermectin and Multiple Sclerosis (MS) - ivermectin as a potential nerve remyelination agent (for restoration of nerve cover in diseases like Multiple Sclerosis)

Rough transcript:

at the 37:08 minute mark:

So yes I have used it - I think you have to have special care with patients with demyelination.

Is what I wanted to say - because ivermectin is also being studied as a remyelinating agent. It can induce back the growth back of lining around nerves.

And paradoxically in my experience when I use it with MS patients - it flares them up like crazy - and we have to go extremely slowly, and then they get a net benefit, but it can take them a year to get up to full dose.

And that's my experience with Ivermectin.

For Lyme disease:

https://www.lyme.no/gjesteskribenter/335-eva-sapi-phd

Eva Sapi Ph.D.

Eva Sapi Ph.D. is an Associate Professor of Biology and Environmental Science at the University of New Haven, where she combines teaching with research, leading graduate students in developing a higher level of understanding of Lyme disease. In her research, Dr. Sapi investigates the presence of different formations (spirochete, round bodies and biofilm) of Borrelia burgdorferi, the Lyme disease bacteria. She also studies resistance of these different forms to antibiotics and natural agents. She organized three national Lyme disease conferences in the last several years.

Lyme disease is caused by the species of bacteria, Borrelia burgdorferi, and is transmitted to humans by a vector ticks, Ixodus scapularis. (1-2) Many investigators, including the University of New Haven Lyme disease research group, focused on identifying novel tick-borne bacteria, viruses and fungal co-infections in ticks or in patients with a tick bite history. (1-2) Despite these efforts and the introduction of novel treatment protocols, there are little improvements in the outcome of some of the Lyme patients.

Can species other than bacteria, virus or fungus be responsible for these chronic problems found in Lyme patients? It has been proposed that certain parasites could also be a factor in Lyme disease. European doctors have already incorporated Ivermectin, an antihelminth drug, into their Lyme disease protocol with surprising success. Ivermectin is well known for its effectiveness against filarial nematode infections and is often used by veterinarians to eradicate parasitic infections. (3)

A google search turns up some papers - search for - ivermectin nerve remyelination.

https://pubs.acs.org/doi/10.1021/acsomega.8b01451

Ivermectin Promotes Peripheral Nerve Regeneration during Wound Healing

October 1, 2018

Taken together, we demonstrate that ivermectin promotes peripheral nerve regeneration by inducing fibroblasts to adopt a glia-like phenotype.

https://www.embopress.org/doi/full/10.15252/emmm.201708743

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis

July 4, 2018

Conversely, potentiation of P2X4R signaling by the allosteric modulator ivermectin (IVM) favored a switch in microglia to an anti-inflammatory phenotype, potentiated myelin phagocytosis, promoted the remyelination response, and ameliorated clinical signs of EAE. Our results provide evidence that P2X4Rs modulate microglia/macrophage inflammatory responses and identify IVM as a potential candidate among currently used drugs to promote the repair of myelin damage.

https://multiplesclerosisnewstoday.com/2018/07/13/anti-parasitic-agent-eases-ms-motor-symtoms-aid-remyelination-in-ms-mice/

Common Anti-Parasitic Agent Eases Motor Symptoms, Aids Remyelination in MS Mouse Model

July 13, 2018

By promoting the activity of a receptor called P2X4R that is present in microglial cells — immune cells that reside in the brain — ivermectin (marketed as Stromectol, or Soolantra) eased the clinical manifestations of experimental autoimmune encephalomyelitis (EAE; an induced autoimmune disease similar to MS in humans).

Specifically, researchers saw evidence suggesting that ivermectin was “a potential candidate among currently used drugs to promote the repair of myelin damage,” they wrote.

Dr Steven Phillips substack article on Ivermectin - anti-cancer, nerve remyelination potential, and use against chronic viral infections:

https://zerospin.substack.com/p/ivermectin-upon-neutral-ground Ivermectin--Upon Neutral Ground The truth will set you free. But first it will piss you off. Mar 1, 2022

May 20, 2022:

Also see this comment on Ivermectin for Lyme disease:

https://old.reddit.com/r/ivermectin/comments/uti3s8/comment/i9e0eqd/

Dec 20, 2023:

An intro article:

https://statcarewalkin.com/info/ivermectin-for-ms-benefits-risks.html Ivermectin for MS: A Comprehensive Guide

This video is interesting also because of the comments there - which mention IVM use for MS:

https://www.youtube.com/watch?v=6-0KcMzLQpA Could ivermectin promote myelin repair? - Pam Bartha April 26, 2019

In this video, Pam Bartha shares an exciting study that suggests ivermectin has the potential benefit to promote remyelination in MS lesions.

Other promising treatments

Also search for minocycline and clemastine for Multiple Sclerosis.

Clemastine - there may be an increased risk of hemorrhagic stroke.

Ivermectin and diabetes

There have been some anecdotal reports that Ivermectin reduces diabetes symptoms to some degree.

Here someone reporting improved sleep after starting Ivermectin - which could possibly be due to reduced urination during sleep (because of reduced diabetic symptoms?):

https://old.reddit.com/r/ivermectin/comments/nv2ypg/sleep_has_improved/h11s3mc

Another anecdote:

https://old.reddit.com/r/ivermectin/comments/rduj0y/antiviral_effects_due_to_lipophyllic_ivm/ho55c0c

My anecdote. I experience severe insulin resistance as a diabetic. When I use IVM in the past the resistance seems to disappear.

Ivermectin and Dengue - antiviral activity

Ivermectin has some activity against Dengue virus as well.

Ivermectin and Dengue - early treatment for Dengue

Here are some ways that early treatment doctors have reported on the use of Ivermectin for Dengue.

Dr Darrell DeMello (Mumbai, India) dengue protocol:

https://twitter.com/DarrellMello/status/1551100539790061568?t=pu3i07YE879C8SEadD7Smw&s=19

DrDarrellDeMello

I have successfully treated patients with Dengue Fever using a combination of Colchicine and Ivermectin. Reversal of platelet count occurs 24-48 hours. Covid-19 has helped me learn a lot!

NOTE: the above tweet has now been deleted by the author (possibly related to his recent temporary ban on Twitter):

https://twitter.com/drakchaurasia/status/1552362119101759488?t=cYDiIzDddhIdaaNjyILwxg&s=09

dr a k chaurasia

Dr D, were you blocked recently by twitter?

https://twitter.com/DarrellMello/status/1552368167476817920?t=v5OUDaLZxvILCy_6FrL-Hw&s=09

DrDarrellDeMello

Yes...for a week

https://twitter.com/DarrellMello/status/1552369945551327235?t=6Uo4pbyI8TAjswbMYjleEw&s=09

DrDarrellDeMello

Worst is LinkedIn.

Deleted my 20+ year account with all my Corporate history, and contacts. For what reason ..don't know. Pathetic Customer Service.

Dr Darrell DeMello has been effective (for covid19) in using Ivermectin + Colchicine from day1 (when possible) - and steroids-at-day8.

His use of Colchicine tends to reduce the need for steroids - or reduce the dose required of steroids-at-day8 (to show reversal of post-day8 hyperinflammation).

A similar strategy seems to be working here for Dengue - since Dengue (like covid19) too has an inflammatory stage - where coagulopathy reduces platelets and leads to bleeding as an obviously recognizable sign of Dengue (in it's advanced stage).

Dr A K Chaurasia (Uttar Pradesh, India) dengue protocol:

Ivermectin + Doxycycline + others (Nitazoxanide, HCQ):

https://twitter.com/drakchaurasia/status/1551105036343582720?t=ZfcRPLWMAygxGcZNpTC1zg&s=19

dr a k chaurasia

before covid, i used to treat dengue with doxy+acyclovir. after covid, this is my antidengue drug list

https://twitter.com/drakchaurasia/status/1448513789649829891?t=x50f9FDf7mPC9sDjG2fz0Q&s=19

Above he is referring to his tweet:

https://twitter.com/drakchaurasia/status/1448513789649829891?t=x50f9FDf7mPC9sDjG2fz0Q&s=19

dr a k chaurasia

for dengue virus,

doxycycline

atremisins

nitazoxanide

ivermectin

hcq

clarithromycin

aciclovir(weak effect)

https://twitter.com/sundaecone888/status/1448514631253708802?t=JzzJ-P8V2fSrWCrdfyoU8Q&s=19

Any peer-reviewed studies to back this up? My son recently got dengue and it has me paranoid.

https://twitter.com/drakchaurasia/status/1448554584226471941?t=e3oWql8X9Egl_FEixQ150g&s=19

dr a k chaurasia

here are few references, i think enough to convince you.

https://pubmed.ncbi.nlm.nih.gov/24142271/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277121/

https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006715

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998463/

Ivermectin and Herpes Simplex Virus type 1 (HSV-1)

Here is one anecdote from reddit for herpes simplex virus type 1 (HSV-1) - cold sores appearing less often with Ivermectin use:

https://old.reddit.com/r/ivermectin/comments/1045j2e/has_anyone_heard_of_neurological_symptoms_due_to/j37dwx5

Timirninja

That’s could only mean that I don’t have holes in my guts 👍

Have you tried ivermectin yourself? Amazing thing, I have herpes (cold) coming out every now and then in the winter, and ivermectin works amazingly to stop the blister from forming

Anecdote on use of L-lysine and Ivermectin for reduction of cold sores:

https://old.reddit.com/r/ivermectin/comments/mfi4qj/_/gsnpwl1

I take 500-1000mg l-lysine daily to control my area cold stores, and I can say they haven't been aggravated by ivermectin every 2 weeks. I haven't had a cold sore in years since starting the lysine. I used to get one every month with my period or more often with stress.

Ivermectin and Herpes zoster virus (shingles)

Shingles is caused by the varicella-zoster virus, the same virus that causes chickenpox:

https://my.clevelandclinic.org/health/diseases/11036-shingles

Ivermectin and Epstein-Barr Virus (EBV)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536980/

Quantitative proteomics reveals a broad‐spectrum antiviral property of ivermectin, benefiting for COVID‐19 treatment

Na Li, Lingfeng Zhao, and Xianquan Zhan

Ivermectin has been demonstrated to limit infection by a number of viruses with potential broad‐spectrum activity (Yang et al., 2020). For example, ivermectin has been reported anti‐HIV‐1 reliant on importin α/β nuclear import (Wagstaff, Sivakumaran, Heaton, Harrich, & Jans, 2012). Ivermectin could reduce MAPK pathway activation through the inhibition of PAK‐1 activity. The high content screening also identified ivermectin as a promising drug against EBV‐positive and EBV‐negative nasopharyngeal carcinoma cells (Gallardo, Mariamé, Gence, & Tilkin‐Mariamé, 2018). Herpes genitalis and infections, which are caused by HPV in males, might have an effective treatment choice for oral ivermectin, but it has not been officially approved until now (Buechner, 2002).

Spironolactone may have some benefit against EBV:

https://healthcare.utah.edu/publicaffairs/news/2020/05/epstein-barr-virus.php STUDY COULD SUGGEST A NEW WAY TO CONTROL EPSTEIN-BARR VIRUS May 2020

Four years ago, the U of U Health research team found that spironolactone, a medicine routinely used to treat heart failure, has an unexpected antiviral activity against EBV. They discovered the drug targets an EBV protein, called SM, that the Swaminathan lab and others previously showed is essential for EBV replication.

Anecdote on Ivermectin for EBV:

https://twitter.com/LacosseVee/status/1409478863432957958?s=19

I can only speak from my personal experience: I had an established CREBV with an EBV EA of more than 150, when I developed CV19 on top of that. 2 doses of ivermectin knocked out BOTH. From bedridden to bicycle in less than a week! #ivermectinworks

Ivermectin and Fatty Liver Disease

Just a single anecdote here for fatty liver disease reversal with Ivermectin - when used at prophylaxis dosing for 26 weeks:

https://twitter.com/stumpie_heart/status/1613880378938343424

Stumpie Collins

Jan 13, 2023

High risk & elderly.Refused to be a human lab rat. Knew Big Pharm was lying. Was an early IVM prophylaxis patient. Still have your txt mssge. On IVM for 26 weeks during Delta. Never once sick. By the way fatty liver went bye-bye while on IVM. PCP impressed. Thank you

For fatty liver disease also see sections:

NAC for Fatty Liver Disease - reversing organ damage

NAC impact on stomach "spare tire" and systemic inflammation

Ivermectin for COVID-19 long haulers

There are a number of reddit posts where users have reported benefit from Ivermectin for long haulers syndrome:

https://old.reddit.com/r/ivermectin/comments/nz88mq/has_anyone_been_able_to_cure_post_vax/h1pu2nv Has anyone been able to cure post vax neurological and numbness?

Ivermectin for COVID-19 post-vaccine injury/issues

Keywords:

Vaccine Long Haulers
Post-Vaccine Inflammatory Syndrome (PVIS)

There are a number of reddit posts where users have reported benefit from Ivermectin for post-vaccine issues:

See this case and my comments there too - for relief of neurological symptoms post-vax:

https://old.reddit.com/r/ivermectin/comments/o5g09s IVR After Pfizer Vaccine [Neurological Side Effects].

https://archive.is/pYhBw

Update:

https://old.reddit.com/r/ivermectin/comments/osx45y/ivermectin_pepcid_liposomal_glutathione_cured_me Ivermectin + Pepcid + Liposomal Glutathione Cured Me. 90% Better After Vaccine Nerve Problems.

https://archive.is/3T86e

Ivermectin for COVID-19 pre and post-vaccine prophylaxis

See:

https://old.reddit.com/r/ivermectin/comments/retnve/interested_in_a_discussion_on_taking_ivermectin/ho9t929

Ivermectin and post-covid19 Anosmia/Fatigue reversal

NOTE: also see the section Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs

NOTE: also see this post which surveys the other treatments available for post-covid19 anosmia reversal:

Archive of above webpage:

https://archive.ph/ZB9qV

NOTE: also see this post for further discussion of anosmia reversal with Ivermectin:

https://www.reddit.com/r/IntellectualDarkWeb/comments/ucexm5/why_do_my_dogs_smell_like_orange_slices_the/ Why do my dogs smell like orange slices? The latest research on how COVID messes with smell - USA TODAY - (April 24, 2022) - article talks about the need for anosmia research and treatments but fails to talk about the treatments that work reliably - like Ivermectin

https://archive.ph/Hnwgx

In the post-day8 period, if a patient has residual anosmia or residual fatigue, usually this course of Ivermectin reverses it:

Ivermectin 0.4mg/kg bodyweight per day - for 3 days

If there is still residual anosmia or residual fatigue, wait a week, and then do the 3 day protocol again.

NOTE: Ivermectin should not be given to children below 15kg weight (2024-02-29 - corrected from 50kg to 15kg). Also avoid giving to pregnant and breastfeeding mothers (since children have a reduced blood-brain barrier). However, historically over it's 40 years of use and 3.7 billion doses given, it has been given to pregnant and breastfeeding mothers without an obvious signal of harm. But still should be avoided in pregnant and breastfeeding mothers.

NOTE: if the patient has been given Ivermectin during the day1-7 period and the doctor feels they already have taken a lot of Ivermectin - then wait a few days - and then do the above protocol. This protocol can be done as a matter of course - to ensure any residual anosmia/fatigue is taken care of.

NOTE: the above protocol assumes the patient was given Ivermectin during day1-7 period as well. However while Ivermectin during day1-7 may reduce anosmia - anosmia can still appear in some of the patients. However, for those patients, the above 3 day course when done in the post-day8 onwards period, is usually sufficient to reverse anosmia and residual fatigue.

NOTE: I (u/stereomatch) have observed 5-7 cases of anosmia reversal with Ivermectin in a retrospective fashion (i.e. anosmia reversal was not specifically targeted - but was reported as having happened in a time-sensitive manner following Ivermectin use). Later I tried suggesting Ivermectin to 6 successive anosmia patients (who agreed on the above protocol to reverse their ongoing anosmia - all 6 were recent post-covid19 cases) - in every one of the cases there was anosmia partial reversal within 12 hours - and complete reversal in 1-2 days. One case had partial reversal - and was advised to wait a week - and then repeat the 3 day course - after which her anosmia was 100% reversed.

NOTE: the 5th of these 6 successive cases was actually Dr Been's mother-in-law - he had reported his mother-in-law was still suffering from anosmia - and I had reminded him that Ivermectin reversed anosmia - he later reported he had given Ivermectin and his mother-in-law's anosmia had reversed in 2 days.

NOTE: this protocol has also been used for post-covid19 residual fatigue in the post-day8 period (when the patient has started steroids-at-day8 and is feeling great - but still has some residual fatigue). If fatigue is reversed partially - then wait a week and do the protocol again.

Ivermectin and post-covid19 Anosmia reversal - Dr Been testimony

Dr Been in his videos has also observed that Ivermectin reverses post-covid19 anosmia.

It started with a video report on his mother-in-law whose anosmia he reversed with a course of Ivermectin 0.4mg/kg per day (see video and transcript below).

In subsequent videos (see video and transcript below) he reported more cases where Ivermectin has shown anosmia reversal within 2 days.

In his words "Ivermectin .. works like magic".

NOTE: in his videos, Dr Been has to take care when mentioning Ivermectin for covid19 - since YouTube will demonetize or remove videos (and author will incur a strike) if Ivermectin is mentioned as treatment for covid19.

NOTE: YouTube Terms of Service explicitly prohibit mention of Ivermectin and HCQ as treatments for covid19

NOTE: Of the successive cases of anosmia reversal I (u/stereomatch) have recounted above - the case of Dr Been's mother-in-law was the 5th. I have added it to the statistics I was accumulating for successive anosmia cases observed. This is how it happened - Dr Been had mentioned his mother-in-law had anosmia in one of his videos - I tweeted a suggestion that Ivermectin at the 0.4mg/kg dosing should be tried - which he apparently did - as he later reported that he had advised Ivermectin at 0.4mg/kg dosing for his mother-in-law - which reversed her anosmia within 1-2 days.

Dr Been - mention 1:

Dr Been says that he gave 0.4mg/kg to mother in law and got taste/smell recovery within 2 days:

https://youtu.be/PkhnEpToVdM

https://odysee.com/@DrMobeenSyed:1/europe,-asia,-africa,-me-covid-17:c

Europe, Asia, Africa, ME - COVID Questions with Dr. Been (#30) May 20, 2021 Drbeen Medical Lectures

at the 38:40 minute mark:

https://youtu.be/PkhnEpToVdM&t=2340

https://odysee.com/@DrMobeenSyed:1/europe%2C-asia%2C-africa%2C-me-covid-17:c?t=2340

Dr Been:

So Amman says Dr Bean I've lost my taste sensation - what can I do?

So I'll tell you what I did for my mother-in-law - my mother-in-law was vaccinated - she went in for the second vaccine dose and she came back and she had covid19.

So now she maybe already had covid19, or she got it from there - something happened.

And so she had covid19 and part of that was that within two days she lost her sense of smell.

And I started her on high dose Ivermectin - it was 0.3 or 0.4mg/kg bodyweight - and within two days her sense of smell came back.

My experience is that the sense of smell usually comes back in weeks or months - but high dose Ivermectin helps return that very fast.

Dr Been - mention 2:

Dr Been later reported another case study of anosmia reversal with Ivermectin:

https://twitter.com/drbeen_medical/status/1398836755088871427

Dr. Mobeen Syed

May 30, 2021

Case report.

Acute COVID patient. Healthy young female. Anosmia occurred. Her doctor brother asked for advice.

Started her on Ivermectin. 0.3 mg/kg body weight. Recovered from anosmia in two days.

Message in the image says, "my sister has recovered. Taste is back."

Dr Been - mention 3:

Dr Been video overview of anosmia - and why it may be recoverable with IVM without long term damage.

Dr Been also discusses Ivermectin doses that he has used for reversing anosmia (this is after he used Ivermectin for reversing anosmia for his mother-in-law):

https://youtu.be/wTQk5BM0L2w (YouTube has removed this video - but it is available on Odysee)

https://odysee.com/@DrMobeenSyed:1/ivermectin-and-covid-anosmia-a-review-of:9

Ivermectin and COVID Anosmia A Review of Studies Drbeen Medical Lectures June 8, 2021

at the 9:34 minute mark:

https://youtu.be/wTQk5BM0L2w&t=574 (YouTube has removed this video - but it is available on Odysee)

https://odysee.com/@DrMobeenSyed:1/ivermectin-and-covid-anosmia-a-review-of:9?t=574

Now how do we fix this (anosmia)? (With) high dose Ivermectin - and what is the high dose that I have used - I have used .. again make sure that the side-effects and (you have made sure) that the person can take this (dose).

What I have done so far are 0.2-0.4mg/kg bodyweight - and within 2-3 days the person recovers from anosmia.

Dr Been - mention 4:

Dr Been discusses Ivermectin for anosmia reversal again here:

https://youtu.be/Md-y01JdxvE

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid-2:8

Dr. Syed Haider Discusses COVID Management (July 2021) Drbeen Medical Lectures Jul 10, 2021

at the 13:20 minute mark:

https://youtu.be/Md-y01JdxvE&t=800

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid-2:8?t=800

Dr Been:

Ivermectin 0.4mg/kg bodyweight in long haulers esp with anosmia it works like magic - 2 or 3 days and done - anosmia goes away.

Dr Been - mention 5:

Dr Been discusses anosmia reversal with Ivermectin - in this more recent video as well:

https://www.youtube.com/watch?v=rgeP5lQiajc Brain Shrinking after Mild COVID (Oxford Study)

https://odysee.com/@DrMobeenSyed:1/brain-size-reduction-after-mild-covid:a Brain Size Reduction after Mild COVID (and Potential Solutions)

Mar 15, 2022

Drbeen Medical Lectures

Brain Size Reduction after Mild COVID (and Potential Solutions)

at the 35:00 minute mark:

https://www.youtube.com/watch?v=rgeP5lQiajc&t=2100

https://odysee.com/@DrMobeenSyed:1/brain-size-reduction-after-mild-covid:a?t=2100

Dr Been:

My takeaway in this all was that the anosmia part we should worry about it if it occurs.

And i think that we have done this discussion that there is a drug (Ivermectin) that can be useful for anosmia and within 2-3 days it can help restore and recover from anosmia

I think that drug (Ivermectin) should be part of the management.

So I'm on Youtube here so I cannot say that IVM will help covid19 because Youtube would then just block my channel and this discussion.

(NOTE: YouTube Terms of Service explicitly forbid the suggestion that Ivermectin helps against covid19)

But I can talk about olfactory nerve and inflammation and Ivermectin reduces that - and that has been very very effective.

at the 35:48 minute mark:

https://www.youtube.com/watch?v=rgeP5lQiajc&t=2148

https://odysee.com/@DrMobeenSyed:1/brain-size-reduction-after-mild-covid:a?t=2148

Dr Been:

So then what are the solutions

So one solution i just spoke about (Ivermectin).

I have been fortunate that the folks I have worked with who were taking IVM (Ivermectin) - they recovered very fast from anosmia.

I would suspect then the brain tissue damage were was reduced as well.

In this followup companion discussions video, Dr Been uses an anatomy program - and does a walkthrough showing brain anatomy and the location of the olfactory bulb:

https://www.youtube.com/watch?v=X6Nwj2-YVRs Discussion for Brain Shrinking After Mild COVID

https://odysee.com/@DrMobeenSyed:1/discussion-for-brain-size-reduction:0 Discussion for Brain Size Reduction After Mild COVID

Mar 15, 2022

Drbeen Medical Lectures

NOTE: also see the section Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs

Ivermectin and post-covid19 Anosmia reversal - others

Dr Gustavo Aguirre Chang early study on post-covid19 anosmia reversal - study had 21 subjects with post-covid19 anosmia - near 100% anosmia reversal using Ivermectin + Aspirin:

https://zenodo.org/record/4065802#.X7yuEh5RU0N

COVID-19 Persistent: TREATMENT WITH IVERMECTIN AND ACETYLSALICYLIC ACID OF PATIENTS WITH THE PERSISTENT SYMPTOM OF ANOSMIA OR HYPOSMIA.

September 26, 2020

Twitter: https://twitter.com/Aguirre1Gustavo

Report of 6 cases from Peter Pham (@peterpham on Twitter) - not clear how many were chronic/recent - anosmia must have been long enough that they sought out help - perhaps he can fill in some details on chronic/recent:

https://twitter.com/peterpham/status/1432040537654128640?s=19

Peter Pham

Had 6 friends already solve anosmia with ivermectin

Dec 31, 2022:

https://twitter.com/peterpham/status/1609119531573874688?t=cP-EmotHodZXYBblJYF1Ww&s=19

Peter Pham

Yup. IVM fixed anosmia for me and about 5 other friends

Dr. Juan M. Luco (Argentina) has been trying to build awareness of Ivermectin impact on anosmia.

Twitter: https://twitter.com/JML21071664/

This twitter thread points to the twitter threads by Dr Juan Luco on Ivermectin and anosmia:

https://twitter.com/stereomatch2/status/1496653830389444609

Dr Bruce Boros - we have this report from Dr Bruce Boros (no longer on Twitter) of 8 month anosmia case responding to IVM:

https://twitter.com/BorosBruce/status/1432027991056470020?s=19

I have personally treated a lot of patients with Ivermectin for CV- Anosmia can return in 2 days of treatment or up to 2 months after. I also had an 8 month long hauler get back t and s after one week of Iver 0.2mg/kg. Called me at 8am shouting "I can smell"

EDIT: adding Oct 5, 2023

Saw this while searching reddit for - ivermectin anosmia.

A report of anosmia reversal by u/007_jmp:

https://www.reddit.com/r/ivermectin/comments/otjhfz/comment/hgnfj7m/

007_jmp

Oct 15, 2021

After reading COUNTLESS articles and forums over the past weeks, I found this one... So I got Ivermectin yesterday and took my first pill then. Started noticing improvement as soon as last night!!! Can not believe the difference today. I am soooooooo relieved!!!!!!!!!

My story: Got the rona in may/june....not too bad but lost taste and smell for about a week then gradually regained those over the next months. About a month ago out of the blue things started tasting chemically...and I would have a persistent chemical smell in my nose...then last week just breathing from my mouth and breath started tasting awful...like rancid chemicals...but only certain foods would trigger...sour cream (which I LOVE) was the worst most vile smelling tasting thing ever (but milk, cheese and ice cream were fine). soda, toothpaste, gum all AWFULL... but many other things tasted mostly normal. Yay for ivermectin.

Anyway hope this helps someone.

Ivermectin and post-covid19 Anosmia reversal - long term anosmia reversal - months to years

Recent post-covid19 anosmia reversal is easy

As described above, the record of recent post-covid19 anosmia reversal is very promising.

Ivermectin when given in the post-day8 period (recent covid19 infection), seems to show palpable reversal of anosmia (taste/smell dysfunction - all variations - reduced smell to burning smell to modified smell) within 12 hours of an Ivermectin dose of 0.4mg/kg for 3 days. Usually anosmia reverses 100% in 1-2 days. If partial, one can wait a week and do a refresher course of Ivermectin - which in nearly 100% of cases is sufficient to reverse anosmia 100%.

Longer term anosmia reversal is a bit harder

The record for longer term anosmia (where the post-covid19 anosmia or taste/smell dysfunction has persisted for 5-6 months or longer with little improvement using other treatments) is promising as well. But a bit more complicated than the recent anosmia cases (as discussed above).

For longer term anosmia cases that I am aware of (where nothing was reversing the anosmia - taste/smell dysfunction - for months) - Ivermectin does seem to have an effect (where nothing else is helping).

And there are cases where 5 months to 1 year old anosmia cases have reversed 100% in a time-sensitive manner after use of Ivermectin.

HOWEVER, there can be cases where the reversal is partial - and may require longer followup with refresher courses.

I describe the longer term anosmia cases (and their experience with Ivermectin) below.

8 month old case

I am aware of an 8 months old anosmia case (incorrectly mentioned by me as "10 months" sometimes in comments on twitter or reddit) - that Dr Bruce Boros reported on Twitter - that was not reversing and then on use of Ivermectin they were able to reverse it.

5 month old case

I (stereomatch) heard from a 5 months old anosmia case who tried everything - but then tried Ivermectin (using the Dr Gustavo Aguirre Chang paper for the 21 cases study). He had been unable to reverse the anosmia using many treatments - but finally Ivermectin reversed him in a short time back to near 100%.

5 months and 6 months old anosmia reversal cases

Twitter user dialucrii31 reports of a 5 months old anosmia case - and a 6 months old anosmia case - both reversing with a 0.3mg/kg bodyweigh per day for 5 days course:

https://twitter.com/dialucrii31/status/1706576237085217209?t=BsfONa91YPdPHYfCT1Pd1g&s=19

My wife and a family friend cured 5 months and 6 months respectively of anosmia with a 5 day course of this.

https://twitter.com/dialucrii31/status/1707488571236429972

Sure, in both cases it was just persistent anosmia that was the lingering issue (plus some ageusia) . In both cases it was a 5 day course with symptoms disappearing gradually each day.

0.3mg/kg iirc though it may have been higher.

https://twitter.com/dialucrii31/status/1707862613130940546

Both back 100%. As of a year or so later, no further issues, no return of symptoms.

Selection bias in reports from the field

The 5 month, 8 month - and 5 month and 6 month - cases of reversals mentioned above may suffer from "selection bias" i.e. only the successful ones report back. So the incidence of reversal may seem higher than it actually is (if you too 100 people with persisting anosmia - and started them on Ivermectin - and observed how many of them had anosmia reversal).

Because those who see success with a treatment are more likely to report back - while those who see no impact may be less motivated to report that.

1 year old case (without selection bias) - modest improvement

I (stereomatch) recently heard from a nearly 1 year old anosmia case - who reported to me that he was starting IVM.

(NOTE: so observation was started first - then treatment was started - so no selection bias here - even failures would be observed as attentively)

He tried Ivermectin at 0.4mg/kg for 3 days - and felt some benefit - then with repeated cycles (refresher courses) he did not see further improvement.

However he may try again later with another refresher IVM course.

So this illustrates that even with Ivermectin, there may be slow progress in some cases.

Long Haulers Treatments - Survey of Anosmia treatments - on Reddit

See the section "Long Haulers Treatments - Survey of Anosmia treatments - on Reddit"

Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs

See the section "Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs"

Ivermectin and post-covid19 Anosmia reversal - standard of care

The standard of care seems to be that there is no cure for post-viral infection anosmia:

https://www.msdmanuals.com/home/ear,-nose,-and-throat-disorders/symptoms-of-nose-and-throat-disorders/loss-of-smell Treatment of Loss of Smell

Doctors treat the cause of the anosmia. For example, people with sinus infections and irritation may be treated with steam inhalation, nasal sprays, antibiotics, and sometimes surgery. However, the sense of smell does not always return even after successful treatment of sinusitis.

There are no treatments for anosmia itself. People who retain some sense of smell may find that adding concentrated flavoring agents to food improves their enjoyment of eating.

Ivermectin and post-covid19 Anosmia reversal - commercial analysis

Here is a non-free analysis of the anosmia market:

https://www.marketwatch.com/press-release/anosmia-market-competition-opportunities-and-challenges-market-players---glaxosmithkline-plc-pfizer-inc-atom-pharma---2022---2027-by-hny-research-2022-04-07

Press Release

Anosmia Market Competition, Opportunities and Challenges, Market Players - GlaxoSmithkline Plc, Pfizer Inc, Atom Pharma - 2022 - 2027 By HNY Research

April 7, 2022

Ivermectin and post-vaccine hearing loss (in one ear)

To be added

Ivermectin safety

Dr Hong has this video for pharmacists:

https://old.reddit.com/r/ivermectin/comments/ok1j43 Pharmacology professor on IVM

Video:

https://www.youtube.com/watch?v=36ummVGN6jA COVID Focus Talk || Ivermectin Pharmacological Considerations || Is this drug suitable for everyone? Jul 5, 2021 Dr. Hong's Pharmacy Classroom

Merck 2002 study conclusion that ivermectin was safe at 10x doses:

https://old.reddit.com/r/ivermectin/comments/mxw8go Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. J Clin Pharmacol (2002)

We have the data from ivermectin use for leukemia in children - they used very high doses of ivermectin - they used 1mg/kg (compared to the typical 0.2mg/kg) for 14 days to 6 months continuously (!) (compared to the typical 1 day to 5 days with refresher doses usually used for covid19):

https://old.reddit.com/r/ivermectin/comments/mrhctp/regular_dosing_of_ivermectin_for_prophylactic/gup3hd4 Regular dosing of ivermectin for prophylactic purposes - was this done in the past?

Ivermectin drug shelf life

See comment by u/Haitchpeasauce: https://old.reddit.com/r/ivermectin/comments/ogonhi/what_happens_to_ivermectin_after_its_expiration/h4kbn41

Ivermectin manufacturings costs

Dr Andrew Hill, who earlier did the meta-analysis for Ivermectin for Unitaid (in support of WHO decisionmaking), has argued in interviews that countries need to stockpile Ivermectin.

At the time of that interview he said the UK did not have a stockpile of the drug.

He has argued that if countries delay approval of Ivermectin too long, then other countries will secure strategic reserves, and later mover countries may not be able to secure supply.

In this report, he examines the manufacturing costs for various generic drugs that may have utility for covid19, including Ivermectin:

See this reddit post:

https://old.reddit.com/r/ivermectin/comments/nt64zb/dr_andrew_hill_author_of_unitaid_paper_that/ Dr Andrew Hill (author of Unitaid paper informed the WHO decision on Ivermectin) pre-print on costs mass production of Ivermectin and repurposed drugs (June 3, 2021)-paper in line with concerns he raised earlier UK lacked strategic stockpiles of Ivermectin

Paper by Dr Andrew Hill:

https://www.medrxiv.org/content/10.1101/2021.06.01.21258147v1 Minimum manufacturing costs, national prices and estimated global availability of new repurposed therapies for COVID-19 Junzheng Wang, Jacob Levi, Leah Ellis, Andrew Hill June 03, 2021

Early Treatment guide for physicians - Ivermectin

Ivermectin - interactions with other drugs

Ivermectin is contraindicated in patients using Warfarin (Coumadin) (Coumarin family that includes Warfarin).

Low dose heparin is ok - and is part of the FLCCC protocol for treatment of covid19.

Calcineurin inhibitors - used by transplant patients - because of interactions. However transplant patients undergoing covid19 treatment are often switched in favor of steroids (instead of calcineurin inhibitors), precisely because steroids also interact with calcineurin inhibitors. And steroids can be used instead for a short while - to prevent rejection.

Please correct any inaccuracy in above paragraph.

Added Feb 22, 2022:

The FLCCC MATH+ extended protocol document PDF includes a section on Ivermectin drug interactions - see "Table 5. Drug Interactions With Ivermectin".

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf

Reference:

https://www.youtube.com/watch?v=OY8QV7lnFFo

Dr. Paul Marik Discusses Ivermectin and Vitamin D

Feb 17, 2021

Drbeen Medical Lectures

at 5:00 minute mark:

Dr Paul Marik starts presentation for 30 minutes

at the 25:20 minute mark:

drug-drug interactions

caution with calcineurin inhibitors used for transplant patients

There may be some interaction with cholera and dengue vaccines:

https://old.reddit.com/r/ivermectin/comments/kfw7de/ivermectin_and_covid_19_dr_john_campbell_reviews/ggb1k0x

(although Dr. Pierre Kory has said in a video interview with Dr Been and Dr Paul Marik - that Ivermectin has no known side-effects or drug interactions - except for some mention of possible interaction with cholera and dengue vaccines)

Ivermectin - few side effects

Ivermectin in general has almost no side-effects (see caveats below) at the 0.2mg/kg bodyweight dosage (FLCCC-recommended for prophylaxis), even when taken over many days.

Many people have taken ivermectin now over 8 months or more, weekly at the 0.2mg/kg bodyweight dosing, without any visible issues.

Ivermectin - Dizziness, visual disturbances

High sensitivity - dizziness, low blood pressure - 1 in 20 people

About 1 in 20 people seem to show signs of dizziness right from the first dose. These people will generally not feel like taking more of the drug.

For this reason it is important that those planning on using Ivermectin later - first do a test with a small dose (Ivermectin 6mg for instance) - so that they can be comfortable that they will be able to use Ivermectin when the time comes - for prophylaxis, for when they get covid19 or for long haulers.

Those who have Ivermectin available, can "pre-qualify" themselves ahead of time. They can do this by taking Ivermectin once and seeing if they have any issue with the drug at that dose.

If they are not feeling any issue, then they can be sure that they will have ability to use Ivermectin in a moment of crisis i.e. when they get covid19.

Sensitivity after prolonged exposure - visual disturbances - dazed feeling

At the 0.4mg/kg bodyweight dosage over 5 days or more (FLCCC recommendation for covid19 treatment) can lead to some side-effects in some people.

These side-effects can be mild dizziness, or visual disturbances (which is similar to the daze one may feel when one has been sleep deficient for a few days).

Those encountering signs of dizziness or visual disturbance - for these patients the dosage can be halved and often the issues go away.

If issues remain, then consider discontinuing Ivermectin - or switching to a spread out dosing strategy. For example for weekly prophylaxis - instead of 12mg every Sunday, you may consider giving 3mg morning + 3mg evening on Sunday, and then 3mg morning + 3mg on Thursday.

Usually Ivermectin at the 0.2mg/kg bodyweight every Sunday (pre-exposure prophylaxis) dosing - does not give any side effects.

However at the 0.4mg/kg bodyweight every day for 3 days (for example when used for post-exposure prophylaxis) or for 5 days or longer (for covid19 treatment or long haulers) - some patients may experience dizziness or visual disturbance (sensation is similar to when you are sleep deprived and start seeing visual artifacts).

In some people, Ivermectin (esp at the 0.4mg/kg dose) may be causing lower blood pressure (which may lead to dizziness).

EDIT: Sept 16, 2022 - another attempt by me (u/stereomatch) to describe what visual disturbances look like: "starting to feel the eye daze ie as if white or brightness button been jacked up so contrast is less but bright more"

EDIT: Feb 7, 2023 - another description by u/RestingLogo on reddit:

https://old.reddit.com/r/ivermectin/comments/10vnrkx/hard_to_balance_benefits_of_ivermectin_against/

https://archive.md/847X0

RestingLogo

The day after I took the ivermectin I did experience some side effects. Everything looked "bright" and sometimes I could see blue flashes. This went away however and I noticed no long term effects.

NOTE: this user took 0.5mg/kg bodyweight dose - and then reported the visual disturbance the next day. This is not typical - usually at the 0.4m/g/kg dose it takes about 5 days for such symptoms to appear. However it is possible this user took the higher 0.5mg/kg dose, and maybe took it all at once (instead of splitting it into morning/evening doses). Or they may have had sensitivity to Ivermectin (which usually occurs in 1 in 20 users - though there usually they have dizziness due to low blood pressure - or just generally don't want to take additional dose). In this case, the user didn't have those side effects and just the visual disturbance - maybe they are not sensitive - but the 0.5mg/kg dose was just too much for them. Note that 0.6mg/kg doses are also given (I have used it on two or more occasions - one a 74 year old severe case and another vaccinated person who was asymptomatic but showed sharp declines at day7-8 with oximeter declines etc. - so higher dose was used to gain some leverage over the declines). This dose of 0.6mg/kg doesn't always give this side effect - so results/responses can vary from person to person.

More details from u/RestingLogo:

https://old.reddit.com/r/ivermectin/comments/10vnrkx/comment/j7n7khf/

https://web.archive.org/web/20230208012438/https://old.reddit.com/r/ivermectin/comments/10vnrkx/hard_to_balance_benefits_of_ivermectin_against/j7n7khf/

RestingLogo

Everything seemed "bright" like I had night vision. It wasn't hard to see. Just felt weird.

When I closed my eyes I would occasionally see instantaneous blue flashes at the sides of my vision.

EDIT: Feb 23, 2023 - Dr Jackie Stone (Zimbabwe) suggests the dazed feeling during the visual disturbances seen with prolonged use (without a break) of Ivermectin - is due to dilated pupils (similar to the feeling you get after an ophthalmologist appointment when they diluate your pupils using eyedrops):

https://twitter.com/DrJackieStone/status/1628459199490412549

https://web.archive.org/web/20230223115943/https://twitter.com/DrJackieStone/status/1628459199490412549

Dr. Jackie Stone

We warn all patients that the pupil may dilate with higher doses of IVM so they may have the sensation of too much light coming in - and colours being brighter. This is always transient, and if they skip a dose it will go away. (1/2 life is >72hrs so safe to miss a dose)

Here she gives her estimate - that about 16-20% of patients should show visual disturbances/artifacts after 6 days of 0.6mg/kg bodyweight dose of IVM (the discussion centers around how the ACTIV-6 trial which was negative for "mortality benefit" for IVM - that had a treatment arm with much less visual side-effect than would be expected at that dose - suggesting perhaps pure Ivermectin was not used or there was an issue with the trial conduct):

https://twitter.com/DrJackieStone/status/1628458361124450305

https://archive.ph/3FypD

Dr. Jackie Stone

I would expect 16-20% at that dose. But once the critical phase is over - we recommend to give IVM at night - as visual side effects peak at 4 hours - so if the patient is asleep - they are not aware that their vision is abnormal if their eyes are closed.

EDIT: Apr 22, 2023 - another description by u/SchlauFuchs on reddit (about an accidental overdose and it's impact):

https://old.reddit.com/r/ivermectin/comments/10vnrkx/hard_to_balance_benefits_of_ivermectin_against/

https://archive.ph/SBr2t

SchlauFuchs

The FLCCC protocol recommends Ivermectin amongst other substances. They have multiple protocols for prophylaxis, early treatment and serious treatments.

Ivermectin at the dosage they suggest has nearly no side effects. If you double the amount they recommend, you might get light sensitivity and visual effects.

I took a tenfold amount once, a comma slipped in the calculation.

I had strong visual interference for about half a day, light was far too bright, moving felt like walking in stroboscopic light. Definitely not in a state to drive any vehicle or heavy machinery.

But that was it.

Yes, it builds up in your fatty tissue, that is why you take more at the beginning and then only one every fortnight for prophylaxis. But it does not accumulate forever, it wears off when you stop taking it.

Ivermectin - Reducing dose

If such side-effects are experienced, the dosage should be halved, and usually the dizziness etc. will go away in most people. The patient can then be continued on that lower doze.

If side-effects continue, the dosage should be halved again, or should be stopped.

And an alternative treatment strategy - using Fluvoxamine, or perhaps easier for many patients the over-the-counter Bromhexine (or other such candidates) may be considered.

Generally 1 in 20 patients have been observed who may have some sort of reaction the first time they use Ivermectin.

Ivermectin - Genetic variation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929173

Rarely, some people may have a genetic variation which weakens the blood-brain barrier. In these folks, Ivermectin may trigger the dizziness etc. side-effects mentioned above.

The 1 in 20 people mentioned above who have side-effects, may have these issues, or may be suffering from parasites.

One possible strategy

For those who are concerned, start with a minor dose instead, and see if patient starts to have dizziness or visual disturbances within half a day perhaps.

If so avoid it.

Or if taking full dose dose, if feel above symptoms, halve the dose or stop entirely.

Ivermectin - Parasites

Occasionally patients can experience a one-time soft stool or mild diarrhea the day after - this is often because of worms being ejected (traditional anti-parasitic action of the drug)

But in such cases, for example the first time they take their prophylaxis weekly dose of ivermectin, they may get mild diarrhea the next day. But this should not happen the next time, or in the weeks thereafter.

Patients with Lyme disease or Multiple Sclerosis (MS) may have a reaction to Ivermectin. This can be due to a herxheimer reaction (as parasites die off), or due to demyelinated nerves (in MS). For these patients, the use of Ivermectin may not be ideal, and the physician should consider using some of the other promising early treatment drugs like Bromhexine (which is also over-the-counter).

Ivermectin - Lyme disease and Multiple Sclerosis

Regarding Ivermectin for treating Lyme disease or Multiple Sclerosis (MS), Dr Steven Phillips author of the best-selling book "Chronic" (in a Dr Been interview) has mentioned that for Lyme or MS, the dosing of Ivermectin should be done very carefully - i.e. start off with very low doses, and then build up the dose over time. He also refers to emerging evidence that Ivermectin may help with nerve remyelination (so may be beneficial for MS in the long run). (TODO: add references to Dr Steven Phillips' interview by Dr Been).

Ivermectin - Kidney disease and Ivermectin

Dr Been addressed this in a Q&A session video recently - someone asked about any precautions for ivermectin and kidney disease.

He suggested there should be no special caution for kidney disease, although there might be some caution for liver disease, since ivermectin is metabolized in the liver.

Ivermectin - Kidney transplant patients with covid19

Here is a review of things to watch for a kidney transplant patient who has covid19:

https://www.tandfonline.com/doi/full/10.1080/0886022X.2021.1876730

State-of-the-Art Review

Immunosuppression in kidney transplant recipients with COVID-19 infection – where do we stand and where are we heading?

Ahmed Daoud, Ahmad Alqassieh, Duaa Alkhader, Maria Aurora Posadas Salas, Vinaya Rao, Tibor Fülöp & show all

24 Jan 2021

Ivermectin

Despite not FDA approved, to date, there are more than 15 peer-reviewed published articles showing high efficacy of the anti-parasitic agent ivermectin in prophylaxis and treatment of all stages of COVID-19 infection [47].

In vitro, ivermectin administered to Vero-hSLAM cells 2 h after SARS-CoV-2 infection showed ∼5000-fold reduction of viral RNA after 48 h [48].

Its anti-viral effect is thought to be mediated through the inhibition of importin α/β-mediated nuclear transport of SARS-CoV-2 proteins [48].

Proposed dose is 0.2 mg/kg for 4–5 days.

Caution is advised when using ivermectin with CNIs, the former being a known cytochrome P450 inducer, potentially altering CNI drug levels.

NOTE: CNIs (Calcineurin inhibitors) are often used as immunosuppressive agents for kidney transplant patients, to reduce risk of rejection.

Ivermectin - Liver disease

Ivermectin has been given to liver transplant patients on occasion, with care.

Dr Pierre Kory addresses ivermectin and impact on liver here:

https://www.youtube.com/watch?v=0S8IOttV-Ew

Vanakkam Tamil Nadu: Not Banning Ivermectin Could Have Saved More Lives: US FLCCC Dr. Pierre Kory

India Ahead News

Jun 11, 2021

at the 21:40 minute mark:

https://youtu.be/0S8IOttV-Ew&t=1300

Dr Pierre Kory:

The idea that it (ivermectin) hurts the liver is a joke.

There are 3 cases reported in the literature of a hepatitis (ie in 40 years and 3.7 billion doses) with ivermectin.

Again today that report out of Argentina (La Pampa province) - they reported that in 3000 patients that they treated, not one serious side effect was reported - none. In 3000.

But we already know that from the billions of doses.

As so, a French toxicologist that just finished a review about a month ago.

And in his report, the famous toxicologist, 350 different articles and studies done on ivermectin and he wrote, in his executive summary, that severe adverse events of ivermectin are unequivocally and exceedingly rare - unequivocally and exceedingly rare.

Early Treatment guide for physicians - Steroids

Steroids - Usage

Prior to starting steroids, one should check for pre-existing conditions that sometimes are present in severe covid19 patients (diabetes predisposes to severe disease, so you may find many patients have uncontrolled blood sugar levels).

Steroids - Bacterial infection

If the patient has yellow/green phlegm then it is an indicator they may have a bacterial infection. NOTE: viral infections (like covid19) typical have clear (transparent) phlegm (the output from lungs).

In such a case, priority should given to reduce the bacterial infection before the start of steroids for covid19 (which are usually needed at day7-8 from first symptoms when hyperinflammatory stage starts appearing).

Antibiotic treatment (and if they are diabetic, their blood sugar level normalization) will help recover from bacterial infection within a few days.

Given the risk of bacterial infection, or the return of a bacterial infectionafter treatment with antibiotics, one may evaluate whether it is wise to start steroids at day7-8 or later.

If hyperinflammation sets in, treating it at day 10 will require a higher steroids dose.

So it could be argued that it is preferable to start on time i.e. at day7-8 but at low dose steroids, i.e. to arrest early, so that the possibility of needing high dose steroids later is avoided.

You cannot start steroids much earlier than day7-8 (unless obvious oximeter levels/pulse rate are suggesting hyperinflammation has started - in which case perhaps day1 was not judged correctly because of very mild early symptoms).

But if you start steroids much later, i.e. allow oximeter readings to fall too much, then more aggressive steroids therapy is required to stop daily decline.

So timing of steroids, and needing to ensure bacterial infection is eliminated - all these considerations have to be balanced.

Please send your criticism or insights into how to deal with bacterial infection at a time when you want to give steroids - by posting a comment to:

https://old.reddit.com/r/ivermectin/comments/oh7xfw/added_a_wiki_for_rivermectin_for_organizing_the

Steroids - unrelated dehydration

In hot/humid climates patients can sometimes lose a lot of water and have electrolyte imbalances. This can be corrected with ORS (oral rehydration salts) and increasing water intake. But may require rehydration with saline IV in severe dehydration cases.

Sometimes patients who have high pulse rate (which increases on standing up or going to the bathroom) may feel they need to reduce the need for urination, and they may wind up reducing their water intake severely - leading to dehydration.

Some patients may not be taking enough water to compensate for fluid loss via sweating and urination.

Common symptoms of dehydration can be:

listlessness
high blood pressure
high pulse rate (100+)

If a patient seems to be dehydrated, saline IV - or lacking that ORS (oral rehydration salts) and water should be increased.

If patient has high pulse rate, and is stressed by getting out of bed, then a pot should be provided for urination while on bed.

Steroids - DKA (diabetic ketoacidosis)

Steroids usually raise the blood sugar level of patients. Some mild increase in sugar levels are ok, but in some patients this can lead to issues.

Paradoxically, in some patients, once they start steroids, their blood sugar levels can remain unchanged, or in some cases may even become better - it is possible such patients had ongoing inflammation issues pre-covid19, and the steroids fixed those issues (?)

During covid19, a lot of patients have not been visiting their doctors for their diabetes and other conditions.

As a result, many may have uncontrolled blood sugar levels in the 250-300 range, despite taking their old diabetes medicines.

Patients who are used to taking insulin using insulin pen, may be in better shape generally, since they have learned a procedure to check sugar on glucometer, and dose according to need. Their blood sugar may be the best managed among diabetes patients. These patients are generally also adept at adjusting their insulin pen doses to deal with rising blood sugar levels (due to starting steroids)(.

Diabetic ketoacidosis can happen in patients with blood sugar levels around 300 for extended periods of time. This can lead to electrolyte imbalances and insulin exhaustion (body unable to provide sufficient insulin).

This is a dangerous condition, and can be remedied in 2-3 days with electrolyte supplementation via saline IV, and administration of solubilized insulin via IV, while monitoring with glucometer every hour - in order to bring down blood sugar levels to 200-250 range or lower.

Common symptoms of DKA can be:

excessive thirst
frequent urination
low blood pressure (though in some cases high blood pressure has been observed)
high pulse rate (100+)

Source: https://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/symptoms-causes/syc-20371551

Blood tests can reveal:

lowered bicarbonate levels
somewhat higher potassium levels (as it leaches out of cells)
high ketone levels in urine

Some more info on diagnosing DKA (adding March 25, 2023)

These symptoms are often reported for DKA:

frequent urination
dry mouth
high blood sugar levels
high ketones in urine

https://www.aafp.org/pubs/afp/issues/2005/0501/p1705.html#:~:text=A%20diagnosis%20of%20diabetic%20ketoacidosis,mEq%20per%20L%20or%20less.

A diagnosis of diabetic ketoacidosis requires the patient’s plasma glucose concentration to be above 250 mg per dL (although it usually is much higher), the pH level to be less than 7.30, and the bicarbonate level to be 18 mEq per L or less.

Beta-hydroxybutyrate is a better measurement of the degree of ketosis than serum ketones.

Intravenous insulin and fluid replacement are the mainstays of therapy, with careful monitoring of potassium levels.

Phosphorous and magnesium also may need to be replaced.

Bicarbonate therapy rarely is needed

Infection, insulin omission, and other problems that may have precipitated ketoacidosis should be treated.

Myocardial infarction is a precipitating cause of diabetic ketoacidosis that is especially important to look for in older patients with diabetes.

Cerebral edema is a major complication that occurs primarily in children.

Steroids - high dose steroids in the ICU - pulse dosing for "organizing pneumonia" - part 1

Dr Been interviews Dr Pierre Kory on the need for steroids.

Capped-to-6mg Dexamethasone and Remdesiriv are still (as of Dec 31, 2021) the standard of care at many large Us hospitals.

If patients require more than 6mg Dexamethasone, they stagnate and wind up on ventilator.

Dr Pierre Kory outlines why high dose steroids are needed to turn some patients around, and pulse dosing for "organizing pneumonia".

Here Dr Pierre Kory highlights the need for early high dose steroids - "250mg methylprednisolone for 1st 3 days in ICU":

https://youtu.be/3UTuT9TSRFQ

Dr. Pierre Kory Talks About Human Rights and The Big Science Disinformation

May 6, 2021

Dr Been Medical Lectures

Rough transcript:

(for each of the timestamps below, a direct link to the section in the video is provided below)

at the 4:30 minute mark:

https://youtu.be/3UTuT9TSRFQ&t=270

Discusses steroids - how Dr Umberto Meduri suggested steroids do have benefit when regulators saying no.

And his US Senate testimony.

at the 5:30 minute mark:

https://youtu.be/3UTuT9TSRFQ&t=330

6 weeks later were validated when Oxford RECOVERY UK trial results came out

at the 6:00 minute mark:

https://youtu.be/3UTuT9TSRFQ&t=360

Mentions his paper on "organizing pneumonia"

(at 6:50 minute mark says - it took him 6 journals to get it published)

Pulse dosing - high dose steroids

And need to adjust to conditions, state of patient - not a rigid protocol of 6mg prednisolone for 10 days.

at the 7:00 minute mark:

https://youtu.be/3UTuT9TSRFQ&t=420

6mg dexamethasone

1 year into pandemic - and gods of science still saying Remdesivir and 6mg dexamethasone

Higher dose and methylprednisolone lead to more benefit

250mg methylprednisolone for 1st 3 days in ICU

at the 8:00 minute mark:

https://youtu.be/3UTuT9TSRFQ&t=480

We are undertreating patients on a global scale and it is really hard to watch

We are using anemic doses of a corticosteroid that doesnt work very well

But is hard to watch the level of doctoring occuring globally

We put this thing (MATH+) back in March - there is such a thing as expertise

Steroids - high dose steroids in the ICU - pulse dosing for "organizing pneumonia" - part 2

Dr John Campbell (YouTuber who appears on Deutsche Welle German TV) interviews Dr Pierre Kory for a more extensive discussion on the uphill task to convince the world to use steroids (in opposition to WHO/CDC/NIH comments against steroids).

See the interview and rough transcript of the steroids-related section below.

The role of RECOVERY UK trial on steroids - how it finally removed obstacles and opposition to steroids.

However, it also led to some unfortunate bad practices - large US hospitals taking the RECOVERY UK trial outcomes literally - as is the practice of placing RCTs on a pedestal without employing common sense and real world observation.

Large US hospitals instituted policies based on their reading of the RECOVERY UK trial:

capping the doses to 6mg Dexamethasone - but primarily not tailoring it to the patient
giving Dexamethasone even though Prednisolone is faster to lungs and better tolerated at high doses (Dr Paul Marik in Dr Been interview)
erroneous conclusion drawn from RECOVERY UK trial on steroids - that there is a signal of harm if steroids given before intubation (!) - a result probably due to lumping of very early and day8 patients in the study. As a result they lose the window of opportunity to give steroids-at-day8 - because they are waiting for oximter levels to decline below 95 or 90 or for intubation (day10-14 time period). And are allowing hyperinflammation to graduate to hypercoagulability.

This strategy means the subset of patients who need more steroids, will stagnate and go to ventilator.

And by denying early treatment, an opportunity is lost for timely intervention. Patient will go home and will usually come to hospital only when gasping for air.

Since patients are not sent home with steroids, they are unable to arrest hyperinflammation at home.

A vicious cycle is created which generates more serious cases, more ICUs, more ventilator beds.

Large US hospitals turned away early patients - asking them to wait for hypoxia and then come back.

These people should have been given a medicine packet in the parking lot (by another team dedicated to this task) - the medicine packet would have included Ivermectin, Famotidine, Zinc, Vitamins, NAC, Aspirin - and Prednisolone (with a strong caution to take it on day8 or after consultation over phone).

An opportunity was lost to arrest early disease.

Ostensibly the reason for this hospital behavior was to do triage in hostile working conditions.

But this lack of treatment itself created more severe patients.

The mild cases of this week became the severe cases of next week.

An opportunity to add extra staff (from the National Guard etc.) in hospital parking lots was lost.

Large US hospitals are still (as of Dec 31, 2021) using Remdesivir in post-day8 patients as standard of care.

The obfuscation of viral timeline and treatment in the public eye has created an opportunity for is the prescription of Remdesivir.

Even now (as of Dec 31, 2021) large US hospital protocols still have Remdesivir as standard of care for post-day8 treatment.

If viral timeline was clear to everyone - how would hospitals be able to justify giving Remdesivir at day8?

Video:

https://youtu.be/JMeP66gdc4o

Dr Pierre Kory, Part 1, Steroids and anticoagulants

Dr. John Campbell

Apr 26, 2021

Rough transcript:

(for each of the timestamps below, a direct link to the section in the video is provided below)

at the 2:28 minute mark:

https://youtu.be/JMeP66gdc4o&t=148

Dr John Campbell:

So I know you are the early proponents of thinking about treatments for covid19.

And you are one of the first people in the world to suggest using steroids.

Now what are steroids and why are they important in covid19.

at the 3:19 minute mark:

https://youtu.be/JMeP66gdc4o&t=199

Dr Pierre Kory:

Live virus is not present generally after about 6-7 days - so these fears of using steroids ..

at the 4:10 minute mark:

https://youtu.be/JMeP66gdc4o&t=250

So I testified back in May 2020, back when every national and international health agency had statements we recommend against ..

all were against steroids - all of them

And so when I testified that it was critical to use steroids, I was roundly attacked and criticized for irresponsible recommendations, even though they were based on my expertise.

And let me answer your question - so why did we know it worked?

...

at the 7:15 minute mark:

https://youtu.be/JMeP66gdc4o&t=435

I told him (a doctor friend) - almost screamed at him on the phone - you have to start steroids.

A bit later he said he is a little bit of a hero in his hospital because of what he tried.

...

at the 8:15 minute mark:

https://youtu.be/JMeP66gdc4o&t=495

I recognized that this disease is actually what's called "organizing pneumonia" ...

It used to be called BOOP (Bronchiolitis obliterans with organizing pneumonia) or COP (Cryptogenic organizing pneumonia)

It's a pretty rare disease and is not well recognized even by lung specialists.

Paper describing Organizing Pneumonia (September 2014):

https://www.sciencedirect.com/science/article/pii/S2211568414000059 Organizing pneumonia: What is it? A conceptual approach and pictorial review September 2014

Paper by Dr Pierre Kory (December 2020):

https://bmjopenrespres.bmj.com/content/7/1/e000724 SARS-CoV-2 organising pneumonia: ‘Has there been a widespread failure to identify and treat this prevalent condition in COVID-19?’ Pierre Kory and Jeffrey P Kanne December 2020

at the 8:35 minute mark:

https://youtu.be/JMeP66gdc4o&t=515

But I noticed that the covid19 patients reminded me so much of organizing pneumonia patients.

And when I talked to one of my colleagues, he's one of the top chest radiologists in the world, I called him up one day and I said Jeff, what would you say if I told you that everybody with covid19 has Organizing Pneumonia ?

And he said of course they do - we published that back in March 2020 - this was like in April 2020.

I said what do you mean.

And he came up - him and a lot of national experts, they reviews all of the CT scans from Wuhan, China - and in their position paper in the Journal of Radiology, the top journal of Radiology in the world, they wrote the predominant form of lung injury in the CAT scans is of Organizing Pneumonia.

at the 9:15 minute mark:

https://youtu.be/JMeP66gdc4o&t=555

Just so you know John, THE gold standard therapy for Organizing Pneumonia - corticosteroids.

...

I tried to publish my paper, saying that why is there a widespread misdiagnosis of this disease and no one is considering that this is Organizing Pneumonia.

It got published by 6 rejections.

One of the rejections by a top pulmonary journal.

The reviewer told me, that to prove my hypothesis I would need to do a randomized control trial of corticosteroids.

So this was before the RECOVERY trial.

And so are the reasons we thought that corticosteroids would work - it is a pandemic of Organizing Pneumonia.

at the 10:10 minute mark:

https://youtu.be/JMeP66gdc4o&t=495

Dr John Campbell:

And this is to do with the idea that covid19 is a phased disease, and again you were one of the first people to identify that.

What is a phased disease and why is it important to know about.

Dr Pierre Kory:

Dr Paul Marik really tried to codify the best way early on, but I will tell you ..

People knew on the ground that it starts to hit around day 5-7.

So one of my former mentors, he got covid19 very early on, before N95s were used widely in hospitals.

And we were really worried about him - and we were watching the data - everyone was really scared, it was like the clock, every day am I going to have trouble breathing.

And he started to develop a little problem breathing, but luckily he didn't advance to the severe phase.

And so we knew that if someone went into the pulmonary phase a little bit later on, and if arrested you went into like late phase pulmonary - which is basically kind of an ARDS pattern - really damaged lung.

at the 11:33 minute mark:

https://youtu.be/JMeP66gdc4o&t=693

Dr John Campbell:

What about anti-coagulants - you were very early proponents of anti-coagulants.

Dr Pierre Kory:

I want to mention one other really important .. about corticosteroids.

So the RECOVERY trial from Oxford - when they came up with showing they tried to save the world that steroids are saving ..

I got texts from all over the world .. we should have listened to Pierre ..

But here's the deal, John I got to tell you, the dose they used in the RECOVERY trial is an absolute farce.

6mg of dexamethasone is about 32mg of methylprednisolone (40mg prednisolone/Deltacortril).

I will give 82 year old COPD patients 40mg prednisolone.

And so to give patients in severe lung disease on ventilators 6mg dexamethasone is a joke.

(NOTE: basically these studies were killing people by being miserly with steroids doses - and these studies have inspired many doctors and hospitals to also use low doses - just as these studies have lamentably according to Dr Paul Marik unnecessarily pushed dexamethasone as the steroid of choice, when prednisolone is better tolerated at high doses and is faster to lungs - according to early Dr Paul Marik interview with Dr Been)

at the 12:25 minute mark:

https://youtu.be/JMeP66gdc4o&t=745

But fulminant cases need pulse dose steroids - look at our protocol - we have been calling for high doses and pulse doses from the beginning.

Yet the entire world is being treated with Remdesivir and 6mg dexamethasone.

It gives me chest pains - and the entire world has this idiotic protocol which is ineffective in most patients.

I call 6mg dexamethasone - "it helps the few, and fails the many".

at the 13:00 minute mark:

https://youtu.be/JMeP66gdc4o&t=780

The second thing about corticosteroids and Organizing Pneumonia - is that you do not prescribe steroids for a defined time.

There is not 5 days or 10 days - we are not built with calendars.

You know we follow disease - secondly, you need to do prolonged durations - number three Organizing Pneumonia it relapses.

at the 13:20 minute mark:

https://youtu.be/JMeP66gdc4o&t=800

And you know .. I admitted patients back in September 2020 who were discharged, off oxygen, and they came back 5-6 days later - the lungs were whited out again (ground glass opacities and infiltrates).

And some of them died.

And it was because of widespread failure to realize you need to treat for long durations with slow tapers.

(NOTE: this is a common mistake by many doctors working from habit - many do a 1 week course of steroids for mild cases, and do a cold stop - instead of tapering off over another week - given that there is a risk of viral debris not having being fully cleared, there exists a risk of renewed irritation and immune excitement again if steroids are stopped too early)

at the 13:40 minute mark:

https://youtu.be/JMeP66gdc4o&t=820

And so I have been trying to communicate that.

And lastly, so many of my trainees are finding my paper, they are recognizing a lot of Organizing Pneumonia in the patients that are discharged - the pulmonologists are able to say hey (Pierre) this is Organizing Pneumonia.

at the 14:00 minute mark:

https://youtu.be/JMeP66gdc4o&t=840

But you asked about anti-coagulation.

You know the first 4 patients we had - we had been doing something called a TEG - you know what a TEG is - it's one of the newer and fancier coagulation assays you can do. In the past it was PP, APTT ..

And now we have in hospitals something called a TEG - and you can get it very quickly.

And it gives you this wealth of information.

And it tells you where in the coagulation cascade you have a deficit - is it platelets, is it clotting factors, and you can also diagnose hypercoagulation states.

We were doing .. because we had heard there was a lot of clotting coming out of China and New York.

So we started doing these TEGs - and they were all what's called hypercoagulable - with zero what's called fibrin lysis.

Fibrin lysis is normally active in the body - (it was) zero.

Once the clots were forming they were not breaking down.

So we knew we had to use anti-coagulation.

So we saw these clots - and we knew these terribly hypercoagulable ..

And we were working with actually the top haematologists, very well published.

And he said this is extremely high risk for clotting.

So we put together a protocol and the anti-coagulation committee did - but we had a chair of medicine who decided to overrule the anti-coagulation.

It was crazy stuff going on in hospitals.

There is like "leaders" telling us what to do what they never did before - covid19's made everyone crazy.

So this chair of medicine said no, I do not want to hear an anti-coagulation protocol, I disagree, you need to wait for the trials.

...

So it is really hard to watch what is going on ..

There is massive widespread "oh we must wait for trials".

People forget how to doctor.

Would you just doctor.

You don't need a trial to tell you wipe your nose after you sneeze.

References:

Source (split into two comments because was 10,000 characters):

https://old.reddit.com/r/ivermectin/comments/mygb2b/dr_pierre_kory_part_1_steroids_and_anticoagulants/gw3i2ng

https://old.reddit.com/r/ivermectin/comments/mygb2b/dr_pierre_kory_part_1_steroids_and_anticoagulants/gw3i493

Steroids - the good and bad impact of RECOVERY UK trial on steroids

Physicians around the world had seen inflammation in their patients. And had used steroids.

Some in the developing world had used steroids very early as well.

Usually by day5 things still work out well.

But much earlier can lead to complications - as you don't want to give steroids too early in the live viral stage.

The FLCCC (authors of MATH+ protocol) had from mid-2020 been clear about the use of steroids at day8.

This is in my (u/stereomatch) opinion their most significant impact on worldwide treatment of covid19.

They clarified the viral timeline in their MATH+ extended PDF - and backed it up by experimental reports (preliminary) that the live virus was near zero by day5 for many patients, and was near zero by day8 for nearly all patients.

This was the foundation of their rationale for prescribing steroids-at-day8 - no earlier (would impair immune response against live virus), and not much later (would allow hyperinflammation to take hold).

They also clarified it was the viral debris (or the processes set in motion) which led to the post-day8 hyperinflammation (which killed the patient).

Yet this crucial information was absent from public visibility.

Why?

Because it was being actively censored - see section a few paragraphs below.

The WHO/CDC/NIH went against steroids - and for a period of months steroids were dissuaged from being used worldwide.

Dr Pierre Kory appeared before the US Senate (having been invited by Senator Ron Johnson).

This appearance was widely seen, and at the same time censored by YouTube. Fox News removed it from their channel.

However this appearance created pressure for steroids to be reexamined.

Months later, the results of RECOVERY UK trial on steroids appeared.

It brought with it the good - the cloud that had been created over steroids, had now been lifted.

However, the RECOVERY UK trial results were also misinterpreted (literal reading of RCTs) - leading to some bad practices.

RECOVERY UK - 6mg Dexamethasone as canonical dose

The RECOVERY UK trial on steroids also led to some unfortunate bad practices - large US hospitals taking the outcomes literally - and capping the doses to 6mg Dexamethasone.

This strategy means the subset of patients who need more tend to stagnate for a few days and then wind up on ventilator.

RECOVERY UK - Dexamethasone use vs Prednisolone

The other unfortunate outcome from RECOVERY UK trial on steroids - is that large US hospitals have remained stuck to Dexamethasone, even though Prednisolone/Methyprednisolone are faster to lungs, and better tolerated at large doses (as Dr Paul Marik of FLCCC often takes pains to point out).

As of Dec 31, 2021, large US hospitals are still capping steroids dose to 6mg Dexamethasone and giving Remdesivir.

RECOVERY UK - erroneous finding that steroids harmful prior to intubation

Another unfortunate reading has been taken from RECOVERY UK trial on steroids. That there is a slight signal that steroids prior to intubation are harmful.

This is the worst misread - as RECOVERY UK probably lumping very early steroids with day7-10 (prior to intubation).

This simple misreading has resulted in US hospitals still (as of Dec 31, 2021) refusing to give steroids when dailiy oximeter declines are happening (post-day7-8).

The patient is on their way down to oximeter 95 and lower, but they will not move - because they are reading RECOVERY UK trial results to mean that steroids should only be given once intubated (i.e. patient is well below oximeter 90 and when hyperinflammation has transitioned to hypercoagulability).

This is the state of affairs.

This is because the majority of folks were until a few months ago (from Dec 31, 2021 - the time of this writing) still clueless about viral timeline.

A concerted effort to obfuscate viral timeline awareness in public?

This viral timeline was elucidated mid-2020 by FLCCC MATH+ and by Dr Paul Marik in his interviews - that the live virus is near zero by day5 or so for some, and by day8 is near zero for nearly all.

This crucial data was behind the FLCCC insistence that steroids can be used post-day8.

Yet, there is still widespread unawareness of this crucial information. Why?

Because there has been systematic censorship of the FLCCC and MATH+ protocol.

Censorship of FLCCC MATH+ - viral timeline - and steroids strategies

On the r/covid19 and r/coronavirus sub-reddits on Reddit, the mere mention of FLCCC or MATH+ protocol could get you a perma-ban. The FLCCC links to MATH+ were blacklisted on these subreddits.

Once a junior moderator re-allowed posting of MATH+ link on my insistence.

He came back apologetic a bit later - saying the full moderator panel of r/covid19 had voted and insisted that the ban on FLCCC links should remain.

This is thanks to the Trusted News Initiative (TNI) (see elsewhere her for more information).

Steroids - Dr Pierre Kory (FLCCC) explains why anemic doses of steroids as standard of care are damaging

Part 1:

https://pierrekory.substack.com/p/hospitalized-covid-19-patients-are

Hospitalized COVID-19 Patients are Systematically Dying from Under-Treatment with Corticosteroids - PART I

US hospitals and their doctors almost never deviate far from the standard, anemic NIH recommended dose of 6mg of dexamethasone daily. Numerous studies support far higher doses far earlier in disease.

Pierre Kory

Dec 30, 2021

Part 2:

https://pierrekory.substack.com/p/hospitalized-covid-19-patients-are-539

Hospitalized COVID-19 Patients are Systematically Dying from Under-Treatment with Corticosteroids - PART 2

US hospitals and their doctors almost never deviate far from the standard, anemic NIH recommended dose of 6mg of dexamethasone daily. Numerous studies support far higher doses far earlier in disease.

Pierre Kory

Dec 31, 2021

Steroids - Dr Pierre Kory (FLCCC) historic May 6, 2020 testimony in front of US Senate

In my (u/stereomatch) view, the greatest contribution of the FLCCC has been in the outlining of the viral timeline, and the implication for steroids use - and the legitimacy of steroids at day8 and beyond.

The work of the FLCCC that was publicized vis Dr Pierre Kory's US Senate testimony (before it was removed from YouTube) and then explained by Dr Paul Marik in his Dr Been interviews - was crucial for the wider dissemination of this understanding. And has saved many patients. Who would otherwise have been mismanaged, steroids stopped too soon, or steroids given too early. Or steroids given in "homeopathic" doses (anemic) as phrased by members of the FLCCC - including Dr Paul Marik in his Dr Been interviews.

Dr Pierre Kory (FLCCC) historic May 6, 2020 testimony in front of US Senate - at a time when steroids were being actively discouraged by WHO/NIH/CDC

https://www.hsgac.senate.gov/covid-19-how-new-information-should-drive-policy Roundtable - COVID-19: How New Information Should Drive Policy Full Committee Hearing May 06, 2020 02:00 PM

Text of testimony:

https://www.hsgac.senate.gov/imo/media/doc/Testimony-Kory-2020-05-06-REVISED.pdf Pierre Kory, MD, MPA Medical Director, Trauma and Life Support Center Critical Care Service Chief Associate Professor of Medicine University of Wisconsin School of Medicine and Public Health

Dr Pierre Kory appeared a second time in front of the US Senate for his testimony on Ivermectin for prophylaxis and early treatment.

Dr Pierre Kory first appeared in front of the US Senate for his testimony in favor of steroids use.

At that time doctors around the world - esp. in the developing world - were widely aware of the hyperinflammatory nature of the later stages of covid19, and were treating with steroids and other drugs. And seeing success.

All that came to an end when the WHO/NIH/CDC put a stop to that with their caution against use of steroids.

This put the brakes on legitimacy of steroids for covid19 - and probably resulted in under treatment and death.

Dr Pierre Kory's testimony in front of the US Senate was aimed to reignite interest in steroids (that had been waning following the WHO/NIH/CDC actions).

The brakes on steroids were lifted when the RECOVERY UK trial results were released - which showed benefit from steroids.

Context

At that time, doctors around the world already had recognized they hyperinflammatory nature of the disease - and were using steroids and other drugs and seeing benefit. Many though (esp. those not aware of the FLCCC MATH+ protocol) were not aware of the viral timeline in such detail as the MATH+ protocol elucidated. As a result some doctors in developing countries were giving steroids very early - giving steroids at day1-3 is usually not advisable and has risk of suppressing immune response at a time when the live virus is still present in large numbers.

What is surprising is how only the folks familiar with MATH+ protocol were generally aware of the day8 timeline, and the need for steroids not earlier and not much later.

Until late 2021, understanding of viral timeline was absent from the public discourse, and among most US doctors.

Only by late 2021 did one start to see acknowledgement of viral timeline - that the live virus was mostly zero by day 5 in some, and mostly zero by day8 in nearly all patients.

This was acknowledged by Dr Fauci in a web conference.

Why this crucial bit of information - which was listed on the MATH+ protocol by mid-2020 was not widely disseminate and publicize is a mystery.

It could be conjectured that if this viral timeline was more widely acknowledged, the motivation for prescribing Remdesivir well past day8 would be absent.

And most US hospitals would not have been able to justify use of Remdesivir.

Thus obfuscation or confusion of the information around viral timeline may have played a role in allowing the continued practice of Remdesivir use in the US and other countries - well after the WHO stated that it was not effective when given late.

Steroids - undesirable impact of RECOVERY UK trial (RCT)

The brakes on steroids were lifted when the RECOVERY UK trial results were released - which showed benefit from steroids.

However RECOVERY UK trial brought with it's own impact. Just because Dexamethasone 6mg was used in the trial, thus 6mg Dexamethasone became the fixed steroid dose in many hospital protocols. Often hospitals would not go above this dose - regardless of the hyperinflammatory state of the patient.

Secondly, Dexamethasone became standard of care at large US hospitals - even though Prednisolone is faster to lungs, and better tolerated at high doses (i.e. if high doses are needed).

The FLCCC MATH+ protocol recommends Methylprednisolone at higher doses. And Dr Paul Marik has lamented the unfortunate choice of Dexamethasone by US hospitals, and the capping of steroids doses to 6mg Dexamethasone - which is an anemic dose for patients that need more aggressive treatment. In the words of the FLCCC's Dr Paul Marik hospitals are using "homeopathic" doses of steroids for patients whose hyperinflammatory state demands more aggressive treatment.

Capping of doses by hospital protocols therefore leads to a subset of patients who slip through and wind up on ventilator.

In addition RECOVERY UK trial made special note of a small signal for harm when steroids taken before intubation.

I (u/stereomatch) suspect this is an erroneous reading - an outcome of bad lumping of very early steroids use in the RECOVERY UK trial.

Real world observation makes it clear that hyperinflammation is apparent on day7-8, and failure to arrest leads to oximeter readings falling to low 90s and thus the need for oxygen. Failure to arrest at this point leads to further declines and eventually ventilator.

Unfortunately many hospitals and commentators have amplified this supposed signal in the RECOVERY UK trial - and hospitals have taken this interpretation to heart.

Resulting in failure to arrest hyperinflammation. Hospitals are starting steroids only when intubated, or when the situation is so dire that oxygen is required (usually when "max achievable" oximeter readings fall below 90 or so).

This treatment algorithm essentially winds up creating severe cases out of mild ones - since the patient's hyperinflammatory state is not arrested earlier, before it has a chance to get out of hand and cause hypoxia etc.

Obfuscation of viral timeline - continued opportunity for Remdesivir

While many doctors were using steroids prior to the WHO/NIH/CDC caution against steroids, many were not aware of the finely tuned explanation of viral timeline that the FLCCC MATH+ protocol had provided.

Which clearly explained the rationale for use of steroids, and the timing of steroids.

In many parts of the developing world, doctors were seeing benefit from steroids, but in their enthusiasm to extend that to newer patients, were sometimes starting steroids earlier (ilke day5 from first symptoms - which can still be ok) - but some were starting them on day1-3 (reason was lack of awareness of viral timeline, and secondly the very real risk that patient may not return later on time and thus lose precious time for steroids administration, so start them on steroids while patient is present in the clinic.

Starting on steroids while patient from a village is available to the doctor - is a strategy which usually works out ok because most patients take some time before appearing at a doctor's clinic.

But some patients can appear in front of doctor at day1 or day2 if they are very observant and aware of the need to get medical attention early.

The problem for these patients then becomes that the doctor may prescribe his blanket protocol without interrogating on timeline (i.e. doctor may not spend time to establish which day the patient is from first symptoms).

For these patients, steroids may be administered earlier than is ideal.

I (u/stereomatch) am aware of cases where a doctor has initiated steroids earlier than day7-8 - for example at day5 - and usually there has been no issue.

However, I am also aware of cases where a doctor has initiated steroids earlier i.e. day1-3 - and things have not turned out that well. That is patient had hypoxia and needed additional steroids at day8.

These cases happened because the doctor was not familiar with viral timeline, and did not interrogate the patient to establish day1 of first symptoms.

Some doctors have a habit of not querying - but applying the same protocol that (usually) works for all others.

This stems from the traditional way to practice medicine - medicate for a disease as if it is one phase (covid19 is biphasic).

This strategy of uniform protocol for all can fail when a patient arrives very early i.e. right after first symptoms i.e. day1-3.

There have been studies earlier which suggested that steroids initiation even very early does not affect outcomes that negatively.

But still from an abundance of caution steroids should probably be delayed until day7-8.

They could be initiated immediately if there is day8-like behavior apparent from the symptoms - daily declining oximeter readings, elevated pulse rate or anomalous fever returning. Or if there is evidence of accelerated decline - in such a case one can assume that day8-like situation is happening and to initiate steroids.

Famotidine - covid19, long haulers and post-vax standard of care

Famotidine (H2 blocker anti-histamine):

can be helpful during covid19 treatment (reduces symptoms within 1 day - 2 days for newer variants)
and can be useful for a subset of long haulers
and is very effective for post-vaccine side-effects - possibly due to it's action against Mast Cell Activation Syndrome (MCAS) - and should be the standard of care for post-vax side effects (instead of Paracetamol/Tylenol which is less effective - and potentially a depleter of Glutathione - the body's natural antioxidant)

FLCCC MATH+ protocol includes Famotidine (optional)

FLCCC MATH+ extended protocol:

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf

Famotidine - proposed mechanisms of action

Dr Robert Malone paper on Famotidine:

https://www.frontiersin.org/articles/10.3389/fphar.2021.633680/full COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms 23 March 2021

Added April 26, 2022: thanks to u/bvw

https://www.frontiersin.org/articles/10.3389/fphar.2022.872736/full

Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells

25 April 2022

Although famotidine, the commonly used histamine H2 receptor (H2R) blocker, was shown to have no antiviral activity, recent reports indicate that it could prevent adverse outcomes in COVID-19 patients. Histamine is a classic proinflammatory mediator, the levels of which increase along with other cytokines during COVID-19 infection. Histamine activates H2R signaling, while famotidine specifically blocks H2R activation.

Investigating the effects of recombinant SARS-CoV-2 spike protein S1 Receptor-Binding Domain (Spike) on ACE2 expression in cultured human coronary artery endothelial cells, we found that the presence of histamine potentiated spike-mediated ACE2 internalization into endothelial cells.

This effect was blocked by famotidine, protein kinase A inhibition, or by H2 receptor protein knockdown. Together, these results indicate that histamine and histamine receptor signaling is likely essential for spike protein to induce ACE2 internalization in endothelial cells and cause endothelial dysfunction and that this effect can be blocked by the H2R blocker, famotidine.

NOTE: there has been some criticism that the levels used in this study may not achievable with Famotidine 20mg+20mg per day for 5 days - as is often used for day1-7 covid19 early treatment:

https://old.reddit.com/r/ivermectin/comments/u46w57/comment/i68t4uh/

SaltZookeepergame691

They used a 10 uM dose of famotidine, and a 1 uM dose of histamine. The dose of famotidine alone is an order of magnitude higher than you get from a high clinical dose.

https://old.reddit.com/r/ivermectin/comments/u46w57/comment/i68xyeu/

SaltZookeepergame691

80 mg three times per day (an enormous dose) gives max 1.69 uM.

Disagree the impact is very obvious.

My (u/stereomatch) counter to that is that Famotidine:

has very obvious benefit in reducing symptoms to tolerable levels during day1-7
is effective for a subset of long haulers
is very effective for post-vax side effects across the spectrum of inactivated/adenovirus/mRNA vaccines (from observation) - and should be in my view the standard of care (instead of the currently recommended Paracetamol/Tylenol)

Famotidine and kidney disease

Famotidine is advised at lower dose for those with kidney disease in the FLCCC MATH+ extended protocol:

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf

pg 14:

Optional: Famotidine 40 mg BID (reduce dose in patients with renal dysfunction) [109-115].

Famotidine and vagus nerve inflammation in long haulers

Famotidine is very effective in reducing symptoms during covid19 day1-7, for a subset of long haulers, and is very effective as treatment for post-vaccine side effects).

Meanwhile treatment to reduce inflammation of the vagus nerve has been reported to benefit long haulers.

Some long haulers suggest the vagus nerve may have a central role in describing the variety of issues long haules have - POTS etc.

This study suggests that Famotidine also may have impact on the vagus nerve - beyond impact on Mast Cells or Mast Cell Activation Syndrome (MCAS).

They however injected Famotidine in a way to bypass the blood-brain barrier - it is not clear if oral Famotidine also has direct effect on the vagus nerve area.

Paper:

https://molmed.biomedcentral.com/articles/10.1186/s10020-022-00483-8

Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm

16 May 2022

Because evidence is lacking for a direct antiviral activity of famotidine, a proposed mechanism of action is blocking the effects of histamine released by mast cells. Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor (α7nAChR) signal transduction, to prevent cytokine storm.

As the inflammatory reflex is integrated and can be stimulated in the brain, and H2R antagonists penetrate the blood brain barrier poorly, famotidine was administered by intracerebroventricular (ICV) or intraperitoneal (IP) routes.

Mice lacking mast cells by genetic deletion also responded to famotidine, indicating the anti-inflammatory effects are not mast cell-dependent. Either bilateral sub-diaphragmatic vagotomy or genetic knock-out of α7nAChR abolished the anti-inflammatory effects of famotidine, indicating the inflammatory reflex as famotidine’s mechanism of action. While the structurally similar H2R antagonist tiotidine displayed equivalent anti-inflammatory activity, the H2R antagonists cimetidine or ranitidine were ineffective even at very high dosages.

Conclusions

These observations reveal a previously unidentified vagus nerve-dependent anti-inflammatory effect of famotidine in the setting of cytokine storm which is not replicated by high dosages of other H2R antagonists in clinical use. Because famotidine is more potent when administered intrathecally, these findings are also consistent with a primarily central nervous system mechanism of action.

References:

Also see discussion of this paper at:

https://www.reddit.com/r/COVID19/comments/usc8et/famotidine_activates_the_vagus_nerve_inflammatory/ Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm

Vagus nerve inflammation as possible factor in long haulers symptoms like POTS:

https://www.reddit.com/r/covidlonghaulers/comments/ushr47/recovery_after_2_years_with_stellate_ganglion/ Recovery after 2 years with stellate ganglion block

Archive of above webpage:

https://archive.ph/012Nv

Vitamin D3 - anti-inflammatory/immuno-modulator

Vitamin D is thought to behave like a vitamin, and also has steroid hormone-like capabilities.

https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.311585 Steroid Hormone Vitamin D Implications for Cardiovascular Disease 25 May 2018

https://pubmed.ncbi.nlm.nih.gov/24739090/ Vitamin D, steroid hormones, and autoimmunity May 2014

https://www.pharmacytimes.com/view/vitamin-d-is-the-new-hormone Vitamin D Is the New Hormone July 20, 2019

Here is a video featuring Dr Roger Seheult (MedCram on YouTube):

https://www.youtube.com/watch?v=8pXuJSxILrQ Is Vitamin D Actually a Steroid? - Roger Seheult Mar 24, 2021

And has impact on immune health, and acts as an immuno-modulator.

It is now believed that low vitamin D levels are a risk factor when it comes to severe covid19.

Most severe patients have low levels of Vitamin D in their blood. There is a question whether this happens because vitamin D levels fall because of the hyperinflammation that has already started in such patients. Or whether they had pre-existing levels of vitamin D which placed them at risk of severe covid19.

Obese patients, and those not getting sufficient sunlight (to make Vitamin D) has long been associated with more severe outcomes for flu - and also for covid19.

The use of the more direct form (calcifediol) of Vitamin D supplementation for severe covid19 patients has been shown to improve outcomes. Since Vitamin D3 takes longer to show effects on Vitamin D blood levels, the use of the direct form was chosen for this study:

https://pubmed.ncbi.nlm.nih.gov/34097036/ Calcifediol Treatment and COVID-19-Related Outcomes Sept 27, 2021

Results: ICU assistance was required by 102 (12.2%) participants. Out of 447 patients treated with calcifediol at admission, 20 (4.5%) required the ICU, compared to 82 (21%) out of 391 nontreated (P < .001).

https://pubmed.ncbi.nlm.nih.gov/34064175/ Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study May 21, 2021

Results: A total of 537 patients were hospitalized with COVID-19 (317 males (59%), median age, 70 years), and 79 (14.7%) received calcifediol treatment. Overall, in-hospital mortality during the first 30 days was 17.5%. The OR of death for patients receiving calcifediol (mortality rate of 5%) was 0.22 (95% CI, 0.08 to 0.61) compared to patients not receiving such treatment (mortality rate of 20%; p < 0.01).

https://www.nature.com/articles/s41598-021-02701-5 Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients 03 December 2021

Vitamin D3 - dosing

In preparing for covid19 infection in the future, one needs to start Vitamin D3 supplementation ahead of time.

This is because after starting Vitamin D3 supplementation, it can take many weeks before Vitamin D levels start to become high.

Maintain a Vitamin D level above 30ng/mL (Vitamin D levels closer to 40ng/mL may be desirable for protective effect against covid19) - such a level is achievable if Vitamin D3 5000 IU is taken daily for an adult - test after 2-3 months if a level above 30ng/mL is achieved - reduce dosage slightly if needed.

See this Dr John Campbell video on dosing:

https://www.youtube.com/watch?v=V5g9AVqRsjo

Vitamin D levels advised

Nov 18, 2021

Dr. John Campbell

Without calcium supplementation, even very high vitamin D3 supplementation does not cause vascular calcification

Vitamin D3 supplementation in the range of 4000 to 10,000 units (100 to 250 µg) needed to generate an optimal 40–60 ng/mL (100 to 150 nmol/L)

has been shown to be completely safe when combined with approximately 200 µg vitamin K2

Vitamin D3 - Magnesium helps bioavailability of Vitamin D3

For those who are unable to raise levels of the bioavailable form of Vitamin D in their blood (even though they may be taking Vitamin D3 5000 IU per day supplementation), consider adding Magnesium supplements (a multi-vitamin that includes Magnesium), or improving your diet to include natural source of Magnesium (nuts, whole grains, green leafy vegetables).

Magnesium is known to be useful for the metabolism of Vitamin D3:

https://www.imaware.health/blog/vitamin-d-and-magnesium Vitamin D and Magnesium - Benefits, Dosages, and Why They Should Go Together Nov 5, 2021

Recent studies have shown that if a person is deficient in magnesium, no amount of Vitamin D3 supplementation will allow a patient to realize the health benefits of adequate Vitamin D. Magnesium is a critical factor in making Vitamin D bioavailable. Without magnesium present, Vitamin D is stored in the body and not used.

The body depends on magnesium to convert Vitamin D into its active form within the body. Magnesium also helps Vitamin D bind to its target proteins, as well as helping the liver and the kidneys to metabolize Vitamin D.

This research shows that supplementing with Vitamin D is pointless if a patient is deficient in magnesium - in fact, as the next section will explain, it may actually have harmful side effects to overload your system with Vitamin D without banking the magnesium needed to use it.

Remember, magnesium deficiency prevents the body from using the Vitamin D you are supplementing it with. Additionally, the Journal of the American Osteopathic Association points out that people with low magnesium levels who supplement with Vitamin D show markedly higher levels of calcium and phosphorus. This is probably due to the role that activated Vitamin D plays in the absorption of calcium into the bones and other tissues.

Excess calcium in the bloodstream can lead to calcification of the inside of the arteries, resulting in poor cardiovascular health. Unabsorbed calcium can also cause nausea, frequent urination, fatigue, and kidney problems like kidney stones.

Before starting a Vitamin D and magnesium supplementation regimen, it is worth discovering whether or not your magnesium levels are deficient first. People considering starting a Vitamin D3 regimen without the advice of a doctor should consider supplementing with magnesium as well to prevent the adverse effects of unabsorbed calcium.

Paper mentioned above:

https://pubmed.ncbi.nlm.nih.gov/29480918/

https://www.degruyter.com/document/doi/10.7556/jaoa.2018.037/html Role of Magnesium in Vitamin D Activation and Function March 1, 2018

All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys. Deficiency in either of these nutrients is reported to be associated with various disorders, such as skeletal deformities, cardiovascular diseases, and metabolic syndrome. It is therefore essential to ensure that the recommended amount of magnesium is consumed to obtain the optimal benefits of vitamin D.

Vitamin D needs to be converted from its storage or inactive form (25[OH]D) to an active form (1,25[OH]2D) before exerting its biological functions. These various stages of vitamin D conversions are actively dependent on the bioavailability of magnesium

Vitamin D3 - Magnesium dosing

Moderate amounts of Magnesium supplementation (taking a multi-vitamin that includes Magnesium for example) may be useful for those taking Vitamin D3 supplementation:

https://www.imaware.health/blog/vitamin-d-and-magnesium Vitamin D and Magnesium - Benefits, Dosages, and Why They Should Go Together Nov 5, 2021

As far as magnesium goes, doctors recommend the following doses of magnesium, with variations between the sexes at older ages:

1–3 years: 65 mg

4–8 years: 110 mg

9 years and older: 350 mg

Lack of magnesium may lead to excess unabsorbed calcium:

Humans absorb and replenish their body’s supply of magnesium by eating foods rich in magnesium, like almonds, cashew nuts, and spinach.

Excess calcium in the bloodstream can lead to calcification of the inside of the arteries, resulting in poor cardiovascular health. Unabsorbed calcium can also cause nausea, frequent urination, fatigue, and kidney problems like kidney stones.

As with any supplementation, watch out for excess dosing - here is some information on magnesium overdosing (from article above):

Over-supplementation with magnesium can lead to hypermagnesemia. Early symptoms of hypermagnesemia include nausea, vomiting, hypotension (excessively low blood pressure), flushing, urine retention, ileus, depression, and lethargy.

Symptoms of advanced hypermagnesemia include breathing trouble, extreme hypotension, muscle weakness, irregular heartbeat, and cardiac arrest. Fatal hypermagnesemia has been observed in very young or very old subjects.

Also see this list of recommended doses for Magnesium, and the foods that contain it (nuts, whole grains, green leafy vegetables):

https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/?ref=NIVvlgXeP3oGR Magnesium

Recommended Intakes

19-30 year olds

400mg for males

310mg for females

Dr. Jin W. Sung videos on Magnesium dosing for Vitamin D3:

https://www.youtube.com/watch?v=PhN6cYDWJ-0 MAGNESIUM the Forgotten Mineral Sep 30, 2021 Dr. Jin W. Sung

https://www.youtube.com/watch?v=I5rcDkYthUY Vitamin D and Magnesium Dec 21, 2021 Dr. Jin W. Sung

Vitamin D3 - Safety

Vitamin D3 maximum recommended doses are usually around 4000 IU per day.

However, if you are deficient, it can take 2-3 months to get Vitamin D levels above 30ng/mL with Vitamin D3 5000 IU per day.

See this paper:

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5402701/ Evaluation of vitamin D3 intakes up to 15,000 international units/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on calcium metabolism in a community setting April 13, 2017

Check out this Dr John Campbell interview of Dr Michael Cohen (Israel):

https://www.youtube.com/watch?v=w9h-XQm2qEY

Vitamin D in Israel

Dec 11, 2021

Dr. John Campbell

at the 10:15 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=615

Dr Michael Cohen:

But as a first line of defence we should be dealing with people's immune systems.

We know 25mg of Zinc (can take up to 40mg per day - going above that can reduce the absorption of Copper so not good taking for too long at that dose).

Vitamin D3 - 4000 IU - overweight may need 8000 or 10,000 IU per day.

Other thing I tell them to take is Vitamin K2 - 200mcg (0.2mg) per day every day.

Vitamin D3 does cause the release of Calcium from the bones into the blood and you do want to try to avoid the deposition of that into the wrong places.

And obviously the other things getting enough sleep etc.

at the 11:50 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=710

My concern is that all the focus has gone into putting the burden on the hospitals and even outpatient care.

And we need to be doing everything to prevent becoming a severe illness.

at the 12:05 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=725

Dr John Campbell:

And a lot of the focus has been on these very clever high tech - like these vaccines.

And expensive.

These vaccines are completely brilliant.

But why have expensive clever things - if can use simple things as well as.

Dr Michael Cohen:

Half the world is not vaccinated - what are we doing for them?

Why wait?

at the 12:50 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=770

Dr John Campbell:

If levels are low in Israel - which is sunny and hot - imagine what the levels must be elsewhere.

at the 13:15 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=795

Dr Michael Cohen:

Someone's supposed to have above 32ng/mL - but it seems from what seen you would want to have above 50.

Even to get to 32 it may help.

But is a cheap vitamin - pretty much no side effects - and it can do a lot.

at the 14:10 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=850

Dr John Campbell:

It is interesting how a modest dose of vitamin d3 is enough to reverse Rickets (vitamin d deficiency).

And then a little more does some more.

And at each level are interacting with more genes.

Dr Michael Cohen:

As every cell has a vitamin d receptor.

And a lot of it is immuno-modulatory.

at the 14:40 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=880

Dr Michael Cohen:

If combine with zinc - which has significant effect on viral infections - there is little to say don't take this concoction.

at the 17:10 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=1030

Dr Michael Cohen:

Important to keep at good levels.

Have seen many people get covid19 twice.

It's important to be taking it throughout.

It takes time for Vitamin D3 to kick in - so better to be taking ahead of time.

at the 18:45 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=1125

Dr Michael Cohen:

It is switching genes off and switching genes off.

For immunomodulatory it takes time.

For some of the effects need to see turnover in the cells i.e. new ones - so can take some time.

Dr John Campbell:

It's like with Iron - if give Iron - it is the new generation of cells which get benefit from that - in slides see half RBCs round and half small i.e. newer ones gotten doses of Iron.

at the 20:11 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=1211

Dr John Campbell:

Why do obese people need more Vitamin D3?

Dr Michael Cohen:

It seems they store vitamin d in the fat cells but not use it.

They don't reach the same level in plasma.

Some patients at 12,000 IU per day - and that's what get to 40-50ng/mL range bracket.

Vitamin D3 - high dose and toxicity

https://www.youtube.com/watch?v=gFYMs94mx4E

Vitamin D Toxicity

Dec 23, 2021

Dr. Jin W. Sung

16 year retrospective study of 73,000 people

most of whom supplementing with Vitamin D3 tablet at home

most people had Vitamin D levels below 80ng/mL

among those with Vitamin D levels above 120ng/mL - only 4 people had symptoms of Vitamin D toxicity (nausea, abdominal pain, constipation)

so is pretty rare to get it from self-supplementation

in his experience, overdoses more common with liquid Vitamin D3 - where doctor may advise 1 drop a day (2000 IU) but patient may think the full dropper

so people may come in with Vitamin D levels at 150-175ng/mL

and still do not show Vitamin D toxicity symptoms

Description section has suggestions for levels that should be targeted:

Vitamin D levels of 60-80ng/mL

His recommendations:

Vitamin D3 - 2000 IU to 5000 IU
Magnesium 200-400 mg

Additional: Vitamin K2, Vitamin E and Vitamin A https://youtu.be/pR9KN7xjxMY

Considerations:

Take vitamin with a fatty meal.

Gallbladder function: ox bile, choline https://youtu.be/ddyx2Z2mbik

Vitamin D target level on testing is 60-80 ng/mL

Additional video:

https://www.youtube.com/watch?v=6E9xfwyX6mQ The Truth About VITAMIN D May 22, 2021 Dr. Jin W. Sung

Vitamin D supplement types:

D2 - ergocalciferol
D3 - cholecalciferol - better absorbed (preferred)

at the 7:20 minute mark:

https://www.youtube.com/watch?v=6E9xfwyX6mQ&t=440

Vitamin D levels can be low due to some factors:

gastrointerstinal issues preventing
age - kidney function may not be as good
skin type - darker skin absorbs less UV-B light
where you live - sun exposure
bile - gall bladder removed or if have liver dysfunction - lower bile - reduces absorption of Vitamin D
insulin resistance
auto-immune issues will suck up your Vitamin D
genetic issues

Vitamin D3 - taking Vitamin K2 and avoiding Calcium supplementation when doing high dose Vitamin D3 supplementation

Taking high dose Vitamin D3 can expose to risk of hypercalcemia, and deposition of Calcium in blood vessels and in calcification of heart valves (also happens with age).

When doing higher dose Vitamin D3 supplementation, a dose of Vitamin K2 will help reduce risk of hypercalcemia.

Avoid excessive Calcium supplementation while on high dose Vitamin D3 - to reduce risk of hypercalcemia.

This is not a big issue during covid19 - since the treatment period is 2-3 weeks usually with early treatment - so if you give Vitamin D3 (but not Vitamin K2 i.e. don't have it available etc.) - that may be ok.

Vitamin K2 maybe more of a factor when doing longer term Vitamin D3 supplementation.

Vitamin K2 supplementation over many months (along with your Vitamin D3 supplementation) - may be beneficial for:

reducing osteoporosis
reducing calcification of soft tissues
reducing plaques in blood vessels

See this Dr John Campbell video on dosing Vitamin K2 to accompany Vitamin D3 supplements:

https://www.youtube.com/watch?v=V5g9AVqRsjo

Vitamin D levels advised

Nov 18, 2021

Dr. John Campbell

Talking about Vitamin D levels in blood:

Preferable, 40–60 ng/mL (100 to 150 nmol/L)

Without calcium supplementation, even very high vitamin D3 supplementation does not cause vascular calcification

Vitamin D3 supplementation in the range of 4000 to 10,000 units (100 to 250 µg) needed to generate an optimal 40–60 ng/mL (100 to 150 nmol/L)

has been shown to be completely safe when combined with approximately 200 µg vitamin K2

However, this knowledge is still not widespread in the medical community, and obsolete warnings about the risks of vitamin D3 overdoses unfortunately are still commonly circulating.

Conclusions

we recommend raising serum 25(OH)D levels to above 50 ng/mL (100 to 150 nmol/L)

to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.

At a time when vaccination was not yet available,

patients with sufficiently high D3 serum levels preceding the infection were highly unlikely to suffer a fatal outcome.

This correlation should have been good news when vaccination was not available but instead was widely ignored.

the lower threshold for healthy vitamin D levels should lie at approximately 125 nmol/L or 50 ng/mL 25(OH)D3,

which would save most lives, reducing the impact even for patients with various comorbidities.

This is—to our knowledge—the first study that aimed to determine an optimum D3 level to minimize COVID-19 mortality

natural vitamin D3 levels seen among traditional hunter/gatherer lifestyles,

in a highly infectious environment,

were 110–125 nmol/L (45–50 ng/mL)

WHO advice may not be correct

30 ng/mL D3 value considered by the WHO as the threshold for sufficiency

See also Dr John Campbell discussing Vitamin K2 for those on Vitamin D3:

https://www.youtube.com/watch?v=LfZpLllgd5Q

Vitamins D and K2

Mar 4, 2021

Dr. John Campbell

For 2000 IU to 4000 IU per day - usually not need to take Vitamin K2.

(NOTE: Vitamin K2 helps reduce risk of calcification in blood vessels and heart valves.)

(NOTE: Vitamin K1 does not - also Vitamin K1 may be contraindicated since it encourages clotting - which want to avoid during covid19)

Official guidelines in UK from NICE - are potentially not helpful.

at the 10:35 minute mark:

https://www.youtube.com/watch?v=LfZpLllgd5Q&t=635

starts talking about Vitamin K2

Check out this Dr John Campbell interview of Dr Michael Cohen (Israel):

https://www.youtube.com/watch?v=w9h-XQm2qEY

Vitamin D in Israel

Dec 11, 2021

Dr. John Campbell

at the 10:15 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=615

Dr Michael Cohen:

...

Vitamin D3 - 4000 IU - overweight may need 8000 or 10,000 IU per day.

Other thing I tell them to take is Vitamin K2 - 200mcg (0.2mg) per day every day.

Vitamin D3 does cause the release of Calcium from the bones into the blood and you do want to try to avoid the deposition of that into the wrong places.

...

at the 20:54 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=1254

Dr John Campbell:

I am very interested that you are advising Vitamin K2 as well - which makes perfect sense. My understanding is the K2 would really only be necessary if you are taking quite high Vitamin D3 - because you'd need quite high doses of Vitamin D3 to release enough Calcium into the blood to even be a risk of hypercalcemia

Dr Michael Cohen:

I think your thinking is correct. But from what I can tell from what I have read, you need at least 100mcg (micrograms) a day of Vitamin K2 if you are taking 4000 IU of Vitamin D3.

And seeing as many people don't get levels of 50ng/mL even with 4000 IU Vitamin D3 - they often need 6000, 7000, or 8000 IU a day - I tell people to take 200mcg (i.e. 0.2mg) once they are above 4000 IU Vitamin D3.

But 100mcg is supposed to be enough if you are taking 4000 IU Vitamin D3.

If you are only taking 1000 or 2000 IU Vitamin D3, you probably don't need Vitamin K2.

Vitamin K1 - increases clotting risk

For completeness I am adding this section on Vitamin K1.

Vitamin K1 enhances blood coagulation or clotting.

So may want to avoid during post-day8 covid19. Although not a lot of people will be doing Vitamin K1 supplementation (not common).

Vitamin K1 dosing is known to interfere with or enhance clotting.

Although people don't usually take Vitamin K1 supplements, still it may be advisable to taper down or reduce use of supplements that increase clotting risk, especially during the post-day8 hyperinflammatory stage.

Discuss this with your doctor.

Since in covid19, there can be hyperinflammation visible at day7-8 onwards.

Which can lead eventually to hypercoagulability (if the hyperinflammation is not arrested with sufficient steroids etc.).

Vitamin K2 - may not increase clotting risk

Vitamin K2 helps osteoporosis sufferers - reduces calcification in blood vessels and soft tissue.

Should one take Vitamin K2 during covid19 - does it also worsen clotting?

Since Vitamin K1 increases clotting risk, there may be some questions on whether Vitamin K2 may do the same.

However, Vitamin K2 does not seem to impact clotting or coagulation too much.

This suggests Vitamin K2 does not directly impact coagulation (clotting) - while Vitamin K1 does:

https://pubmed.ncbi.nlm.nih.gov/34115006/

Vitamin K2 (Menaquinone-7) supplementation does not affect vitamin K-dependent coagulation factors activity in healthy individuals

Conclusions:

MK-7 supplementation at recommended dosage does not affect vitamin K-dependent coagulation factors' coagulation activity, and does not enhance the carboxylation of prothrombin in healthy individuals. This indicated that MK-7 administration does not alter hemostatic balance in healthy populations without anticoagulation treatment.

Vitamin K2 is beneficial for avoiding calcification of soft tissue - avoiding heart valve calcification in old age - avoiding calcification/plaques in blood vessels.

And ensuring calcium is deposited in the bones (so Vitamin K2 may help reduce osteoporosis).

For this reason, if you are taking Vitamin D3 over the long term, you could add Vitamin K2 supplementation for that (to avoid hypercalcification from taking high dose Vitamin D3 - and especially so if you are also using calcium supplements).

https://www.healthline.com/nutrition/vitamin-k1-vs-k2

Vitamin K1 vs K2: What’s the Difference?

Vitamin K1, also called phylloquinone, is mostly found in plant foods like leafy green vegetables. It makes up about 75–90% of all vitamin K consumed by humans (2Trusted Source).

Vitamin K2 is found in fermented foods and animal products, and is also produced by gut bacteria. It has several subtypes called menaquinones (MKs) that are named by the length of their side chain. They range from MK-4 to MK-13.

Vitamin K activates a protein that helps prevent calcium from depositing in your arteries. These calcium deposits contribute to the development of plaque, so it’s not surprising that they are a strong predictor of heart disease (16Trusted Source, 17Trusted Source).

Vitamin K1 and K2 helpful for reducing hypercalcemia and deposition of calcium in blood vessels and calcification of heart valves:

Several observational studies have suggested that vitamin K2 is better than K1 at reducing these calcium deposits and lowering your risk of heart disease (18Trusted Source, 19Trusted Source, 20Trusted Source).

However, higher quality controlled studies have shown that both vitamin K1 and vitamin K2 (specifically MK-7) supplements improve various measures of heart health

Zinc as antiviral

Zinc dosage

The typical dosage of Zinc during treatment is around 40mg "elemental zinc".

The entry of zinc into cells tends to hinder viral replication. This is why many lozenges for flu include zinc. Some children's syrups for flu include zinc - the syrup is to be given on an age or weight adjusted basis (described on the bottle).

Hydroxychloroquine (HCQ) is a zinc ionophone - i.e. it helps zinc get into cells.

And Quercetin is also a zinc ionophone.

Check out this Dr John Campbell interview of Dr Michael Cohen (Israel):

https://www.youtube.com/watch?v=w9h-XQm2qEY

Vitamin D in Israel

Dec 11, 2021

Dr. John Campbell

at the 10:15 minute mark:

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=615

Dr Michael Cohen:

We know 25mg of Zinc (can take up to 40mg per day - going above that can reduce the absorption of Copper so not good taking for too long at that dose).

Reference:

FLCCC MATH+ extended protocol:

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf

Zinc 30–50 mg/day (elemental zinc).

Zinc is essential for innate and adaptive immunity. In addition, Zinc inhibits RNA dependent RNA polymerase in vitro against SARS-CoV-2 virus. Due to competitive binding with the same gut transporter, prolonged high dose zinc (> 50mg day) should be avoided as this is associated with copper deficiency.

Commercial zinc supplements contain 7 to 80 mg of elemental zinc, and are commonly formulated as zinc oxide or salts with acetate, gluconate, and sulfate. 220 mg zinc sulfate contains 50 mg elemental zinc.

Zinc - elemental zinc

Different zinc compounds will have different amounts of actual zinc - since it depends on the compound's molecule - how much actual zinc there is.

Then there maybe bioavailability - for example zinc gluconate supposedly makes it more bioavailable. But most HCQ+zinc studies are using Zinc Sulphate.

Here is the elemental zinc in different zinc compounds:

zinc sulfate 220mg - 50mg elemental zinc
zinc gluconate 50mg - 7mg elemental zinc

So if the zinc sulphate 220mg (50mg elemental zinc) is the benchmark, one would match that.

I think the multivitamins which list the zinc in milligrams etc. are referring to the elemental zinc.

Some phrase it like "22mg elemental zinc (as zinc sulphate)".

Other phrasings can be confusing - whether they are referring to the zinc sulphate or elemental.

Reference:

https://old.reddit.com/r/covid19/comments/hs015m/_/fy8c6fa

N-acetyl cysteine (NAC) as anti-oxidant

NAC usage

NAC has been found to be beneficial for a range of respiratory diseases.

NAC helps reverse the depletion of glutathione levels (the body's main antioxidant), and also breaks disulphide bonds that may be beneficial against clotting. NAC action on disulphide bonds is useful for breaking up phlegm as well (which is why it is mainly known for it's mucolytic usage). But it has strong anti-oxidant value as well.

NAC seems to be a useful addition to treatment measures to reduce or reverse organ damage in (see sections for these below):

Heat stroke (heat stress related illness)
Fatty Liver Disease
Tylenol overdose (is used in emergency rooms to counter the effects of Tylenol overdose - and can protect the liver and kidneys from damage)
MRI contrast agents - NAC is used to counter the effects of radioactive dyes used as contrast agents for MRI scans

NAC impact on stomach "spare tire" and systemic inflammation

I have observed also that daily use of NAC 200mg+200mg for a month may reduce stomach "spare tire" to some degree.

I mentioned this to someone - he later reported his brother had used NAC for this and had similar effect.

If inflammation is implicated in accumulation of body fat or weight gain, there may be a possible link there.

But this could also have been coincidental.

NAC explanatory videos

MedCram (Dr Seheult) and Dr Been (Dr Mobeen Syed) have a number of videos covering potential usability of NAC for covid19 - primarily as an anti-oxidant (to counter glutathione depletion during oxidative stress during the hyperinflammatory phase post-day8 of covid19).

MedCram:

https://www.youtube.com/watch?v=Dr_6w-WPr0w Coronavirus Pandemic Update 69: "NAC" Supplementation and COVID-19 (N-Acetylcysteine) May 11, 2020

https://www.youtube.com/watch?v=eQO1PB8-xtg Coronavirus Update 114: COVID 19 Death Rate Drops; NAC (N acetylcysteine) Data Oct 23, 2020

https://www.youtube.com/watch?v=NM2A2xNLWR4 Coronavirus Update 59: Dr. Roger Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC) Apr 21, 2020

https://www.youtube.com/watch?v=kK-DNyKnb5c Coronavirus Pandemic Update 92: Blood Clots & COVID-19 - New Research & Potential Role of NAC Jul 3, 2020

Dr Been:

https://www.youtube.com/watch?v=K8kKWgsGIU8 NAC N-Acetylcysteine May 15, 2020

Whiteboard Doctor:

https://www.youtube.com/watch?v=PjDNzhS-mc0 N-Acetylcysteine (NAC) And COVID-19: Does This Medication Help Prevent And/Or Treat COVID-19? Oct 30, 2020

NAC and covid19

NAC may have direct activity against covid19:

https://chemrxiv.org/articles/preprint/Conformational_Perturbation_of_SARS-CoV-2_Spike_Protein_Using_N-Acetyl_Cysteine_a_Molecular_Scissor_A_Probable_Strategy_to_Combat_COVID-19/12687923 N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation

NAC (and L-glutathione) can be beneficial during covid19.

There is a small study that showed L-glutathione reduced hypoxia within hours:

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32322478/ Efficacy of Glutathione Therapy in Relieving Dyspnea Associated With COVID-19 Pneumonia: A Report of 2 Cases Richard I Horowitz et al. Respir Med Case Rep. 2020.

Also see this review:

https://www.dovepress.com/n-acetylcysteine-as-adjuvant-therapy-for-covid-19--a-perspective-on-th-peer-reviewed-fulltext-article-JIR N-Acetylcysteine as Adjuvant Therapy for COVID-19 – A Perspective on the Current State of the Evidence 6 July 2021

In vitro data have depicted that N-acetylcysteine increases antioxidant capacity, interferes with virus replication, and suppresses expression of pro-inflammatory cytokines in cells infected with influenza viruses or respiratory syncytial virus. Furthermore, findings from in vivo studies have displayed that, by virtue of immune modulation and anti-inflammatory mechanism, N-acetylcysteine reduces the mortality rate in influenza-infected mice animal models.

NAC for long haulers and post-vax

See this case and my (u/stereomatch) comments there too - for relief of neurological symptoms post-vax:

https://old.reddit.com/r/ivermectin/comments/o5g09s IVR After Pfizer Vaccine [Neurological Side Effects].

Update:

https://old.reddit.com/r/ivermectin/comments/osx45y/ivermectin_pepcid_liposomal_glutathione_cured_me Ivermectin + Pepcid + Liposomal Glutathione Cured Me. 90% Better After Vaccine Nerve Problems.

NAC dosage

NAC is typically given at 400mg+400mg per day (or 800mg-1200mg) per day for covid19 patients - until recovery (i.e. until steroids-at-day8 have been tapered off to zero).

After that NAC may be continued for a month or more after recovery at 200mg+200mg per day levels.

After that NAC at 200mg per day can be continued - though long term issues should be considered (see below).

NAC dosing and safety

See this review of dosing and safety for NAC:

https://link.springer.com/article/10.1007/s40264-020-01026-y Safety of N-Acetylcysteine at High Doses in Chronic Respiratory Diseases: A Review 16 December 2020

When treatment requires chronic use, as in COPD and cystic fibrosis, the maximum licensed dose is 600 mg/day, but doses > 600 mg daily have been studied in some clinical trials.

Studies of high doses of NAC (up to 3000 mg/day) in respiratory diseases with explicit reports on safety found that NAC was safe and well tolerated. In general, the safety profile is similar at both the high and standard doses.

NAC can be found in chicken soup:

https://www.hamilton.edu/news/story/mom-was-right-chicken-soup-is-the-cure Mom was Right ... Chicken Soup is the Cure November 3, 2003

.. suggests that an amino acid released from chicken during cooking chemically resembles the drug acetylcysteine, prescribed for bronchitis and other respiratory problems.

https://www.researchgate.net/publication/261983964_Saha_et_al_2012_SFN_and_Erucin_from_Fresh_Frozen_broccoli_MNFR_PUBLISHED Saha et al (2012) SFN and Erucin from Fresh Frozen broccoli (MNFR) (PUBLISHED) April 2014

https://www.researchgate.net/figure/Sulforaphane-N-acetyl-cysteine-and-erucin-N-acetyl-cysteine-urinary-excretion-after_tbl2_261983964

Table 2

Sulforaphane N-acetyl cysteine and erucin N-acetyl-cysteine urinary excretion after consumption of soups made with lightly cooked fresh and frozen broccoli

NAC concerns - interactions

https://www.pharmacytimes.com/view/nac-a-natural-product-so-powerful-it-is-used-in-hospitals NAC: A Natural Product So Powerful It Is Used in Hospitals January 11, 2017 Gunda Siska, PharmD

People who take nitroglycerine should not take NAC unless supervised by a physician since it can cause the nitroglycerine to work more intensely and cause an unsafe drop in blood pressure.

NAC and alcohol

One may want to avoid consuming alcohol (ethanol) with NAC:

https://pubmed.ncbi.nlm.nih.gov/16439183/ A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice March 2006

Pretreatment with NAC prevent from acute ethanol-induced liver damage via counteracting ethanol-induced oxidative stress. When administered after ethanol, NAC might behave as a pro-oxidant and aggravate acute ethanol-induced liver damage.

This study suggests pre-treatment with NAC protected the liver from alcohol injury, but post-treatment with NAC may exacerbate i.e. worsen liver injury.

NAC concerns - cancer

Some studies have raised concern that since NAC is an antioxidant, and for ongoing elimination of cancer cells etc., reactive oxygen species are used, that it can hinder ongoing cancer removal.

However other studies have suggested NAC may help against cancer.

Here is a comment on newer FDA restrictions on availability of NAC - also discusses the criticism of the pro-cancer potential, and anti-cancer potential:

https://old.reddit.com/r/ivermectin/comments/ncz95h/_/gy7tqpj

July 24, 2022: also see the section NAC for COVID-19 patients with cancer

NAC for COVID-19 patients with cancer

This small study suggests that NAC use for covid19 patients (who are also cancer patients) gives positive results:

Paper:

https://www.researchsquare.com/article/rs-1836295/v1

A phase II study of N-acetylcysteine in cancer patients with severe COVID-19: clinical outcomes and biological correlates

18 Jul, 2022

NAC and copper chelation

There is some concern that NAC use long term may reduce copper availability.

NAC does seem to be useful as a chelating agent to remove heavy metals:

https://link.springer.com/chapter/10.1007/978-981-10-5311-5_10 The Use of N-Acetylcysteine as a Chelator for Metal Toxicity Daniel A. Rossignol 21 September 2018

NAC for Tylenol (Acetaminophen, Paracetamol) overdose - preventing and reversing organ damage (liver, kidneys)

NAC is used to prevent organ damage in liver and kidneys in the case of Tylenol overdose.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637612/

Acetylcysteine for Acetaminophen Poisoning

Kennon J. Heard, M.D.

Feb 9, 2009

https://journals.lww.com/em-news/fulltext/2004/03000/n_acetylcysteine_and_acetaminophen_toxicity__two.22.aspx

N-Acetylcysteine and Acetaminophen Toxicity Two Common Misconceptions

Gussow, Leon MD

2004

https://www.mdcalc.com/acetaminophen-overdose-nac-dosing

Acetaminophen Overdose and NAC Dosing

Calculates PO/IV NAC dosing for acetaminophen overdose (and nomogram to determine toxic 4 hour level).

Dr. Barry H. Rumack

https://www.tylenolprofessional.com/sites/tylenol_hcp_us/files/acetaminphen_overdose_treatment_info.pdf

Guidelines for the Management of Acetaminophen Overdose

https://www.nejm.org/doi/full/10.1056/NEJM198812153192401

Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose

December 15, 1988

https://www.uptodate.com/contents/acetaminophen-paracetamol-poisoning-in-adults-treatment

Acetaminophen (paracetamol) poisoning in adults: Treatment

May 2022

https://ubccriticalcaremedicine.ca/academic/jc_article/Acetaminophen%20Poisoning%20(Jan-30-14).pdf

A Review of Acetaminophen Poisoning

2012

https://www.hindawi.com/journals/cricc/2021/6695967/

Case Report

Massive Acetaminophen Overdose Treated Successfully with N-Acetylcysteine, Fomepizole, and Hemodialysis

12 Jul 2021

NAC for MRI Contrast Agent Injury - reversing organ damage

NAC is used to prevent MRI contrast agent injury to liver (Contrast Induced Nephropathy)

https://pubmed.ncbi.nlm.nih.gov/28934030/

Metabolomic Analysis of N-acetylcysteine Protection of Injury from Gadolinium-DTPA Contrast Agent in Rats with Chronic Renal Failure

Sept 2017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769030/

N-acetylcysteine for prevention of radiocontrast induced nephrotoxicity: the importance of dose and route of administration

August 2005

Push towards neutral trend for NAC in MRI Contrast Injury

There has been some argument in the literature against the perceived benefit of NAC for MRI Contrast Injury.

However since some studies suggest great benefit, while others are neutral, one wonders if this is another example of RCTs giving erroneous negative signals (when the studies are not timed correctly for instance).

This type of phenomenon has been seen with other protocols:

anosmia signal in Ivermectin trials (if you don't account for fact it is more effective in post-day8 period then may not get good signal for efficacy)
Dr Paul Marik's sepsis protocol

Because of which RCTs taken literally are used to set religious stances in the practice of medicine (for example some set of doctors hate Dr Paul Marik for his sepsis protocol).

And it could be argued that if a subset of practitioners are seeing benefit - while others are not - it could be due to some other factor which smears out the signal for those who are not timing dosing or duration correctly or some such factor.

More importantly if a treatment does not show harm (and occasionally great benefit), then it could be considered standard of care - until contrary evidence emerges.

https://cjasn.asnjournals.org/content/3/1/281

N-Acetylcysteine in the Prevention of Contrast-Induced Nephropathy Steven Fishbane

January 2008

https://rhochistj.org/RhoChiPost/role-n-acetylcysteine-contrast-induced-nephropathy/

Clinical: The Role of N-Acetylcysteine in Contrast Induced Nephropathy

Neal Shah, Co-Editor-In-Chief

August 1, 2012

NAC for Heat Stroke - reversing organ damage in heatstroke

NAC seems to be effective as part of a treatment plan to prevent and reverse organ damage from heat stroke.

Heat Stroke - other names:

Exertional Heat Illness

https://pubmed.ncbi.nlm.nih.gov/30811527/

N-Acetylcysteine (NAC) for the Prevention of Liver Failure in Heat Injury-Mediated Ischemic Hepatitis

Oct 1, 2019

https://www.ajemjournal.com/article/S0735-6757(19)30768-5/fulltext

Case Report

A knack for “NAC”: Treatment for heat stroke induced acute liver injury

November 28, 2019

NAC for Fatty Liver Disease - reversing organ damage

NAC seems to be effective as part of a treatment plan to reverse fatty liver disease - esp. non-alcoholic fatty liver disease (NAFLD).

https://pubmed.ncbi.nlm.nih.gov/22308119/

N-acetylcysteine improves liver function in patients with non-alcoholic Fatty liver disease

March 1, 2010

https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01274-y

Long term N-acetylcysteine administration rescues liver steatosis via endoplasmic reticulum stress with unfolded protein response in mice

25 May 2020

https://www.frontiersin.org/articles/10.3389/fphar.2021.636204/full

N-Acetyl Cysteine Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Intracellular Triglyceride Accumulation by Preserving Mitochondrial Function

13 September 2021

https://mdpi-res.com/d_attachment/antioxidants/antioxidants-09-01283/article_deploy/antioxidants-09-01283-v2.pdf?version=1608167628

Review

N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature

16 December 2020

Inhaled Budesonide (steroids)

Inhaled Budesonide (steroids) - usually available as Rota-caps (capsules which contain steroid powder designed to be inhaled from a plastic container - as you breathe in, the powder gets drawn into your lungs).

These consist of a plastic device - and rota-caps or capsules which you insert into the plastic device.

You then rotate the plastic device, so the capsule gets opened up inside, and it's powder gets dumped inside the device.

Then you suck (breathe in) from the plastic device, in such a way that the air rushing into your lungs brings the powder along with it.

Here is a YouTube video explaining how to use a Rota-caps-based inhaled budesonide device:

https://youtu.be/fVPKNl2tNu4 Learn how to use a Rotahaler Inhaler Sep 16, 2010

Inhaled budesonide rota-caps typically have a very low steroids dose - usually less than 1mg.

So do not have much effect systemically - i.e. your other steroids (oral or intravenous) dosing doesn't need to be changed.

That is, if you are already taking steroids orally or intravenously, the inhaled budesonide can safely be added on top of it.

If a patient has been started on steroids, then it is safe to also start on Inhaled Budesonide.

Usually steroids will be started if sufficient time has passed so the live virus is near zero - i.e. usually by day7-8 from first symptoms.

Sometimes day1 counting is unclear (patient is not sure or there is some confusion when symptoms started, or as with Delta and the already-vaccinated patient, the day1-7 period may be asymptomatic).

In such cases one should watch for oximeter SpO2 daily declines (or alternatively pulse rate going high in 90s or 100+ while at rest and while there is no fever) - usually this is a good indication that "day7-8" has arrived and the hyperinflammatory stage is in full swing. And so steroids can be started.

In some cases, where you are wary of starting steroids (oral, intravenous) - it may be possible to start the Inhaled Budesonide first to start to give some relief in breathing.

However, usually the signal to use Inhaled Budesonide will be similar to that for oral or intravenous steroids.

From studies, and from practical observation, Inhaled Budesonide give very strong and immediate relief to the patient.

So for example you have started the patient on steroids, but their breathing capacity is diminished due to inflammation, or oximeter levels are around 95 and only slowly improving.

Then in such situations, adding inhaled budesonide - 4-5 times a day i.e. every 4 hours or so - will give very visible relief to the patient - both in breathing capacity (i.e. breathing will become less shallower) and in terms of oximeter SpO2 levels also.

However for such a patient, systemic steroids (oral or intravenous) are essential - since in covid19, the hyperinflammatory stage can have impact all over the body i.e. in the blood vessels - so systemic steroids are essential.

But Inhaled Budesonide can be a valuable addition on top of that - in order to give additional relief to the patient.

Just as a patient in this situation - oximeter at 95 and at home - would be told to do prone positioning (lying face down in bed).

Similarly Inhaled Budesonide should be added as well.

NOTE: as with all steroids use - patient should be told to keep a watch on phlegm color - if it changes from white/clear (normal during viral infection) - to yellow/green - that may then be an indication of bacterial infection.

Viral fevers generally go up to 101 Fahrenheit - however bacterial fevers can go higher i.e. to 102-103 or higher. And so a fever that is higher than 101 should always put you on alert to watch for any signs of bacterial infection (phlegm color changing from white/clear to more yellow/green is an indication of bacterial infection).

In such a case, pre-emptive Doxycycline should be started:

Doxycycline 100mg - 1+1 per day - for 5 days

This will keep the bacterial infection in check and in 1-2 days the yellow/green phlegm will turn back to white/clear.

Steroids (Prednisolone or Dexamethasone)

Usually at day7-8 from first symptoms, the first signs of oximeter declines will start to become obvious in most patients.

Even the mild patients (or who would have recovered on their own) seem to show some decline at day7-8 as well.

So in order to prevent long haulers, and since you don't know which patient will have a serious downturn in the next few days, it is wise to start steroids for all patients at day7-8.

Of course care should be exercised for those patients who are immuno-compromised, or who have potential for viral persistence (in such cases a higher dose of Ivermectin 0.6mg/kg bodyweight could be tried, or if you are comfortable with Remdesivir, it could be used - to provide a safety net for preventing viral persistence).

And care should be exercised for those likely to get bacterial infections - one should watch for signs of bacterial infection starting (sputum or phlegm color changing from white/clear to yellow/green).

Prednisolone is the steroid of choice for the MATH+ protocols, and it's author Dr Paul Marik - who advises that Prednisolone is faster to the lungs, and is better tolerated by humans at higher doses (since in covid19 high steroids doses are sometimes required to achieve turnaround in the patient - the assurance of better tolerability at high dose is welcome).

Dexamethasone is often preferred by hospitals and physicians - primarily because it was chosen as the steroid for the RECOVERY UK trial on steroids use for covid19.

Because of that RECOVERY UK trial, a number of bad behaviors have become common as well in hospitals:

Dexamethasone is not escalated beyond 6mg dose (the dose that RECOVERY UK trial used)
Beyond this, generally prior attitudes wind up informing current behavior and hospitals often wind up giving much less doses than are needed for patients - something Dr Paul Marik calls "homeopathic" doses of steroids. If a patient is at day10 and declining - you may need to give Prednisolone 120mg per day even or higher to start to show daily improvement. While a patient at day7 may only require 40mg Prednisolone to show reversal.
RECOVERY UK trial also has another negative impact - many hospitals are under the impression that steroids should not be used unless patient is intubated or in extremely dire straits. This is an incorrect reading from RECoVERY UK trial. In practice it is best to give steroids not much earlier than day7-8, and not much later than day7-8. And if patient oximeter SpO2 are falling daily, then that should be seen as a sign that "day7-8" has arrived or already happened, and that aggressive steroids therapy is needed.

NOTE: as described above for Inhaled Budesonide, once steroids are given to the patient, they should be watched for signs of bacterial infection, and if phlegm turns from white/clear to yellow/green then should start antibiotics to prevent bacterial infection from taking hold:

Doxycycline 100mg - 1+1 per day - for 5 days

Once this is started, usually the yellow/green phlegm will start to turn back to white/clear.

Since viral infections typically don't go over 101 Fahrenheit, while bacterial infections can lead to fever that is higher i.e. 101-103 Fahrenheit - for this reason, if a patient is showing fever above 101 Fahrenheit, then you will need to watch for any signs of bacterial infection (like phlegm color changing from white/clear to yellow/green).

Fluvoxamine

Fluvoxamine - may simplify protocols if reduces need for time sensitive steroids-at-day8

If Fluvoxamine is given early, there is potential that you may not need steroids-at-day8.

This is the implication of the Fluvoxamine studies since they show efficacy (in reducing deaths) when Fluvoxamine is given during disease (preferably earlier one would think).

The Serotonin Syndrome preventing action of Fluvoxamine also suggests it should be given earlier in the day1-8 period before hyperinflammatory stage appears at day7-8.

Dr Syed Haider is one of the early users of Fluvoxamine - he uses it as Ivermectin + Fluvoxamine - and has confirmed on Twitter in replies that if given early, there may be no need for steroids-at-day8.

If this remains true - that would remove a complication from outpatient treatment practices for doctors - as it removes dependence on the (time sensitive) administration of steroids-at-day8.

Fluvoxamine - issues with patient compliance

There remains an issue of patient compliance - as SSRIs can have side effects, which some patients may not tolerate well.

Dr Syed Haider also has said from the earliest use, that some patients do have issues with Fluvoxamine and for them one can then fall back to other treatments.

For instance, if Fluvoxamine is not given, then the safety net of steroids-at-day8 should be ensured. So patient is caught if hyperinflammatory stage appears, and that they survive it without long haulers syndrome or organ damage from hyperinflammation.

However, lately Dr Syed Haider has suggested in twitter messages, that he resorts to reducing the Fluvoxamine dose to half or to whatever level is tolerable by the user.

Fluvoxamine - side effects

EDIT: November 13, 2021 - taken from: https://saidit.net/s/Ivermectin2/comments/8imo/here_is_an_account_of_the_early_history_of_how/vulq

There is a concern that some patients may have issues with Fluvoxamine from the start.

So it adds an extra layer of logistics to handle for an outpatient doctor - more monitoring and more abrupt change of medications (if patient cannot tolerate Fluvoxamine then have to fall back to steroids-by-day8).

However, I (u/stereomatch) asked this of Dr Angela Reiersen on twitter - and she said that a one week course should not make dependent.

However, we have direct feedback from Dr Syed Haider who is using it as his main line of defence i.e. ivermectin + fluvoxamine - and the idea being that this avoids need for steroids-at-day8 (I (u/stereomatch) pressed him on this).

Though I am not sure of the edge cases - i.e. if start Fluvoxamine late or later patient arrives.

Dr Syed Haider also addressed the dependence issue on Fluvoxamine in a tweet response - and he also is less concerned about that.

But he has said from the start that some proportion of patients do have issue with Fluvoxamine i.e. cannot continue with it etc.

Fluvoxamine has been reported by some on reddit as does have impact on libido and ejaculation.

(in fact it is used by urologists to treat premature ejaculation in men it seems - private communication by a urologist from South Africa where it is commonly prescribed for this purpose)

Here are some comments about difficulty weaning off SSRIs:

https://old.reddit.com/r/askscience/comments/qhexf7/_/hiea9zy

Fluvoxamine - treatment for covid19 - early history

EDIT: October 5, 2022 - taken from: https://saidit.net/s/Ivermectin2/comments/8imo/here_is_an_account_of_the_early_history_of_how/

Cyproheptadine (SSRI)

At day7-8 onwards, Cyproheptadine (also an H1 blocker anti-histamine) can be started to counter the possibility of serotonin syndrome.

Dr Farid Jalali has been highlighting the potential role of serotonin syndrome for months on Twitter and elsewhere to his fellow physicians. Cyproheptadine is now considered an essential addition to the FLCCC MATH+ protocol for hospitals:

Reference:

MATH+ protocol for hospitals:

https://covid19criticalcare.com/covid-19-protocols/math-plus-protocol/

Cyproheptadine 8mg - 3 times a day

Conjecture: A possible sign serotonin syndrome has started

u/stereomatch conjecture: If a patient takes this dosage and still does not feel sleepy, it may be a sign of ongoing serotonin syndrome. The drug takes about 36 hours to take effect (according to Dr Farid Jalali in an interview with Dr Been), and after 2-3 days the patient can start to feel sleepy again. (TODO: add confirmation of this conjecture)

If this is potentially a good way to diagnose ongoing serotonin syndrome, then it may be possible to use this test to decide whether a patient already on steroids needs to be put on additional Cyproheptadine or not.

Evidence for Cyproheptadine reversing lung damage within 1-2 days

Dr Farid Jalali reports on twitter about cases where Cyproheptadine has reversed lung injury in cases where there was serotonin syndrome (platelets hold 90+ percentage of serotonin - when platelets deaggregate they can release their serotonin, which can lead to clotting).

Reference:

https://www.youtube.com/watch?v=Wetdq9vX__c

Dr. Farid Jalali Discusses COVID Management

May 3, 2021

Drbeen Medical Lectures

Cyproheptadine - do not stop suddenly but taper off

Cyproheptadine should not be stopped suddenly (can make matters worse), but should be tapered off over a few days.

Cyproheptadine - side effects

Cyproheptadine 8mg - 3 times a day (FLCCC protocol) for post-day7-8 use in severe cases - dosage will make patient sleepy.

So that they only get up for meals.

Patients who are severe or have oximeter near 90 etc. will usually not mind this sleepiness that much.

But mild patients or those who are wanting to be active may complain that they are not able to do their daily chores at home - if they are on Cyproheptadine.

Organizations and individuals supporting Early Treatment

BIRD Group UK (Dr Tess Lawrie)

Dr Tess Lawrie has also had her videos on YouTube removed - the Trusted News Initiative (TNI) at work.

The BIRD Group UK is the UK version of the FLCCC in the US.

Website: https://www.bird-group.org

Telegram: t.me/birdgroupuk

Reddit: https://www.reddit.com/u/EbMCsquared

Video channel:

https://odysee.com/@The_BiRD_Group:3 The BiRD Group

Jan 11, 2023 - Dr Tess Lawrie had her account blocked by Twitter (restored after Elon Musk acquisition of Twitter)

Twitter: https://twitter.com/lawrie_dr

Canadian Covid Care Alliance

Twitter: https://www.twitter.com/CCCAlliance

Website: https://www.canadiancovidcarealliance.org/

Canadian Covid Care Alliance (CCCA) is affiliated with the BIRD Group UK (Dr Tess Lawrie):

https://bird-group.org/bird-affiliates/

Since the censorship situation in Canada is worse than the UK or USA - with physicians licenses being under threat for having prescribed or advocated for Ivermectin - the CCCA has had to take the unusual step of not publicizing it's membership list:

https://www.canadiancovidcarealliance.org/faq/

Why won't the Canadian Covid Care Alliance (CCCA) publish a list of its members and their professional credentials?

We regret that the state of affairs, censorship of free speech, and rampant tyranny and coercion is such now in Canada that CCCA must protect the identity of its scientific, MD, academic and other health care professional (HCP) members.

This serves to shield them from career-impacting reactions by their universities, professional colleges and healthcare system employers.

Sadly, some of our MDs have had their medical licenses to practice suspended or restricted because they are not on board with the mainstream narrative.

Likewise, some of our university professors have had their contracts terminated. These are dark times, and while we appreciate that some people want to know identities, frankly it would be hazardous to the careers of many of our members for us to reveal them.

While there are publicly identified directors of CCCA, it should be apparent from the quantity and quality of the work published on our website that our scientists, HCPs, ethicists, lawyers and other professionals in CCCA have broad and deep scientific, medical, and professional expertise.

A representative listing of a number of these credentials of our more than 500 scientists, medical doctors and health care and other professional members are listed on our website.

If people are willing to think critically, they will appreciate the quality of our work; if they are not, no amount of personal disclosures will convince them in this cancel culture era.

References:

https://old.reddit.com/r/ivermectin/comments/out7zw/hey_canadians_i_just_found_out_about_this/ Hey Canadians - I just found out about this Canadian Covid Care Alliance

https://covexit.com/canadian-group-calls-for-off-label-use-of-early-treatment-drugs-with-informed-consent/ Canadian Group Calls for Off-Label Use of Early Treatment Drugs with Informed Consent June 19, 2021

FLCCC - Front Line COVID-19 Critical Care Alliance

https://www.flccc.net

https://covid19criticalcare.com/

The FLCCC has also had videos removed by YouTube - the Trusted News Initiative (TNI) at work.

Dr Pierre Kory of the FLCCC even had his US Senate testimony removed from YouTube. His appearance there was a matter of public record.

FLCCC YouTube channel:

https://www.youtube.com/c/FLCCCWeeklyUpdate FLCCC Weekly Update

Because YouTube has removed many FLCCC videos, they started using Odysee instead.

FLCCC Odysee channel:

https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c

Dr Bret Weinstein - Dark Horse Podcast

Dr Bret Weinstein and Dr Heather Heying - who are evolutionary biologists and run the Dark Horse Podcast - have had their videos removed from YouTube, and YouTube channel demonetized - which is an example of how the Trusted News Initiative (TNI) impacts flow of information.

He has decided to switch to Odysee (open video platform).

Dr Bret Weinstein (evolutionary biologist) video channel:

https://odysee.com/@BretWeinstein:f

Robert Malone MD - pioneer of mRNA vaccine technology

Dr Robert Malone is a pioneer in the development of mRNA vaccine technology. He was the originator of the idea that Lipid Nano Particles (LNPs) could be used to ensure mRNA gets entry into cells.

His Twitter account was removed for suggesting mRNA vaccines may have issues.

He then moved to gettr: https://gettr.com/user/rwmalonemd

Website: https://www.rwmalonemd.com/

Substack: https://rwmalonemd.substack.com/

Alexandros Marinos - critiques of TOGETHER trial

Alexandros is the Founder/CEO of baleno.io

Video of Alexandros Marinos with Dr Bret Weinstein:

https://www.youtube.com/watch?v=kLXiQEihg8s

https://odysee.com/@BretWeinstein:f/cold-confusion-alexandros-marinos:7

Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret

May 2nd, 2022

Bret Weinstein

Twitter: https://twitter.com/alexandrosm

Substack: https://doyourownresearch.substack.com/

Ivory Hecker - whistleblower - formerly at Fox News

Ivory Hecker has had her videos removed from YouTube - the Trusted News Initiative (TNI) at work.

She has created a channel on bitchute:

https://www dot bitchute dot com/channel/nJZpoljWM26e/

https://tinyurl.com/w7c9r8uh

(reddit does not allow bitchute links)

Experts who post on r/ivermectin

Frequently Asked Questions (FAQ)

The FLCCC authors of MATH+ protocol are quacks and no one takes them seriously

Answered here:

https://old.reddit.com/r/ivermectin/comments/p03pvh/lesson_learned/h84a1ta

As well as here:

https://old.reddit.com/r/ivermectin/comments/o9th7b/meet_the_quacks_kooky_covid_doctors_who_use/

Meet the Quacks: Kooky COVID Doctors Who Use Dangerous Animal Drugs - Censor Them! (June 28, 2021) - article provides a resume of the FLCCC doctors and their prior contributions to medicine

Article:

https://degraw.substack.com/p/meet-the-quacks-kooky-covid-doctors Meet the Quacks: Kooky COVID Doctors Who Use Dangerous Animal Drugs - Censor Them!

Courageous COVID Doctors With the Lowest Death Rates #TeamLifeSaving

David DeGraw

June 28, 2021

Books

Chronic - Dr Steven Phillips, Dana Parish

Dr Steven Phillips has suffered through a chronic illness, and his book is highly recommended by Dr Been (should be on everyone's bookshelf) because of it's insights into chronic diseases - especially Lyme disease, and now long haulers syndrome due to covid19:

https://www.amazon.com/Chronic-Hidden-Autoimmune-Pandemic-Healthy/dp/0358064716/ref=tmm_hrd_swatch_0?_encoding=UTF8&qid=1639185296&sr=8-2

Chronic: The Hidden Cause of the Autoimmune Pandemic and How to Get Healthy Again Hardcover – February 2, 2021

by Steven Phillips (Author), Dana Parish (Author)

Dr Steven Phillips also had an online chapter for his book that addresses covid19 as well - not clear if it is available on the website, or will appear in next version of the book:

https://stevenphillipsmd.com

Dr Been interviews with Dr Steven Phillips:

https://youtu.be/FqVlOfzZJH0

Dr. Steven Phillips Discusses Chronic Diseases (Lyme and COVID)

Drbeen Medical Lectures

Jan 30, 2021

https://www.youtube.com/watch?v=xwMwR6IJC3o

Chronic Diseases Talk with Dr. Steven Phillips (Lyme, COVID Long Haul and More)

March 19, 2021

Drbeen Medical Lectures

https://www.youtube.com/watch?v=CzIrtvjNY2M

Long COVID, Lyme - Dr. Steven Phillips, Dana Parish (Authors of The Book Chronic)

Dec 11, 2021

Drbeen Medical Lectures

The Real Anthony Fauci - Robert F. Kennedy Jr.

Robert F. Kennedy Jr. on Dr Fauci, and the role of Bill Gates and Big Pharma:

https://www.amazon.com/Real-Anthony-Fauci-Democracy-Childrens/dp/1510766804 The Real Anthony Fauci: Bill Gates, Big Pharma, and the Global War on Democracy and Public Health (Children’s Health Defense) Hardcover – November 16, 2021 by Robert F. Kennedy Jr. (Author)

Overcoming the COVID-19 Darkness - Dr George Fareed, Dr Brian Tyson

https://www.amazon.com/dp/B09PVNF24K/ref=cm_sw_r_tw_api_glt_fabc_8ZZCA61Z034CJH3PQF1F Overcoming the COVID-19 Darkness: How Two Doctors Successfully Treated 7000 Patients Paperback – January 7, 2022

by Brian Tyson (Author), George Fareed (Author), Mathew Crawford (Author)

Dr George Fareed & Dr Brian Tyson (AAPS affiliated) have also reported great success with early treatment (reduced mortality, and lower incidence of long haulers syndrome).

Their protocol includes moderate amounts of Ivermectin, Hydroxychloroquine (HCQ) and other supplements.

COVID-19 and the Global Predators - Peter Roger Breggin

https://www.amazon.com/COVID-19-Global-Predators-are-Prey/dp/0982456069 COVID-19 and the Global Predators: We Are the Prey Paperback – September 30, 2021 by Peter Roger Breggin (Author), Ginger Ross Breggin (Author)

Foreword by:

Dr Peter McCullough

Dr Elizabeth E. Vliet

Dr Vladimir "Zev" Zelenko

Pandemic Blunder - Peter Roger Breggin

https://www.amazon.com/Pandemic-Blunder-Public-Blocked-Treatment/dp/197723822X/ref=nav_signin?dchild=1&keywords=Pandemic+Blunder&qid=1612289098&sr=8-1&&

Pandemic Blunder - Fauci and Public Health Blocked Early Home COVID Treatment

Joel S Hirschhorn

Dr Peter McCullough tweet about the book:

https://twitter.com/P_McCulloughMD/status/1489287815334707202?t=HzIyD9top4oYPw5RlkXXZQ&s=19

Rogan asked "who is behind all of this?" I did not give opinions or make claims, I referred him to this book by Dr. Peter and Ginger Breggin which lays out the field of stakeholders and their connections and how it was put together. Not my opinion but in published nonfiction.

Return to Ivermectin

# **Ivermectin Table of Contents**


*Template for reddit wiki editing copied from: https://gist.github.com/anonymous/5928646*


&nbsp;



## **About this Wiki**


&nbsp;




### **Changes**


&nbsp;


**Dec 20, 2022** - added some links to papers to "Ivermectin for Multiple Sclerosis (MS), Lyme disease and for nerve remyelination" section

**Oct 5, 2023** - added anosmia reversal anecdote from reddit user u/007_jmp


**Oct 3, 2023** - added "Ivermectin and post-covid19 Anosmia reversal - long term anosmia reversal - months to years"


**Aug 25, 2023** - added "Sodium butyrate topical application and Psoriasis"


**Aug 14, 2023** - added "Ivermectin - taking on empty stomach - or taken with fatty meal - and the impact on anti-IVM trials"

**Aug 14, 2023** - added "Ivermectin - dosing at 0.2mg/kg bodyweight - or 0.4mg/kg bodyweight - and the impact on anti-IVM trials"

**Aug 14, 2023** - added "Ivermectin - dosing by weight - or dosing non-linearly - and the impact on anti-IVM trials"

**Aug 14, 2023** - added "Ivermectin - beyond dosing by weight - dosing by body mass index (BMI) - and the impact on plasma levels"



**July 18, 2023** - added "Ivermectin - availability in various countries"

**May 18, 2023** - added "Ivermectin and gum disease"

**May 7, 2023** - added Ivmmeta.com - and c19ivermectin.com censorship - reddit-wide blacklisting" - split into separate topic

**May 4, 2023** - added the reddit comment text directly to the section "Ivermectin and mold toxicity" for easier reading

**May 2, 2023** - added Dr Dave Cartland - Gettr url

**Apr 22, 2023** - added additional descriptions of Ivermectin and visual disturbances in the section "Ivermectin - Dizziness, visual disturbances" - by u/SchlauFuchs on reddit

**Mar 25, 2023** - added "Some more info on diagnosing DKA" 

**Feb 23, 2023** - added additional descriptions of Ivermectin and visual disturbances in the section "Ivermectin - Dizziness, visual disturbances" - by Dr Jackie Stone (Zimbabwe)

**Feb 7, 2023** - added additional descriptions of Ivermectin and visual disturbances in the section "Ivermectin - Dizziness, visual disturbances" - by u/RestingLogo on reddit

**Jan 14, 2023** - added "Ivermectin and Fatty Liver Disease"

**Jan 14, 2023** - added to "Early Treatment situation in UK"


**Jan 11, 2023** - added Dr Tess Lawrie Twitter account

**Jan 10, 2023** - added "Ivermectin and Herpes Simplex Virus type 1 (HSV-1)"

**Jan 10, 2023** - added "Ivermectin and Herpes zoster virus (shingles)"

**Jan 10, 2023** - added "Ivermectin and Epstein-Barr Virus (EBV)"

**Jan 10, 2023** - added anecdote to "Ivermectin and mold toxicity"


**Jan 7, 2023** - added Dr Mollie James jamesclinic.com website


**Dec 31, 2022** - added Peter Pham anecdote on Ivermectin reversing post-covid19 anosmia in 6 people

**October 5, 2022** - added "Fluvoxamine - treatment for covid19 - early history"

**October 5, 2022** - corrected "Dr Angela Rieirsen" to "Dr Angela Reiersen"


**September 16, 2022** - added "Long Haulers Treatments - Survey of Anosmia treatments - on Reddit"

**September 16, 2022** - added "Long Haulers Treatments - React19 survey of treatments for long haulers and vaccine long haulers"

**September 16, 2022** - added "Long Haulers Treatments - LongCovidPharmD (organichemusic on Twitter) survey of treatments for long haulers"

**September 16, 2022** - added "Long Haulers Treatments - Nattokinase, Serrapeptase, Lumbrokinase"


**September 16, 2022** - added "Ivermectin and migraines"

**September 16, 2022** - for "Ivermectin - Dizziness, visual disturbances" - added additional explanation for what "visual disturbances" look like


**August 4, 2022** - added "Early Treatment Protocols - my simplified protocol for early treatment and preventing long haulers"


**July 31, 2022** - added "Twitter and LinkedIn censorship - Dr Darrell DeMello (Mumbai, India)"

**July 31, 2022** - added "Twitter and LinkedIn censorship - Dr Robert Malone"


**July 27, 2022** - added "Ivermectin - assessing the quality of tablets ordered online from other countries"


**July 24, 2022** - added "NAC for COVID-19 patients with cancer"


**July 24, 2022** - added "Ivermectin and Dengue - antiviral activity"

**July 24, 2022** - added "Ivermectin and Dengue - early treatment for Dengue"


**June 17, 2022** - added "Dr Paul Marik invaluable advice in appearances on Dr Been show"

**June 17, 2022** - added "Dr Paul Marik (FLCCC co-founder)"


**June 17, 2022** - added "NAC for Tylenol (Acetaminophen, Paracetamol) overdose - preventing and reversing organ damage (liver, kidneys)"

**June 17, 2022** - added "NAC for MRI Contrast Agent Injury - reversing organ damage"

**June 17, 2022** - added "NAC for Heat Stroke - reversing organ damage in heatstroke"

**June 17, 2022** - added "NAC for Fatty Liver Disease - reversing organ damage"

**June 17, 2022** - added "NAC impact on stomach "spare tire" and systemic inflammation"


**May 13, 2022** - added to "Ivermectin - regions offering over the counter (OTC)" section

**May 13, 2022** - added to "Pharmacies which fulfil Ivermectin prescriptions" section

**Apr 29, 2022** - added Dr Syed Haider's new YouTube and Odysee channels

**Apr 26, 2022** - added new Famotidine paper reference

**Apr 24, 2022** - added to pinned posts

**Apr 15, 2022** - added some links to papers to "Ivermectin for Multiple Sclerosis (MS), Lyme disease and for nerve remyelination" section

**Apr 15, 2022** - added "Dr Steven Phillips (author of bestseller 'Chronic')" section

**Mar 26, 2022** - cleaned up/reorganized "Links to Wiki", "Corrections and Feedback", "Archives of .." sections

**Mar 20, 2022** - added "Canadian Covid Care Alliance" section

**Mar 20, 2022** - added to meta-analysis websites: c19ivermectin.com, c19vitamind.com, c19hcq.com

**Mar 20, 2022** - added website and twitter info to "Dr Tina Peers (UK)" section

**Mar 20, 2022** - added "Early Treatment situation in UK" section

**Mar 20, 2022** - added "Early Treatment situation in Canada" section

**Mar 19, 2022** - added "YouTube censorship - Sky News Australia" section

**Mar 19, 2022** - added "YouTube censorship - Sen Ron Johnson" section

**Mar 19, 2022** - added "YouTube censorship - Kim Iversen (journalist - The Hill)" section

**Mar 19, 2022** - added to "Early Treatment discussion - censorship by YouTube" section - YouTube Terms of Service mentions Ivermectin and HCQ by name

**Mar 19, 2022** - added Dr Been (Dr Mobeen Syed) section - that mentions his substack etc.

**Mar 19, 2022** - added "Ivermectin - regions offering over the counter (OTC)" section


**Mar 16, 2022** - added "Ivermectin and post-covid19 Anosmia/Fatigue reversal" section

**Mar 16, 2022** - added Ivermectin and post-vaccine hearing loss (in one ear) section

**Mar 6, 2022** - added Ivermectin and Vitiligo section

**Mar 6, 2022** - added Ivermectin and Scabies section

**Mar 6, 2022** - updated Ivermectin and Rosacea section

&nbsp;

**Mar 3, 2022** - added to pinned posts

&nbsp;

**Mar 1, 2022** - added Dr Darrell DeMello Twitter link and contact info to Early Treatment Doctors section

**Mar 1, 2022** - added Dr Syed Haider Twitter links

**Mar 1, 2022** - added Dr AK Chaurasia info


&nbsp;

**Feb 28, 2022** - added Alternatives to TNI-signatory Media Platforms section

&nbsp;

**Feb 20, 2022** - added Books section


&nbsp;


**Nov 23, 2021** - replaced www.reddit.com links by old.reddit.com links

The reddit quarantine on r/ivermectin has placed some roadblocks to easy viewing of content on r/ivermectin.  One is that the wiki is no longer easily visible.  And users not logged into reddit are asked to log in before viewing the sub-reddit.

However, if an old.reddit.com version of the url is used, then non-logged-in viewers don't have to log in - but just have to click on the "Continue" button.

**Dec 20, 2022** - one other restriction due to quarantine seems to be that if you tag (i.e. mention a user) in a comment - they don't seem to get a ntification about it.

https://old.reddit.com/r/ivermectin/comments/zqffvi/quarantine_disadvantages_you_cant_tag_users_they/


&nbsp;





### **Links to Wiki**


&nbsp;



To mention this wiki to others, use this mirror link:

**https://saidit.net/s/Ivermectin2/wiki/index**

The reddit link for this wiki is no longer visible (one of the negatives of being quarantined by reddit - see below).


&nbsp;


The direct link to this wiki on Reddit is:

https://old.reddit.com/r/ivermectin/wiki

or

https://old.reddit.com/r/ivermectin/about/wiki/index



&nbsp;



**NOTE:** after decision by reddit to quarantine r/ivermectin (under pressure from PowerMod attack), the wiki for r/ivermectin became inaccessible (even though it exists and is being updated).

For this reason, the mirror on saidit.net should be used when suggesting wiki to others.

Mirror of wiki on Saidit.net - s/Ivermectin2:

https://saidit.net/s/Ivermectin2/wiki/index


Historical note: a copy of the wiki was placed on the Saidit.net - s/Ivermectin forum initially - but since it may have been controversial for that forum (we are not top mods there, but secondary mods), it was removed from there, and placed in the s/Ivermectin2 forum (where we are top mods).




&nbsp;





### **Corrections and Feedback**


&nbsp;


Message the moderators for r/ivermectin on reddit.

If you are on Twitter, send a tweet to:

https://www.twitter.com/stereomatch2



&nbsp;



### **Instructions for Moderators**


&nbsp;


Historical note: the wiki was announced on r/ivermectin here:

https://old.reddit.com/r/ivermectin/comments/oh7xfw/added_a_wiki_for_rivermectin_for_organizing_the

Asked for viewer review of wiki content (July 27, 2021):

https://old.reddit.com/r/ivermectin/comments/oswmfb/factchecking_the_wiki_updated_the_wiki_still



&nbsp;



**Moderators:** this wiki was enabled for this sub-reddit using Mod Tools - Community Settings - change "Disabled" to "Mods only" for now - then Mod Tools - Community Appearance - Menu Links - Wiki - turn this On - now shows Wiki button at top.

**TODO:** search for TODO below for the areas still needing clarification.



&nbsp;



**Moderators and editors:** please keep multiple copies of your edits as text files on your computer/phone, since content here may be inadvertently deleted by another editor - so keep your own copies for later reconcilation/merging.



&nbsp;




* * *





## **History of pinned (stickied) posts on r/ivermectin**


&nbsp;


You can only have 2 stickied posts on reddit - so sometimes it is used to highlight Dr Tess Lawrie's GoFundMe page, but then switches to highlight some new podcast, and then switches back.


&nbsp;



https://old.reddit.com/r/ivermectin/comments/k4824u/where_to_find_the_results_of_ivermectin_trials/
**Where to find the results of ivermectin trials quickly and easily**
Posted by u/TrumpLyftAlle


https://old.reddit.com/r/ivermectin/comments/lk54ix
**Anybody know a doctor who I can get a prescription from in STL**
Posted by u/Jolly_Difficulty3617


https://old.reddit.com/r/ivermectin/comments/mg00ag
**Petition: Provide Access and Information on Ivermectin; Stop the COVID-19 Deaths Now**
Posted by u/Inner_G84


https://old.reddit.com/r/ivermectin/comments/mq1ima
**Help us get life-saving drug (ivermectin) approved for covid-19... Dr.Tess Lawrie & E-BMC GoFundMe**
Posted by u/Inner_G84


2021-05-14 (?):

https://old.reddit.com/r/ivermectin/comments/nbez5n
**Goa (India) residents mass administration of Ivermectin - Frequently Asked Questions**
Posted by u/stereomatch

Archive of above webpage:

https://archive.md/J8ybq



2021-05-31 (?):

https://old.reddit.com/r/ivermectin/comments/nofm87
**Indian Bar Association serves legal notice upon Dr. Soumya Swaminathan, the Chief Scientist, WHO**
Posted by u/Inner_G84

Archive of above webpage:

https://archive.md/htW4w


Also see:

Background on legal notice in Indian court against WHO Chief Scientist Dr. Soumya Swaminathan:

https://old.reddit.com/r/ivermectin/comments/nofm87/indian_bar_association_serves_legal_notice_upon/h00ej70

Archive of above webpage:

https://archive.is/GTjq9




2021-06-02:

https://old.reddit.com/r/ivermectin/comments/npyafw
**Dr. Pierre Kory LIVE NOW at the Dark Horse Podcast: COVID, Ivermectin, and the Crime of the Century: DarkHorse Podcast with Pierre Kory & Bret Weinstein**
Posted by u/giddyrobin


2021-06-07:

https://old.reddit.com/r/ivermectin/comments/nscleb/gavi_the_vaccine_alliance_is_paying_for_adwords
**Gavi, the Vaccine Alliance, is paying for AdWords against Ivermectin**
Posted by u/HeeeeeyNow

Archive of above webpage:

https://archive.ph/liXxi


2021-06-26:

https://old.reddit.com/r/ivermectin/comments/o67v62
**Joe Rogan Experience #1671 - Bret Weinstein & Dr. Pierre Kory**
Posted by u/AlrightyAlmighty


2021-07-09:

https://old.reddit.com/r/ivermectin/comments/ogij5u/another_fascinating_effect_of_ivermectin_faster/h4mcviv
**Announcing World Ivermectin Day!**
Posted by u/EbMCsquared


&nbsp;


2021-08-25:

https://old.reddit.com/r/ivermectin/comments/pb9h1s/time_to_tighten_comment_mod_rules/
**Time to tighten comment mod rules?**
Posted by u/akaariai


&nbsp;


2021-08-29:

https://old.reddit.com/r/ivermectin/comments/pdnodz/anatomy_of_a_powermod_hit_august_25_2021_5pm_est/
**Anatomy of a Powermod Hit (August 25, 2021 - 5pm EST) - Powermods at Reddit, Brigading, the revolving door at the FDA/NIH vs. on the ground clinicians/ICU specialists like the FLCCC - IVM use up 10-20x but poison center calls up 5x - why the hue and cry - is Merck's Molnupiravir approval imminent?**
Posted by u/stereomatch


&nbsp;


Archive of above webpage:

https://archive.ph/35blb



&nbsp;



NOTE: this story was featured in Forbes as Editor's Pick (though still had some inaccuracies):

https://www.forbes.com/sites/roberthart/2021/09/02/internet-vigilantes-are-fighting-ivermectin-misinformation-with-memes-and-explicit-horse-cartoons/
Internet Vigilantes Are Fighting Ivermectin Misinformation With Memes And Explicit Horse Cartoons
Sep 2, 2021


Archive:

https://archive.is/VdQur



&nbsp;


2021-08-31:

https://old.reddit.com/r/ivermectin/comments/pfa1lt/newsweek_has_4_articles_on_ivermectin_august_31/
Newsweek has 4 articles on Ivermectin (August 31, 2021) - if there was ever a sign that we are reaching a tipping point this is it
Posted by u/stereomatch


&nbsp;


2021-09-14:

https://old.reddit.com/r/ivermectin/comments/podm0e/international_covid_summit_2021_rome_italy/
International Covid Summit 2021 - Rome, Italy - ongoing 3 day event (Sept 12-14, 2021) - Dr Robert Malone, Dr George Fareed, Dr Bruce Patterson and others from FLCCC, AAPS, and independent researchers and physicians - Day 2 includes a presentation to Italian government officials



&nbsp;


2021-10-21:

https://old.reddit.com/r/ivermectin/comments/qca4ho/reddit_admins_require_that_we_limit_discussion_on/
Reddit admins require that we limit discussion on veterinary forms of ivermectin - this is also a good signal of further restrictions to come - so a good time to start posting new content to saidit forums



&nbsp;


Mar 3, 2022:

https://old.reddit.com/r/ivermectin/comments/t4x3w6/large_study_retrospectively_comparing_outcomes
Large study retrospectively comparing outcomes data for Remdesivir vs Ivermectin - finds Ivermectin had 1/3 the mortality vs those given Remdesivir, after propensity score matching (Feb 28, 2022)


&nbsp;


Mar 26, 2022:

https://old.reddit.com/r/ivermectin/comments/tnw90n/is_the_rivermectin_wiki_gone/
Is the r/ivermectin wiki gone?



&nbsp;


Apr 24, 2022:

https://old.reddit.com/r/ivermectin/comments/u90dje/survey_of_anosmia_treatments_ivm_or_other/
Survey of Anosmia treatments - IVM or other treatments - share your experiences reversing covid19 anosmia (taste/smell loss) esp. if reversal was immediately after treatment start (i.e. looks like treatment helped immediately) (April 21, 2022)

Archive of above webpage:

https://archive.ph/ZB9qV



&nbsp;



* * *




## **About r/Ivermectin and r/gettingIvermectin**


&nbsp;



### **Archives of r/Ivermectin**


&nbsp;


u/ivm_archive has archived the content in r/ivermectin:


&nbsp;


https://old.reddit.com/r/ivermectin/comments/n03x8m/a_complete_archive_of_this_community_including

A complete archive of this community. Including every single comment, post and link that has ever been posted here. Just in case this community ever disappears.

April 28, 2021


&nbsp;


**The entire archive can viewed online here: https://ivm.netlify.app.**

The download link to save the archive to your computer can be downloaded here: https://disk.yandex.com/d/hTXiAeObkoBNDw

If you decide to download the archive to your computer, here is how it works:

- Download the zip file.

- Double click on the zip file and extract it. If you don't extract it and just start clicking the files, it won't work.

- In the extracted folder (called Ivermectin) click on index.html.

- It should now open the archive in your browser. If it doesn't try right clicking on index.html and search for something along the lines of "Open With" and then select your browser.



&nbsp;



**Update: August 25, 2021**

https://old.reddit.com/r/ivermectin/comments/pbe9o5/updated_a_full_downloadable_archive_of_this

\[Updated\] A full downloadable archive of this subreddit, including every submission and comment ever posted.

August 25, 2021


&nbsp;


**Download zip file: https://www.swisstransfer.com/d/d496dbb1-36a2-4936-a5fd-d4e3473face9**

Here's how you can use the archive:

1. Download the zip file.

2. Double click on the zip file and **extract** it. If you don't extract it and just start clicking the files, it won't work.

3. In the extracted folder (called Ivermectin) click on the folder Index and then on ivermectin_date.html.

4. It should now open the archive in your browser. If it doesn't try right clicking on **ivermectin_date.html** and search for something along the lines of "Open With" and then select your internet browser.


&nbsp;


u/ivm_archive reports also:

>I will be providing a copy that is viewable online too, and different mirrors. Please give me an hour or so to update this post.
>
>For the nerds like me: there is also a database called ivermectin.db file in the archive, feel free to use it however you'd like.


&nbsp;




### **Archives of r/gettingIvermectin**


&nbsp;


u/ivm_archive has recovered the information in r/gettingIvermectin (which was removed by reddit, after reddit banned u/TrumpLyftAlles - another casualty of the Trusted News Initiative (TNI) impact on censorship rules at social media companies):

https://old.reddit.com/r/ivermectin/comments/n1zh13/hi_team_ivermectin_im_back_this_time_with_an

Hi team ivermectin! I'm back. This time with an archive of the blocked community "gettingIvermectin

April 30, 2021


&nbsp;


If the above link doesn't work, here is the direct link to the archive - from where it can be downloaded as a zip file:

**https://disk.yandex.com/d/Ff0u0mjyUJ5tkA**

It is also available online - viewable as a webpage at:

**https://ivm.netlify.app/gettingivermectin/**



&nbsp;



* * *




## **Alternative to Reddit - start posting on Saidit**


&nbsp;


### **Reddit quarantine**

Reddit has quarantined the r/ivermectin subreddit, which will lead to eventual ban:

https://old.reddit.com/r/ivermectin/comments/qca4ho/reddit_admins_require_that_we_limit_discussion_on/
Reddit admins require that we limit discussion on veterinary forms of ivermectin - this is also a good signal of further restrictions to come - so a good time to start posting new content to saidit forums

Start posting on Saidit: **https://saidit.net/s/Ivermectin2**

The wiki is already there at: **https://saidit.net/s/Ivermectin2/wiki/index**


&nbsp;


More information on Saidit.net:


**August 29, 2021:** In case we are banned from Reddit, the mods were invited by the top mod for the saidit subreddit s/Ivermectin to become moderators (which we accepted): https://saidit.net/s/Ivermectin

**September 26, 2021:** In order to house a copy of the Wiki (which contains controversial and opinionated material), we created a new subreddit s/Ivermectin2 (2 suggesting it is a successor forum): https://saidit.net/s/Ivermectin2 - a copy of the Wiki is now placed there as well at: https://saidit.net/s/Ivermectin2/wiki

NOTE: Saidit.net is a fork of the Reddit open source code, and the look and feel of the site is similar to the old Reddit.  Just some minor changes in the naming - for example s/subreddit is used instead of r/subreddit.




&nbsp;




### **Making a Saidit account**

Creating an account on saidit is easy - just go to the link below (use a desktop browser), choose a username and password (e-mail is optional) - fill in the captcha to verify you are human and click "Sign Up":

https://saidit.net/login

NOTE: e-mail is optional - useful for security or to recover an account in case forget password etc.

You can also create an account using the Saidit app on Android as well (see below).


&nbsp;


### **Saidit Android app**

The saidit app for Android is available on F-Droid (open source, reliable app):

https://github.com/libertysoft3/RedReader

Direct link to APK:

https://f-droid.org/packages/org.saiditnet.redreader/


&nbsp;


### **Saidit iOS app**

For iOS there is no app currently, but you can use a browser to do the same thing.



&nbsp;




* * *




## **Alternatives to Media Platforms (that are Trusted News Initiative (TNI) signatories)**


&nbsp;


Most of the big media and social media outlets are signatories to the Trusted News Initiative (TNI) - see elsewhere here for more information.

These platforms decide if content is diversionary - if in their view, it contributes to "vaccine hesitancy" - if so they feel it is justifiable to censor that information.

Oftentimes that judgement is made by fact-checking organizations who go overboard in censoring early treatments, questions about vaccine side-effects, and reports of rare vaccine-related events.

This deprives oxygen from ideas that would drive innovation and improvements in treatment strategies etc.


&nbsp;


For example, early treatment is seen by some fact-checkers as some fantasy.

This perpetuates the perception in the public and many doctors that there is no early treatment.

The reason for hostility - that if early treatment was acknowledged, it would lead to vaccine hesitancy.



&nbsp;


However, early treatment is complementary to vaccination - if vaccinated folks get a breakthrough infection, early treatment could save their lives.


&nbsp;


TNI-inspired censorship includes suppression of early treatment, questions about vaccine side effects, and questions about vaccine severe side effects.

This censorship has contributed to:

- the lack of awareness of early treatment

- lack of awareness of viral timeline

- lack of awareness of treatment strategies for severe cases, such as for long haulers - and especially for post-vax side effects



&nbsp;


Google search results routinely suppress content - that same content is more easily found on DuckDuckGo.com - which has less harsh filter.


&nbsp;


Are there any alternative platforms where such censorship is not happening?

Yes - but these are mostly smaller companies which were not signatories to TNI, and thus can offer censorship-free participation.

In an environment where users are banned or face censure on the mainstream platforms, these smaller companies see opportunity to grow and attract new users, by offering less censorship.



### **Reddit alternative**

- saidit.net (r/ivermectin wiki which is now not visible because of quarantine - is mirrored on saidit)

### **Twitter alternative**

- Gettr.com (Dr Robert Malone moved there when banned on Twitter)

### **YouTube alternatives**

- Bitchute.com (bitchute links can't be posted on Reddit from pre-covid19 times)

- Rumble.com (famously offered Joe Rogan to move off Spotify to Rumble for $100M)

- Odysee.com (this is an interesting new outlet - where automatic mirroring of YouTube videos to Odysee is one of the features) - Dr Bret Weinstein, FLCCC and Dr Been are also on Odysee.  Ivory Hecker is on Bitchute.

### **Medium alternative**

- Substack.com - FLCCC, and many others have blogs on Substack

### **Discord alternative**

- ??

### **Google alternative**

Google often censors results that fall awry of the TNI.

In such cases, use DuckDuckGo:

- duckduckgo.com

Another option may be:

- search.brave.com




&nbsp;



* * *



## **COVID-19 - Timeline of Events (Mika Turkia)**


&nbsp;


Mika Turkia has an excellent **timeline of events** related to Ivermectin and covid19.

New parts are added over time - these are the parts created so far:

Part 1: https://doi.org/10.13140/RG.2.2.13705.36966

Part 2: https://doi.org/10.13140/RG.2.2.16973.36326

Part 3: https://doi.org/10.13140/RG.2.2.23081.72805

Part 4: https://doi.org/10.13140/RG.2.2.26000.53767

Part 5: https://doi.org/10.13140/RG.2.2.35015.16807


More details are given below.



&nbsp;



**April 04, 2021:**

https://twitter.com/Covid19Crusher/status/1379899467504173056?s=19

>The Ivermectin Chronicles
>
>"A Timeline of Ivermectin-Related Events in the COVID-19 Pandemic"
>
>57 pages and growing...
>
>https://www.researchgate.net/publication/350610718_A_Timeline_of_Ivermectin-Related_Events_in_the_COVID-19_Pandemic_April_3_2021



&nbsp;


**Part 1:**

https://www.researchgate.net/publication/350610718_A_Timeline_of_Ivermectin-Related_Events_in_the_COVID-19_Pandemic_April_3_2021

A Timeline of Ivermectin-Related Events in the COVID-19 Pandemic [April 3, 2021]

April 2021

DOI:10.13140/RG.2.2.13705.36966

Project: COVID-19

Authors: Mika Turkia



&nbsp;



**Part 2:**

https://www.researchgate.net/publication/352853743_A_Continuation_of_a_Timeline_of_Ivermectin-Related_Events_in_the_COVID-19_Pandemic_June_30_2021

A Continuation of a Timeline of Ivermectin-Related Events in the COVID-19 Pandemic [June 30, 2021]

June 2021

DOI:10.13140/RG.2.2.16973.36326

Project: COVID-19

Mika Turkia



&nbsp;



**Part 3:**

https://www.researchgate.net/publication/354967795_Third_part_of_a_timeline_of_ivermectin-related_events_in_the_COVID-19_pandemic_September_30_2021

Third part of a timeline of ivermectin-related events in the COVID-19 pandemic [September 30, 2021]

September 2021

DOI:10.13140/RG.2.2.23081.72805

Project: COVID-19

Authors: Mika Turkia



&nbsp;


**EDIT: January 7, 2022:**

**Part 4:**

https://www.researchgate.net/publication/357469228_Fourth_parth_of_a_timeline_of_ivermectin-related_events_in_the_COVID-19_pandemic_December_31_2021

Fourth parth of a timeline of ivermectin-related events in the COVID-19 pandemic [December 31, 2021]

December 2021

DOI:10.13140/RG.2.2.26000.53767

Project: COVID-19

Authors:

Mika Turkia




&nbsp;



**EDIT: February 12, 2022:**

**Part 5:**

https://www.researchgate.net/publication/358248142_Fifth_part_of_a_timeline_of_ivermectin-related_events_in_the_COVID-19_pandemic_January_31_2022

Fifth part of a timeline of ivermectin-related events in the COVID-19 pandemic [January 31, 2022]

January 2022

DOI:10.13140/RG.2.2.35015.16807

Project: COVID-19

Authors: Mika Turkia





&nbsp;


* * *




## **Caution - Veterinary Ivermectin**


&nbsp;


We generally avoid discussing the veterinary version of Ivermectin.  However you can try some of these venues:


Discord channel created by u/foggynotion:

* https://discord.gg/bajet7GDfw

**EDIT: August 27, 2021** - u/foggynotion reports that his discord server has been removed as a consequence of the current crackdown on ivermectin on social media.  This happened coincidentally at the same time that supermods of reddit (those who moderate multiple sub-reddits) joined together to protest the existence of sub-reddits like r/NoNewNormal (which is seen as anti-mask and right-of-center) - and r/ivermectin (which they were perceiving as forum advocating horse dewormer).


&nbsp;


Dr Been's Discord server:

* https://discord.com/invite/bkmg3rk3sQ


&nbsp;


There are some websites also dedicated to sources of ivermectin - via prescription and internationally from places (it is also available over the counter in many countries):

https://www.getivermectin.com/


&nbsp;


Users should be cautioned about the **risks and cautions regarding use of veterinary ivermectin** - there is a risk of inadvertent overdosing - see these posts for warning and cautionary information:

https://old.reddit.com/r/ivermectin/comments/ocbmly/how_to_get_ivm_new_resource_page
How to get IVM - new resource page



&nbsp;



**2021-09-27:**

Another website examining dosing issues around veterinary ivermectin:

https://nonvenipacem.com/2021/02/04/ivermectin-whats-good-for-the-horse-is-good-for-the-handler/
Ivermectin… what’s good for the horse is good for the handler
February 4, 2021



&nbsp;


**2021-09-27:**

This webpage also examines measurement and dosing issues associated with veterinary ivermectin:

https://www.barnhardt.biz/ivermectin/

Some of the information needs to be updated to match the newer FLCCC recommendations for treatment (which are now higher than 0.2mg/kg bodyweight).

The webpage also talks about monthly dosing for prophylaxis - which may not be sufficient, as weekly dosing was recommended for a long time, and now more recently with Delta variant and increased virulence, a twice a week dosing is recommended to avoid breakthrough cases (prophylaxis).



&nbsp;



**2021-09-27:**

This video and webpage from 2014, explains some of the details regarding dosing - with fatty meal for 2.5x bioavailability for systemic use and on empty stomach if want for worms.  It also explains half-life, as well as the issues around use of veterinary ivermectin and understanding of dosing:

https://www.maximpulse.com/permethrin/ivermectin-calculating-a-dose.html
Calculating a dose of ivermectin for scabies

However the use of odd mathematics on this webpage is confusing:

>Take your weight in pounds, divide by 33 and that’s how many 3 mg ivermectin pills you get.

It would be much simpler to say 0.2mg/kg bodyweight weekly or twice a week for prophylaxis, and 0.4-0.6mg/kg bodyweight per day for treatment (once someone has shown symptoms i.e. is past day1 of symptoms).  This mg/kg dosing is how dosing is presented on the FLCCC protocols.


&nbsp;




* * *




## **Ivermectin - availability in various countries**


&nbsp;


If your pharmacy is not giving you Ivermectin - you can get it from a compounding pharmacy who are more cooperative (though may be more expensive).


&nbsp;


Finding early treatment doctors - getting prescription and medicines:

[https://saidit.net/s/Ivermectin2/wiki/index#wiki_early_treatment_and_long_haulers.2Fpost-vaccine_treatment_-_finding_doctors_and_obtaining_a_prescription](https://saidit.net/s/Ivermectin2/wiki/index#wiki_early_treatment_and_long_haulers.2Fpost-vaccine_treatment_-_finding_doctors_and_obtaining_a_prescription)



&nbsp;



Glenn Chan - LongHaulWiki section on getting Ivermectin in various countries of the world:

[https://www.longhaulwiki.com/index.php/Ivermectin#How_to_get_ivermectin](https://www.longhaulwiki.com/index.php/Ivermectin#How_to_get_ivermectin)



&nbsp;



* * *




## **Ivermectin - assessing the quality of tablets ordered online from other countries**


&nbsp;



Many people order direct from Indian online pharmacy websites like Indiamart dot com.

Many in the US and UK have reported ordering from such websites.

However there also have been reports from UK etc. that such orders are sometimes not delivered - as they are stopped by customs.

So the situation may vary - you will have to consult on online forums to gauge what the situation currently is regarding the practicality of online delivery of Ivermectin to your country.


&nbsp;


Do the Ivermectin drugs from India have the right dose?  Are they adulterated with filler material?

Adam Gaertner (a prominent and early Ivermectin researcher and proponent) has conducted a study of the tablets available online - and the overall conclusion was that most of the tablets being sold as Ivermectin are pretty good quality (i.e. sometimes the doses may be slightly less - but since there is a wide dosage range which is tolerable - such a small difference doesn't make much difference in practical terms).

So Ivermectin tablets imported from India are probably ok - especially since Ivermectin, as a generic drug, is not expensive (and given the media negativity against Ivermectin, there is not such a huge demand for Ivermectin as would have been otherwise).  So there is little incentive to cut corners on Ivermectin, when the real drug is available relatively cheaply in less developed countries of the world (where it is used more commonly as an anti-parasitic drug).




&nbsp;



* * *




## **Ivermectin - Guides, Methods of Action**


&nbsp;


### **FLCCC FAQ**

https://covid19criticalcare.com/ivermectin-in-covid-19/faq-on-ivermectin


&nbsp;



### **u/iResistDe4iAm guide to Ivermectin**

https://old.reddit.com/r/ivermectin/comments/oe8two/quick_guide_to_ivermectin_version_2
Quick Guide to Ivermectin (version 2)


&nbsp;


### **u/albenstein has a guide as well**

https://old.reddit.com/r/ivermectin/comments/oh7xfw/added_a_wiki_for_rivermectin_for_organizing_the/h53mrug

>Here is a google doc i use to organize links for myself. Maybe there is something useful in there for you.  
>
>https://docs.google.com/document/d/1UIPA1nIwZL6gEIywraAZVpWzHHirB7PGmWjlWnaJFIs/edit?usp=drivesdk


&nbsp;



### **Dr Been**

These two videos by Dr Been were **removed by YouTube** (the Trusted News Initiative (TNI) at work) - and are now available here:

- https://odysee.com/@DrMobeenSyed:1/Ivermectin:7 Ivermectin Mechanism of Action

- https://odysee.com/@DrMobeenSyed:1/Ivermectin-Dosage:7 Ivermectin Dose


&nbsp;

See:

https://old.reddit.com/r/ivermectin/comments/ohlti4/youtubegoogle_book_burning_during_pandemic_two
YouTube/Google book burning during pandemic - two more of Dr Been videos removed (July 10, 2021)



&nbsp;

Here is Dr Been announcing the removal of 2 videos by YouTube:


https://twitter.com/drbeen_medical/status/1413536962091184132?s=19

>Behold the work of modern era book burners - our ushers to dark ages. @YouTube censorship. 
>
>Two books burned!


https://twitter.com/drbeen_medical/status/1413567511795101696?s=19

>Yes. Moving to odysee and bitchute.



&nbsp;







### **Whiteboard Doctor**


&nbsp;


Whiteboard Doctor has covered many Ivermectin studies - like Dr Been, MedCram, Dr John Campbell, and others, he has had **his videos on Ivermectin demonetized** - the Trusted News Initiative (TNI) at work.


&nbsp;


Video:

https://www.youtube.com/watch?v=VlP3rIAw6rw
Ivermectin Binding SARS-CoV-2 Spike Protein In COVID-19: A Possible Mechanism Of Action?
Mar 24, 2021
Whiteboard Doctor


&nbsp;


also see:


&nbsp;


https://www.youtube.com/watch?v=9bgcgiutrw8&t=0s
Ivermectin And COVID-19: How Is It Proposed To Work? Review Of All Theorized Mechanisms Of Action.
Nov 2, 2020


&nbsp;


https://www.youtube.com/watch?v=cJHPMIRMjPY
Ivermectin, STAT3, And COVID-19: A Possible New Mechanism To Explain Efficacy Against SARS-CoV-2!
Oct 26, 2020



&nbsp;


### **Some other sources**


https://old.reddit.com/r/ivermectin/comments/l2rkvz
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents - study highlights why ivermectin may be effective vs COVID-19


&nbsp;


https://www.nature.com/articles/s42003-020-01577-x
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
20 January 2021



&nbsp;



* * *



## **Guidelines for Companies**


&nbsp;


### **Guidelines for Companies - risk management**


&nbsp;


Companies can take certain steps to reduce incidence of covid19 among their employees.

While social distancing, ensuring there is no stagnant air inside buildings and such measures are already being used, more direct, safe and cost-effect methods are available as well.

One direct step is relatively safe (short term use of Ivermectin), and cost-effective - the administration of Ivermectin to all close contacts of an index case.

If employees are tested regularly using rapid tests, or PCR tests, or even if employees are just monitored for symptoms like fever, bodyache, headache, minor cough, runny nose - their close contacts can be administered Ivermectin for 2-3 days to ensure covid19 is not spread beyond the index case.

Because in adults there is a 4-5 day gestation period before symptoms appear (day1 of symptoms - which coincides with live viral peak) - it is possible to identify all close contacts of an index case, and administer Ivermectin for 2 or 3 days in order to ensure all exposed personnel receive Ivermectin well before day1 of symptoms (before live viral peak).

One complication is the presence of asymptomatic covid19 cases who may be spreading the live virus, while being asymptomatic.

With increased intramuscular vaccination (which produces humoral immunity but not mucosal immunity in the respiratory airways), it becomes possible for vaccinated individuals to be infected in their respiratory airways and to spread live virus to others from their respiratory airways.



&nbsp;


### **Guidelines for Companies - Diabetes, Vitamin D3**


&nbsp;


Companies around the world that are worried about employee sickness due to covid19 or sickness in their families can consider some actions:

- ask employees that are diabetic to maintain their blood glucose levels - many employees may have stopped visiting their doctors and may have under-managed blood glucose levels.  Since out of control diabetes can affect outcomes negatively, restoring to normal levels will improve outcomes.

- have employees maintain a Vitamin D level above 30ng/mL (Vitamin D levels closer to 40ng/mL may be desirable for protective effect against covid19) - such a level is achievable if Vitamin D3 5000 IU is taken daily for an adult - test after 2-3 months if a level above 30ng/mL is achieved - reduce dosage slightly if needed



&nbsp;


### **Guidelines for Companies - Prevent Household Spread**


&nbsp;


You can also adopt more aggressive guidelines regarding treatment to ensure there are near zero deaths, and zero long haulers.  A single death in a family will impact employee health and productivity for months from an employer viewpoint.

The following guidelines may be more difficult as long as there is regulatory hostility towards Ivermectin specifically, and Early Treatment generally.

- if an employee or family member gets sick, all family members should start the weight-specific pre-exposure prophylaxis I-MASK+ FLCCC protocol (pregnant, breastfeeding and children under 15kg weight should avoid Ivermectin).  This will ensure that no one (beyond the index case) progresses to symptomatic disease, or if they do that it is mild.  The index case can be treated with the outpatient treatment in the I-MASK+ or MATH+ FLCCC treatment protocols.


&nbsp;


### **Guidelines for Companies - Critical Employees**


&nbsp;


For employees who are critical to the functioning of an organization, an even more aggressive prophylaxis approach can be adopted:

- have the crucial employees take Ivermectin weekly according to the pre-exposure prophylaxis FLCCC protocols - for both vaccinated and un-vaccinated employees

- this will ensure nearly zero employees have symptomatic disease

- the reason a weekly prophylaxis dose works is that Ivermectin has a half-life of 18 hours, which means it's levels in blood fall by half within 18 hours, and to a quarter in a further 18 hours.  Monthly doses reduce incidence, and every two weekly also reduces cases, but not perfectly.  Weekly dosing is effective because covid19 has a 5 day gestation period - from exposure to live viral peak (at day 1 of first symptoms).  This means **regardless of which day of the week you get exposed, during the gestation period the live virus will get exposed to an Ivermectin peak before viral peak, or very soon after.

- if exposures to virus are likely to happen over the weekend, then a weekly dose of Ivermectin every Sunday may be a good strategy

- if exposure to virus is likely to happen at the workplace (Monday to Friday), then a weekly dose of Ivermectin every Wednesday may be better.  It will arrest exposures that happened on Monday, Tuesday (which will have only had 2-3 days to grow), as well as Thurday and Friday (Ivermectin impact will still be strong for some days after dosing).

- additionally, for obvious exposure events, a critically important employee can take a one day additional dose of Ivermectin (in addition to the weekly doses of Ivermectin they are taking).  For example if they took a long airline flight, and feel they were exposed, or took a crowded bus or train, they can come home and take an additional Ivermectin dose that day, or within the next 2 days (well before the live viral load has had a time to peak in 5 days).


&nbsp;



* * *



## **Understanding COVID-19 Timelines - for physicians**


&nbsp;

NOTE: please consult the FLCCC MATH+ extended protocol document, and the earlier MATH+ versions from Dr Paul Marik for explanations of viral timeline


&nbsp;


The timeline of COVID-19 symptoms appearance, and deterioration follows a predictable pattern.

After exposure, it typically takes (gestation period) 4-5 days for first symptoms to appear ("day 1 of symptoms").

The live viral load peaks on day 1.

After exposure, the virus is replicating exponentially, and within 4-5 days achieves peak (at day1), and then starts going down.

By day 5-6, the live viral load is near zero in many people.

By day 8, for nearly all people the live viral load is near zero.


&nbsp;


**Viral timeline - a blind spot for regulators and in media coverage**


&nbsp;


This pattern was examined in the FLCCC MATH+ protocol old documents first, and were the only location where this information was discussed and disseminated.

For months after that regulators, and media have failed to highlight the pattern and timeline of infection.

This "confusion" has allowed for the rampant use of drugs like Remdesivir - under the guise that "the virus is still alive".  And that has been repeated all over the world, most recently around May 1, 2021.  During that wave there was a rush by patients, desperate appeals, and campaigns to increase the supply of Remdesivir.  Even state governments pledged to increase supply.  However, Remdesivir is not helpful esp. in late stages of the disease.  This has been known from the time the pre-print study was revealed.

The lack of understanding shown by regulators and the media (around day 8 and the likelihood that live virus is near zero) has continued to this day (July 2021) - however, in the last few months some officials have mentioned (usually in videoconference calls released to the public) that the virus is nearly zero by day 8.

The FLCCC has from very early in 2020 been showing that the live virus is deady by day 8 in most people.

This has been the reason they have argued that steroids CAN and should be used by day 8 if you want to stop the hyperinflammatory stage (post-day-8) from happening.

This is also why the FLCCC (Dr Pierre Kory) testified in front of the US Senate in 2020 that steroids should be used to save lives - this was at the time that NHS, CDC, WHO had all guided for non-use of steroids - bringing the use of steroids to a halt around the world (that doctors were already using according to their judgement).

It is unclear how many lives were lost due to this hiccup in the use of steroids.  For a time, the use of steroids became associated with bad behavior because of the pronouncements of the WHO.

It was only after the RECOVERY UK trial some time later, that NHS, CDC, WHO and then regulators around the world relaxed their guidelines around non-use of steroids.


&nbsp;


**Foundational work by FLCCC MATH+ protocol**


&nbsp;


From the early days of the disease, the FLCCC MATH+ protocol document has remained the pre-eminent document for understanding the timeline and the reasoning for that timeline.

I (u/stereomatch) have observed a number of covid19 cases, and have found the FLCCC timeline to be spot on.

Once exposed it takes 4-5 days for live virus to peak (this coincides with "day 1 of symptoms).


&nbsp;


**Understanding timeline for diagnosing day 1**


&nbsp;


This gestation period can be used to rationalize the timeline stories you collect from members of an infected household - it can sometimes allow you discover the actual day1 for a patient based on who and when he infected someone.

From the live virus graphs from Dr Michael Mina, it becomes clear that the live virus goes from what seems nearly zero to max peak from 4th day (after exposure) to the 5th day.

Probably a person is infectious at day 1 (and from one day before day1) - and remains infectious for some days after that, until the live viral load achieves near zero by day 5-6 in some and by day 8 in nearly all patients.

This is why after day 8, it becomes hard for a person to infect another.

For safety, quarantining may continue until day 10 or so or day 14, depending on the policy adopted.


&nbsp;


**Hyperinflammatory stage - post-day-8**

&nbsp;


While the virus expands after exposure within 4-5 days to achieve peak (day 1), and then starts going down (probably because ACE2 receptor targets on cells get exhausted and growth slows, and meanwhile the immune response catches up).

By day 8 it is near zero in nearly all patients.

However (as Dr Paul Marik explains in his appearances on Dr Been YouTube channel) the viral debris is huge - and this continues to trigger an immune reaction.

This hyperinflammatory reaction grows exponentially.

If it is not arrested early, it can get out of control - to the point where even steroids are unable to reign in the immune response.  As Dr Paul Marik explains at that point, plasma exchange (not to be confused with convalescent plasma) has been shown to help - as it removes the viral debris irritants.  Dr Paul Marik reported there have only a very few cases where plasma exchange was used.


&nbsp;


**Timing the steroids dose - day 1 and oximeter observations**


&nbsp;


For this reason, we can rougly split the timeline into a day1-7 stage (so-called "viral stage"), and a day8-onwards stage (hyperinflammatory stage).

While Ivermectin, Famotidine, Vitamin D, Vitamin C, NAC (N-acetyl cysteine) and other supplements can be given at any time, **it is the timing of the steroids which is the real crucial decision for anyone treating a covid19 patient.**

The timing of steroids depends on having a firm grasp on when "day 1" was.

This means interviewing the patient comprehensively to establish when they first had symptoms.

With earlier patients it was a very clear fever, or cough, or backache or bodyache.

But now with new variants, early symptoms can sometimes be very mild - that combined with imprecise recollections by patients (usually won't remember mild symptoms) - can lead to difficulty in ascertaining "day 1" for some patients.

This used to be a problem with earlier variants as well, but with newer variants this seems to have become a bit more common.


&nbsp;


**Newer variants with milder early symptoms - deciding day 1**


&nbsp;


It is possible that this change may be behind the perception among some Indian doctors on Twitter that the May 1, 2021 wave in India had patients becoming severe "within a few days".  There were suggestions that this was more common in vaccinated individuals, and that this behavior may be an outcome of ADE (antibody dependent enhancement).

ADE may be familiar because it happens with dengue, where a second infection by a variant leads to the earlier antibodies in a patients binding imprecisely in a non-neutralizing way to the variant dengue virus - and it can lead to a situation where the antibody fast-tracks the entry of the varient into the cell.

It is not clear if ADE was responsible for this perception.

But I (u/stereomatch) proposed that one possibility is that the new milder symptoms at day 1 may be missed by patients.

And I quote the example of a case I (u/stereomatch) observed, where a 74 year old diabetic (pre-covid19 blood sugar of 280), obese, patient was reported as having "had fever for 3 days".  Yet his oximeter was 90, pulse rate 98, and looked like a day 10 or a day 14 case.

On further query, it appeared he may have had earlier symptoms a week earlier, and then on matching "who infected whom" it became apparent that the patient was at day 14 from first symptoms - which matched his condition - he couldn't speak, couldn't get out of bed, oximeter would drop to mid-80s on going t o the bathroom or on effort.

This case may naively have been reported by patient's caregivers as day 3-4, if they are only seeing fever as a symptoms, and are ignoring the very mild cough he had 2 weeks ago.


&nbsp;


**Lacking day 1 precision - aiming for middle ground**


&nbsp;


Once day 1 is confidently ascertained, it becomes earlier to watch for oximeter declines (or pulse rate increases) around day 8.

In the absence of a clear handle on when day1 was, the treating physician has to balance his approximate estimate for day 8, with the observational oximeter/pulse changes - if there is a steady drop of oximeter below 97 (i.e. patient is not able to reach 97 even with breathing deeply), then this may be a sign that hyperinflammatory stage is starting.


&nbsp;


**Steroids timing - not too early, not too late**

&nbsp;


Steroids are used to reduce the rising inflammation starting with day7-8.

You cannot start steroids too early (while live virus is still dominant and is growing) - since suppressing the immune system with steroids will allow the live virus an advantage.

For this reason steroids are started, but not too much earlier than day 8.

And steroids are not delayed too much longer after day 8.  Otherwise the inflammation has had a chance to reach high levels (becomes harder to quell), and in the meantime has started to damage organs.

The oximeter declines visible at day7-8 onwards, are evidence of vascular changes - inflammation leading to leaky blood vessel walls, leading to leakage (and potentially spread any remaining small amounts of live virus to new virgin territory for infection and growth).

In addition the inflammatory damage to blood vessel walls (endothelial damage) can lead to clotting factors being released.

Other ways in which the virus can wind up coalescing RBCs (red blood cells) via CD147 receptor, can also lead to coagulation, hindering blood flow.


&nbsp;



* * *




## **What is Inflammation?**



&nbsp;


Inflammation as a regular part of machinery in the body - for repair and responses to infection etc.

But then if gets out of hand (as with covid19 post-day7-8) or when become never-ending (chronic or auto-immune disease - and in covid19 long haulers).

For a general discussion on inflammation with Dr Roger Seheult (MedCram on YouTube):


&nbsp;


https://youtu.be/63synatP-D4

The MAIN CAUSES Of Inflammation & How To REDUCE IT TODAY! - Roger Seheult

Dec 16, 2021



&nbsp;



* * *




## **PCR testing**



&nbsp;



### **PCR testing - understanding positive and negative results**


&nbsp;


PCR tests are a useful way of identifying whether parts of the virus are present in the test sample - usually taken with a nasal swab from nasal area.

PCR positive is thus reliable in terms of detection of viral debris (excepting rare case of contamination while testing).

If a PCR test is positive, it indicates that the virus has touched you at some point in the recent past.

However, a positive PCR test is NOT indicative of infectivity.

The reason is that the PCR test is not a test for presence of live virus alone - but it can also be triggered by the presence of viral debris.

This is relevant because the viral timeline for covid19 has the virus grow after exposure - within 4-5 days it leads to a live viral peak (usually day 1 of first symptoms as well) - after which the live viral load starts going down.  By day 5-6 it is near zero in many, and for nearly all patients it is near zero by day 8.

However there is a lot of viral debris - which continues to trigger the body's immune system.

By day 7-8, this hyperinflammatory response is becoming evident.

A PCR test can show positive results well beyond day 8 (when the live virus is near zero) - and can be PCR positive for a month or longer.

So while a PCR positive test does show that virus was there at some point, it is not diagnostic for infectivity.

That being said, there is probably a slighly higher probability someone is infective if they have tested PCR positive.


&nbsp;


A PCR negative test result is not diagnostic at all (except for some statistical or demographic sense).

The reason is that a lot of infective people can show up as PCR negative.

In fact a person can test PCR negative one day, then PCR positive the next, and PCR negative the next day, and so on.

By my (u/stereomatch) estimate testing active cases will lead to nearly half testing PCR negative (seen for a family - a mother and 3 daughters - who all had symptoms but half tested negative).

PCR negative is a dangerous thing as many patients and doctors who may otherwise have treated for covid19 can be lulled into being complacent, and assume it is "only pneumonia" (as happened with the husband of above family - he wound up in ICU).

Nowadays PCR lab results have a disclaimer that **PCR negative is not diagnostic**.


&nbsp;


Live viral persistence


After day 8 live virus is dead in most people.

However a large amount of viral debris is still present.

The PCR test can continue to be triggered by this viral debris for a month or more in some patients.

In some immuno-compromised patients, the live virus been found to persist for 100+ days (rare).

The live virus may also persist in some immuno-privileged sites in the body.

Live virus has also been found to reside in some parts of the gut in some patients.



&nbsp;





### **PCR testing - should one wait for PCR testing before starting Ivermectin for suspected covid19 case?**


&nbsp;


The current FLCCC suggestion is to start Ivermectin at the first signs of flu-like or symptoms that look like they could be covid19 - see reference below.

That is don't wait for test results.

The reason is that even if it is not covid19, the downside to taking ivermectin is minimal.  The downside of waiting a day for a PCR test, is time you are not going to get back.

In any case, if PCR test comes back negative, it is not diagnostic (as explained in the PCR section).  That is, you could have covid19, and it can still give a PCR negative test result.

Some people have wasted time this way thinking they have "pneumonia" just because their PCR test came back negative.  It later turned out to be covid19.

See this section in the wiki on PCR positive and PCR negative test results:

https://old.reddit.com/r/ivermectin/wiki/index#wiki_pcr_testing_-_understanding_positive_and_negative_results



&nbsp;


**References:**

https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/flccc-weekly-update%E2%80%948-11-21%E2%80%94dr.:1?
FLCCC WEEKLY UPDATE—8/11/21—Dr. Pierre Kory & Dr. Paul Marik on the Delta Variant & Protocol Changes

August 12th, 2021



&nbsp;



**at the 29:10 minute mark:**

https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/flccc-weekly-update%E2%80%948-11-21%E2%80%94dr.:1?r=A87JUB8GGGxTjvnFWiLEfU7fVGtj7LH5

due to safety of ivermectin

Totally reasonable to do treat then test

Rather than waiting for test


Time matters, early treatment is key



&nbsp;



**at the 30:05 minute mark:**

Dr Paul Marik

If you have flu like symptoms

Likelihood is it is covid19

If it is not have no downside to taking ivermectin






&nbsp;





### **PCR testing - for airline travel and at work**


&nbsp;


Fallibility of the PCR negative test

Despite it's unreliability as a screening tool (PCR negative does not guarantee you are not currently infective), a negative PCR test is often used for airline travel or by human resources departments - for lack of any other tool for testing.

While a negative PCR test does not GUARANTEE you are disease-free/non-infective, as a demographic tool it MAY have some efficacy.

That is, if you took out all the PCR positive people, the people you are left with (who are testing PCR negative) are more likely to have fewer actual non-infective people.

So you can use a PCR negative as a ROUGH screening tool.

But it will not guarantee that every infective person has been screened out.


&nbsp;


Fallibility of the PCR positive test

The PCR positive test result is more reliable (barring contamination during testing or processing).

However, it is only reliable in the sense that it will indicate that:

- either you have the disease currently

- or you had it sometime in the past month or two

Yet many human resource departments in companies use a PCR positive test to prevent the return of an employee to work.

Since the live virus is near zero by day 8 from first symptoms, after that there is little culturable live virus present.

That is, a person is USUALLY non-infective after day 8 from first symptoms.

Exceptions are those who are immune-compromised (were taking immuno-suppressants for an organ transplant or for some other disease).

And there can be occasion for viral persistence in immuno-privileged sites in the body.  Live virus has been found to persist in some parts of the gut as well in some people.

However the bulk of people are not infective much beyond day 8 from first symptoms.

Yet their PCR tests can continue to test positive due to viral debris.

These people will be excluded from returning to work by human resources departments - even though they are not actually infective.


&nbsp;


A far better way to screen may be to expect a robust recovery and 10 days (14 days for even more safety) or more having passed from day 1 of first symptoms.






&nbsp;




### **PCR testing - Dr Michael Mina (Harvard) comments on PCR testing**


&nbsp;

Michael Mina has been an advocate for testing for high viral load as a proxy for active infection - since testing for any low viral load is not diagnostic (since in some, while they may stop being infectious, the PCR test may continue to test positive for a month because of viral debris).

Dr Michael Mina is a strong advocate of rapid testing.

He argues that a rapid test does not have to be extremely sensitive - but that one which is only triggered by high viral loads may be a sufficient tool to screen for infectivity in individuals.

While it may not be an accurate tools for the individual - as there can be variation, he argues that on a demographic scale, it will on average (statistically) reduce the community spread of disease.

As someone testing positive on it in the morning, will know he has a very high viral load, and should not go to work.


**August 9, 2021:**

**Michael Mina (Harvard) graphs for live viral load**

Michael Mina's graphs for live viral load suggest that the bulk of the viral expansion occurs in the last day of the 4-5 day gestation period (which is expected for exponential growth).

For this reason, a person is expected to be infectious from one day before their "day1" and onwards - by day5-6 the live viral loads is very low:


&nbsp;


https://www.hsph.harvard.edu/news/features/coronavirus-covid-19-press-conference-with-michael-mina-01-22-21/

Coronavirus (COVID-19): Press Conference with Michael Mina, 01/22/21


>It’s really hard to appreciate, but if you put that on a linear scale, something that our minds can really understand, the peak viral titers on that same graph, if you put it on a linear scale, will be extremely narrow. It’s not this broad kind of curve like that. 95 percent of that curve is essentially really, really low viral load compared to the peak. 

>that PCR stays positive for a long time. So if you’re asymptomatic and you just happen to go get a PCR test through surveillance, it’s more likely than not that if it’s a very low viral load, very high CT value, that you probably already were infectious and you maybe don’t need to be isolated in your recent contacts yesterday.
>
>And this is one of the reasons I feel very strongly that we should not try to scale up PCR any more than we have, because when you try to scale PCR, you’re playing with fire. It’s an extremely easy technology to get wrong, it’s easy to get false negatives, it’s easy to get false positives. If used appropriately, and all the steps are put in place and designed and everyone’s following every rule perfectly, then the tests can be amazing and amazingly sensitive. But when you’re scaling up testing for one of the highest complexity tests, we could do, which is manual PCR, where if you drop one specimen that has already been amplified with PCR and it splashes, you could contaminate your entire lab because the PCR can detect one molecule and one specimen post amplification makes literally trillions of trillions of molecules. So if it crystallizes and goes airborne, not the virus, just the molecules, then all of a sudden you can get whole plates for a week that are false positive, you could misstep and lead to a lot of false negatives.




&nbsp;



* * *




## **Early Treatment**



&nbsp;



### **Early Treatment - ivermectin is one part of the wider need for Early Treatment**


&nbsp;


Better medicines may emerge later, and Ivermectin may or may not remain an issue.

However, Early Treatment and the widespread denial of Early Treatment is the actual crime of the century.

Despite a year of experience, there still is no official recognition of early treatment as a strategic necessity in order to reduce mortality to near zero, and long haulers to near zero.

US guidelines as of July 2021 still predominantly favor supportive care - giving Tylenol and waiting for patient to become hypoxic at home.  This is an unnecessary and cruel imposition.

The public has been conditioned to also not seek out early treatment - which creates a vicious cycle.  Once hypoxic, the patient will come to hospital out of desperation, however in the period prior to that, they feel they are doing the right thing by staying at home and not seeking help.

By telegraphing that there is no treatment available, regulators are criminally negligent for misdirecting public thinking away from mitigation strategies that are known to reduce mortality and incidence of long haulers syndrome.

While mortality is a low risk per individual, long haulers is a very palpable risk, because nearly 25-30 percent of covid19 patients (not receiving early treatment) experience long hauler syndrome.


&nbsp;



### **Early Treatment - denial of early treatment**


&nbsp;


Widespread denial of early treatment is contributing to unnecessary deaths and disability as long hauler syndrome seems to be affecting 25-30% of covid19 patients when they are given Paracetamol and sent home from hospital.

There is slow mobilization to address long haulers syndrome - the NIH has allocated funds for the study of long hauler syndrome.

However there still is no examination of Early Treatment - perhaps because it is seen as a "distraction" from vaccination strategy.  Reduction of threat of the disease (down to near zero mortality) may dissuade people away from vaccination.

Early Treatment (ivermectin + steroids at day 8, or anti-histamines + steroids by day 8 or such variants of early treatment) are capable of achieving near zero mortality, and zero long haulers.

Yet it is not universally recognized as an option by regulators, hospitals, and even by patients themselves.  The Trusted News Initiative (TNI) further cements the silence around this topic.

The **Denial of Early Treatment** by both the public and the hospitals, has led to a toxic situation:

- Hospitals turn away the mild cases of this week with just Paracetamol (a policy that was adopted due to early triage conditions) - these mild cases then become the severe cases of next week.  We are witnessing a case of triage protocols gone wrong.

- Patients have been made to believe there is nothing they can do to improve outcomes - they have been told to stay at home and wait for hypoxia to appear.  As a result, patients ignore advice from those who argue for early treatment - but when day 8 arrives, their hypoxia then forces them to seek oxygen.  As a result, an unnecessarily large portion of patients arrive at hospitals at day 10 or day 14 when it becomes much more difficult to save them.



&nbsp;




### **Early Treatment - understanding early treatment denial**



&nbsp;


A possible explanation for why early triage protocols at hospitals may have led to entrenchment of denial of early treatment:

https://old.reddit.com/r/ivermectin/comments/n0y2uj/the_concerned_citizens_guide_to_proselytizing_to/
The Concerned Citizen's guide to proselytizing to Early Treatment deniers

April 29, 2021



&nbsp;



An introduction to denial of treatment - in response to Dr Jordan Peterson's question about Ivermectin:

https://old.reddit.com/r/ivermectin/comments/no8jty/how_would_you_explain_the_psychological/
How would you explain the psychological denial-of-treatment phenomenon around Ivermectin?  Dr Jordan Peterson (renowned psychologist) would like to know!


&nbsp;


Ivory Hecker - whistleblower - formerly of Fox News - examines media censorship of Early Treatment she experienced when reporting on FLCCC affiliated hospital - with mortality of 6 percent compared to 18 percent at area hospitals.  She explains how mention of the treatments that accomplished that was forbidden at Fox News:

https://old.reddit.com/r/ivermectin/comments/o6su0t
Reporter/whistleblower Ivory Hecker covers censorship of Ivermectin use at Houston hospital


&nbsp;


Dr Bret Weinstein interviews Dr Pierre Kory of the FLCCC (authors of MATH+ protocol) - this podcast was removed from YouTube (the Trusted News Initiative (TNI) at work):

https://odysee.com/@BretWeinstein:f/COVID-Ivermectin-and-the-Crime-of-the-Century-DarkHorse-Podcast-with-Pierre-Kory-Bret-Weinstein:f
COVID, Ivermectin, and the Crime of the Century: DarkHorse Podcast with Pierre Kory & Bret Weinstein
Bret Weinstein
June 1, 2021

Transcript:

https://www.betterskeptics.com/transcript-covid-ivermectin-and-the-crime-of-the-century-darkhorse-podcast-with-pierre-kory-bret-weinstein/
Transcript: COVID, Ivermectin, and the Crime of the Century
July 14, 2021


&nbsp;


Bret Weinstein talks with Dr Robert Malone pioneer of mRNA vaccine technology, and Steven Kirsch entrepreneur and funder of trials for Fluvoxamine, another promising generic drug - this podcast was also removed by YouTube (the Trusted News Inititive (TNI) at work):

https://odysee.com/@BretWeinstein:f/how-to-save-the-world,-in-three-easy:0?t=3391
How to save the world, in three easy steps.
Bret Weinstein
June 10, 2021


&nbsp;


This shorter segment covers some of the denial of early treatment, ivermectin and other such issues:

https://odysee.com/@ivermort:4/Tucker-Carlson-Today---Bret-Weinstein---July-9,-2021:9
Tucker Carlson Today - Bret Weinstein - July 9, 2021
July 13th, 2021



&nbsp;



### **Early Treatment - is early treatment denial heartfelt or feigned?**


&nbsp;


**EDIT: November 13, 2021** - taken from: https://old.reddit.com/r/ivermectin/comments/qsup2b/comment/hkhi76h/

We don't know if all this **incredulity by skeptics of early treatment is real or feigned.**

But they have mired themselves so severely into an impossibility universe, that it will be a real internal reckoning for them to justify why they delayed early treatment and the attendant deaths.

That is, if their skepticism was heartfelt.


&nbsp;


If their **skepticism was feigned**, in service of an agenda, they will not do too badly, since plenty of camoflage available with all the other people they have convinced.

Fortunately for the feigned skeptics, they have **convinced so many people to be skeptics**, that skeptics of early treatment are a majority.

So nothing will happen to those who played a part in delaying early treatment, and the attendant deaths.


&nbsp;


Those skeptics who are feigning are also likely to speak in absolutes, to be brash, callous even.  As they have nothing to lose - **can't be more wrong than being party to a killing.**

No wonder they act not curious, but keep quiet about real world reporting by early treatment practitioners ("oh we only look at RCTs" is the refrain - and certainty of paper reports is what they are looking for - they don't need alerts from the battlefield).


&nbsp;


**Unrelenting shift**

But the tide is only going one way - the list of **early practitioners is growing.**

While the US is bedeviled by hijinks (medical license threats, removal of ability to prescribe MATH+ and denial of prescriptions by pharmacists), the rest of the world is not so constrained and **early treatment is the norm in all the unregulated countries.**

Recognition of early treatment is not ebbing but **growing.**

Not one, but **every early treatment practitioner**, is saying **early treatment is leading to near zero deaths**, and zero long haulers.

What were a few emerging early treatment physicians with their protocols, are now more numerous.


&nbsp;


**Public display of abuse-by-RCT**

All the shenanigans with the ivermectin RCTs (**Lopez-Medina**) - done right in front of a mainstream audience this time (since pandemic is everybody's business) - has made it completely plausible that a **similar fate may have befallen Dr Paul Marik's vitamin c-thiamine protocol for sepsis** (used often as a preamble to belittle him).

If Dr Paul Marik is SO right in what he has said about covid19 - **viral timeline, justification for steroids** (and has been pilloried at every stage for that) - could his sepsis protocol also have had similar authenticity?


&nbsp;



That sepsis protocol was shot down as standard industry practice with no outsiders looking.

This pandemic is different - all this is playing out with many interested viewers from outside the industry.

And it is not looking good - when industry insiders/authority figures lack common sense, common tools of science like curiosity are absent (zero interest in interviewing the early treatment doctors).

And zero interest in learning anything that distracts away from the research THEY currently are doing in their department.


&nbsp;


From the outside, all this is not looking so good - **more like turf wars than science, curiosity and exploration.**

The entrenched mores in pharmaceutical and medical industry look **less like science than high dogma.**




&nbsp;




### **Early Treatment - labelling of early treatments as "Right Wing"**


&nbsp;


Currently in the U.S., the standard of care for covid19 is **paracetamol, isolation, and to come to hospital only when hypoxic.** This means organ damage has already started before a patient feels he can get back to the hospital.

As a result patients often delay going - feeling they have to comply with hospital orders - and thus wind up going several days too late, when the hyperinflammatory post-day8 stage has taken it's toll, not only on their lungs, but also on other organs.  Often tachycardia due to pericarditis is present and ignored by the patient, because they feel they would be a burden going to the hospital with such a minor ailment.

The result is, not only are hospitals remiss in not treating early, they have convinced the patients that they too should not seek out help unless they are hypoxic.

The mild patient of this week is being turned back - to become the severe patient of next week.

Triage conditions may have allowed such practices to prevail earlier - though even then separate teams of volunteers should have handed out medicine packs in the car park.  Medicine packets could have included Ivermectin (or even HCQ) - but most importantly steroids like prednisolone at 30mg per day - to be taken on day7-8 from first symptoms, or if oximeter was not able to reach 97 persistently, or if pulse rate was elevated in 90s or 100+ at rest.  Patients should have been advised over phone to take steroids in that situation, and then report daily via phone.

Continuation of triage conditions at hospitals - and failure of govt agencies to institute parallel support for outpatients is burdening hospitals unnecessarily, and also failing to deliver treatment to outpatients in time.


&nbsp;


There are two major groups of doctors in the US which are lobbying for early treatment to become standard of care.

- FLCCC - which is generally leaning towards Democrats

- AAPS - which is right-leaning and generally pro-Trump

BOTH organizations say the same thing:

- **Ivermectin should be part of the multi-drug protocol for early treatment**

AAPS differs in that it also includes HCQ in the multi-drug protocol, while the FLCCC feels HCQ, while beneficial, is not beneficial enough, and is not included because more effective drugs are available - like Ivermectin.

Thus there is **little difference between left-leaning and right-leaning doctors** in the U.S. regarding the necessity for early treatment.


&nbsp;


**Trump was given Famotidine and HCQ - and Ivermectin?**


There has been an effort to politicize Ivermectin - in the same way that Hydroxychloroquine (HCQ) was during the Trump administration.

Thankfully, Trump did not mention Ivermectin.


This article, however, by journalist Michael Capuzzo suggests Trump got not only HCQ (as is usually reported), but **also Ivermectin** at Walter Reed Hospital:


https://covid19criticalcare.com/wp-content/uploads/2021/05/The-Drug-that-Cracked-Covid-by-Michael-Capuzzo.pdf
The Drug that Cracked Covid
Michael Capuzzo

>In  addition, Kory, Marik, et. al published the first comprehensive COVID-19 prevention and  early  treatment  protocol  (which  they  would  eventually  call  I-MASK).  It  is  centered  around  the  drug  Ivermectin,  which President Trump used at Walter Reed hospital,  unreported  by  the  press,  though  it  may  well  have  saved  the  president’s  life  while  he  was  instead  touting  new  big  pharma drugs.



&nbsp;



For HCQ, a campaign was launched which leveraged the hatred for Trump to turn off the anti-Trump voter from HCQ, and any possibility that it may just help a bit.


&nbsp;


Although some of the better studies from that time did suggest some benefit for HCQ - for example one NYU Langone study showed that HCQ was lowering IL-6, and had some benefit.

Recent studies - like this large Iranian study suggest HCQ has some benefit as well:

https://old.reddit.com/r/ivermectin/comments/njwm60/large_28759_patient_study_iran_suggests/
Large 28,759 patient study (Iran) suggests Hydroxychloroquine beneficial for early treatment - results match those seen in earlier smaller studies of HCQ - hospitalizations reduced by 38% and deaths by 73% (April 6, 2021) - how long before pundits stop using HCQ as argument against ivermectin?


&nbsp;


**A Right Wing Drug**

Whether HCQ has benefit, that pales in comparison to the benefit Ivermectin seems to be showing in the numerous trials.

And meta-analyses have been published showing a signal in favor of Ivermectin.

Yet, even though Trump is not around to use as a prop, there still is an ongoing effort to paint Ivermectin as a "Right Wing" drug.


&nbsp;


The Hill discusses Matt Taibbi's article on how Early Treatments for covid19 are labelled as "Right Wing" in order to make them distasteful to half the population.

This is ironic, since the effort to counter "fake news" was motivated by the evidence on Cambridge Analytica where politically divisive fault lines were exploited to divide people.

Yet the same Trusted News Initiative (TNI) is engaging in similar practices - labelling Early Treatment as a right wing effort - essentially **polarizing** public perceptions on Ivermectin along political lines.

The opponents of Early Treatment are doing **exactly the same thing** as Cambridge Analytica did - they are seeking to label Early Treatments as somehow antithetical to the left-of-center voters, and trying to gain followers for the anti-ivermectin view by proxy.


&nbsp;


https://old.reddit.com/r/ivermectin/comments/obslza
(The Hill) The Rising show converses with Journalist Matt Taibbi about unfounded censorship & Right-wing designation of Ivermectin


&nbsp;


Video:

https://www.youtube.com/watch?v=MJQBK1L9tu0
Matt Taibbi: Silicon Valley Makes Ivermectin ‘Right-Wing,’ Medical Community Held HOSTAGE By MSM
The Hill
Jul 1, 2021

>Journalist, Matt Taibbi, details his reporting on the controversy surrounding the Covid-19 treatment Ivermectin.


&nbsp;


The Hill article accompanying above video:

https://thehill.com/hilltv/rising/561153-matt-taibbi-reporting-on-potential-covid-19-treatments-like-ivermectin-shouldnt
Matt Taibbi: Reporting on potential COVID-19 treatments like ivermectin shouldn't be taken as an endorsement
July 01, 2021


&nbsp;


**Matt Taibbi article:**

https://old.reddit.com/r/ivermectin/comments/o8s3cs
(Matt Taibbi) Ivermectin: Can a Drug Be "Right-Wing"?


&nbsp;


https://taibbi.substack.com/p/ivermectin-can-a-drug-be-right-wing
Ivermectin: Can a Drug Be "Right-Wing"?
A potential Covid-19 treatment has become hostage to a larger global fight between populists and anti-populists
Matt Taibbi
June 26, 2021


&nbsp;


**When does social media censorship become State Censorship?**


&nbsp;


In this article Matt Taibbi argues that when **social media platforms censor while following governmental guidelines**, that may be equated with state censorship (which goes against the First Amendment of the US).

YouTube explicitly forbids (as of July 2021) any mention of Ivermectin or HCQ as possible treatments for covid19.


&nbsp;


Article:

https://taibbi.substack.com/p/a-case-of-intellectual-capture-on
If Private Platforms Use Government Guidelines to Police Content, is that State Censorship?
Matt Taibbi
Jul 3, 2021

>YouTube's decision to demonetize podcaster Bret Weinstein raises serious questions, both about the First Amendment and regulatory capture



&nbsp;




### **Early treatment - understanding Trusted News Initiative (TNI) and regulatory capture**


&nbsp;


The Trusted News Initiative (TNI) was launched to coordinate media censorship of "fake news" - but seems to have wound up censoring discussions about early treatment as well.

While this censorship by private companies is harder to prosecute, an argument under development is that if private companies are censoring according to some government guidelines, then it may fall awry of the First Amendment i.e. right to free speech in the US:

https://taibbi.substack.com/p/a-case-of-intellectual-capture-on
If Private Platforms Use Government Guidelines to Police Content, is that State Censorship?
Matt Taibbi
Jul 3, 2021

>YouTube's decision to demonetize podcaster Bret Weinstein raises serious questions, both about the First Amendment and regulatory capture



&nbsp;


Also see:

https://old.reddit.com/r/ivermectin/comments/obslza
(The Hill) The Rising show converses with Journalist Matt Taibbi about unfounded censorship & Right-wing designation of Ivermectin



&nbsp;


This comment has a summary of the video:

https://old.reddit.com/r/ivermectin/comments/obslza/the_hill_the_rising_show_converses_with/h3rw7uk

Archive of above webpage:

https://archive.ph/MjgPA


&nbsp;


Dr Edmund Fordham (BIRD Group UK) analysis of the early treatment denial syndrome plaguing most countries:

https://www.conservativewoman.co.uk/scandal-of-the-suppressed-case-for-ivermectin/
Scandal of the suppressed case for ivermectin
By Edmund Fordham
June 29, 2021



&nbsp;


* * *


&nbsp;





## **Early Treatment Protocols**



&nbsp;



### **Early Treatment Protocols - my simplified protocol for early treatment and preventing long haulers**


This is roughly the protocol I have used on 75+ cases - with zero long haulers.

With some who were on oxygen at home and quickly reversed.

As explained elsewhere - the lifesaver is steroids-at-day8 (Prednisolone) in sufficient quantity to show reversal of post-day8 hyperinflammatory signals.

Other standouts are that Ivermectin works very obviously (once you have seen enough cases) for:

- pre/post-exposure prophylaxis

- post-day8 residual anosmia/fatigue reversal


Famotidine is very effective in reducing symptoms during day1-7 period.

Cyproheptadine and Inhaled Budesonide is effective post-day8 for severe cases.

These are all on the FLCCC I-MASK+ outpatient/at-home and MATH+ for-hospitalized protocols.


&nbsp;


In this series of substack posts, I take the example of Queen Elizabeth to outline the treatment options available for a person of that age and susceptibility:


https://stereomatch.substack.com/p/queen-elizabeth-tests-positive-for?utm_source=url&s=w

Queen Elizabeth tests positive for covid19 - what early treatments will she be getting - will those be advertised to the public? (Feb 20, 2022)
Will it include Ivermectin, or at the very least steroids-at-day8 to avoid risk of death, and avoid risk of long haulers?

Feb 21, 2022


&nbsp;


Also covered here:

https://old.reddit.com/r/ivermectin/comments/sxcl34/queen_elizabeth_tests_positive_for_covid19_what/

Queen Elizabeth tests positive for covid19 - what early treatments will she be getting - will those be advertised to the public? (Feb 20, 2022) - will it include Ivermectin, or at the very least steroids-at-day8 to avoid risk of death, and avoid risk of long haulers?



&nbsp;



Update on preventing long haulers in the post-covid19 period - again using the case of Queen Elizabeth who had started showing some residual long hauler type symptoms in the post-covid19 period:


https://stereomatch.substack.com/p/update-to-queen-elizabeth-post-evidently

Update to Queen Elizabeth post - evidently she now has some mild long covid19 (which should not have had if treated correctly) (April 12, 2022)
Here are some suggestions for what she could be given in her current condition (post-covid19 residual fatigue)

Apr 12, 2022



&nbsp;



https://old.reddit.com/r/ivermectin/comments/u1u3rr/update_to_queen_elizabeth_post_evidently_she_now/

Update to Queen Elizabeth post - evidently she now has some mild long covid19 (which should not have had if treated correctly) (April 12, 2022) - here are some suggestions for what she could be given in her current condition (post-covid19 residual fatigue)

April 12, 2022




&nbsp;





### **FLCCC Prophylaxis and Treatment protocols (MATH+, I-MASK+, I-MASS, I-RECOVER)**


&nbsp;


Check out:

https://www.flccc.net

it takes you to:

https://covid19criticalcare.com


&nbsp;


Check out the I-MASK+ protocol for prophylaxis and early outpatient/home:
https://covid19criticalcare.com/covid-19-protocols/i-mask-plus-protocol/

I-MASS protocol for mass administration:
https://covid19criticalcare.com/covid-19-protocols/i-mass-protocol/

MATH+ hospital:
https://covid19criticalcare.com/covid-19-protocols/math-plus-protocol/

I-RECOVER long haulers:
https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/


&nbsp;


And the longer MATH+ extended PDF - which has more explanations (61 pages):

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf


&nbsp;


Also of interest is their webpage for optional medicines (Inhaled Budesonide, Nitazoxanide, Colchicine):

https://covid19criticalcare.com/covid-19-protocols/medical-evidence-and-optional-medicines/optional-medicines/



&nbsp;


**Original MATH+ protocol**

Earlier MATH+ protocol as it was published by Dr Paul Marik (now been updated by the protocols above) - but the original one had some good commentary - here dated Dec 27, 2020:

Summary PDF:

https://www.evms.edu/media/evms_public/departments/internal_medicine/Marik-Covid-Protocol-Summary.pdf

Extended PDF:

https://www.evms.edu/media/evms_public/departments/internal_medicine/Marik_Critical_Care_COVID-19_Protocol.pdf



&nbsp;


**EDIT: Jan 7, 2022** - here is a very early review of the MATH+ protocol (June 8, 2020) - provided here for historical purposes:

https://www.youtube.com/watch?v=zeUhYixexHk

MATH+ Treatment Protocol for COVID-19 Explained!

Jun 8, 2020

ICU Advantage

322K subscribers

>In this lesson we take a look at the MATH+ treatment protocol for COVID-19, put together by the Frontline COVID-19 Critical Care work group. This protocol was designed in a time when people were desperately looking for something to use to treat these patients, and this work group of critical care and emergency medicine clinical scholars combined the best available evidence and best practices in to a protocol to treat COVID-19.
>
>The most important take away with this protocol is that timing is imperative
>and that this is meant for early intervention.  The goal by utilizing this protocol and these medications aggressively is that we can prevent the 2 major complications of COVID-19; the hyper-inflammatory state, or cytokine storm, as well as the hyper coagulable state that we see in these patients. By doing this and doing this early, we can try to prevent ICU admission, ventilator usage, and ultimately save lives.
>
>The name MATH+ is an acronym for the medications. Methylprednisolone, Ascorbic Acid, Thiamine, low molecular weight Heparin, and PLUS additional options, such as zinc, vitamin D and other treatments the provide may determine. I go through each of these talking about why we use them as well as the recommended dosing.
>
>Finally we finishing up covering a few points that they make regarding hypoxemia in COVID patients.  Hopefully at the end of this lesson, you will have a much better understanding of what is involved in this treatment protocol, how to use it, and more importantly, why.
>
>0:00 Intro
>1:42 What is MATH+?
>5:46 The Protocol
>11:15 Hypoxemia
>13:20 Conclusion


&nbsp;


A few comments in the above video are interesting - for how some doctors agreed with the protocol and strategies:

https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgxKNuegEFxTAlImTdx4AaABAg

**Hannibal EnemyofRome**
1 year ago

>Have used this, plus Ivermectin since June. Clearly mortality is down. One key point vs Recovery decadron, is that you adjust the methylprednisolone to the patient and the CRP. You do not just plop them on decadron 6 mg daily. Have used as much as 125 mg every 6 hours. Thanks for doing this....it is largely considered witch doctoring and homeopathy in my State by organized medicine types. The politicizing of Medicine is the biggest CoVid tragedy. 


&nbsp;

https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgxKNuegEFxTAlImTdx4AaABAg.9GqfIDQ56lu9Gz6JlMN6dJ

**ICU Advantage**
1 year ago

>I couldn't agree more with the politicizing. It is sad. As for your dosing to CRP, how are you determining the dose/frequency? Sounds like you are also weighing other factors such as the patients presentation I imagine. 


&nbsp;


https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgxKNuegEFxTAlImTdx4AaABAg.9GqfIDQ56lu9GzKnCskD6I

**Hannibal EnemyofRome**
1 year ago (edited)

>@ICU Advantage  if they are at less than 4 lt/mn nasal cannula, I will often use decadron  6 mg orally. But sick patients, I bolus 80 mg Solumedrol and start 40 mg IV BiD. I follow CRP daily; if CRP and patient better, I can consider going down in steroid dose, but if either is worse, you go up. A common feature is that the CRP will fall, but the patient is needing more oxygen. Then you must increase steroids till the patients oxygen requirements also fall.  That is where I have used up to 125 mg every 6 hours. Use high flow up to FI02 of 60 %, but not beyond. That is the point to use your BiPAP machine in CPAP ( PEEP ) mode. Too many lungs have been fried by days of high flow or BiPAP above 70%! Have been experimenting with hyperoxia in some patients stuck at high oxygen levels, ( the home concentrators that can be used on discharge are maxed a 5 lt/ min flow ). I take them to a tight fitting mask with rebreather that can go to about 80% for four hours, then back to their previous oxygen. Their sats go from 88 to 98% on the mask and then back to 88% on their previous. Trying to use the relative hypoxia to engender Hypoxia Inducing Factor - 1 alpha and furins to transcribe more ACE 2 for their lungs and restore the RAAS system from inflammation and fibrosis to goodness and anti- inflammatory niceness.  Cheers! 


&nbsp;


https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgzQGOQ9Wod0_gr--qh4AaABAg

Dawood Azeemy
1 year ago

>Enjoyed this and helped a lot of my patients. Thank you



&nbsp;



https://www.youtube.com/watch?v=zeUhYixexHk&lc=UgzQGOQ9Wod0_gr--qh4AaABAg.9AP_E7L1nWS9RCx3xahark

Thom Zydervelt
4 months ago

>I find it fascinating that suddenly directly after big pharma “donates” 4.5 million dollars to Vietnam the highly profitable but ineffective Remdesivir suddenly appears. While ivermectin cheap, overwhelmingly shown to be effective, generic, readily available is never mentioned. A bit suspect? 



&nbsp;





### **Mika Turkia - review of FLCCC MATH+ protocol**


&nbsp;


Mika Turkia has also reviewed the FLCCC and MATH+ protocol in this report:

https://old.reddit.com/r/ivermectin/comments/kt7lg9
A brief review of FLCCC Alliance's MATH+ protocol and I-MASK+ ivermectin protocol


&nbsp;


Report:

https://www.cureus.com/articles/47669-the-history-of-methylprednisolone-ascorbic-acid-thiamine-and-heparin-protocol-and-i-mask-ivermectin-protocol-for-covid-19

TECHNICAL REPORT 

PEER-REVIEWED

The History of Methylprednisolone, Ascorbic Acid, Thiamine, and Heparin Protocol and I-MASK+ Ivermectin Protocol for COVID-19

Mika Turkia

Published: December 31, 2020 (see history)

DOI: 10.7759/cureus.12403


&nbsp;


Alternate links:

https://www.researchgate.net/publication/348077948_The_History_of_Methylprednisolone_Ascorbic_Acid_Thiamine_and_Heparin_Protocol_and_I-MASK_Ivermectin_Protocol_for_COVID-19

or

https://ssrn.com/abstract=3762097




&nbsp;





### **Dr George Fareed & Dr Brian Tyson - protocol**


&nbsp;


Dr George Fareed & Dr Brian Tyson (AAPS affiliated) have also reported great success with early treatment (reduced mortality, and lower incidence of long haulers syndrome).

https://www.thedesertreview.com/news/dr-george-fareed-and-dr-brian-tyson-share-early-treatment-protocol/article_7728815e-3ca2-11eb-8a08-7b4b0156c181.html
Dr. George Fareed and Dr. Brian Tyson share early treatment protocol
Dec 12, 2020
Updated Apr 16, 2021

Their protocol includes moderate amounts of Ivermectin, Hydroxychloroquine (HCQ) and other supplements.


&nbsp;


Dr George Fareed and Dr Brian Tyson protocol for Imperial Valley, California is covered in this news article:

https://www.thedesertreview.com/health/local-frontline-doctors-modify-covid-treatment-based-on-results/article_9cdded9e-962f-11eb-a59a-f3e1151e98c3.html

Local frontline doctors modify COVID treatment based on results

Apr 5, 2021



&nbsp;



### **Dr Dirk Koekemoer (South Africa) protocol**


&nbsp;


Dr Dirk Koekemoer (South Africa) - well written protocol that is similar to FLCCC, and includes elements of Dr Shankara Chetty protocol - ie includes H1/H2 blocker antihistamines.

And steroids at day 8 (just as in FLCCC protocol).

u/JosephTheManJohnson brought this protocol to our attention here:

https://old.reddit.com/r/ivermectin/comments/okj4jw
A 26 page continuously updated Google Docs document on Ivermectin


&nbsp;


Protocol:

https://docs.google.com/document/d/1aLWOUC7Z1VD60Fbm0rxvkOYl92LAEP0G6BSaNiDRD24/edit?fbclid=IwAR1vTQrVZkJNSRYbIscnFwCLy7xPY9W2NSPqiyDqV2SizENMTMvsHGCk8v4

Taking Ivermectin for COVID-19

Dr Dirk Koekemoer

MBChB (South Africa)

Last updated (26 June 2021)


&nbsp;


See my (u/stereomatch) review of it here:

https://old.reddit.com/r/ivermectin/comments/okj4jw/_/h58nzqc





&nbsp;



### **Dr Peter McCullough protocol**


&nbsp;


Dr Peter McCullough is one of the most published cardiologists in the U.S.

He has been active in early treatment and his group has published a paper on treatment strategies:


&nbsp;


https://rcm.imrpress.com/EN/10.31083/j.rcm.2020.04.264

**Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)**

Peter A. McCullough1,*, Paul E. Alexander2, Robin Armstrong3, Cristian Arvinte4, Alan F. Bain5, Richard P. Bartlett6, Robert L. Berkowitz7, Andrew C. Berry8, Thomas J. Borody9, Joseph H. Brewer10, Adam M. Brufsky11, Teryn Clarke12, Roland Derwand13, Alieta Eck14, John Eck14, Richard A. Eisner15, George C. Fareed16, Angelina Farella17, Silvia N. S. Fonseca18, Charles E. Geyer, Jr.19, Russell S. Gonnering20, Karladine E. Graves21, Kenneth B. V. Gross22, Sabine Hazan23, Kristin S. Held24, H. Thomas Hight25, Stella Immanuel26, Michael M. Jacobs27, Joseph A. Ladapo28, Lionel H. Lee29, John Littell30, Ivette Lozano31, Harpal S. Mangat32, Ben Marble33, John E. McKinnon34, Lee D. Merritt35, Jane M. Orient36, Ramin Oskoui37, Donald C. Pompan38, Brian C. Procter39, Chad Prodromos40, Juliana Cepelowicz Rajter41, Jean-Jacques Rajter41, C. Venkata S. Ram42, Salete S. Rios43 , Harvey A. Risch44, Michael J. A. Robb45, Molly Rutherford46, Martin Scholz47, Marilyn M. Singleton48, James A. Tumlin49, Brian M. Tyson50, Richard G. Urso51, Kelly Victory52, Elizabeth Lee Vliet53, Craig M. Wax54, Alexandre G. Wolkoff55, Vicki Wooll56, Vladimir Zelenko571Baylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, 75226, TX, USA

2 Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, L8S 4L8, Ontario, Canada

3 Armstrong Medical Group, Texas City, 75510, TX, USA

4 North Suburban Medical Center and Vibra Hospital, Thornton, 80229, Colorado, USA

5 Chicago Health and Wellness Alliance, Chicago, 60603, IL, USA

6 Recipient of the Texas HHS Meritorious Service Award, 78751, Texas, USA

7 PianoPsych, LLC, Natick, 01760, MA, USA

8 Division of Gastroenterology, Department of Medicine, Larkin Community Hospital, S. Miami, 33143, FL, USA

9 Centre for Digestive Diseases, Five Dock, 2046, NSW, Australia

10 Infectious Diseases, St. Luke's Hospital, Kansas City, 64111, MO, USA

11 University of Pittsburgh, Department of Medicine, Pittsburgh, 15213, PA, USA

12 Clarke Neurology, Newport Beach, 92660, CA, USA

13 Alexion Pharma Germany GmbH, 80687, Munich, Germany

14 Affordable Health, Inc., Piscataway, 08854, NJ, USA

15 Eisner Laser Center, Macon, 31210, GA, USA

16 Pioneers Medical Center, Brawley, 92227, CA, USA

17 Privia Medical Group, Webster, 24510, TX, USA

18 Hapvida HMO, Ribeirão Preto,14015-130, SP, Brazil

19 Houston Methodist Cancer Center, Houston, 77030, TX, USA

20 The Medical College Of Wisconsin, Milwaukee, 53226, WI, USA

21 Personal Healthcare Network, Kansas City, 64116, MO, USA

22 Fusion Clinical Multimedia, Inc., Philadelphia, 19019, PA, USA

23 Ventura Clinical Trials, PROGENABIOME, Malibu Specialty Center, Ventura, 93003, CA, USA

24 Stone Oak Ophthalmology, Immediate Past President, Association of American Physicians and Surgeons, San Antonio, 78258, TX , USA

25 Cardiosound, Atlanta, 30342, GA, USA

26 Rehoboth Medical Center, Houston, 77083, TX, USA

27 Complex Primary Care Medicine, Pensacola, 32507, FL, USA

28 University of California Los Angeles, Los Angeles, 90095, CA, USA

29 Emergency Medicine, Phoenix, 85016, AZ, USA

30 Family Medicine, Kissimmee, 34741, FL, USA

31 Lozano Medical Clinic, Dallas, 75218, TX, USA

32 Howard University College of Medicine, Mangat and Kaur, Inc., Germantown, 20876, MD, USA

33 President, MyFreeDoctor.com Pensacola Beach, 3256, FL, USA

34 Department of Medicine, Henry Ford Hospital, Wayne State University School of Medicine, Detroit, 48202, MI, USA

35 Orthopaedic and Spinal Surgery, Private Practice, Omaha, 68135, NE, USA

36 Internal Medicine, Executive Director, Association of American Physicians and Surgeons, Tucson, 85716, AZ, USA

37 Foxhall Cardiology, PC, Washington, 20016, DC, USA

38 Orthopedic Surgery, Salinas, 93907, CA, USA

39 McKinney Family Medicine, McKinney, 75070, TX, USA

40 Illinois Sports Medicine and Orthopaedic Center, Glenville, 60025, IL, USA

41 Pulmonary and Sleep Consultants, Ft. Lauderdale, 33316, FL, USA

42 MediCiti Medical College, 500005, Hyderabad, India

43 University of Brasília, Brasilia , 70910-900, DF, Brazil

44 Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, 06510, CT, USA

45 Robb Oto-Neurology Clinic, Phoenix, 85012, AZ, USA

46 Bluegrass Family Wellness, Crestwood, 40014, KY, USA

47 Heinrich Heine University, Düsseldorf, 40225, Germany

48 Past Pres. Association of American Physicians and Surgeons, Tucson, 85716, AZ, USA

49 NephroNet Clinical Trials Consortium, Buford, 30518, GA, USA

50 All Valley Urgent Care, El Centro, 92243, CA, USA

51 Houston Eye Associates, Houston, 77025, TX, USA

52 Victory Health, LLC., 80487, Colorado, USA

53 Vive Life Center, 85728, Arizona & Texas, USA

54 Family Medicine, Mullica Hill, 08062, NJ, USA

55 CMO Emergency Hapvida Saude, HMO, Fortaleza, 60140-061, CE, Brazil

56 National Healthcare Coalition, Family Medicine, Eagle, 83616, ID, USA

57 Affiliate Physician, Columbia University Irving Medical Center, New York City, 10032, NY, USA

30 December 2020


&nbsp;


Also available on the AAPS website:


https://aapsonline.org/stem-the-tide-of-covid-hospitalizations-deaths/

Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)

December 30, 2020


&nbsp;


**Their main points:**

- early treatment is essential

- early treatment is not being done currently in large hospitals (instead it is "wait at home until you turn hypoxic")

- multi-drug therapy is essential to cover all bases and reduce risk of breakthrough to severe disease


**Their multipronged therapeutic approach includes:**

- adjuvant nutraceuticals

- combination intracellular anti-infective therapy

- inhaled/oral corticosteroids

- antiplatelet agents/anticoagulants

- supportive care including supplemental oxygen, monitoring, and telemedicine

They emphasize that relying on RCTs (randomized clinical trials) do not provide the nuanced treatment protocols that doctors develop from practice:

- "Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed .."





&nbsp;



### **Steven Kirsch protocol**


&nbsp;


Steven Kirsch, a tech entrepreneur (inventor of the optical mouse), has spent his own money for trials for repurposed drugs (where the NIH has been notably absent - as they have been busy with big pharma drug candidates, and have neglected the old drugs with well established safety results).

He had funded a trial of Fluvoxamine - which has allowed it to be included in further trials.  It has yielded positive results in the TOGETHER trial as well.

Fluvoxamine is in the FLCCC I-MASK+ and MATH+ protocols as well.

Here Steven Kirsch discusses various early treatment options:


&nbsp;


https://www.quora.com/Is-there-any-cure-for-COVID-19/answer/Steve-Kirsch
Is there any cure for COVID-19?

Steve Kirsch, High tech serial entrepreneur based in Silicon Valley

April 16, 2021


&nbsp;


His website has a tutorial on early treatments, finding early treatment telemedicine doctors who will prescribe the necessary medicines (including ivermectin for prophylaxis), and for long haulers syndrome, and post-vax side-effects (see the section Post-Vaccine Inflammatory Syndrome PVIS):


https://www.skirsch.io/how-to-treat-covid

How to treat COVID, long-haul, and COVID vaccine side-effects

Steven Kirsch

4 MAY 2021





&nbsp;



### **AIMMS, New Delhi, India protocol**

&nbsp;


Recent AIIMS, New Delhi, India guidelines for at home treatment:

https://pbs.twimg.com/media/EzHEzagUYAQKHEu?format=jpg&name=900x900
AIIMS, New Delhi

INTERIM CLINICAL GUIDANCE FOR MANAGEMENT OF COVID-19 (Version 1.6)

7th April 2021


&nbsp;


https://medicaldialogues.in/news/coronavirus/aiims-releases-interim-clinic-guidance-for-management-of-covid-19-76799

AIIMS releases Interim Clinic Guidance for Management of COVID-19



&nbsp;


* * *




## **Early Treatment Deniers**


&nbsp;



&nbsp;


* * *




## **Early Treatment cases**


&nbsp;



* * *





## **Long Haulers Syndrome (long COVID-19)**

**Synonyms for long haulers:**

- long haulers

- long covid or long covid19

- post-acute sequelae of covid (PASC)

- post-acute covid-19 syndrome (PACS)

While SARS-CoV-2 virus infection is called COVID-19.

Long haulers syndrome refers to those who have evidently "recovered" from covid19 i.e. 2-3 weeks since day1 of first symptoms, and yet are still suffering from some symptoms.

Some of these symptoms can be due to continuing inflammation (usually recoverable with ivermectin, famotidine, short course of prednisolone (steroids), or other drugs).

And some of these symptoms can be due to organ damage (usually for cases who were in hospital or needed oxygen for a long time and had some lung damage.  These symptoms can take time to slowly recover from - for example if there is structural damage in the lung, it may take a longer time to recover.



&nbsp;




### **Long Haulers Treatment cases**



&nbsp;



### **Long Haulers Treatment protocols**



&nbsp;



### **Long Haulers Treatment Deniers**



&nbsp;



### **Long Haulers Treatments - React19 survey of treatments for long haulers and vaccine long haulers**


&nbsp;


**Results:** https://react19.org/treatment-outcomes/ 

or (newer results):

https://longhaulwiki.com/treatment-outcomes/


**EDIT: May 16, 2023** - react19 survey is now not being updated - but is being continued by Glenn Chan (@LongHaulWiki on Twitter)



&nbsp;



**Glenn Chan:**

React19 stopped publishing the survey of treatments - which Glenn Chan was involved with).

So now Glenn Chan has continued that effort with his LongHaulWiki website and treatment surveys.


&nbsp;


LongHaulWiki Treatment Survey (long haulers and post-vax):
https://longhaulwiki.com/treatment-outcomes/

Blog post - guide to treatment results:
https://forum.sickandabandoned.com/t/has-anybody-tried-heres-how-you-can-get-answers-to-that-question-fast/228

Video - guide to treatment results:
https://odysee.com/@LongHaulWiki:2/What-worked-for-those-who-recovered-Feb-2023:d

Presentation slides: https://longhaulwiki.com/resources/assets/What-worked-Feb-16-2023.pdf

Survey results data dump: https://longhaulwiki.com/treatment-outcomes/2022-11-26-living-survey-b.html


&nbsp;


Pharma access to treatment drugs:

https://odysee.com/@LongHaulWiki:2/Dallas-Buyers-Club:c
Dallas Buyers Club - How To Get Access To Healthcare
January 23, 2023

Presentation slides:
https://longhaulwiki.com/resources/assets/Dallas-Buyers-Club.pdf

ME/CFS forum thread on finding reliable online pharmacies: 
https://forums.phoenixrising.me/threads/tips-for-finding-reliable-and-trustworthy-prescription-free-online-pharmacies.8113/



&nbsp;


LongHaulWiki section on getting Ivermectin in various countries of the world:

https://www.longhaulwiki.com/index.php/Ivermectin#How_to_get_ivermectin





&nbsp;


Website:
https://www.LongHaulWiki.com

Blog posts and forum:
https://forum.sickandabandoned.com



&nbsp;



Reddit: https://www.reddit.com/u/glennchan

Twitter: https://www.twitter.com/LongHaulWiki

Twitter: https://www.twitter.com/glennchanWordpr

Twitter list - Chronic illness support - For people suffering from chronic illness:
https://twitter.com/i/lists/1623781364330889219

Related:

Twitter list - COVIDVax/Injured /Adv. - VACCINE INJURED- ADVOCATES - DR/MED PROFESSIONALS 
https://twitter.com/i/lists/1612610684868775937




&nbsp;


Glenn Chan is also the moderator of these sub-reddits:

https://www.reddit.com/r/VaxRecoveryGroup/

https://www.reddit.com/r/longcovidhaulers/




&nbsp;



**React19:**

Twitter: https://twitter.com/React19org

Facebook: https://www.facebook.com/react19org/

Instagram: https://www.instagram.com/react19org/


Website:

https://react19.org/

https://react19.org/symptoms-and-solutions/

https://react19.org/for-patients/

https://react19.org/stories/



&nbsp;


**References:**

https://old.reddit.com/r/vaccinelonghaulers/comments/wwzod0/the_react19_treatment_outcomes_survey_needs_your/
The React19 Treatment Outcomes survey needs your experiences with treatments, good or bad


&nbsp;


The survey takes 3-9 minutes and can be completed through this link:

https://docs.google.com/forms/d/e/1FAIpQLSdUdMgkWSUswVl7wQbltbVGLIE572IPYUl6vP18DlwQKIwKww/viewform?usp=pp_url&entry.1840324711=r/VaccineLongHaulers 


&nbsp;

Once you're done the survey, you can take a sneak peak at the results here:

https://react19.org/treatment-outcomes/ 

or (newer results):

https://longhaulwiki.com/treatment-outcomes/


&nbsp;


Results for other vax injury surveys from React19 and others can be found here: 

https://www.longhaulwiki.com/index.php/Vax_injury_research_surveys
Vax injury research surveys



&nbsp;

&nbsp;



Video:


NOTE: Glenn Chan (LongHaulWiki) has reported benefit using Ivermectin for his post-vaccination issues (neurological - twitching of fingers etc.).


https://odysee.com/@LongHaulWiki:2/data-driven-long-haul-treatment:9
A data-driven approach to Long COVID and COVID vaccine injury treatment (July 2022)
July 30th, 2022
Long Haul Wiki

Presentation slides are here:

https://longhaulwiki.com/resources/assets/Long-Haul-Treatment-2022-07-29.pdf

Please fill out the Treatment Outcomes survey if you haven't already:

https://forms.gle/ryc6gcJLpUmbjNZ77

Survey results are here (and are constantly being updated):

https://react19.org/treatment-outcomes/

COVID early treatment and prevention info:

https://www.longhaulwiki.com/index.php/COVID_prevention_and_treatment



&nbsp;



My (u/stereomatch) comments on the survey:

https://old.reddit.com/r/vaccinelonghaulers/comments/wwzod0/comment/ilunfd9/



&nbsp;





### **Long Haulers Treatments - LongCovidPharmD (organichemusic on Twitter) survey of treatments for long haulers**


&nbsp;



https://twitter.com/organichemusic/status/1566364020709462016?t=AMrhGtztxJeodBm-41PyvQ&s=19

LongCovid Prescription Survey RESULTS‼️

Lots of charts & data - don't miss anything:

1) comparison charts
2) individual drug pie charts 
3) Observations on data

Let's get started!



&nbsp;


Twitter: https://twitter.com/organichemusic (LongCovidPharmD)

Website: https://pharmd.substack.com



&nbsp;


My (u/stereomatch) comments on the survey (where I suggested that Ivermectin should also be included):

https://twitter.com/stereomatch2/status/1566529233207558145?t=6F18RbDNo6WpyFeJs94WHg&s=19

>IVM makes a reasonable showing in react19 survey
>
>But seems to be missing in @organichemusic -perhaps same peer-pressure in academia issue



&nbsp;


Here my (u/stereomatch) requrest for chart for Paxlovid:

https://twitter.com/stereomatch2/status/1570398248451424256?t=OXzN5chpGY4t8hhqAwE_cQ&s=19

>Do you have a similar chart for Paxlovid?




&nbsp;





### **Long Haulers Treatments - Nattokinase, Serrapeptase, Lumbrokinase**


&nbsp;

Keywords: Nattokinase, Serrapeptase, Lumbrokinase, fibrinolytics, micro-clots, amyloid, fibrin


&nbsp;


After other treatments have reached a plateau (FLCCC I-RECOVER protocol for long haulers and similar protocols - using Ivermectin, Famotidine, steroids, NAC and so on) - and the patient is not improving further - it is now clearer that that last bit of long haulers may be due to micro-clots and amyloid fibrils (and similar buildup of protein complexes).

While some have resorted to more complicated measures like HELP apheresis (Dr Resia Pretorius and others), those groups have also used triple anti-coagulant therapy.

And use of Nattokinase and similar drugs (fibrinolytics).


&nbsp;


Nattokinase has been used more - and thus has a stronger anecdotal base than Serrapeptase, Lumbrokinase etc.

Anecdotally in a good percentage of chronic long haulers, Nattokinase seems to help.

Although as with other drugs that nearly always help some (like Ivermectin, Famotidine) - there can be a plateau associated with this as well.


&nbsp;


However, more information has become available about Nattokinase dosing - and a recent study suggests that Nattokinase 8000-12000 FU seems to be effective - taking lower doses does not seem to give visible effects.


See this Twitter thread by @organichemusic (LongCovidPharmD) for explanation of the paper:


https://twitter.com/organichemusic/status/1572885502457704453

>NEW STUDY on NATTOKINASE!
>
>With further evidence of microclots in #LongCovid emerging, this NK study is timely.
>
>Typical NK dose is 2,000 FU qd, but is that high enough in Long Covid? And is NK safe w/ aspirin? Read ahead for answers, details and Q&A.
>
>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441630/



&nbsp;



Nattokinase seems to be promising (because it is one of the drugs - along with Ivermectin, Famotidine etc.which seems to help long haulers to some extent) - and will be in FLCCC protocols soon (is mentioned already)


&nbsp;


**FAQ by @organichemusic - Frequently Asked Questions**

For more on Nattokinase follow @organichemusic (LongCovidPharmD) on Twitter - or check out the FAQ website they have recently made:

https://twitter.com/organichemusic/status/1595184415717707776?t=heMPZhYMqwmLKjFJ3rhPsQ&s=19

>I get a lot of DMs inquiring about nattokinase dosing, brands, benefits, etc. Please check out my new FAQ section here for all your questions on nattokinase, lumbrokinase and serrapeptase!
>
>https://pharmd.substack.com/p/frequency-asked-questions-nattokinase?utm_source=twitter&sd=pf



&nbsp;





### **Long Haulers Treatments - Survey of Anosmia treatments - on Reddit**


&nbsp;


https://old.reddit.com/r/ivermectin/comments/u90dje/survey_of_anosmia_treatments_ivm_or_other/
Survey of Anosmia treatments - IVM or other treatments - share your experiences reversing covid19 anosmia (taste/smell loss) esp. if reversal was immediately after treatment start (i.e. looks like treatment helped immediately) (April 21, 2022)

Archive of above webpage:

https://archive.ph/ZB9qV




&nbsp;





### **Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs**


&nbsp;


NOTE: also see the section **Ivermectin and post-covid19 Anosmia/Fatigue reversal**


Post-covid19 anosmia is linked to inflammation of the area around or surrounding the olfactory bulb (and not necessarily the nerves or olfactory bulb itself).

Also see the section **Ivermectin and post-covid19 Anosmia reversal - Dr Been testimony**.



&nbsp;


The olfactory bulb is the area that covid19 can enter the brain - and the anosmia seems to be an outcome of the inflammatory efforts to block that passage.

In studies on brain MRI scans, there has been evidence of impact on brain - and is via the olfactory bulb:


&nbsp;



Generally post-covid19 anosmia seems to reverse without issue with Ivermectin.

And even in some anosmia cases that persisted 5 months or more, there has been near complete reversal of anosmia with Ivermectin.

Thus the clinical anecdotal evidence also suggests that for most post-covid19 anosmia cases that persist for long, there is likely to be near 100% reversal of anosmia.

Since the damage is to the lining and not the nerves/olfactory bulb itself.


&nbsp;



That is the sense in that Dr Been video on olfactory bulb - see the wiki:

[https://saidit.net/s/Ivermectin2/wiki/index#wiki_ivermectin_and_post-covid19_anosmia.2Ffatigue_reversal](https://saidit.net/s/Ivermectin2/wiki/index#wiki_ivermectin_and_post-covid19_anosmia.2Ffatigue_reversal)

However, the longer the anosmia, I (u/stereomatch) suspect the more refresher doses may be required.

And it is not clear if 99-100pct anosmia reversal is always possible for those with many months old post-covid19 anosmia - though anecdotally nearly everyone who takes Ivermectin is able to recover a large part of their taste/smell (anosmia reversal).

 
 
&nbsp;


https://www.youtube.com/watch?v=rgeP5lQiajc Brain Shrinking after Mild COVID (Oxford Study)

or

https://odysee.com/@DrMobeenSyed:1/brain-size-reduction-after-mild-covid:a Brain Size Reduction after Mild COVID (and Potential Solutions)

Mar 15, 2022

Drbeen Medical Lectures

 
 
&nbsp;



In this followup companion discussions video, Dr Been uses an anatomy program - and does a walkthrough showing brain anatomy and the location of the olfactory bulb:
 
 
https://www.youtube.com/watch?v=X6Nwj2-YVRs Discussion for Brain Shrinking After Mild COVID

or

https://odysee.com/@DrMobeenSyed:1/discussion-for-brain-size-reduction:0 Discussion for Brain Size Reduction After Mild COVID

Mar 15, 2022

Drbeen Medical Lectures

 
&nbsp;


So it could be argued that complete anosmia reversal is a good sign, or that early intervention using Ivermectin may avoid larger issues.




&nbsp;





### **Long haulers and vagus nerve inflammation**


Some long haulers suggest that Vagus Nerve inflammation may explain many of the typical long hauler symptoms.



&nbsp;



Vagus nerve inflammation as possible factor in long haulers symptoms like POTS:


https://www.reddit.com/r/covidlonghaulers/comments/ushr47/recovery_after_2_years_with_stellate_ganglion/
Recovery after 2 years with stellate ganglion block

Archive of above webpage:

https://archive.ph/012Nv




&nbsp;






* * *




## **Post-vax - pre-vaccine protocols for reducing vaccine injury**


&nbsp;



**Rationale for pre-vaccine protocols for reducing vaccine injury**

While risk of vaccine injury is low, it is not zero.

There are protocols which can be used to reduce that risk.

Most of these protocols are based on treatment protocols that have been effective in reversing post-vaccine injury/severe side effects either in 1-2 hours, or in severe cases within 3-4 days.

In order to be completely sure these protocols are preventing side effects, one would need to do a trial using a large number of vaccinated cases.

However, it can be reasonably assumed that what works for post-vax injury should also work in a protective way if used early enough (soon after vaccination, or just before).


&nbsp;


**The reality of mandated vaccinations in a post-Omicron vaccine-hesitant world**

Some folks are not comfortable with mRNA vaccines, have already gotten covid19, or feel they have already been exposed to Omicron by now (given it's high transmissability and ubiquity).

A person may already have gotten covid19 (which has superior immunity compared to vaccination according to some studies).

Or a person may be unvaccinated, but is reasonably sure they have been exposed to the ubiquitous and highly transmissable Omicron variant.

They may feel they have little to gain from an mRNA vaccination.

In addition, in a post-Omicron world, there may be less urgency overall for mandated vaccination.

However not all organizations have understood this.

As a result, some employees are stuck between a rock and a hard place - with their workplace-imposed mandated vaccination requirements at odds with their vaccine hesitancy.

Or they may have to travel, and some airline or some country is still requiring mandated vaccinations.


&nbsp;



**Protocol**

See:

https://old.reddit.com/r/ivermectin/comments/retnve/interested_in_a_discussion_on_taking_ivermectin/
Interested in a discussion on taking Ivermectin post vaccine

And the answer there by u/stereomatch:

https://old.reddit.com/r/ivermectin/comments/retnve/interested_in_a_discussion_on_taking_ivermectin/ho9t929

Archive of above webpage:

https://archive.ph/v54k5



&nbsp;




* * *



### **Post-vax - side-effects or injury and treatments**


&nbsp;


This is just a preliminary entry.

Discuss the following with your doctor:

See this case and my (u/stereomatch) comments there too - if you want you can contact the author of that post by replying there with a link to your post here so you don't have to retype.

They also reported benefit with the proposed treatment protocol:


https://old.reddit.com/r/ivermectin/comments/o5g09s
IVR After Pfizer Vaccine [Neurological Side Effects].


&nbsp;


Update:


https://old.reddit.com/r/ivermectin/comments/osx45y/ivermectin_pepcid_liposomal_glutathione_cured_me
Ivermectin + Pepcid + Liposomal Glutathione Cured Me. 90% Better After Vaccine Nerve Problems.




&nbsp;


Check out Dr Syed Haider (who has a lot of experience with Ivermectin + Fluvoxamine - and is current with FLCCC protocols and Dr Bruce Patterson/Dr Yo efforts for long haulers).

In this 2nd interview with Dr Been, he says he is now getting 2/3 cases who are long haulers, vaccine injury etc. and 1/3 covid19 patients.

You can get consultation with him as well if you want:

https://www.youtube.com/watch?v=Md-y01JdxvE

or

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid-2:8

Dr. Syed Haider Discusses COVID Management (July 2021)
Drbeen Medical Lectures
July 9, 2021



&nbsp;





### **Post-vax - treatment cases**


&nbsp;


* * *



### **Post-vax - treatment protocols**


&nbsp;


* * *



### **Post-vax - treatment deniers**




&nbsp;


* * *





## **Early Treatment and Long Haulers/Post-vaccine treatment - finding doctors and obtaining a prescription**



&nbsp;


* * *




## **Early Treatment Doctors**


The FLCCC dot net maintains a list of doctors that do early treatment.

However currently there are few doctors there for Canada and the UK.

Canada has even prosecuted doctors doing early treatment, and seems to have a toxic atmosphere for doctors.


&nbsp;


**Early treatment doctors lists**

FLCCC maintains a list of early treatment doctors - who will prescribe medicines for prophylaxis, treatment, long haulers, and post-vaccine side effects:

https://covid19criticalcare.com/i-mask-prophylaxis-treatment-protocol/how-to-get-ivermectin/
How to Get Ivermectin

Usually a doctor who is capable of prescribing for covid19 treatment, also will have built up the toolset for treating long haulers and post-vaccine side effects to some degree.


&nbsp;


May 13, 2022 - here is another FLCCC webpage with a list of covid19 care providers:

https://covid19criticalcare.com/ivermectin-in-covid-19/covid-19-care-providers/



&nbsp;


Here is another list of early treatment doctors:

https://www.exstnc.com/
Directory of Doctors Prescribing  
Effective Outpatient COVID-19 Therapy
Updated: 21 March 2021

Many of the doctors in this list are also in the FLCCC list above.


&nbsp;


**Jan 14, 2023:** Here is a crowd-sourced list of long covid19 (long haulers) doctors.  The public can add doctors they know of who they have found helpful for treatment of long haulers:

https://longcoviddoctors.org

Most of the additions are for the US, but by searching one can see many in the UK as well.



**Reference:**

https://www.reddit.com/r/LongCovid/comments/xytydp/website_for_long_covid_doctors/

Website for Long Covid doctors

ginger_turmeric

>Hi Everyone,
>
>I've made a website where you can add useful long covid doctors. Here's the link: https://longcoviddoctors.org/
>
>Please add any doctors that have helped you. Thanks! Also (if you can) I'd appreciate if you could share the link on social media to spread the word.



https://www.reddit.com/r/LongCovid/comments/xytydp/website_for_long_covid_doctors/irkiqqt

ginger_turmeric

>All the doctors here are submitted by long haulers (not me). I checked each doctor's website to make sure they are real/not a scammer, then I approved the submission. So we are relying on each long hauler's opinion here.



https://www.reddit.com/r/LongCovid/comments/xytydp/comment/irmcgia/

ginger_turmeric

>Most of the submissions have come from the US, but this website is for the whole world. Just I'm not getting many submissions from outside the US.



&nbsp;



### **Early Treatment situation in UK**


&nbsp;


The early treatment doctors lists above have very few or zero doctors listed from the UK.

Here are a few in the UK:


&nbsp;


**Dr Tina Peers** - is one early treatment doctor - who is active in treatment of long haulers (search this document for Dr Tina Peers).

But may be hard to get appointment with her - heard that from someone many months ago.

She co-authored the FLCCC I-RECOVER protocol for long haulers - along with Dr Mobeen Syed

https://www.twitter.com/DrTinaPeers


&nbsp;


**Jan 14, 2023:**

**Dr Dave Cartland** - has started telehealth services in the UK

Twitter: https://www.twitter.com/dr_cartland

Gettr: https://gettr.com/user/drcartland

YouTube channel: https://www.youtube.com/@drcartland2439

Remote telemedicine service: https://drcartland.com/


&nbsp;


**Dr Philip A McMillan** - has been active from the start on early treatment and has interviewed many of the prominent early treatment doctors on his YouTube channel - Vejon Health.

Twitter: https://www.twitter.com/philamillan

Substack 1: https://philipmcmillan.substack.com/

Substack 2: https://drphilipmcmillan.substack.com/

YouTube channel: https://www.youtube.com/@VejonHealth


&nbsp;


**Dr Claire Taylor** - is a doctor specializing in long covid19/long haulers - and is also active on Twitter.

Not as much early treatment aware maybe (and not experienced in Ivermectin) - but is specializing in micro-clots - and may be running a long haul clinic.

Twitter: https://twitter.com/drclairetaylor



&nbsp;




### **Early Treatment situation in Canada**


&nbsp;


The early treatment doctors lists above have very few or zero doctors listed from Canada.

**EDIT:** but now we can see one doctor listed at:

https://www.exstnc.com/

>CANADA
>
>**Dr. Umbrine Fatima** (Ontario only)
>
>+1 (716) 407-3250
>
>admin@myhealth360wellness.com
>
>myhealth360wellness.com
>
>Prophylaxis, Active, Long COVID (appointments only ... no walk ins)


&nbsp;


Dr Ira Bernstein based in Toronto, is an active early treatment campaigner who is active on Twitter (search this document for Dr Ira Bernstein).

But he may not be taking new patients.


&nbsp;



The early treatment situation in Canada is worse than in the US.

In the US there is a push to censure early treatment doctors with the American Medial Association (AMA) writing to state medical boards to penalize doctors, and to pharmacist associations to deny delivery of early treatment drugs.

However, there is also pushback by early treatment doctors and those in support of early treatment.


&nbsp;


In Canada the situation is much worse than the US - with the few who have tried to treat early having been debarred or censured.

Very few doctors in Canada are listed in the list of early treatment doctors.


&nbsp;


While one can get a consult with an early treatment doctor in the US or India, they will find it harder to get their prescription respected by a pharmacy in Canada.

It will be difficult to get a pharmacy in Canada to fill a prescription for Ivermectin.

However Ivermectin is not the only drug to use.

Far more important is the availability of steroids-at-day8 - which can be a lifesaver (to quell the post-day8 hyperinflammatory stage).

So even though a Canadian doctor may be afraid to prescribe Ivermectin (for fear of being debarred by his medical accreditation board), they should still be able to prescribe other drugs suggested by the FLCCC MATH+ protocol.

For example Famotidine, and steroids-at-day8 (Prednisolone) - or Cyproheptadine and Inhaled Budesonide (inhaled steroids) for serious patients post-day8.

So even if Ivermectin is not available, there are plenty of other non-controversial drugs that an early treatment doctor can use to ensure there are zero deaths and zero long haulers (notably the availability of steroids-at-day8 protocol).



&nbsp;



**Reference:**

https://old.reddit.com/r/ivermectin/comments/nkibab/someone_close_to_me_is_sick_with_covid_i_would/gzdc54x

https://old.reddit.com/r/ivermectin/comments/nmbuab/seriously_how_do_i_get_this_in_canada/



&nbsp;




### **Dr Been (Dr Mobeen Syed)**


Dr Been is a licensed doctor and engineer.

Dr Been is only licensed to practice in Pakistan.

Dr Been is an educator with a long list of important videos esp on the covid19 pandemic.

He has also interviewed a number of early treatment doctors about treatment strategies.

Dr Been has also contributed to the FLCCC I-RECOVER protocol for long haulers.

And has hosted some of the FLCCC conferences.

From: https://covid19criticalcare.com/drbeen/

>A medical doctor and software engineer, Dr. Mobeen Syed (known to his fans as Dr. Been) has been teaching medicine since 1994. He collaborated with the FLCCC Alliance to create the I-RECOVER protocol to treat long COVID.


&nbsp;


Dr Been's YouTube channel:

https://www.youtube.com/c/USMLEOnline
Drbeen Medical Lectures

Dr Been's newer YouTube channel - for discussion (created March 2022):

https://www.youtube.com/channel/UCKt2yqtcxJtqjJujr93yX4A
KoolBeens Cafe Live


&nbsp;


YouTube has been censoring some of his videos on Ivermectin.

YouTube is a signatory to the Trusted News Initiative (TNI).

Dr Been often has to use other names for the drug in his discussions:

- Loofymectin (Loofy is one of his cats)


&nbsp;


Dr Been now has a presence on Odysee:

https://odysee.com/@DrMobeenSyed:1


&nbsp;


And Bitchute as well.  There is a reddit-wide ban on bitchute links, but you can use a tinyurl or bit dot ly url shortener instead:

https://www dot bitchute dot com/channel/bbZOpTZkmPY0

or

https://tinyurl.com/v3x8yx53


&nbsp;


And on Rumble:

https://rumble.com/user/drmobeensyed


&nbsp;


Website:

https://www.drbeen.com


Twitter:

https://twitter.com/drbeen_medical


Dr Been's substack:

https://mobeensyedmd.substack.com


Dr Been on reddit:

https://www.reddit.com/u/mastcell



&nbsp;



&nbsp;



### **Dr Syed Haider**

&nbsp;


Dr Syed Haider is a pioneer in the use of Fluvoxamine (along with Ivermectin).

Dr Syed Haider has a lot of experience with Ivermectin + Fluvoxamine - and is current with FLCCC protocols and Dr Bruce Patterson/Dr Yo (IncellDx and covidlonghaulers.com) efforts for long haulers.


&nbsp;


In this 2nd interview with Dr Been (from July 9, 2021), he says he is now getting 2/3 cases who are long haulers, vaccine injury etc. and 1/3 covid19 patients.

You can get consultation with him as well if you want via his website (see below).


&nbsp;



In his 2nd interview with Dr Been, he said his website is free for signup, and the chat feature there is free for asking him questions:

https://www.youtube.com/watch?v=Md-y01JdxvE

or

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid-2:8

Dr. Syed Haider Discusses COVID Management (July 2021)
Drbeen Medical Lectures
July 9, 2021


&nbsp;


The above interviews are examples of how responsive doctors have been thinking about the management of covid19 disease, long haulers and post-vax side effects.

Compare this to how doctors at large US hospitals are following rigid hospital-mandated protocols (6mg dexamethasone + Remdesivir) - protocols which have remained unchanged for 1.5 years - despite the excessive mortality seen at these hospitals (when compared to hospitals which use FLCCC MATH+ protocol for example) - or as compared to the early treatment doctors (who have near zero deaths, and near zero long haulers).



&nbsp;


Here is his 1st appearance on Dr Been:

https://www.youtube.com/watch?v=v8-J1ES86os

or

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid:9

Dr. Syed Haider Discusses COVID Management
Drbeen Medical Lectures
May 2, 2021


&nbsp;


As one of the moderators of r/ivermectin I (u/stereomatch) had been hearing a lot of feedback on patient experiences with Dr Syed Haider.  In this post on r/ivermectin, I discussing the telemedicine doctors available that have been vetted by the FLCCC, as well as Dr Syed Haider:

https://old.reddit.com/r/ivermectin/comments/malbqw/telemedicine_doctors_dr_syed_haider_an/
Telemedicine doctors - Dr Syed Haider - an interesting telemedicine doctor and emerging resource for Ivermectin and Fluvoxamine


&nbsp;



Dr Syed Haider mentions in the video above that signup is free on his website - and he mentions that **asking questions via chat is free.**

Website: https://www.drsyedhaider.com

Dr Syed Haider lists these websites in his video descriptions:

https://mygotodoc.com - prepper antibiotics and med refills.

https://drsyedhaider.com - COVID protocols


&nbsp;


Twitter: https://twitter.com/DrSyedHaider (Twitter banned this account - reinstated after Elon Musk acquisition of Twitter)

Twitter: https://twitter.com/DrSyedHaider2 (however this account is not used that much)

Facebook: https://www.facebook.com/docsyedhaider

Facebook: https://www.facebook.com/syedhaidermd


**April 29, 2022** - Dr Syed Haider now has his own YouTube channel as well (mirrored to Odysee as well):

YouTube: https://www.youtube.com/channel/UCUTZ04QJ1OF24lfhGjof33A

Odysee: https://odysee.com/@drsyedhaider:e

Rumble: https://rumble.com/c/DrSyedHaider




&nbsp;



**2021-12-30**

Some users had reported that Dr Syed Haider is focusing more on delivering medicines ahead of time to the patient.

FLCCC also recommends having the protocol drugs available at home ahead of time because of the delays in getting drugs delivered to patients, pharmacies that are refusing to fill generic drugs for covid19 (like Ivermectin).  Thus having these medicines at home in the medicine cabinet ahead of time is preferred.



&nbsp;





### **Dr Miguel Antonatos (Text2MD.com)**


&nbsp;


Dr Miguel Antonatos is also one of the pioneers in the use of Ivermectin + Fluvoxamine:

https://www.youtube.com/watch?v=0G2nBJT_xUk
Dr. Antonatos Discusses COVID management
May 11, 2021
Drbeen Medical Lectures


He also has made a 2nd appearance on Dr Been:

https://youtu.be/gfskyH8pXlM
Dr. Antonatos Discusses COVID management (7/14/2021)
Drbeen Medical Lectures
July 14, 2021



&nbsp;


He is also listed on the early treatment doctor's list:

https://www.exstnc.com/

>Dr. Miguel Antonatos
>
>(855) 767-8559
>
>https://text2md.com
>
>(States: AL, AZ, CO, FL, GA, IA, ID, IL, KS, KY, MD, ME, MI, MN, MS, ND, NE, NJ, NV, NY, OK, SC, SD, TN, UT, VT, WA, WI, WV)



&nbsp;


Dr Miguel Antonatos also treats long haulers.

You may want to check out some of the comments for this Dr Been video - similar symptoms - neurological etc.

And the one comment below has mention of Dr Miguel Antonatos (Text2MD.com):



&nbsp;



https://youtu.be/rGCgc1mX4cg

Post COVID Long Haul Syndrome (PCLHS) Management
Drbeen Medical Lectures
Jun 17, 2021

Post COVID Long Haul Syndrome (PCLHS) Management Let’s discuss the first release of the post COVID long-haul syndrome management.


Comments:

>Lisa Tipton
>
>My husband and I have just completed the entire FLCCC I-recover protocol and happy to report all of our symptoms have resolved. We are patients of Dr. Antonatos/text2MD and we are happy he gave us this protocol even before it was published on the FLCCC site. We did take IVM + protocol during COVID but 2 months later found some of the symptoms returned after we resumed exercise, or a few had just not completely gone away. This protocol works!!!




&nbsp;




### **Dr Ben Marble (myfreedoctor.com)**


&nbsp;


**Aug 4, 2023:** Dr Ben Marble founded myfreedoctor.com - donation based and free telemedicine in 50 states of US.

Dr Ben Marble created the service myfreedoctor.com keeping in mind that there were a large number of patients in the US suffering from covid19 and allied conditions - who may not be able to afford early treatment.

So he adopted a donation model - those who could pay would pay, while those who could not would be able to get a free consult (though would still have to pay for the medicines).


Twitter: https://twitter.com/BenMarble_MD (suspended then reinstated)

Twitter: https://twitter.com/MarbleBenjamin (Account suspended)



&nbsp;



Dr Syed Haider interviews Dr Ben Marble of myfreedoctor.com:

https://www.youtube.com/watch?v=NU9nCGdZids

>This video has been removed for violating YouTube's Community Guidelines


&nbsp;


Mirror:

https://odysee.com/@drsyedhaider:e/dr-ben-marble-free-online-healthcare:3
DR BEN MARBLE: FREE ONLINE HEALTHCARE
Dr Syed Haider
June 20, 2022

at 5:30 minute mark:

250,000 patients treated - only lost 6 patients



&nbsp;



Covexit interview of Dr Ben Marble:

https://youtu.be/W-HFRuII6W4
Let's Talk Telemedicine with Dr. Ben Marble
Covexit News and Analysis
Jun 28, 2021



&nbsp;



Mirror:

https://rumble.com/vj42yd-interview-of-dr-ben-marble-from-myfreedoctor.com.html

Interview of Dr Ben Marble, from MyFreeDoctor.com
June 27, 2021

>With over 20,000 consultations, MyFreeDoctor.com has become a leading telemedicine service for the early treatment of COVID-19 in the USA. Learn about how this initiative came to birth, how it evolved, and what are the plans for Dr Marble has for further expanding the initiative, both nationally and internationally.



&nbsp;


Dr Ben Marble at the US Senate roundtable:

https://rumble.com/vth9i3-dr.-ben-marble-md-founder-of-myfreedoctor.com-has-99.99-survival-rate.html

Dr. Ben Marble MD, Founder of MyFreeDoctor.com, Has 99.99% Survival Rate
Jan 28, 2022



&nbsp;



**References:**


&nbsp;


u/Full_Food6568 has a walkthrough for getting a prescription from myfreedoctor.com (founded by Dr Ben Marble) - they ask for a donation from those who can pay, free for others:

https://old.reddit.com/r/ivermectin/comments/oihckh
IVM prescriptions from myfreedoctor.com (see captions for how to)


&nbsp;


u/botfantasies has another walkthrough for getting a doctor's consult and prescription for ivermectin from myfreedoctor.com:

https://old.reddit.com/r/ivermectin/comments/ojulud
CONFIRMED: FASTEST, CHEAPEST, SAFEST WAY TO GET IVERMECTIN IN THE USA




&nbsp;





### **Dr Mollie James (Telemedicine - US)**


&nbsp;


Dr Mollie James is familiar with the FLCCC protocols and was one of the panel members on stage at the Global Covid Summit.


Twitter: https://twitter.com/molsjames/

Website:

https://www.ivermectincan.com

https://www.ivermectincan.com/about

**adding Jan 7, 2023:** https://www.jamesclinic.com/about


&nbsp;


**References:**

https://twitter.com/molsjames/status/1612089014802169856

**Dr Mollie James**

>Here’s how to:
>
>Become a patient:  http://jamesclinic.com
>
>or 636-751-9440
>
>Request speaking: hello@jamesclinic.com
>
>Follow more:
>
>IG: @molsjames @james_clinic
> 
>Facebook: same
>
>Listen:  http://realtalk933.com or thru app @RealTalk933FM - T-Th-Fri 9-11 central


&nbsp;


**adding Sept 9, 2023:** Twitter thread on Dr Mollie James' podcast:

https://twitter.com/molsjames/status/1699030308681658464

>Todays the day!
>
>My podcast drops!  Episodes linked below:




&nbsp;



### **Dr Mary Talley Bowden (Florida, US)**


&nbsp;


For Florida residents, Dr Mary Talley Bowden offers monoclonal antibody treatments and early treatment protocols (is familiar with FLCCC).


Twitter:

https://twitter.com/MdBreathe

Dr Mary Talley Bowden


Dr. Bowden’s practice Breathe MD is here - website:

https://breathemd.org/



&nbsp;




### **Dr Darrell DeMello (Mumbai, India)**


&nbsp;


Mumbai based Dr Darrell DeMello favors use of Colchicine (which has not done so well in studies - but perhaps they are using it incorrectly).

Currently has incorporated Ivermectin - but still used Colchicine (anti-oxidant/anti-inflammatory) and steroids.

https://old.reddit.com/r/ivermectin/comments/nri2mz/dr_darrell_demello_discusses_covid_outpatient
Dr. Darrell DeMello Discusses COVID Outpatient (June 3, 2021) - Dr DeMello shares his experiences treating in Mumbai, India with Dr Been


Colchicine is used for pericarditis - it's use for covid19 may prevent the heart rate issues that are common in long haulers.


Twitter: https://twitter.com/DarrellMello

>COVID Telemedicine.  Treated over 10,000 cases of Acute Covid Infection successfully. Treat Post/Long COVID.  Vaccine Prophylaxis.
>
>Mumbai
>
>**Call/WhatsApp: +918097249586**
>
>**Website: https://www.darrelldemello.in/**

Dr Darrell DeMello offers telemedicine services in India and in some countries outside India as well - possibly the UK (?)

For the US - although he may be able to consult in the US, if he is not registered to practice there, his prescription may not be filled by a pharmacist.

He also offers consultation to corporations:

https://www.darrelldemello.in/faq


&nbsp;


### **Dr AK Chaurasia (UP, India)**

Dr AK Chaurasia (Anil Kumar Chaurasia) is located in Uttar Pradesh, India.

He is well regarded among early treatment-aware users on Twitter for his insights into covid19 treatment.

He is quite accessible, and answers questions, and may be contacted for consultations as well:

Twitter: https://twitter.com/drakchaurasia



&nbsp;



### **Dr Shankara Chetty (South Africa)**


&nbsp;


Dr Shankara Chetty has had to work without access to Ivermectin (South Africa initially jailed doctors for prescribing Ivermectin - has now relented in the face of legal action by doctors).

https://old.reddit.com/r/ivermectin/comments/o6kw7t/covid_management_with_dr_shankara_chetty_june_23
COVID Management With Dr. Shankara Chetty (June 23, 2021) - Dr Been interviews Dr Chetty from South Africa who has been treating covid19 with an H1/H2 anti-histamine protocol (and steroids at day 8 - similar to MATH+ protocol)


&nbsp;


He has crafted a protocol that uses H1/H2 blocker anti-histamines initially - and then steroids at day 8 (similar to FLCCC protocol).

Now he argues that using anti-histamines usually shows recovery within 4 hours.

If patient is not showing recovery within 4 hours, he sees that as a sign that this is post-day-8 hyperinflammatory stage which will require steroids.

And then he treats them aggressively with steroids.

Essentially he is treating with steroids by day 8 - however since with newer variants it can be difficult to pinpoint day 1 (because of mild initial symptoms) - one needs to be independently assessing patient state for day 8 hyperinflammatory stage.  Declines in oximeter settings is another.



&nbsp;


### **Dr Ira Bernstein (Canada)**


&nbsp;


Dr Ira Bernstein is an active early treatment campaigner who is also active on Twitter in support of early treatment strategies for covid19.

Twitter: https://twitter.com/search?q=ira%20bernstein

Website: https://doctorirabernstein.ourmd.ca/our-team


Dr Ira Bernstein in based in Toronto.

However does not take many new patients last we heard (from comments on reddit from some time ago).




&nbsp;




### **Dr Tina Peers (UK)**


&nbsp;


UK based doctor specializing in Mast Cell Activation Syndrome (MCAS).

Active in treatment of long haulers - which may also have MCAS involvement.

Treatment includes H1/H2 blocker antihistamines.


Twitter: https://twitter.com/DrTinaPeers

Website: https://www.drtinapeers.com/

See also:

https://www.drtinapeers.com/mcas

https://www.drtinapeers.com/histamine-intolerance


&nbsp;



See Dr Been interview of Dr Tina Peers:

https://www.youtube.com/watch?v=NOkUDh3vHVU
Dr. Tina Peers from UK Discusses the Management of Long Haul Syndrome
Drbeen Medical Lectures
May 21, 2021

Dr Tina Peers has also contributed along with Dr Been on the FLCCC I-RECOVER protocol for long haulers (search for I-RECOVER in this document).



&nbsp;


Dr Been interviewed her here:

https://www.youtube.com/watch?v=NOkUDh3vHVU
Dr. Tina Peers from UK Discusses the Management of Long Haul Syndrome
May 21, 2021
Drbeen Medical Lectures


&nbsp;


Dr Been has a related video on dietary impact on MCAS:

https://youtu.be/KvFsUS4XcHQ
Low Histamine diets for MCAS and long COVID patients
May 22, 2021
Drbeen Medical Lectures



&nbsp;


Dr Been and Dr Tina Peers have contributed to the FLCCC's I-RECOVER long hauler protocol.

H1/H2 blocker antihistamines are now part of the FLCCC I-RECOVER protocol.



&nbsp;




### **Dr Steven Phillips (author of bestseller 'Chronic')**


&nbsp;


Dr Steven Phillips is the bestselling author of "Chronic" and has been interviewed by Dr Been many times:

https://www.youtube.com/watch?v=xwMwR6IJC3o
Chronic Diseases Talk with Dr. Steven Phillips (Lyme, COVID Long Haul and More)
March 19, 2021
Drbeen Medical Lectures


&nbsp;


He has some interesting insights into Lyme disease, Multiple Sclerosis.

And auto-immune disease, dementia and chronic pain.

And is aware of Ivermectin use for nerve remyelination in Multiple Sclerosis (see the section **Ivermectin for Multiple Sclerosis (MS), Lyme disease and for nerve remyelination**).

He has expertise in covid19 treatment, long haulers (long covid19) as well.


&nbsp;


Twitter: https://twitter.com/StevePhillipsMD

Substack: https://zerospin.substack.com

Website: https://stevenphillipsmd.com/

Consult: https://stevenphillipsmd.com/our-practice/



&nbsp;



Dr Steven Phillips substack article on Ivermectin - anti-cancer, nerve remyelination potential, and use against chronic viral infections:

https://zerospin.substack.com/p/ivermectin-upon-neutral-ground
Ivermectin--Upon Neutral Ground
The truth will set you free. But first it will piss you off.
Mar 1, 2022



&nbsp;







### **Dr Pierre Kory (President - FLCCC)**


&nbsp;



Dr Pierre Kory is one of the founding members of the FLCCC, and has been very active in his advocacy for early treatment protocols.

He is well known for his testimony at the US Senate, first in favor of steroids-at-day8 (at a time when WHO/NIH/CDC had campaigned to dissuade doctors from using it), and then for Ivermectin for prophylaxis and treatment.

Prior to his advocacy for early treatment, Dr Pierre Kory was an Associate Professor and Medical Director of the Trauma and Life Support Center, and Chief of the Critical Care Service at the University of Wisconsin, in the US.


&nbsp;


**Advocacy for early treatment cost jobs**

Dr Pierre Kory recounts how his advocacy for early treatment landed him in hot water at his job:

https://pierrekory.substack.com/p/how-i-lost-three-icu-jobs-during?r=iutjw&utm_campaign=post&utm_medium=web

How I Lost Three ICU Jobs During the COVID-19 Pandemic - Job 1

Prior to COVID, I was a nationally known expert in Pulmonary & Critical Care Medicine. Despite the massive need for specialists like me across the US, I had to leave 3 different US medical centers.


Pierre Kory, MD, MPA

January 19, 2022



&nbsp;



Dr Pierre Kory's substack blog:

https://pierrekory.substack.com/


&nbsp;


Dr Pierre Kory now has a website (April 2022) - for telemedicine appointments for covid19, long haulers (long covid19), and post-vax injury for most states in the US:

https://drpierrekory.com/

https://drpierrekory.com/contact/


&nbsp;


https://twitter.com/PierreKory/status/1510992408854601729?t=7weqhH8JrZH5_pUSiZNi3A&s=19

**Pierre Kory, MD MPA**

>Me and my http://drpierrekory.com team are happily learning more and more about the treatment of long haul and post-vax syndromes..and our patients are even happier. Check out our reviews, let us know if we can help anyone, we are seeing most states now!
>
>https://drpierrekory.com/reviews/


&nbsp;


Dr Pierre Kory is active on Twitter: https://twitter.com/PierreKory

Instagram: https://www.instagram.com/pierrekorymd/?hl=en

LinkedIn: https://www.linkedin.com/in/pierre-kory-md-mpa-8021731b6

Facebook: https://www.facebook.com/Dr-Pierre-Kory-105970911953636

Gab: https://gab.com/PierreKoryofficial

Telegram: https://t.me/PierreKoryFLCCCofficial



&nbsp;







### **Dr Paul Marik (FLCCC co-founder)**


&nbsp;


Dr Paul Marik is the co-founder of FLCCC, and the author of the original MATH+ protocol which:

- first (early to mid-2020) clearly laid out the viral timeline (that live virus is near zero by day5 for many, and near zero by day8 for nearly all) - which justifies the use of steroids-at-day8

- outlined a plan of treatment - that was updated over time

- Ivermectin originally appeared as optional, and steadily was elevated as more evidence became apparent



&nbsp;



### **Dr Paul Marik invaluable advice in appearances on Dr Been show**


&nbsp;


Dr Paul Marik has appeared a few times on Dr Been show - where he has outlined invaluable advice about covid19 patient management - often nuances that are not evident from reading MATH+ protocol:

- outlining the need for ESCALATING steroids if hypoxia (inflammatory signals) are not reversing immediately - as reversing the hyperinflammatory explosion early is crucial and to use however much steroids it takes to achieve that (they can later be tapered down to levels while keeping them high enough so there is no rebound of hyperinflammatory signals)

- outlining the problem with large US hospital protocols which oddly CAP the dosage of Dexamethasone at 6mg (equivalent to Prednisolone 40mg) which is sometimes not enough for the most severe patients or those who arrive late - and their use of Remdesivir at day8 which is seen negatively by the WHO, yet continues to be practiced widely in the US and overseas - Dr Paul Marik says these hospitals are using "homeopathic doses of steroids"



&nbsp;


Here is the list of appearances of Dr Paul Marik on Dr Been's YouTube show:


&nbsp;


https://www.youtube.com/watch?v=xZJixjgu3tk

COVID-19 Patient Management with Dr. Paul Marik (Author of MATH+ Protocol)

Jul 16, 2020



&nbsp;



https://www.youtube.com/watch?v=cy1kdZhXsP8

COVID-19 Management With Dr. Paul Marik - Author Of MATH+ Protocol

Sep 16, 2020



&nbsp;



https://www.youtube.com/watch?v=DOWEPqHtt-0

Dr. Paul Marik Discusses Vitamin D, COVID Prophylaxis (IMASK+ Protocol)

Mar 8, 2021



&nbsp;



https://www.youtube.com/watch?v=O4gkLn-z4II

Dr. Paul Marik Discusses Latest Trends In COVID Management

Jun 30, 2021



&nbsp;



https://www.youtube.com/watch?v=bXiDpMBvsO8

A Talk With Prof. Dr. Paul Marik (11/17/2021)

Nov 18, 2021



&nbsp;



**Dr Joe Varon - co-founder FLCCC**


Dr Joe Varon is one of the most interviewed doctors in the US on covid19.

See Ivory Hecker's interview with Dr Joe Varon - where he mentions the media interviews have steered clear of mentioning Ivermectin:


&nbsp;


https://www.bitchute.com/video/rvccR4Tg6fRS

or

https://odysee.com/@ChristopherKennethBowser:6/Ivory-Hecker-Sends-A-Message-Of-Courage:3

Pursuing Truth in COVID Drug Treatment Amid a Censored Media Landscape

Ivoryhecker

June 25, 2021




* * *





## **Early Treatment discussions - censorship by YouTube, Facebook and others**


YouTube along with other Big Tech media (that are signatories of the Trusted News Initiative (TNI)) have been censoring discussion of early treatment.

The FLCCC and other groups of ICU doctors who have been trying to get the word out (and have been right in their advice than the WHO/NIH/CDC/FDA) - have been banned.

For example, the FLCCC YouTube channel got banned a long time ago:

FLCCC Press: https://www.youtube.com/channel/UC5rJlf5jdr_I6qiozbQdx-g

>"This account has been terminated for violating YouTube's Community Guidelines.")


&nbsp;



YouTube Terms of Service explicitly prohibits **Ivermectin and Hydroxychloroquine** as drugs that should NOT be suggested as treatments for covid19:


&nbsp;


https://support.google.com/youtube/answer/9891785?hl=en
COVID-19 medical misinformation policy

Or archive.org snapshot (May 24, 2021):

https://web.archive.org/web/20210524215029/https://support.google.com/youtube/answer/9891785?hl=en


>YouTube doesn't allow content that spreads medical misinformation that contradicts local health authorities’ or the World Health Organization’s (WHO) medical information about COVID-19. This is limited to content that contradicts WHO or local health authorities’ guidance on:


**NOTE:** are they aware that WHO's own meta-analysis (based on Dr Andrew Hill for UNITAID) found 81 percent mortality benefit, and yet a recommendation to use in clinical trials only?

**NOTE:** WHO decision seems to be a political decision - as Dr Andrew Hill suggested in a video presentation earlier, EU and other countries without a strategic stockpile of ivermectin need time to acquire such stocks


&nbsp;


>Note: YouTube’s policies on COVID-19 are subject to change in response to changes to global or local health authorities’ guidance on the virus. This policy was published on May 20, 2020. 


>If you're posting content
>
>Don’t post content on YouTube if it includes any of the following:
>
>Treatment misinformation: 

> **Content that recommends use of Ivermectin** or Hydroxychloroquine for the treatment of COVID-19
>
> **Claims that Ivermectin** or Hydroxychloroquine are effective treatments for COVID-19

>Prevention misinformation: Content that promotes prevention methods that contradict local health authorities or WHO.

> **Content that recommends use of Ivermectin** or Hydroxychloroquine for the prevention of COVID-19



&nbsp;



NOTE: text below is taken from: https://old.reddit.com/r/ivermectin/comments/mrdisk/comment/guli1wm/


Mary Beth Pfeiffer reports on YouTube's warning to content creators about mentioning ivermectin:

https://twitter.com/marybethpf/status/1382362064170156040?s=19

>The folks at YouTube, who think they know best, have updated their medical misinformation policy. IVM & HCQ are off the menu. Step out of line, censor cops strike. 
Legit medical debate is being squelched. Free speech is being stomped on by this monopoly. 


&nbsp;


The tweet above is not visible because it's author Mary Beth Pfeiffer has been banned from Twitter (!)

However the rest of the thread can still be viewed using the above link.


&nbsp;



Other articles on YouTube censorship:


https://olhardigital.com.br/2021/04/16/coronavirus/youtube-vai-remover-videos-que-defendem-uso-de-cloroquina-e-ivermectina-para-tratar-covid-19/

Archive of above webpage:

https://archive.ph/neDue

YouTube will remove videos advocating the use of chloroquine and ivermectin to treat Covid-19
By Ana Paula Ruiz , edited by Lyncon Pradella
April 16, 2021

>YouTube has updated its rules regarding content about Covid-19 . Now, the platform has announced that it will remove videos that recommend the use of ivermectin or hydroxychloroquine for the treatment or prevention of Covid-19. The update, according to YouTube, is in line with current guidance from health authorities on the effectiveness of substances.
>
>Since the beginning of the pandemic, YouTube has already removed 850,000 videos that violate the platform's content policies on the coronavirus. Between October and December 2020, 9.3 million pieces of content were excluded because they violated some platform rule.



&nbsp;



**Conflating early treatment with promoting "vaccine hesitancy"**

Promotion of early treatment is often conflated with anti-vaccine sentiment - using the expectation that availability of early treatment options in the minds of the public will lead to "vaccine hesitancy":

https://www.nytimes.com/2021/09/29/technology/youtube-anti-vaxx-ban.html
YouTube bans all anti-vaccine misinformation.
Davey Alba
Sept. 29, 2021

Archive of above webpage:

https://archive.ph/0j5yQ

>In addition to banning Dr. Mercola and Mr. Kennedy, YouTube removed the accounts of other prominent anti-vaccination activists such as Erin Elizabeth and Sherri Tenpenny, a company spokeswoman said.
>
>The new policy puts YouTube more in line with Facebook and Twitter. In February, Facebook said that it would remove posts with erroneous claims about vaccines, including taking down assertions that vaccines cause autism or that it is safer for people to contract the coronavirus than to receive vaccinations against it. But the platform remains a popular destination for people discussing misinformation, such as the unfounded claim that the pharmaceutical drug ivermectin is an effective treatment for Covid-19.



&nbsp;



**Censorship by Facebook**

https://www.nytimes.com/2021/09/28/technology/facebook-ivermectin-coronavirus-misinformation.html
Facebook groups promoting ivermectin as a Covid-19 treatment continue to flourish.
By Davey Alba
Sept 28, 2021

Archive of above webpage:

https://archive.ph/j6gmQ

>Media Matters for America, a liberal watchdog group, found 60 public and private Facebook groups dedicated to ivermectin discussion, with tens of thousands of members in total. After the organization flagged the groups to Facebook, 25 of them closed down. The remaining groups, which were reviewed by The New York Times, had nearly 70,000 members. Data from CrowdTangle, a Facebook-owned social network analytics tool, showed that the groups generate thousands of interactions daily.
>
>After The Times contacted Facebook about the Ivermectin vs. Covid group, the social network removed it from the platform.


So the media groups which are party to the Trusted News Initiative (TNI) actively were policing each other to ensure compliance.



&nbsp;




### **YouTube censorship - Sen Ron Johnson**

Sen Ron Johnson (Wisconsin) - has played a strong role in advocacy for early treatment in covid19.

He led the Senate hearings on early treatment - which highlighted Dr Pierre Kory testimony favoring use of steroids for covid19.

This was at a time when WHO/NIH/CDC had started dissuading doctors from using steroids for covid19 (a wrong move - since steroids-at-day8 is THE way to prevent progression to death and to get zero long haulers).

His second set of hearings at end of 2020 led to Dr Pierre Kory's famous plea for inclusion of Ivermectin in early treatment protocols - especially their use for prophylaxis.


&nbsp;


Listen to the tone of this piece from Forbes - written by a Professor of Health Policy and Management at CUNY (previous research has been funded by Gates Foundation as well):

https://www.forbes.com/sites/brucelee/2021/06/12/youtube-suspends-republican-senator-ron-johnsons-account-for-violating-covid-19-policy/?sh=14a010f946eb
YouTube Suspends Republican Senator Ron Johnson’s Account For Violating Covid-19 Policy
Bruce Y. Lee
June 12, 2021


>Senator Ron Johnson (R-Wisconsin) is neither a medical doctor nor a scientific researcher. And he isn’t the Johnson in Johnson & Johnson. But that didn’t keep him from talking about the use of hydroxychloroquine and ivermectin against Covid-19 and his YouTube account from posting a video featuring his comments. And now surprise, surprise this video has gotten his account banned from YouTube for seven days. 

>According to Bill Glauber reporting for Milwaukee Journal Sentinel, a YouTube spokesperson said the following about the Johnson video: “We removed the video in accordance with our Covid-19 medical misinformation policies, which don’t allow content that encourages people to use Hydroxychloroquine or Ivermectin to treat or prevent the virus.” Per Glauber, Johnson apparently stood up and made the comments at the Milwaukee Press Club on June 3. Glauber also quoted Johnson criticizing the U.S. government for “not only ignoring but working against robust research [on] the use of cheap, generic drugs to be repurposed for early treatment of Covid.” 

So these journalists and their outlets were instrumental in the suppression and generation of derision for early treatment options.


>YouTube’s policy about ivermectin and hydroxychloroquine is pretty clear. It says, “Don’t post content on YouTube if it includes any of the following:
>
>>Content that recommends use of Ivermectin or Hydroxychloroquine for the treatment of Covid-19
>
>>Claims that Ivermectin or Hydroxychloroquine are effective treatments for Covid-19
>>
>>Content that recommends use of Ivermectin or Hydroxychloroquine for the prevention of Covid-19”
>
>This is completely in line with what’s indicated by the National Institutes of Health (NIH) Covid-19 Treatment Guidelines about hydroxychloroquine and ivermectin. 

Note how these draconian measures against Ivermectin are an overreaction - compared to NIH's own ambivalence about Ivermectin - don't recommend for OR AGAINST Ivermectin:

>And here’s what the guidelines say about ivermectin: “There are insufficient data for the COVID-19 Treatment Guidelines Panel (the Panel) to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin in the treatment of COVID-19.”


This statement about the number killed by vaccines may be not far from the mark - from new disclosures about Pfizer clinical trial (as of March 19, 2022 today):

>And in May, Joy Reid on her MSNBC show Joy Reid called Johnson a “dangerous disinformation peddler” after Johnson inaccurately claimed that Covid-19 vaccines had killed over 3,000 people:



&nbsp;



### **YouTube censorship - Sky News Australia**


https://www.bbc.com/news/world-australia-58045787
Sky News Australia barred for week by YouTube over Covid misinformation
1 August 2021

Archive of above webpage:

https://archive.ph/56P80


>YouTube has barred Sky News Australia from uploading new content for a week, saying it had breached rules on spreading Covid-19 misinformation.
>
>YouTube did not point to specific items but said it opposed material that "could cause real-world harm".
>
>A YouTube statement said it had "clear and established Covid-19 medical misinformation policies based on local and global health authority guidance".
>
>A spokesperson told the Guardian it "did not allow content that denies the existence of Covid-19" or which encouraged people "to use hydroxychloroquine or ivermectin to treat or prevent the virus". Neither has been proven to be effective against Covid.


&nbsp;


https://www.skynews.com.au/business/media/youtubes-sky-news-australia-suspension-disturbing-assault-on-freedom-of-thought/news-story/cc2ce1cad0dd5ec9693e2192759eab8b#top
YouTube’s Sky News Australia suspension ‘disturbing’ assault on freedom of thought

Digital Editor Jack Houghton argues YouTube’s decision to suspend Sky News Australia is a disturbing attack on the ability to think freely.
Jack Houghton
Digital Editor
August 1, 2021

Archive of above webpage:

https://archive.ph/prUmk



&nbsp;



### **YouTube censorship - Kim Iversen (journalist - The Hill)**

Kim Iversen's YouTube channel was suspended (removed) from YouTube after she covered a study on efficacy of Ivermectin.

Another example of the Trusted News Initiative (TNI) at work.


Here she discusses her suspension on a segment of The Rising show on The Hill in which she appears:


&nbsp;

https://old.reddit.com/r/ivermectin/comments/th8vtx/kim_iversen_is_suspended_from_youtube_over/
Kim Iversen Is SUSPENDED from YouTube Over Segment On Covid Therapeutic Study and IVM
prosperouslife


**Video:**

https://www.youtube.com/watch?v=lnsByps85gE

Kim Iversen Is SUSPENDED From YouTube Over Segment On Covid Therapeutic Study

Mar 14, 2022

The Hill

>Kim Iversen details the suspension of The Kim Iversen Show's YouTube channel. 
>
>According to the CDC: Ivermectin is not authorized or approved by FDA for prevention or treatment of COVID-19. The National Institutes of Health’s (NIH) COVID-19 Treatment Guidelines Panel has also determined that there are currently insufficient data to recommend ivermectin for treatment of COVID-19.


&nbsp;





### **YouTube censorship - Dr Been (Dr Mobeen Syed)**


&nbsp;


Dr Been now has a presence on Odysee and Bitchute as well:

https://odysee.com/@DrMobeenSyed:1

There is a reddit-wide ban on bitchute links, but you can use a tinyurl or bit dot ly url shortener instead:

https://www dot bitchute dot com/channel/bbZOpTZkmPY0

or

https://tinyurl.com/v3x8yx53


&nbsp;


At one point, Dr Been had **54 of his videos demonetized by YouTube** - the Trusted News Initiative (TNI) at work:

https://old.reddit.com/r/ivermectin/comments/mm3ju6
Dr. Been mentions at 5:20 that all of his past videos mentioning ivermectin have been demonetized and he won't be speaking that word going forward.


&nbsp;


**In Dr Been's own words:**

https://twitter.com/drbeen_medical/status/1379575228670435332?s=19

>**54 videos demonetized in one day** by @YouTube.
>
>All are medical concept videos for education. No conspiracy. Just medical concepts.



&nbsp;



### **YouTube censorship - MedCram (Dr Roger Seheult)**

Has also reported videos removed by YouTube for discussing academic papers about Ivermectin - the Trusted News Initiative (TNI) at work.


&nbsp;


### **YouTube censorship - WhiteBoard Doctor**


&nbsp;

Has also reported videos removed by YouTube for discussing academic papers about Ivermectin - the Trusted News Initiative (TNI) at work.

Very active YouTube doctor who has analyzed papers on Ivermectin and other treatment options very actively.


&nbsp;



### **YouTube censorship - Dr Yo**


&nbsp;

Has also reported videos removed by YouTube for discussing academic papers about Ivermectin - the Trusted News Initiative (TNI) at work.

Dr Yo is a prominent YouTube doctor.  Joined Dr Bruce Patterson (IncelDX) work on characterizing long haulers syndrome, and is active in their outreach effort to collate blood samples so a test could be fine-tuned for long haulers (a test will go a long way to dispelling the notion among many doctors who don't know how to treat it - that it is a psycho-somatic disease):

https://www.covidlonghaulers.com

He also has had YouTube videos fall victim to the Trusted News Initiative (TNI).



&nbsp;



### **YouTube censorship - Dr John Campbell**


&nbsp;

Has also reported videos removed by YouTube for discussing academic papers about Ivermectin - the Trusted News Initiative (TNI) at work.


&nbsp;


Mainstream YouTuber - frequent guest on Deutsche Welle TV (DW TV).

Has always maintained Vitamin D deficiency needs to be addressed for improved outcomes in covid19.


&nbsp;


Has also been repeatedly disappointed by WHO and NIH/CDC guidelines and how far off the mark they are or always late to the game.


&nbsp;


Has invited Dr Tess Lawrie on his YouTube channel (see Dr Tess Lawrie section above for videos).

Slow convert to Ivermectin.


&nbsp;


Now urges UK govt to strongly consider ivermectin for further investigation:

https://old.reddit.com/r/ivermectin/comments/o0xzp9/_/
Dr. John Campbell reviews Egyptian nasal spray study and re-issues an urgent call to all health authorities and ministers to immediately address the evidence on ivermectin!


Video:

https://youtu.be/R0-90kvoQac
Vaccination and ivermectin

Dr. John Campbell

994K subscribers

Jun 16, 2021



&nbsp;



Dr John Campbell discusses how there is money and support for patented antivirals still in development (with no safety profiles).

Yet generic drugs with excellent safety records that are promising (like Ivermectin) remain unfunded and unsupported - the NIH has (as of July 2021) not funded a single trial of Ivermectin (despite pleas by Dr Rajter author of the first Ivermectin study in the US - at the Broward County Hospital system):


https://www.youtube.com/watch?v=Of5_oiuqDp8
Money for antivirals

160,834 views

Jun 20, 2021

Dr. John Campbell

1.05M subscribers



&nbsp;



Dr John Campbell - social media:


Twitter:
https://twitter.com/Johnincarlisle

Substack:
https://substack.com/@johninengland

YouTube:
https://www.youtube.com/channel/UCF9IOB2TExg3QIBupFtBDxg

Website:
https://drjohncampbell.co.uk/




&nbsp;





### **Twitter and LinkedIn censorship - Dr Darrell DeMello (Mumbai, India)**


&nbsp;


Dr Darrell DeMello has been censored on Twitter and LinkedIn for talking about early treatment for covid19 and for dengue:


https://twitter.com/DarrellMello/status/1551100539790061568?t=pu3i07YE879C8SEadD7Smw&s=19

**DrDarrellDeMello**

>I have successfully treated patients with Dengue Fever using a combination of Colchicine and Ivermectin. Reversal of platelet count occurs 24-48 hours.  Covid-19 has helped me learn a lot!


&nbsp;



**NOTE:** the above tweet has now been deleted by the author (possibly related to his recent temporary ban on Twitter):


https://twitter.com/drakchaurasia/status/1552362119101759488?t=cYDiIzDddhIdaaNjyILwxg&s=09

**dr a k chaurasia**

>Dr D, were you blocked recently by twitter?




https://twitter.com/DarrellMello/status/1552368167476817920?t=v5OUDaLZxvILCy_6FrL-Hw&s=09

**DrDarrellDeMello**

>Yes...for a week



https://twitter.com/DarrellMello/status/1552369945551327235?t=6Uo4pbyI8TAjswbMYjleEw&s=09

**DrDarrellDeMello**

>Worst is LinkedIn.
>
>Deleted my 20+ year account with all my Corporate history, and contacts. For what reason ..don't know. Pathetic Customer Service.




&nbsp;



https://twitter.com/DarrellMello/status/1555816797550419968?t=b7vPo5PnjJoyKtpWhVIW-w&s=19

**DrDarrellDeMello**

>I am not a big account!
>
>Suspended by Twitter 3 times, for 7 days each
>
>By Facebook ....stopped counting.. and shadow banned.
>
>LinkedIn: permanent deletion of my 20+ year old account, with no access to my old contacts.
>
>Reason has never been communicated to me.




&nbsp;




### **Twitter and LinkedIn censorship - Dr Robert Malone**


&nbsp;


Dr Robert Malone - an early contributor to the technology that led to the mRNA vaccine - and a critic of the mRNA vaccine's choice of the spike protein (which is toxic in it's own right) as a target.

He has had his Twitter and LinkedIn accounts blocked.

He has been forced to move to other platforms like Gettr.



&nbsp;

&nbsp;




* * *




## **Pharmacies which fulfil Ivermectin prescriptions**


&nbsp;



**August 15, 2021:**

The FLCCC has a list of pharmacies that will fill ivermectin prescriptions:

https://covid19criticalcare.com/pharmacies/

May 13, 2022 - this list of pharmacies is now quite large.

From the above webpage, this Sept 2021 pdf document is "to help guide you in how to effectively push back with any pharmacists that deny filling your prescription":

https://covid19criticalcare.com/wp-content/uploads/2021/09/Overcoming-Pharmacy-Barriers.pdf
Overcoming the Barriers to Access Ivermectin Prescriptions


&nbsp;


It has been reported by patients that some pharmacists (see reddit.com/r/pharmacy) have decided they will not fulfil prescriptions for Ivermectin.

The reason for this is the signaling coming out of Merck - which has reneged on it's 2003 opinion on the safety of Ivermectin, and now suggests it is not safe - a change which may have to do with Merck's rollout of the drug Molnupiravir which aims to do some of the same functions as Ivermectin - except at much higher price.



&nbsp;


**August 28, 2021:**

Dr Fauci has recently started to dream of a pill - he is probably dreaming of Molnupiravir and the drug coming out of Pfizer - since the NIH has been a laggard in their support for Repurposed Drugs.

Dr Fauci dream pill:

https://old.reddit.com/r/ivermectin/comments/oy03fk/faucis_great_pivot_toward_oral_drug_therapies_to/h7qdcml



&nbsp;


**September 19, 2021:**

The FLCCC had a discussion video on the difficulties posed by pharmacists who are refusing to fill prescriptions from doctors for Ivermectin:


https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/FLCCC-WEBINAR-091521_Pharmagedon:7?t=810

FLCCC Weekly Update September 15, 2021: Pharmageddon Unleashed on Ivermectin

September 16th, 2021


This week's FLCCC Weekly Update hosted by Betsy Ashton features Dr. Paul Marik, Dr. Pierre Kory, and attorney Alan Dumhoff.

This episode discusses the issues that doctors and nurses are facing writing prescriptions for their patients and how pharmacies are blocking needed prescriptions from being filled. Alan Dumhoff discusses the legal implications of all of this for healthcare providers and patients.





at the 44:00 minute mark:

Attorney Alan Dumhoff has some suggestion for doctors worried about medical boards coming after them

Should have ivermectin consent form (patient recognizes was informed vaccines as top recommendation but still wants IVM) filled by patient not at front desk, but signed after discussion with doctor



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**October 22, 2021:**

Dr Syed Haider provides a list of pharmacies that will fill and ship ivermectin to the 40 states in the US that he is licensed to practice in.

https://twitter.com/DrSyedHaider/status/1451345062839963653?t=OHkSDl1TtAd3EQqblrEfkA&s=19

**Dr. Syed Haider**

>My staff has spent months scouring the country for pharmacies that will fill and ship ivermectin to each of the 40 states I'm licensed in. Here's the master list.

https://docs.google.com/spreadsheets/d/1S4X0PAx1BA1zI_KxulHjVZnWdcmrIv4b-RYSm9zmuys/edit#gid=101247289&fvid=278659903

or

https://tinyurl.com/3h89a4de




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Dr Syed Haider also outlines the difficulties he has had with pharmacies:

https://twitter.com/DrSyedHaider/status/1451285955743207427?t=H-DoX2y3vKuIB-mRYZ3Tcg&s=19

**Dr. Syed Haider**

>My experience using ivermectin and fluvoxamine in 4000 acute COVID-19 patients: 5 hospitalized. 0 dead. 4000 recovered. 5 pharmacist threats. 1 medical board complaint. 1 lawyer retained. Hundreds of medication transfers for pharmacist refusals.




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* * *




## **Ivermectin**


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Ivermectin is considered a safer drug than Tylenol or Aspirin according to the adverse events data collected over 40 years and 3.7 billion doses administered.

(TODO: add reference)


NOTE: Ivermectin should generally only be given to those above 15kg in weight, and those who are not pregnant and not breastfeeding a baby.  Since Ivermectin is neuro-toxic but does not cross the blood-brain barrier in humans, care should still be taken for those who have weakened blood-brain barrier - small children and those who have an active ongoing meningitis infection.


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About 1 in 20 people may show signs of dizziness or visual disturbance - for these patients the dosage can be halved and often the issues go away.  If issues remain, then consider discontinuing ivermectin - or switching to a spread out dosing strategy (for example instead of 12mg every Sunday, you may consider giving 3mg morning + 3mg evening on Sunday, and then 3mg morning + 3mg on Thursday).

Usually Ivermectin at the 0.2mg/kg bodyweight every Sunday (pre-exposure prophylaxis) dosing - does not give any side effects.

However at the 0.4mg/kg bodyweight every day for 3 days (post-exposure prophylaxis) or for 5 days or longer (for treatment) - some patients may experience dizziness or visual disturbance (sensation is similar to when you are sleep deprived and start seeing visual artifacts).

In some people, ivermectin (esp at the 0.4mg/kg dose) may be causing lower blood pressure (which may lead to dizziness).

See the section **Ivermectin - Dizziness, visual disturbances**.



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**Genetic variation**

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929173

Rarely, some people may have a genetic variation which weakens the blood-brain barrier.  In these folks, Ivermectin may trigger the dizziness etc. side-effects mentioned above.

The 1 in 20 people mentioned above who have side-effects, may have these issues, or may be suffering from parasites.





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* * *



## **Ivermectin - taking on empty stomach - or taken with fatty meal - and the impact on anti-IVM trials**


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When Ivermectin is being given for worms (or parasitic infections) - it is usually given on an empty stomach.

The idea is to increase concentrations of Ivermectin in the gastro-intestinal tract.

The perception that Ivermectin should be taken on an empty stomach - comes from this history of use.


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However for covid19 - or wherever Ivermectin needs to be systemically available i.e. throughout the body - there it should be given with a fatty meal.

Since Ivermectin with a fatty meal - increases bioavailability by 2.5 times (2.5x).

This higher bioavailability is mentioned in the specification sheet for Ivermectin.

The reason is that Ivermectin is a fat soluble drug (not as water soluble) - and is better absorbed when it is taken with a fatty meal.



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**Impact of anti-IVM trials' use of Ivermectin-on-empty-stomach**

The anti-IVM trials on "mortality benefit" (Lopez-Medina, TOGETHER, ACTIV-6) seem to share a quirk in their dosing protocols (possibly attributable to the input of trial designers that were common to these trials).

That quirk is that they all chose to give Ivermectin on an empty stomach.

This despite calls from early treatment doctors to administer with a fatty meal (or with a meal) - and NOT on an empty stomach.

However, these appeals were consistently refused.

So there was a degree of hostility in the TOGETHER trial - first on advocacy from early treatment doctors that a higher 0.4mg/kg dose was required (this was acceded to).

But the advocacy for use with a fatty meal - was refused.



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The reason given by them - is that the FDA already has a convention for use of Ivermectin on empty stomach - and it was easier to go with that.

(TODO - add reference)

(TODO - check this if this is correct).



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**References:**


https://www.reddit.com/r/gettingivermectin/comments/kn4v3n/_/ghikixj

bikes4paul

>I was confused about this too. Dr. Carvallo answered it very clearly in a recent interview with WhiteBoard Doctor. For antiparasitic uses take on empty stomach. This maximized the concentration in the GI tract to kill the parasites. If taking for C19 take with a fatty meal. This increases the systemic absorption by 250% (i.e. lungs) which is what's desired in C19.




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https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3714649

Antiviral Effect of High-Dose Ivermectin in Adults with COVID-19: A Pilot Randomised, Controlled, Open Label, Multicentre Trial

11 Nov 2020

Alejandro Krolewiecki et al.

>Diet is a key variable affecting the oral bioavailability of IVM, with increased plasma 
concentrations achieved with fed state, mostly related to the fat content of the meal



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https://twitter.com/sudokuvariante/status/1690296205123690497

**Fred Stalder**

>The most obvious point is the administration on an empty stomach in almost all RCTs published in high IF journals while experts (@SabinehazanMD and @Covid19Critical group) recommended from the beginning to administer with food based on published data.


https://twitter.com/sudokuvariante/status/1658153669190205440

**Fred Stalder**

>People don't understand how much Guzzo et al. is devastating to all ivermectin "empty stomach" trials.
>
>https://accp1.onlinelibrary.wiley.com/doi/abs/10.1177/009127002237994
>
>Max. concentration and AUC with 347-541 μg/kg in a fed state are similar than those with 1404-2000 μg/kg in a fasted state.



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https://twitter.com/Aguirre1Gustavo/status/1482418466900647940

**Dr. Gustavo Aguirre-Chang**

>There are at least 3 studies indicating that the bioavailability of IVM is better when taken with high-fat meals
>
>In the link is the study of February2020 in which it was obtained as a result that the effect of IVM was 18% better when it was given with food
>
>https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkz466/5613771?login=false


https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkz466/5613771?login=false
 The effect of food on the pharmacokinetics of oral ivermectin
Urs Duthaler, Rory Leisegang, Mats O Karlsson, Stephan Krähenbühl, Felix Hammann
February 2020

>For this analysis, we investigated the influence of fasted versus fed dosing on the oral PK of ivermectin as published data so far have been ambiguous.
>
>Guzzo et al. reported a 2.6-fold increase in AUC with high-fat meals for fixed doses of 30 mg ivermectin in healthy volunteers (fasted: n=12, fed: n=11).
>
>Miyajima et al. reported a more modest increase (1.25%) in AUC in 13 Japanese patients with scabies.
>
>Homeida et al. reported no effect of either food or alcohol intake on bioavailability.
>
> ...
>
>Our findings are similar to the recent publication by Miyajima et al., who also administered a dose of 12 mg, but much lower than the value of 2.6 reported by Guzzo and colleagues.
>
>A possible reason for this discrepancy may be the high doses (30 mg) given in the latter trial.
>
>This could be due to ivermectin being a good substrate for active efflux pumps such as P-glycoprotein (P-gp, MDR1, ABCB1). P-gp is prominently expressed in the gastrointestinal tract, and at higher doses, along with an exposure increased by meals, concentrations could saturate the active efflux process. This in turn would lead to greater systemic concentrations.



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Alexandros Marinos and Fred Stalder have examined issues with the anti-IVM trials on "mortality benefit" (Lopez-Medina, TOGETHER, ACTIV-6):


https://doyourownresearch.substack.com/p/the-problem-with-the-together-trial
The Problem with the TOGETHER Trial
The most sophisticated trial of early treatments for COVID-19 doesn't quite add up.
Alexandros Marinos
Apr 13, 2022



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https://doyourownresearch.substack.com/p/activ-6-trial-ivermectin-scientists
ACTIV-6 Trial on Ivermectin: NIH Scientists Behaving Badly
Alexandros Marinos
Oct 28, 2022



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https://www.youtube.com/watch?v=kLXiQEihg8s
Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret
Bret Weinstein
May 2, 2022
Bret speaks with Alexandros Marinos, who has analyzed the TOGETHER trial, which aims to identify effective repurposed therapies to prevent the disease progression of COVID-19.

Mirror:
https://odysee.com/@BretWeinstein:f/cold-confusion-alexandros-marinos:7
Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret
Bret Weinstein
May 2, 2022



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https://odysee.com/@DarkHorsePodcastClips:b/dosing-and-weight-limit-anomaly-on:3
Dosing and weight limit anomaly on ivermectin TOGETHER trial (Alexandros Marinos & Bret Weinstein)
DarkHorse Podcast Clips
May 17, 2022



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* * *




## **Ivermectin - dosing at 0.2mg/kg bodyweight - or 0.4mg/kg bodyweight - and the impact on anti-IVM trials**


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As Omicron arrived, the FLCCC and other early treatment doctors started noticing that the 0.2mg/kg bodyweight per week dosing was not 100% preventing appearance of symptoms during day1-7.

For this reason the FLCCC issued an update and the dosing for prophylaxis was increased to 0.2mg/kg - taken twice a week.

Similarly the doses using during treatment were increased (by this time early treatment doctors had also become more comfortable with using higher doses of Ivermectin - having seen how the lower doses worked, and having seen how some of the severe patients performed when they had to use higher doses).

So after Omicron, the Ivermectin 0.4mg/kg bodyweight dosing became more common.


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**Impact of anti-IVM trials' use of 0.2mg/kg vs 0.4mg/kg bodyweight dosing**

The anti-IVM trials on "mortality benefit" (Lopez-Medina, TOGETHER, ACTIV-6) did increase the dosing from 0.2mg/kg as Omicron appeared.

But this was after much lobbying by early treatment doctors - that they need to use at least a 0.4mg/kg dose for TOGETHER trial.

TOGETHER trial did however refuse to give Ivermectin with fatty meal - and instead advocated for using on empty stomach.

TOGETHER trial also used non-linear dosing - so the most obese did not get the full 0.4mg/kg (see below).



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* * *



## **Ivermectin - dosing by weight - or dosing non-linearly - and the impact on anti-IVM trials**


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Most trials of Ivermectin use a 0.2mg/kg dosing - later trials may use a 0.4mg/kg bodyweight dosing.  Some have used 0.6mg/kg bodyweight.

However, some of the anti-IVM trials seem to share a quirk - that they said they were using a 0.4mg/kg dosing - but then capped the maximum dose arbitrarily.

The result was that the highest bodyweight individuals did not receive the full 0.4mg/kg bodyweight dosing.


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The impact of this quirky choice was that obese patients (overrepresented in the high bodyweight subset) - would be getting lower than optimal Ivermectin dosing.

Yet the obese patients are usually the higher risk group in covid19 trials on mortality benefit.

Thus these trials may have (deliberately or inadvertently - by choice of predetermined protocol) - have ensured that the treatment arm could not turn around the patient subset which would contribute the most deaths.

Thus the protocol could have led to a higher than expected death rate in the treatment arm (if the treatment arm is not allowed to work using the optimal dose).



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**Impact of anti-IVM trials' use of non-linear dosing**


The anti-IVM trials on "mortality benefit" (Lopez-Medina, TOGETHER, ACTIV-6) seem to share a quirk in their dosing protocols (possibly attributable to the input of trial designers that were common to these trials).

The quirk is that if they said Ivermectin dosing was 0.4mg/kg bodyweight - in actual practice the dosing was lower for higher bodyweight patients.

(specifically the TOGETHER and ACTIV-6 trials)

(the reason why most of these trials had this bias - may be attributable to some trial designers being common to all these trials)

(TODO check this - Dr Boulware was common to TOGETHER and ACTIV-6 trials)



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Since the trials used 0.4mg/kg - but then also capped the total dose to an absolute maximum milligram dose for all patients.

Meaning higher dosing subset did not get the full 0.4mg/kg dose.


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The impact of this quirky choice was that obese patients (overrepresented in the high bodyweight subset) - would be getting lower than optimal Ivermectin dosing.

Yet the obese patients are usually the higher risk group in covid19 trials on mortality benefit.

Thus these trials may have (deliberately or inadvertently - by choice of protocol) - have ensured that the treatment arm could not turn around the patient subset which would contribute the most deaths.

Thus the protocol could have led to an unnecessarily high death rate in the treatment arm.



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**References:**

(TODO: See Alexandros Marinos substack articles on the Ivermectin dosing cap in TOGETHER and ACTIV-6 trials - and Fred Stalder discussion - and the link to possible common trial designers (Dr Boulware))



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* * *



## **Ivermectin - beyond dosing by weight - dosing by body mass index (BMI) - and the impact on plasma levels**


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Does the same Ivermectin 0.4mg/kg bodyweight dosing have different impact for a lean vs an obese patient - on blood plasma levels of Ivermectin ?

Ivermectin tends to accumulate in fatty tissue - so if a person has higher percentage fat - the concentration in blood plasma is likely to be lower in the obese vs the lean person.


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If all patients are given the same 0.4mg/kg bodyweight dosing of Ivermectin - the obese patients may not reach the same plasma levels of Ivermectin as the lean patients.

So the highest risk patients may not have gotten the dose they needed for optimal benefit.



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However, most Ivermectin trials - not just the anti-IVM trials - but even the positive ones - generally do not use dosing by BMI - but usually just adopt a dosing-by-weight protocol (0.2mg/kg bodyweight or 0.4mg/kg bodyweight - for example).

However, some earlier trials - have shown that at the same 0.2mg/kg or 0.4mg/kg dosing - the patients had widely different blood plasma levels of Ivermectin.

(TODO - provide references - is it Krolewiecki paper?)


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And in those trials - according to a separate analysis - the death rates were lower in the patients who achieved high Ivermectin levels in blood plasma.

(TODO - add reference - is it Krolewiecki paper? - see Fred Stalder tweets mentioning reference)




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**References:**

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524481/

Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2–12 years

>Ivermectin is a lipophilic drug and therefore accumulates in fat tissue. When ivermectin is administered to patients with higher BMI, it is **likely that a larger proportion of ivermectin accumulates in fat tissue, leading to smaller amounts available in the blood and thus to lower AUC values.** 




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* * *



## **Ivermectin - regions offering over the counter (OTC)**


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https://old.reddit.com/r/ivermectin/comments/tgkjlo/list_of_country_where_ivermectin_is_available/
List of country where Ivermectin is available over the counter


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Tennessee, USA (April 22, 2022):

https://old.reddit.com/r/ivermectin/comments/ucmf29/ivermectin_may_be_sold_or_purchased_as_an/
Ivermectin may be sold or purchased as an over-the-counter medication in Tennessee without a prescription or consultation with a pharmacist or other healthcare professional (signed by Governor - April 22, 2022) - IVM becomes available OTC in Tennessee


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New Hampshire, USA (May 10, 2022):

https://old.reddit.com/r/ivermectin/comments/uodvjx/ivermectin_gets_approval_for_over_the_counter_otc/
Ivermectin gets approval for over the counter (OTC) use in New Hampshire (May 10, 2022) - earlier IVM was approved for OTC use in Tennessee (USA)



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## **Ivermectin - Meta-analyses of studies**



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### **Ivmmeta.com - informal meta-analysis/study aggregation**


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https://www.ivmmeta.com

Ivmmeta.com by @CovidAnalysis is an informal website that collects references for studies and their results, and presents a near real-time meta-analysis of studies.

As another example of clampdown (see Trusted News Initiative (TNI)), evidently @CovidAnalysis twitter account was suspended by twitter:

https://ivmmeta.com/twitter.html

Ivmmeta.com has come under attack by pro-vaccine or pro-Trusted News Initiative (TNI) employees for pushing an imprecise meta-analysis.

The reason for their ire is the frequent quotation of the ivmmeta.com website by pro-ivermectin personalities like Craig Kelly MP (Australia).

As a result the ire falls on the website for a free service this website has been providing for months - pointing researchers to new studies.

Ivmmeta.com does not make claims of being a rigorous meta-analysis, but is a best-effort service provided free to the world.


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But that is not all.  Ivmmeta.com has tabs at the top that point to other meta-analyses for researchers to get a birds-eye view of potential generic drug candidates for covid19.

https://c19early.com/

https://c19ivermectin.com/

https://c19vitamind.com/

https://vdmeta.com/ (calcifediol (fast acting) and Vitamin D3)

https://c19proxalutamide.com/

https://c19fluvoxamine.com/

https://c19pvpi.com/ (povidine-iodine nasal flush/spray)

https://c19budesonide.com/

https://c19bromhexine.com/

https://c19ly.com/ (bamlanivimab)

https://c19regn.com/ (casirivimab/indevimab)

https://c19hcq.com/

https://hcqmeta.com/ (hydroxychloroquine)

https://c19nitazoxanide.com/

https://c19colchicine.com/

https://c19curcumin.com/



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### **Ivmmeta.com - and c19ivermectin.com censorship - reddit-wide blacklisting**


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**EDIT: 2021-11-17** - it has become apparent that on reddit as well, the ivmmeta.com and c19ivermectin.com type websites are blacklisted (reddit-wide blacklisting).  That is, the default reddit behavior is to remove the comment that includes that url - if moderators see it and approve it - only then does that comment become visible (so default behavior is to censor).  The ostensible reason given by fact-checkers/critics for hating these websites is that they are not legitimate meta-analyses (which some users tend to categorize them as).  However these websites are important because they remain as clearinghouses for early treatment candidate drugs (even if you don't recognize them as meta-analysis websites).



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### **Dr Tess Lawrie/BIRD Group UK**

Dr Tess Lawrie and the BIRD Group UK meta-analysis final peer-reviewed meta-analysis:

https://old.reddit.com/r/ivermectin/comments/ny528m/dr_tess_lawrie_metaanalysis_now_available_as/
Dr Tess Lawrie meta-analysis now available as peer-reviewed paper (June 12, 2021) - in the American Journal of Therapeutics (same journal that the FLCCC paper was published in)


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Paper:

https://journals.lww.com/americantherapeutics/abstract/9000/ivermectin_for_prevention_and_treatment_of.98040.aspx
Ivermectin for Prevention and Treatment of COVID-19 Infection


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Video:

https://odysee.com/@The_BiRD_Group:3/Thank-You_June2021_2k_titleA:9
Dr. Tess Lawrie thanks her team and supporters from around the globe for the publication of the BiRD group meta-analysis on ivermectin.


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Dr John Campbell reviews the meta-analysis by Dr Tess Lawrie group:

https://youtu.be/3j7am9kjMrk

Best ivermectin meta analysis

Dr. John Campbell

Jun 25, 2021



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Dr John Campbell discussion with Dr Tess Lawrie:

https://youtu.be/D2ju5v4TAaQ
Ivermectin discussion with Dr Tess Lawrie

Dr. John Campbell

Published on Apr 7, 2021



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Dr John Campbell earlier interview of Dr Tess Lawrie:


https://old.reddit.com/r/ivermectin/comments/lza64t/dr_john_campbell_interviews_dr_tess_lawrie/
Dr John Campbell interviews Dr Tess Lawrie (meta-analysis and BIRD panel) - interesting because Campbell has a large viewership, and appears on Deutsche Welle TV as well (March 7, 2021)


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Video - 1st part:

https://www.youtube.com/watch?v=UY92vb-9vEw
Evidence based practice, Dr Tess Lawrie
Mar 6, 2021
Dr. John Campbell

Video - 2st part:

https://www.youtube.com/watch?v=vYF8bnmdQfY
Ivermectin Evidence with Dr Tess Lawrie
Mar 7, 2021




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### **FLCCC meta-analysis**

The FLCCC peer-reviewed meta-analysis paper on Ivermectin and early treatment:

https://old.reddit.com/r/ivermectin/comments/n1v3gm
FLCCC paper was published by American Journal of Therapeutics: Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19


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Paper:

https://journals.lww.com/americantherapeutics/Fulltext/2021/06000/Review_of_the_Emerging_Evidence_Demonstrating_the.4.aspx
Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19



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### **Dr Andrew Hill meta-analysis for Unitaid (which informed WHO decision-making)**


Peer-reviewed final paper by Dr Andrew Hill while sponsored by Unitaid. His conclusions in the pre-print were found to have been influenced by Unitaid (his sponsors). This research informed the WHO as well, which chose to wait for more studies.

Unlike the earlier pre-prints, this final paper no longer recommends further trials (i.e. evidence is sufficient).  It shows a clear signal for early treatment, and a dose-dependent effect, which an important factor in judging efficacy:

https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofab358/6316214?guestAccessKey=16d25c42-5820-456b-b8e9-b5e289b0188a
Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection 
06 July 2021



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### **Bayesian analysis of studies**

https://old.reddit.com/r/ivermectin/comments/ok6l1e
Bayesian Meta Analysis of Ivermectin Effectiveness in Treating Covid-19 Disease

Paper:

https://www.researchgate.net/publication/353195913_Bayesian_Meta_Analysis_of_Ivermectin_Effectiveness_in_Treating_Covid-19_Disease
Bayesian Meta Analysis of Ivermectin Effectiveness in Treating Covid-19 Disease
July 2021

 
&nbsp;




### **Dr Andrew Hill - the controversy and the opportunity lost**


Dr Andrew Hill was the right person in the right place - who could single-handedly have changed the direction of the once-in-a-century pandemic.  But failed to do so.

His critics claim it was because he remained indebted to his sponsor (Unitaid - and an influential French bureaucrat there) - and to the constraints of his university employer (Univ of Liverpool which was to receive a large grant from the Gates Foundation later).

For many this many be a much smaller goal than the saving of human lives - and for this reason many fail to understand Dr Andrew Hill's actions fully.


&nbsp;


Dr Andrew Hill was in a unique position in early 2021 - he was examining Ivermectin benefit for covid19.  The sponsor of his report was Unitaid and was to inform WHO policy later.

Prior to the release of the report he was very positive - his preliminary report was positive as well - and he made presentations to South African audiences and others that suggested Ivermectin should be adopted and stockpiled by governments.

That is, he suggested that governments should be stockpiling Ivermectin - and that the longer they wait (and as word gets out of it's efficacy) - it will be harder to procure stockpiles of Ivermectin.

When the meta-analysis report was finally revealed the body of the report was generally positive to Ivermectin - but the Conclusion section was confusingly skeptical and proposed waiting for more studies.


&nbsp;


This was a shock to many who had been expecting Dr Andrew Hill to not wait any further - and to deliver to the WHO an endorsement of Ivermectin (for prophylaxis and treatment).

Dr Tess Lawrie - an advocate of early treatment and of Ivermectin as one of the remedies - was in talks with Dr Andrew Hill, according to her account, to work on a Cochrane review of Ivermectin (Dr Tess Lawrie has prior experience writing Cochrane reviews and in advising the WHO).

She was also surprised by the conclusions presented by Dr Andrew Hill.

She reported that she had confronted him about this decision - and had been told that the "sponsors" (Unitaid - and specifically an influential French cancer researcher) had ghost-written the Conclusion part to downplay the immediate use of Ivermectin.

She chose to part ways with Dr Andrew Hill on the Cochrane review - and do the review herself.

Later, Cochrane chose another group to do the evaluation - and turned in a negative review of Ivermectin - as they hand-picked the studies that were included in the meta-analysis.


&nbsp;


An audio recording later emerged - confirming Dr Tess Lawrie's narration of events.

It was a video recording of a zoom call between Dr Andrew Hill and Dr Tess Lawrie - which corroborated the earlier accounts of the discussion by Dr Tess Lawrie (see links below for a video excerpt).


&nbsp;


Other audio also emerged where Dr Andrew Hill seemed to be downplaying the delay's impact on the UK  arguing tha since the UK didn't have Ivermectin stockpiles anway, a delay would have little impact on the UK.

It is possible that the delay of confirmation may have had a strategic reason - to provide time for the UK to secure strategic reserves of Ivermectin.

However we don't have compelling evidence to suggest that Ivermectin was used at all in the highest echelons of power in the UK either.  So even if it was stockpiled - it was never used.  Or was not even stockpiled.


&nbsp;


Critics of Dr Andrew Hill say that his concession to UNITAID ("the sponsors") was an unattributed change to his paper - where Conclusion was written by a third party (and not one of the authors).


&nbsp;


To his credit, Dr Andrew Hill did contribute to the promotion of Ivermectin - with his talks and presentations on video to various audiences.

His failing was that he did not go against his sponsors - and did not play the hero that people had expected him to be.

For a person to be in a crucial position at an opportune time - and to fail to leverage that position - was a tragic opportunity missed in the eyes of early treatment advocates.

That is - they were hoping Dr Andrew Hill would stick to his guns - and become a whistleblower of sorts at a time when all attention was on him.

My defence of him has been that not everyone can be a hero.  We also do not know what compulsions Dr Andrew Hill was at that time.


&nbsp;


This case however highlights the weakness of the public as well - where such policy and power is abdicated to 3 letter organizations - who in turn are under government and private influence (like the Gates Foundation has excessive influence over the WHO - being large funder - and over the field of epidemiology - being primary funder).

It is a major weakness for the world to depend on the bravery and fortitude of a single scientist - to set things right.

And signals the lack of preparedness of the public for such events.

When the Gates Foundation is prepared - he gets a place at the table ahead of the public.

Gates Foundation - as the sugar daddy of epidemiology - has built up an influence networks within the army of epidemiologists (to the point that it would be dangerous to their career to go against what GAVI is advocating - when GAVI was advertising against Ivermectin, which epidemiologist would buck that signal?).


&nbsp;


This article has portions of the zoom video call between Dr Andrew Hill and Dr Tess Lawrie - where they argue over the need for releasing the results to the public (Dr Tess Lawrie) - and Dr Andrew Hill arguing for more time - and that there is pressure from his sponsors (Unitaid).


https://bird-group.org/watch-dr-tess-lawrie-sends-a-video-letter-to-dr-andrew-hill-one-year-on-from-his-u-turn-on-ivermectin/

Watch. Dr Tess Lawrie sends a video letter to Dr Andrew Hill one year on from his U-turn on ivermectin

March 7, 2022



&nbsp;



Video:

https://odysee.com/@OracleFilms:1/2022.03.04-A-Letter-to-Andrew-Hill-V8_HD:3

A Letter to Dr Andrew Hill | Dr Tess Lawrie | Oracle Films

March 4th, 2022

Oracle Films



&nbsp;


TrialSite News coverage of the controversy:

https://www.trialsitenews.com/a/the-case-of-dr-andrew-hill-was-their-unethical-activity-associated-with-his-ivermectin-meta-analysis-or-just-another-drug-dev-day

The Case of Dr. Andrew Hill: Was there Unethical Activity Associated with his Ivermectin Meta-Analysis or Just Another Drug Dev Day?

TrialSite Staff

Dec. 13, 2021


See this reddit comment - for Dr Pierre Kory response to Dr Andrew Hill's change of posture regarding Ivermectin:

https://old.reddit.com/r/ivermectin/comments/ov3z28/pierre_kory_md_replying_to_dr_andrew_hill/h77wbhw

Archive of above webpage:

https://archive.ph/GE8bO



&nbsp;


See this reddit comment - for Dr Robert Malone's defense of Dr Andrew Hill (this was when there was hope of positive news eventually from Dr Andrew Hill):

https://old.reddit.com/r/ivermectin/comments/o6oclg/andrew_hill_finally_tweets_about_ivermectin_again/h2x1v33

Archive of above webpage:

https://archive.ph/AnoEy



&nbsp;


Discussions on whether Dr Andrew Hill or his university (Univ of Liverpool) benefitted somehow by complying to pressure in the report on Ivermectin to Unitaid/WHO:

https://twitter.com/carriepricecox3/status/1558121047483899905?t=Z9bFFkI-MsEOSX7Y-8daQw&s=19

>How much grant money did Andrew Hill’s department at University of Liverpool receive from the Bill & Melinda Gates Foundation in the mist of his..shifting of position? Sizable. We see how this works.


&nbsp;


https://www.healtheconomics.com/industry-news/researcher-andrew-hills-conflict-a-40-million-grant-from-bill-and-melinda-gates-vs-a-half-million-human-lives

Researcher Andrew Hill’s conflict: A $40 million grant from Bill and Melinda Gates vs a half million human lives

by WorldTribune Staff

December 9, 2021



&nbsp;


https://twitter.com/alexandrosM/status/1558146599678750720?t=RQaGpcX4zdXBGh2qpW-Dnw&s=19

**Alexandros Marinos**

>I think the precise details of that grant are not correct there, though I do think the grant was a big factor in what happened.



&nbsp;


Other coverage:


https://gettr.com/post/pyj4qa87b1

>In this video, the single most influential person in the anti-Ivermectin narrative, Dr. Andrew Hill, admits to knowingly shaping his findings based on institutional influence and withholding information about the efficacy of Ivermectin while millions of people were dying.  
>
>This video is absolutely stunning.
>
>WATCH:
>
>https://theconservativetreehouse.com/blog/2022/03/04/dr-andrew-hill-the-man-who-killed-millions/


&nbsp;


https://theconservativetreehouse.com/blog/2022/03/04/dr-andrew-hill-the-man-who-killed-millions/

Dr. Andrew Hill, The Man Who Killed Millions?

March 4, 2022



&nbsp;



Example of the type of reactions:

https://twitter.com/LizEarleMe/status/1500345790526636032?t=09IjAkSTAIIp3RBelioxpg&s=19

>Andrew Hill seemed so very pro ivermectin and the studies looked as tho extremely helpful. I contacted many times for an interview/comment - then he dropped off the face of the earth, went silent. Always wondered why. Devastating if this is as true as it seems.



&nbsp;



* * *





## **Ivermectin - Proposed mechanisms of action**


&nbsp;


https://www.nature.com/articles/s41429-021-00430-5
The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article
15 June 2021


&nbsp;


This video by Dr Been was removed by YouTube - and is now available here:

- https://odysee.com/@DrMobeenSyed:1/Ivermectin:7 Ivermectin Mechanism of Action


&nbsp;


u/Haitchpeasauce analysis of mechanisms of action:

https://old.reddit.com/r/ivermectin/comments/ooncz9/3_existing_drugs_fight_coronavirus_with_almost/h604qi8


&nbsp;



* * *



## **Ivermectin and cancer**


&nbsp;


https://old.reddit.com/r/ivermectin/comments/l3keqr/ivermectin_and_cancer/

Ivermectin and cancer

Archive of above webpage:

https://archive.ph/Ter6B



&nbsp;



* * *



## **Ivermectin and Scabies**


&nbsp;


Ivermectin is NOT approved by the FDA for treatment of Scabies - yet is widely considered the treatment of choice for Scabies:

https://ijdvl.com/wonder-drug-for-worms-a-review-of-three-decades-of-ivermectin-use-in-dermatology/
Wonder drug for worms: A review of three decades of ivermectin use in dermatology
2019

>Scabies
>
>Ivermectin is the only recommended oral medication for scabies.  Two doses of oral ivermectin are given 7 days apart, to act on newly hatched scabietic nymph. In severe or resistant cases, it is often combined with topical medications like permethrin.  Two doses of topical ivermectin were also found to be as effective as two applications of permethrin.  In case of crusted scabies, multiple doses of oral ivermectin are given as shown in [Table - 2].


&nbsp;


**Papers:**

https://pubmed.ncbi.nlm.nih.gov/25911032/
The efficacy of topical and oral ivermectin in the treatment of human scabies
2015

https://pubmed.ncbi.nlm.nih.gov/22960817/
Comparative efficacy and safety of topical permethrin, topical ivermectin, and oral ivermectin in patients of uncomplicated scabies
2012

https://pubmed.ncbi.nlm.nih.gov/19584457/
Crusted scabies
2009



&nbsp;


* * *



## **Ivermectin and Rosacea**

&nbsp;


Ivermectin is approved by the FDA for treatment of Rosacea:

https://ijdvl.com/wonder-drug-for-worms-a-review-of-three-decades-of-ivermectin-use-in-dermatology/
Wonder drug for worms: A review of three decades of ivermectin use in dermatology
2019

>Rosacea
>
>Ivermectin 1% cream is now approved by US FDA for inflammatory rosacea. Ivermectin not only targets Demodex folliculorum, but also reduces the inflammation associated with the condition.[16]


&nbsp;


**Papers:**

https://pubmed.ncbi.nlm.nih.gov/27504249/
The efficacy, safety, and tolerability of ivermectin compared with current topical treatments for the inflammatory lesions of rosacea: a network meta-analysis 
2016



&nbsp;



* * *


## **Ivermectin and Psoriasis**


&nbsp;


I (u/stereomatch) could not find much evidence for Ivermectin benefit for Psoriasis.


&nbsp;


However, this article suggests some interesting treatment possibilities:

https://www.aad.org/public/diseases/psoriasis/treatment/medications/off-label
Psoriasis treatment: “Off-label” medicines that work throughout the body

>6-thioguanine
>
>Azathioprine
>
>Fumaric acid esters
>
>Hydroxyurea
>
>Leflunomide
>
>Mycophenolate mofeti
>
>Sulfasalazine
>
>Tacrolimus


&nbsp;


Some cases of Psoriasis may be due to Crusted Scabies - in which case Ivermectin may be beneficial:

https://pubmed.ncbi.nlm.nih.gov/18257840/
Psoriasis or crusted scabies 
2008

>We describe a case of a 67-year-old woman with a 1-year history of nail thickening and a non-itchy erythematous scaly eruption on the fingertips. She was diagnosed with psoriasis and started on methotrexate after having had no response to topical calcipotriol. The diagnosis was reviewed after it was revealed by another consultant that the patient's husband had been attending dermatology clinics for several years with chronic pruritus, which had been repeatedly thought to be due to scabies. Our patient was found to have crusted scabies after a positive skin scraping showed numerous mites. She was treated with topical permethrin, keratolytics and oral ivermectin. We also review the literature on crusted scabies and its management, with recommendations. 


And:

https://pubmed.ncbi.nlm.nih.gov/33781644/
Crusted scabies mimicking psoriasis in a patient with type 1 diabetes mellitus 
2021



&nbsp;





* * *



## **Sodium butyrate topical application and Psoriasis**


&nbsp;


This section is speculative - however it covers the potential benefit of butyrate topical application on skin to alleviate the symptoms of psoriasis.

See this section in this paper on topical butyrate applications for skin conditions:


&nbsp;


https://www.mdpi.com/1420-3049/27/6/1849/htm

Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases

Serena Coppola, Carmen Avagliano, Antonia Sacchi, Sonia Laneri, Antonio Calignano, Luana Voto, Anna Luzzetti and Roberto Berni Canan

12 March 2022


&nbsp;


**3. Butyrate in Psoriasis Disease**

Psoriasis is a chronic immune-mediated inflammatory skin disease, affecting more
than 125 million people globally [30 ]. This condition is typified by enhanced tumor necrosis
factor-α (TNF-α)/interleukin-23 (IL-23)/IL-17 axis, with hyperproliferating epidermal ker-
atinocytes, and with anomalous differentiation [ 31 , 32]. Dendritic cells (DCs) secrete TNF-α,
which acts on themselves and induces the secretion of IL-23, which in turn induces the
conversion of Tregs into type 17 helper T (Th17) cells, which proliferate and overproduce IL-17A. IL-17A reduces forkhead box protein 3 (Foxp3) expression, suppressing Tregs
functional activity and stability [31 ]. Indeed, functional defects in CD4+CD25+ Foxp3 Tregs
affect patients with psoriasis, the main suppressors of the excess immune response and
mediators of homeostasis. Defects in Tregs may contribute to psoriasis disease development
and exacerbation [ 33 ].

The metabolites SCFAs of specific gut microbic populations (e.g., Bacteroides fragilis, Faecalibacterium prausnitzii, Clostridium cluster VI and XIVa) influence Tregs activity and number [ 34, 35], and several pieces of evidence reported that psoriatic patients show a decrease in the GM abundance of protective taxa producing butyrate, which may contribute to the defects in Tregs, such as Parabacteroides and Coprobacillus [36 ], Prevotella and Ruminococcus [37 ], Akkermansia muciniphila [ 38], and Faecalibacterium prausnitzii [ 39 ].

Furthermore, it has been shown that the gut microbial genes encoding the enzymes involved in butyrate synthesis, butyrate kinase, and phosphate butyryltransferase are less abundant in psoriatic patients compared to matched non-psoriatic controls [40].

Acetylation of H3 histones is associated with the activity of Tregs, and it has been described that H3 acetylation is significantly decreased in Tregs of patients with psoriasis, compared to healthy controls [ 41].

Since butyrate acts on DCs to promote Foxp3 expression in Tregs, and it has a well-known role as an HDAC inhibitor, it has been demonstrated that it induces on Foxp3 intronic enhancer the histone H3 acetylation, allowing the expression of Foxp3 in naïve CD4+ T cells, inducing their differentiation into Tregs [42].

The impaired number and activity of Tregs in psoriasis determine deleterious effects on the ability to control the inflammatory response [ 43 ,44 ]. It has been shown that Tregs isolated from the blood of psoriatic patients have an altered suppressive activity, which was normalized through the topical application of sodium butyrate on human biopsies of psoriatic lesions [41 ].

Sodium butyrate topically applied normalizes the enhanced expression of IL-17 and IL-6 and restores IL-10 and FOXP3-expression levels [ 41 ].

Moreover, in the same study it has been demonstrated that sodium butyrate, though only topically applied, reduced also systemic inflammation response, since it was able to reduce splenomegaly
and IL-17 expression and to induce IL-10 and Foxp3 in the spleen [41].

A more decreased expression of keratinocytes in psoriatic patients than in healthy controls of the butyrate binding receptors GPR43 and GPR109a [45 ] has been described.

The topical appliance of sodium butyrate was able to increase the reduced expression of both receptors and was able to restore the altered cytokine balance in psoriasis via GPRs. Butyrate topical application caused an increase in IL-10 and IL-18 production, and a reduction in the cytokines, which block the suppressive activation of Tregs, IL-17, and IL-6 [45].

Altogether, this evidence indicates that the restoration of defective Tregs represents a
promising therapeutic target for psoriasis disease. As stated, butyrate restores the defected
Tregs, and it may represent a promising tool in the management of psoriasis.



&nbsp;



**Improving the production of butyric acid in the gut**


&nbsp;


If topical application of sodium butyrate helps - then one could potentially address butyrate production by improving the gut synthesis of butyrate.

A probiotic which contains bifidobacteria - plus some dietary fiber like psyllium husk in water - maybe given over some period could alleviate the psoriasis (?).



&nbsp;



**Dietary butyric acid from food sources**


&nbsp;


One can get butyric acid from dietary sources - for example from butter - but it seems dietary butyric acid is at low levels in food sources (compared to what can be produced in the gut - by bifidobacteria digestion of dietary fiber):


&nbsp;


https://www.healthline.com/health/butyric-acid
What Is Butyric Acid, and Does It Have Health Benefits?

>The amount of butyric acid in food is small compared to the amount your gut bacteria produce.
>...
>Butter is one of the best dietary sources of butyric acid. About 11 percent of the saturated fat in butter comes from SCFAs. Butyric acid makes up about half of these SCFAs.



&nbsp;



**Oral sodium butyrate supplementation - caution for pregnant women**


&nbsp;


NOTE: some caution also, as this section suggests (this applies to sodium butyrate oral supplementation - not topical use for skin - which would lead to much less systemic dosage):


&nbsp;


https://www.healthline.com/health/butyric-acid
What Is Butyric Acid, and Does It Have Health Benefits?

>However, if you’re pregnant or breastfeeding, you may want to avoid butyric acid supplementation.
>
>One animal study found that giving pregnant and breastfeeding rats sodium butyrate led to insulin resistance and increased fat storage in their offspring.




&nbsp;





* * *



## **Ivermectin and Vitiligo (Leucoderma)**


&nbsp;


Some anecdotal cases of Ivermectin helping Vitiligo:

https://old.reddit.com/r/ivermectin/comments/t1umwi/ivermectin_and_vitiligo_leucoderma/
Ivermectin and Vitiligo (Leucoderma)

Archive of above webpage:

https://archive.ph/2EyDB


&nbsp;


Also see u/realopticsguy confirmation of similar results in his case:

https://old.reddit.com/r/ivermectin/comments/t1umwi/comment/hzb2i65/

Archive of above webpage:

https://archive.ph/sqmQA



&nbsp;



* * *





## **Ivermectin and gum disease**


&nbsp;


Just a single anecdote on Ivermectin impact on gum disease from u/realopticsguy:


&nbsp;


https://www.reddit.com/r/ivermectin/comments/t1umwi/ivermectin_and_vitiligo_leucoderma/hzb2i65

Archive of above webpage:

https://archive.ph/sqmQA


&nbsp;


u/realopticsguy says there:

>I have vitiligo.   My spots stopped growing after I took ivm for covid last summer.   Some have filled in. I was going to post here about it but I'm more impressed with how my gum disease has gone away.
>
>I found several papers about parasitic origins of gum disease,  and toxoplasmosis and an amoeba were mentioned.   Ivermectin treats both.





&nbsp;



* * *




## **Ivermectin and Asthma**


&nbsp;


https://old.reddit.com/r/ivermectin/comments/l3fbgb
Ivermectin and asthma


Archive of above webpage:

https://archive.ph/4Z3LC



&nbsp;


* * *


## **Ivermectin and seasonal allergies**


&nbsp;


Ivermectin seems to reduce seasonal allergies for some - which may or may not have a link to strongyloides exposure:

https://old.reddit.com/r/ivermectin/comments/mzet2x/allergy_cures/
Allergy Cures


Archive of above webpage:

https://archive.ph/1Qjgr




&nbsp;


* * *




## **Ivermectin and mold toxicity**


&nbsp;


Dr Syed Haider in his 2nd appearance on Dr Been YouTube channel, mentions that he has seen phenomenal benefit of ivermectin with mold toxicity patients. Normally they have to change residences etc.

https://youtu.be/Md-y01JdxvE Dr. Syed Haider Discusses COVID Management (July 2021) Drbeen Medical Lectures July 9, 2021

 

at the 5:15 minute mark:

https://youtu.be/Md-y01JdxvE&t=315

**Dr Syed Haider:**

>Like I've seen a few mold toxicity patients who responded very very well to Ivermectin - I mean it was shocking - I mean I told the lady you have mold toxicity - you don't have long covid19 - you don't have covid19 - you need to leave your house you know - you're not going to get better unless you leave your house.
>
>She was almost normal after starting Ivermectin - I mean it was just incredible - I mean I don't treat mold toxicity but i've read about it and you know the people who do treat it, they tell you you basically have to leave the mold - you know there's no other solution.
>
>You know you can you know detox all you want but as long as you're in the house with the mold there's you're just not going to get better - but um that was one of the most remarkable things - mold toxicity.

 

&nbsp;



Reference:

https://old.reddit.com/r/ivermectin/comments/ohtmt3/topical_calcineurin_inhibitors_are_an_effective/h4stj9t

Archive of above webpage:

https://archive.ph/bjUjP



&nbsp;



**Jan 10, 2023:** additional anecdote on mold toxicity (unfortunately that account seems to have been deleted):

https://twitter.com/LacosseVee/status/1409495091497013248?s=19

>repeated exposure to black mold tanked my immune system and allowed the dormant EBV to reactivate. A year and a half of every treatment published had little effect, until i tried IVM.



&nbsp;


* * *


## **Ivermectin and migraines**


&nbsp;


Found this interesting comment for a YouTube video:


&nbsp;


https://www.youtube.com/watch?v=Gz4adJXLHgA&lc=UgxzRme9wI8GLqEX9WF4AaABAg

Gold Country Russ

>Vindication is within sight, finally! I started prophylaxis with the FLCCC I-Mask+ protocol including Ivermectin on 12-23-20.
>
>Was infected in Jan-21 but that was only 1 night with head congestion, felt perfect the next day.
>
>So far, I have taken 70 doses at .2mg/kg, mostly on a once weekly basis.
>
>**The Ivermectin's only side effect has been to eliminate my migraine**, what's not to love about that? 



&nbsp;



* * *



## **Ivermectin for Multiple Sclerosis (MS), Lyme disease and for nerve remyelination**


&nbsp;


See:

https://old.reddit.com/r/ivermectin/comments/oxc4x8/taking_ivermectin_for_the_first_time_12mg/h7wxsde

>If you plan to start ivermectin for Lyme or Multiple Sclerosis (MS), you may want to start with a low dose so you can assess any side-effects for your case.
>
>Some Lyme disease patients, and Multiple Sclerosis (MS) patients may experience herxheimer reactions to the killing of parasites (Lyme), or to reaction with demyelinated nerves (MS) - since ivermectin is neuro-toxic but in humans does not cross blood-brain barrier.
>
>So as Dr Steven Phillips bestselling author of "Chronic" explains it is best to start with a low dose and build up - since ivermectin seems to help in the long run even with MS, because of it's nerve remyelination potential.
>
>Keep us updated.
>
>
>&nbsp;
>
>
>For more info on Lyme, MS and nerve remyelination potential, check out:
>
>https://old.reddit.com/r/covidlonghaulers/comments/ma4zal/pruned_fingers/gructg7



&nbsp;



See:

https://old.reddit.com/r/covidlonghaulers/comments/ma4zal/pruned_fingers/gructg7

>Regarding neuropathy mention in other comments - in the recent interview by Dr Been of recent bestselling book "Chronic" author Dr Steven Phillips, Dr Phillips said ivermectin may have remyelination impact.
>
>Since ivermectin helps with covid19 treatment, and anecdotally some subset of long haulers, I don't know if this is relevant.
>
>
>https://old.reddit.com/r/ivermectin/comments/mavt6e/ivermectin_and_multiple_sclerosis_ms_ivermectin/
>
>Ivermectin and Multiple Sclerosis (MS) - ivermectin as a potential nerve remyelination agent (for restoration of nerve cover in diseases like Multiple Sclerosis)
>
>
>Rough transcript:
>
>at the 37:08 minute mark:
>
>So yes I have used it - I think you have to have special care with patients with demyelination.
>
>Is what I wanted to say - **because ivermectin is also being studied as a remyelinating agent.  It can induce back the growth back of lining around nerves.**
>
>And paradoxically in my experience when I use it with MS patients - it flares them up like crazy - and we have to go extremely slowly, and then they get a net benefit, but it can take them a year to get up to full dose.
>
>And that's my experience with Ivermectin.



&nbsp;


For Lyme disease:


https://www.lyme.no/gjesteskribenter/335-eva-sapi-phd

Eva Sapi Ph.D.

>Eva Sapi Ph.D. is an Associate Professor of Biology and Environmental Science at the University of New Haven, where she combines teaching with research, leading graduate students in developing a higher level of understanding of Lyme disease. In her research, Dr. Sapi investigates the presence of different formations (spirochete, round bodies and biofilm) of Borrelia burgdorferi, the Lyme disease bacteria. She also studies resistance of these different forms to antibiotics and natural agents. She organized three national Lyme disease conferences in the last several years. 
>
>
>>Lyme disease is caused by the species of bacteria, Borrelia burgdorferi, and is transmitted to humans by a vector ticks, Ixodus scapularis. (1-2) Many investigators, including the University of New Haven Lyme disease research group, focused on identifying novel tick-borne bacteria, viruses and fungal co-infections in ticks or in patients with a tick bite history. (1-2) Despite these efforts and the introduction of novel treatment protocols, there are little improvements in the outcome of some of the Lyme patients.
>>
>>Can species other than bacteria, virus or fungus be responsible for these chronic problems found in Lyme patients?  It has been proposed that certain parasites could also be a factor in Lyme disease.  **European doctors have already incorporated Ivermectin, an antihelminth drug, into their Lyme disease protocol with surprising success.** Ivermectin is well known for its effectiveness against filarial nematode infections and is often used by veterinarians to eradicate parasitic infections. (3)



&nbsp;


A google search turns up some papers - search for - ivermectin nerve remyelination.


&nbsp;



https://pubs.acs.org/doi/10.1021/acsomega.8b01451

Ivermectin Promotes Peripheral Nerve Regeneration during Wound Healing

October 1, 2018

>Taken together, **we demonstrate that ivermectin promotes peripheral nerve regeneration by inducing fibroblasts to adopt a glia-like phenotype.**



&nbsp;



https://www.embopress.org/doi/full/10.15252/emmm.201708743

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis

July 4, 2018

>Conversely, potentiation of P2X4R signaling by the allosteric modulator ivermectin (IVM) favored a switch in microglia to an anti-inflammatory phenotype, potentiated myelin phagocytosis, promoted the remyelination response, and ameliorated clinical signs of EAE. Our results provide evidence that P2X4Rs modulate microglia/macrophage inflammatory responses and **identify IVM as a potential candidate among currently used drugs to promote the repair of myelin damage.**



&nbsp;



https://multiplesclerosisnewstoday.com/2018/07/13/anti-parasitic-agent-eases-ms-motor-symtoms-aid-remyelination-in-ms-mice/

Common Anti-Parasitic Agent Eases Motor Symptoms, Aids Remyelination in MS Mouse Model

July 13, 2018


>By promoting the activity of a receptor called P2X4R that is present in microglial cells — immune cells that reside in the brain — ivermectin (marketed as Stromectol, or Soolantra) eased the clinical manifestations of experimental autoimmune encephalomyelitis (EAE; an induced autoimmune disease similar to MS in humans).
>
>Specifically, researchers saw evidence suggesting that ivermectin was “a potential candidate among currently used drugs to promote the repair of myelin damage,” they wrote.



&nbsp;



Dr Steven Phillips substack article on Ivermectin - anti-cancer, nerve remyelination potential, and use against chronic viral infections:

https://zerospin.substack.com/p/ivermectin-upon-neutral-ground
Ivermectin--Upon Neutral Ground
The truth will set you free. But first it will piss you off.
Mar 1, 2022



&nbsp;


**May 20, 2022:**

Also see this comment on Ivermectin for Lyme disease:

https://old.reddit.com/r/ivermectin/comments/uti3s8/comment/i9e0eqd/



&nbsp;


**Dec 20, 2023:**

An intro article:

https://statcarewalkin.com/info/ivermectin-for-ms-benefits-risks.html
Ivermectin for MS: A Comprehensive Guide


&nbsp;


This video is interesting also because of the comments there - which mention IVM use for MS:

https://www.youtube.com/watch?v=6-0KcMzLQpA
Could ivermectin promote myelin repair? - Pam Bartha
April 26, 2019

>In this video, Pam Bartha shares an exciting study that suggests ivermectin has the potential benefit to promote remyelination in MS lesions.


&nbsp;


**Other promising treatments**

Also search for minocycline and clemastine for Multiple Sclerosis.

Clemastine - there may be an increased risk of hemorrhagic stroke.



&nbsp;



* * *



&nbsp;




## **Ivermectin and diabetes**


&nbsp;


There have been some anecdotal reports that Ivermectin reduces diabetes symptoms to some degree.

Here someone reporting improved sleep after starting Ivermectin - which could possibly be due to reduced urination during sleep (because of reduced diabetic symptoms?):

https://old.reddit.com/r/ivermectin/comments/nv2ypg/sleep_has_improved/h11s3mc


&nbsp;


Another anecdote:

https://old.reddit.com/r/ivermectin/comments/rduj0y/antiviral_effects_due_to_lipophyllic_ivm/ho55c0c

>My anecdote. I experience severe insulin resistance as a diabetic. When I use IVM in the past the resistance seems to disappear.



&nbsp;


* * *



&nbsp;




## **Ivermectin and Dengue - antiviral activity**


&nbsp;


Ivermectin has some activity against Dengue virus as well.



&nbsp;




* * *



&nbsp;




## **Ivermectin and Dengue - early treatment for Dengue**


&nbsp;


Here are some ways that early treatment doctors have reported on the use of Ivermectin for Dengue.


&nbsp;



**Dr Darrell DeMello (Mumbai, India) dengue protocol:**

https://twitter.com/DarrellMello/status/1551100539790061568?t=pu3i07YE879C8SEadD7Smw&s=19

**DrDarrellDeMello**

>I have successfully treated patients with Dengue Fever using a combination of Colchicine and Ivermectin. Reversal of platelet count occurs 24-48 hours.  Covid-19 has helped me learn a lot!


&nbsp;



**NOTE:** the above tweet has now been deleted by the author (possibly related to his recent temporary ban on Twitter):


https://twitter.com/drakchaurasia/status/1552362119101759488?t=cYDiIzDddhIdaaNjyILwxg&s=09

**dr a k chaurasia**

>Dr D, were you blocked recently by twitter?




https://twitter.com/DarrellMello/status/1552368167476817920?t=v5OUDaLZxvILCy_6FrL-Hw&s=09

**DrDarrellDeMello**

>Yes...for a week



https://twitter.com/DarrellMello/status/1552369945551327235?t=6Uo4pbyI8TAjswbMYjleEw&s=09

**DrDarrellDeMello**

>Worst is LinkedIn.
>
>Deleted my 20+ year account with all my Corporate history, and contacts. For what reason ..don't know. Pathetic Customer Service.




&nbsp;

&nbsp;




Dr Darrell DeMello has been effective (for covid19) in using Ivermectin + Colchicine from day1 (when possible) - and steroids-at-day8.

His use of Colchicine tends to reduce the need for steroids - or reduce the dose required of steroids-at-day8 (to show reversal of post-day8 hyperinflammation).

A similar strategy seems to be working here for Dengue - since Dengue (like covid19) too has an inflammatory stage - where coagulopathy reduces platelets and leads to bleeding as an obviously recognizable sign of Dengue (in it's advanced stage).



&nbsp;

&nbsp;



**Dr A K Chaurasia (Uttar Pradesh, India) dengue protocol:**


&nbsp;


Ivermectin + Doxycycline + others (Nitazoxanide, HCQ):


&nbsp;



https://twitter.com/drakchaurasia/status/1551105036343582720?t=ZfcRPLWMAygxGcZNpTC1zg&s=19

**dr a k chaurasia**

>before covid, i used to treat dengue with doxy+acyclovir. 
after covid, this is my antidengue drug list
>
>https://twitter.com/drakchaurasia/status/1448513789649829891?t=x50f9FDf7mPC9sDjG2fz0Q&s=19



&nbsp;



Above he is referring to his tweet:


https://twitter.com/drakchaurasia/status/1448513789649829891?t=x50f9FDf7mPC9sDjG2fz0Q&s=19

**dr a k chaurasia**

>for dengue virus,
>
>doxycycline
>
>atremisins
>
>nitazoxanide
>
>ivermectin
>
>hcq
>
>clarithromycin
>
>aciclovir(weak effect)



&nbsp;


https://twitter.com/sundaecone888/status/1448514631253708802?t=JzzJ-P8V2fSrWCrdfyoU8Q&s=19

>Any peer-reviewed studies to back this up? My son recently got dengue and it has me paranoid.


&nbsp;



https://twitter.com/drakchaurasia/status/1448554584226471941?t=e3oWql8X9Egl_FEixQ150g&s=19

**dr a k chaurasia**

>here are few references, i think enough to convince you.
>
>https://pubmed.ncbi.nlm.nih.gov/24142271/
>
>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277121/
>
>https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006715
>
>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998463/




&nbsp;


* * *




## **Ivermectin and Herpes Simplex Virus type 1 (HSV-1)**


&nbsp;


Here is one anecdote from reddit for herpes simplex virus type 1 (HSV-1) - cold sores appearing less often with Ivermectin use:


&nbsp;


https://old.reddit.com/r/ivermectin/comments/1045j2e/has_anyone_heard_of_neurological_symptoms_due_to/j37dwx5

**Timirninja**

>That’s could only mean that I don’t have holes in my guts 👍
>
>Have you tried ivermectin yourself? Amazing thing, I have herpes (cold) coming out every now and then in the winter, and ivermectin works amazingly to stop the blister from forming



&nbsp;



Anecdote on use of L-lysine and Ivermectin for reduction of cold sores:

https://old.reddit.com/r/ivermectin/comments/mfi4qj/_/gsnpwl1

>I take 500-1000mg l-lysine daily to control my area cold stores, and I can say they haven't been aggravated by ivermectin every 2 weeks. I haven't had a cold sore in years since starting the lysine. I used to get one every month with my period or more often with stress.




&nbsp;


* * *




## **Ivermectin and Herpes zoster virus (shingles)**

Shingles is caused by the varicella-zoster virus, the same virus that causes chickenpox:

https://my.clevelandclinic.org/health/diseases/11036-shingles


&nbsp;


* * *




## **Ivermectin and Epstein-Barr Virus (EBV)**


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536980/

Quantitative proteomics reveals a broad‐spectrum antiviral property of ivermectin, benefiting for COVID‐19 treatment

Na Li, Lingfeng Zhao, and Xianquan Zhan

>Ivermectin has been demonstrated to limit infection by a number of viruses with potential broad‐spectrum activity (Yang et al., 2020). For example, ivermectin has been reported anti‐HIV‐1 reliant on importin α/β nuclear import (Wagstaff, Sivakumaran, Heaton, Harrich, & Jans, 2012). Ivermectin could reduce MAPK pathway activation through the inhibition of PAK‐1 activity. **The high content screening also identified ivermectin as a promising drug against EBV‐positive and EBV‐negative nasopharyngeal carcinoma cells** (Gallardo, Mariamé, Gence, & Tilkin‐Mariamé, 2018). **Herpes genitalis and infections, which are caused by HPV in males, might have an effective treatment choice for oral ivermectin, but it has not been officially approved until now** (Buechner, 2002). 



&nbsp;


Spironolactone may have some benefit against EBV:

https://healthcare.utah.edu/publicaffairs/news/2020/05/epstein-barr-virus.php
STUDY COULD SUGGEST A NEW WAY TO CONTROL EPSTEIN-BARR VIRUS
May 2020

>Four years ago, the U of U Health research team found that spironolactone, a medicine routinely used to treat heart failure, has an unexpected antiviral activity against EBV. They discovered the drug targets an EBV protein, called SM, that the Swaminathan lab and others previously showed is essential for EBV replication. 



&nbsp;


Anecdote on Ivermectin for EBV:

https://twitter.com/LacosseVee/status/1409478863432957958?s=19

>I can only speak from my personal experience: I had an established CREBV with an EBV EA of more than 150, when I developed CV19 on top of that. 2 doses of ivermectin knocked out BOTH. From bedridden to bicycle in less than a week! #ivermectinworks


&nbsp;



* * *




## **Ivermectin and Fatty Liver Disease**


Just a single anecdote here for fatty liver disease reversal with Ivermectin - when used at prophylaxis dosing for 26 weeks:


&nbsp;


https://twitter.com/stumpie_heart/status/1613880378938343424

**Stumpie Collins**

Jan 13, 2023

>High risk & elderly.Refused to be a human lab rat. Knew Big Pharm was lying. Was an early IVM prophylaxis patient. Still have your txt mssge. On IVM for 26 weeks during Delta. Never once sick. By the way fatty liver went bye-bye while on IVM. PCP impressed. Thank you


&nbsp;


For fatty liver disease also see sections:

**NAC for Fatty Liver Disease - reversing organ damage**

**NAC impact on stomach "spare tire" and systemic inflammation**



&nbsp;


* * *



## **Ivermectin for COVID-19 long haulers**


&nbsp;


There are a number of reddit posts where users have reported benefit from Ivermectin for long haulers syndrome:

https://old.reddit.com/r/ivermectin/comments/nz88mq/has_anyone_been_able_to_cure_post_vax/h1pu2nv
Has anyone been able to cure post vax neurological and numbness?



&nbsp;


* * *



## **Ivermectin for COVID-19 post-vaccine injury/issues**


&nbsp;

Keywords:

- Vaccine Long Haulers

- Post-Vaccine Inflammatory Syndrome (PVIS)


&nbsp;


There are a number of reddit posts where users have reported benefit from Ivermectin for post-vaccine issues:


&nbsp;


See this case and my comments there too - for relief of neurological symptoms post-vax:

https://old.reddit.com/r/ivermectin/comments/o5g09s
IVR After Pfizer Vaccine [Neurological Side Effects].

or

https://archive.is/pYhBw



&nbsp;


Update:

https://old.reddit.com/r/ivermectin/comments/osx45y/ivermectin_pepcid_liposomal_glutathione_cured_me
Ivermectin + Pepcid + Liposomal Glutathione Cured Me. 90% Better After Vaccine Nerve Problems.

or

https://archive.is/3T86e



&nbsp;


* * *



## **Ivermectin for COVID-19 pre and post-vaccine prophylaxis**


&nbsp;


See:

https://old.reddit.com/r/ivermectin/comments/retnve/interested_in_a_discussion_on_taking_ivermectin/ho9t929



&nbsp;



* * *



## **Ivermectin and post-covid19 Anosmia/Fatigue reversal**


&nbsp;


NOTE: also see the section **Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs**


&nbsp;



NOTE: also see this post which surveys the other treatments available for post-covid19 anosmia reversal:

https://old.reddit.com/r/ivermectin/comments/u90dje/survey_of_anosmia_treatments_ivm_or_other/
Survey of Anosmia treatments - IVM or other treatments - share your experiences reversing covid19 anosmia (taste/smell loss) esp. if reversal was immediately after treatment start (i.e. looks like treatment helped immediately) (April 21, 2022)

Archive of above webpage:

https://archive.ph/ZB9qV



&nbsp;



NOTE: also see this post for further discussion of anosmia reversal with Ivermectin:

https://www.reddit.com/r/IntellectualDarkWeb/comments/ucexm5/why_do_my_dogs_smell_like_orange_slices_the/
Why do my dogs smell like orange slices? The latest research on how COVID messes with smell - USA TODAY - (April 24, 2022) - article talks about the need for anosmia research and treatments but fails to talk about the treatments that work reliably - like Ivermectin

or

https://archive.ph/Hnwgx


&nbsp;



In the post-day8 period, if a patient has residual anosmia or residual fatigue, usually this course of Ivermectin reverses it:

- Ivermectin 0.4mg/kg bodyweight per day - for 3 days

If there is still residual anosmia or residual fatigue, wait a week, and then do the 3 day protocol again.


&nbsp;


NOTE: Ivermectin should not be given to children below 15kg weight (2024-02-29 - corrected from 50kg to 15kg).  Also avoid giving to pregnant and breastfeeding mothers (since children have a reduced blood-brain barrier).  However, historically over it's 40 years of use and 3.7 billion doses given, it has been given to pregnant and breastfeeding mothers without an obvious signal of harm.  But still should be avoided in pregnant and breastfeeding mothers.

NOTE: if the patient has been given Ivermectin during the day1-7 period and the doctor feels they already have taken a lot of Ivermectin - then wait a few days - and then do the above protocol.  This protocol can be done as a matter of course - to ensure any residual anosmia/fatigue is taken care of.

NOTE: the above protocol assumes the patient was given Ivermectin during day1-7 period as well.  However while Ivermectin during day1-7 may reduce anosmia - anosmia can still appear in some of the patients.  However, for those patients, the above 3 day course when done in the post-day8 onwards period, is usually sufficient to reverse anosmia and residual fatigue.

NOTE: I (u/stereomatch) have observed 5-7 cases of anosmia reversal with Ivermectin in a retrospective fashion (i.e. anosmia reversal was not specifically targeted - but was reported as having happened in a time-sensitive manner following Ivermectin use).  Later I tried suggesting Ivermectin to 6 successive anosmia patients (who agreed on the above protocol to reverse their ongoing anosmia - all 6 were recent post-covid19 cases) - in every one of the cases there was anosmia partial reversal within 12 hours - and complete reversal in 1-2 days.  One case had partial reversal - and was advised to wait a week - and then repeat the 3 day course - after which her anosmia was 100% reversed.

NOTE: the 5th of these 6 successive cases was actually Dr Been's mother-in-law - he had reported his mother-in-law was still suffering from anosmia - and I had reminded him that Ivermectin reversed anosmia - he later reported he had given Ivermectin and his mother-in-law's anosmia had reversed in 2 days.

NOTE: this protocol has also been used for post-covid19 residual fatigue in the post-day8 period (when the patient has started steroids-at-day8 and is feeling great - but still has some residual fatigue).  If fatigue is reversed partially - then wait a week and do the protocol again.


&nbsp;




### **Ivermectin and post-covid19 Anosmia reversal - Dr Been testimony**


&nbsp;


Dr Been in his videos has also observed that Ivermectin reverses post-covid19 anosmia.

It started with a video report on his mother-in-law whose anosmia he reversed with a course of Ivermectin 0.4mg/kg per day (see video and transcript below).

In subsequent videos (see video and transcript below) he reported more cases where Ivermectin has shown anosmia reversal within 2 days.

In his words "Ivermectin .. works like magic".


&nbsp;


NOTE: in his videos, Dr Been has to take care when mentioning Ivermectin for covid19 - since YouTube will demonetize or remove videos (and author will incur a strike) if Ivermectin is mentioned as treatment for covid19.

NOTE: **YouTube Terms of Service explicitly prohibit mention of Ivermectin and HCQ as treatments for covid19**

NOTE: Of the successive cases of anosmia reversal I (u/stereomatch) have recounted above - the case of Dr Been's mother-in-law was the 5th.  I have added it to the statistics I was accumulating for successive anosmia cases observed.  This is how it happened - Dr Been had mentioned his mother-in-law had anosmia in one of his videos - I tweeted a suggestion that Ivermectin at the 0.4mg/kg dosing should be tried - which he apparently did - as he later reported that he had advised Ivermectin at 0.4mg/kg dosing for his mother-in-law - which reversed her anosmia within 1-2 days.



&nbsp;

&nbsp;



**Dr Been - mention 1:**

Dr Been says that he gave 0.4mg/kg to mother in law and got taste/smell recovery within 2 days:


https://youtu.be/PkhnEpToVdM

or

https://odysee.com/@DrMobeenSyed:1/europe,-asia,-africa,-me-covid-17:c

Europe, Asia, Africa, ME - COVID Questions with Dr. Been (#30)
May 20, 2021
Drbeen Medical Lectures


&nbsp;



**at the 38:40 minute mark:**

https://youtu.be/PkhnEpToVdM&t=2340

or

https://odysee.com/@DrMobeenSyed:1/europe%2C-asia%2C-africa%2C-me-covid-17:c?t=2340


**Dr Been:**

So Amman says Dr Bean I've lost my taste sensation - what can I do?

So I'll tell you what I did for my mother-in-law - my mother-in-law was vaccinated - she went in for the second vaccine dose and she came back and she had covid19.

So now she maybe already had covid19, or she got it from there - something happened.

And so she had covid19 and part of that was that within two days she lost her sense of smell.

And I started her on high dose Ivermectin - it was 0.3 or 0.4mg/kg bodyweight - and within two days her sense of smell came back.

My experience is that the sense of smell usually comes back in weeks or months - but high dose Ivermectin helps return that very fast.




&nbsp;

&nbsp;



**Dr Been - mention 2:**

Dr Been later reported another case study of anosmia reversal with Ivermectin:


https://twitter.com/drbeen_medical/status/1398836755088871427

**Dr. Mobeen Syed**

May 30, 2021

Case report. 

Acute COVID patient. Healthy young female. Anosmia occurred. Her doctor brother asked for advice. 

Started her on Ivermectin. 0.3 mg/kg body weight. Recovered from anosmia in two days. 

Message in the image says, "my sister has recovered. Taste is back."




&nbsp;

&nbsp;



**Dr Been - mention 3:**

Dr Been video overview of anosmia - and why it may be recoverable with IVM without long term damage.

Dr Been also discusses Ivermectin doses that he has used for reversing anosmia (this is after he used Ivermectin for reversing anosmia for his mother-in-law):


https://youtu.be/wTQk5BM0L2w (YouTube has removed this video - but it is available on Odysee)

or

https://odysee.com/@DrMobeenSyed:1/ivermectin-and-covid-anosmia-a-review-of:9

Ivermectin and COVID Anosmia A Review of Studies
Drbeen Medical Lectures
June 8, 2021


&nbsp;


**at the 9:34 minute mark:**

https://youtu.be/wTQk5BM0L2w&t=574 (YouTube has removed this video - but it is available on Odysee)

or

https://odysee.com/@DrMobeenSyed:1/ivermectin-and-covid-anosmia-a-review-of:9?t=574

>Now how do we fix this (anosmia)?  (With) high dose Ivermectin - and what is the high dose that I have used - I have used .. again make sure that the side-effects and (you have made sure) that the person can take this (dose).
>
>What I have done so far are **0.2-0.4mg/kg bodyweight - and within 2-3 days the person recovers from anosmia.**



&nbsp;

&nbsp;



**Dr Been - mention 4:**

Dr Been discusses Ivermectin for anosmia reversal again here:


https://youtu.be/Md-y01JdxvE

or

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid-2:8

Dr. Syed Haider Discusses COVID Management (July 2021)
Drbeen Medical Lectures
Jul 10, 2021



&nbsp;



**at the 13:20 minute mark:**

https://youtu.be/Md-y01JdxvE&t=800

or

https://odysee.com/@DrMobeenSyed:1/dr.-syed-haider-discusses-covid-2:8?t=800


**Dr Been:**

Ivermectin 0.4mg/kg bodyweight in long haulers esp with anosmia it works like magic - 2 or 3 days and done - anosmia goes away.


&nbsp;


&nbsp;



**Dr Been - mention 5:**

Dr Been discusses anosmia reversal with Ivermectin - in this more recent video as well:


https://www.youtube.com/watch?v=rgeP5lQiajc
Brain Shrinking after Mild COVID (Oxford Study)

or

https://odysee.com/@DrMobeenSyed:1/brain-size-reduction-after-mild-covid:a
Brain Size Reduction after Mild COVID (and Potential Solutions)

Mar 15, 2022

Drbeen Medical Lectures

Brain Size Reduction after Mild COVID (and Potential Solutions)



&nbsp;



**at the 35:00 minute mark:**

https://www.youtube.com/watch?v=rgeP5lQiajc&t=2100

or

https://odysee.com/@DrMobeenSyed:1/brain-size-reduction-after-mild-covid:a?t=2100

**Dr Been:**

My takeaway in this all was that the anosmia part we should worry about it if it occurs.

And i think that we have done this discussion that there is a drug (Ivermectin) that can be useful for anosmia and within 2-3 days it can help restore and recover from anosmia

I think that drug (Ivermectin) should be part of the management.

So I'm on Youtube here so I cannot say that IVM will help covid19 because Youtube would then just block my channel and this discussion.

(NOTE: YouTube Terms of Service explicitly forbid the suggestion that Ivermectin helps against covid19)

But I can talk about olfactory nerve and inflammation and Ivermectin reduces that - and that has been very very effective.



&nbsp;



**at the 35:48 minute mark:**

https://www.youtube.com/watch?v=rgeP5lQiajc&t=2148

or

https://odysee.com/@DrMobeenSyed:1/brain-size-reduction-after-mild-covid:a?t=2148

**Dr Been:**

So then what are the solutions

So one solution i just spoke about (Ivermectin).

I have been fortunate that the folks I have worked with who were taking IVM (Ivermectin) - they recovered very fast from anosmia.

I would suspect then the brain tissue damage were was reduced as well.



&nbsp;



In this followup companion discussions video, Dr Been uses an anatomy program - and does a walkthrough showing brain anatomy and the location of the olfactory bulb:


https://www.youtube.com/watch?v=X6Nwj2-YVRs
Discussion for Brain Shrinking After Mild COVID

or

https://odysee.com/@DrMobeenSyed:1/discussion-for-brain-size-reduction:0
Discussion for Brain Size Reduction After Mild COVID

Mar 15, 2022

Drbeen Medical Lectures




&nbsp;


NOTE: also see the section **Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs**



&nbsp;

&nbsp;




### **Ivermectin and post-covid19 Anosmia reversal - others**


&nbsp;



Dr Gustavo Aguirre Chang early study on post-covid19 anosmia reversal - study had 21 subjects with post-covid19 anosmia - near 100% anosmia reversal using Ivermectin + Aspirin:

https://zenodo.org/record/4065802#.X7yuEh5RU0N

COVID-19 Persistent: TREATMENT WITH IVERMECTIN AND ACETYLSALICYLIC ACID OF PATIENTS WITH THE PERSISTENT SYMPTOM OF ANOSMIA OR HYPOSMIA.

September 26, 2020

Twitter: https://twitter.com/Aguirre1Gustavo



&nbsp;



Report of 6 cases from Peter Pham (@peterpham on Twitter) - not clear how many were chronic/recent - anosmia must have been long enough that they sought out help - perhaps he can fill in some details on chronic/recent:

https://twitter.com/peterpham/status/1432040537654128640?s=19

**Peter Pham**

>Had 6 friends already solve anosmia with ivermectin


&nbsp;


**Dec 31, 2022:**

https://twitter.com/peterpham/status/1609119531573874688?t=cP-EmotHodZXYBblJYF1Ww&s=19

**Peter Pham**

>Yup. IVM fixed anosmia for me and about 5 other friends




&nbsp;




Dr. Juan M. Luco (Argentina) has been trying to build awareness of Ivermectin impact on anosmia.

Twitter: https://twitter.com/JML21071664/


This twitter thread points to the twitter threads by Dr Juan Luco on Ivermectin and anosmia:

https://twitter.com/stereomatch2/status/1496653830389444609



&nbsp;

&nbsp;



Dr Bruce Boros - we have this report from Dr Bruce Boros (no longer on Twitter) of 8 month anosmia case responding to IVM:

https://twitter.com/BorosBruce/status/1432027991056470020?s=19

>I have personally treated a lot of patients with Ivermectin for CV- Anosmia can return in 2 days of treatment or up to 2 months after. I also had an 8 month long hauler get back t and s after one week of Iver 0.2mg/kg. Called me at 8am shouting "I can  smell"



&nbsp;

&nbsp;



**EDIT:** adding Oct 5, 2023

Saw this while searching reddit for - ivermectin anosmia.

A report of anosmia reversal by u/007_jmp:


&nbsp;



https://www.reddit.com/r/ivermectin/comments/otjhfz/comment/hgnfj7m/

007_jmp

Oct 15, 2021

>After reading COUNTLESS articles and forums over the past weeks, I found this one... So I got Ivermectin yesterday and took my first pill then. Started noticing improvement as soon as last night!!! Can not believe the difference today. I am soooooooo relieved!!!!!!!!!
>
>My story: Got the rona in may/june....not too bad but lost taste and smell for about a week then gradually regained those over the next months. About a month ago out of the blue things started tasting chemically...and I would have a persistent chemical smell in my nose...then last week just breathing from my mouth and breath started tasting awful...like rancid chemicals...but only certain foods would trigger...sour cream (which I LOVE) was the worst most vile smelling tasting thing ever (but milk, cheese and ice cream were fine). soda, toothpaste, gum all AWFULL... but many other things tasted mostly normal. Yay for ivermectin.
>
>Anyway hope this helps someone.




&nbsp;

&nbsp;





### **Ivermectin and post-covid19 Anosmia reversal - long term anosmia reversal - months to years**


&nbsp;


**Recent post-covid19 anosmia reversal is easy**

As described above, the record of recent post-covid19 anosmia reversal is very promising.

Ivermectin when given in the post-day8 period (recent covid19 infection), seems to show palpable reversal of anosmia (taste/smell dysfunction - all variations - reduced smell to burning smell to modified smell) within 12 hours of an Ivermectin dose of 0.4mg/kg for 3 days.  Usually anosmia reverses 100% in 1-2 days.  If partial, one can wait a week and do a refresher course of Ivermectin - which in nearly 100% of cases is sufficient to reverse anosmia 100%.


&nbsp;


**Longer term anosmia reversal is a bit harder**

The record for longer term anosmia (where the post-covid19 anosmia or taste/smell dysfunction has persisted for 5-6 months or longer with little improvement using other treatments) is promising as well.  But a bit more complicated than the recent anosmia cases (as discussed above).

For longer term anosmia cases that I am aware of (where nothing was reversing the anosmia - taste/smell dysfunction - for months) - Ivermectin does seem to have an effect (where nothing else is helping).

And there are cases where 5 months to 1 year old anosmia cases have reversed 100% in a time-sensitive manner after use of Ivermectin.

HOWEVER, there can be cases where the reversal is partial - and may require longer followup with refresher courses.

I describe the longer term anosmia cases (and their experience with Ivermectin) below.


&nbsp;



**8 month old case**

I am aware of an 8 months old anosmia case (incorrectly mentioned by me as "10 months" sometimes in comments on twitter or reddit) - that Dr Bruce Boros reported on Twitter - that was not reversing and then on use of Ivermectin they were able to reverse it.


&nbsp;


**5 month old case**

I (stereomatch) heard from a 5 months old anosmia case who tried everything - but then tried Ivermectin (using the Dr Gustavo Aguirre Chang paper for the 21 cases study).  He had been unable to reverse the anosmia using many treatments - but finally Ivermectin reversed him in a short time back to near 100%.


&nbsp;


**5 months and 6 months old anosmia reversal cases**

Twitter user dialucrii31 reports of a 5 months old anosmia case - and a 6 months old anosmia case - both reversing with a 0.3mg/kg bodyweigh per day for 5 days course:


&nbsp;


https://twitter.com/dialucrii31/status/1706576237085217209?t=BsfONa91YPdPHYfCT1Pd1g&s=19

>My wife and a family friend cured 5 months and 6 months respectively of anosmia with a 5 day course of this.


&nbsp;


https://twitter.com/dialucrii31/status/1707488571236429972

>Sure, in both cases it was just persistent anosmia that was the lingering issue (plus some ageusia) . In both cases it was a 5 day course with symptoms disappearing gradually each day.
>
>0.3mg/kg iirc though it may have been higher.


&nbsp;


https://twitter.com/dialucrii31/status/1707862613130940546

>Both back 100%. As of a year or so later, no further issues, no return of symptoms.



&nbsp;




**Selection bias in reports from the field**

The 5 month, 8 month - and 5 month and 6 month - cases of reversals mentioned above may suffer from "selection bias" i.e. only the successful ones report back.  So the incidence of reversal may seem higher than it actually is (if you too 100 people with persisting anosmia - and started them on Ivermectin - and observed how many of them had anosmia reversal).

Because those who see success with a treatment are more likely to report back - while those who see no impact may be less motivated to report that.



&nbsp;



**1 year old case (without selection bias) - modest improvement**

I (stereomatch) recently heard from a nearly 1 year old anosmia case - who reported to me that he was starting IVM.

(NOTE: so observation was started first - then treatment was started - so no selection bias here - even failures would be observed as attentively)


&nbsp;


He tried Ivermectin at 0.4mg/kg for 3 days - and felt some benefit - then with repeated cycles (refresher courses) he did not see further improvement.

However he may try again later with another refresher IVM course.

So this illustrates that even with Ivermectin, there may be slow progress in some cases.



&nbsp;

&nbsp;




### **Long Haulers Treatments - Survey of Anosmia treatments - on Reddit**

See the section "Long Haulers Treatments - Survey of Anosmia treatments - on Reddit"



&nbsp;



### **Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs**

See the section "Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs"



&nbsp;

&nbsp;




### **Ivermectin and post-covid19 Anosmia reversal - standard of care**


&nbsp;


The standard of care seems to be that there is no cure for post-viral infection anosmia:

https://www.msdmanuals.com/home/ear,-nose,-and-throat-disorders/symptoms-of-nose-and-throat-disorders/loss-of-smell
Treatment of Loss of Smell 

>Doctors treat the cause of the anosmia. For example, people with sinus infections and irritation may be treated with steam inhalation, nasal sprays, antibiotics, and sometimes surgery. However, the sense of smell does not always return even after successful treatment of sinusitis.
>
>There are no treatments for anosmia itself. People who retain some sense of smell may find that adding concentrated flavoring agents to food improves their enjoyment of eating. 




&nbsp;





### **Ivermectin and post-covid19 Anosmia reversal - commercial analysis**


&nbsp;


Here is a non-free analysis of the anosmia market:

https://www.marketwatch.com/press-release/anosmia-market-competition-opportunities-and-challenges-market-players---glaxosmithkline-plc-pfizer-inc-atom-pharma---2022---2027-by-hny-research-2022-04-07

Press Release

Anosmia Market Competition, Opportunities and Challenges, Market Players - GlaxoSmithkline Plc, Pfizer Inc, Atom Pharma - 2022 - 2027 By HNY Research

April 7, 2022



&nbsp;







* * *



## **Ivermectin and post-vaccine hearing loss (in one ear)**


&nbsp;


To be added


&nbsp;



* * *




## **Ivermectin safety**


&nbsp;


Dr Hong has this video for pharmacists:

https://old.reddit.com/r/ivermectin/comments/ok1j43
Pharmacology professor on IVM


Video:

https://www.youtube.com/watch?v=36ummVGN6jA
COVID Focus Talk || Ivermectin Pharmacological Considerations || Is this drug suitable for everyone?
Jul 5, 2021
Dr. Hong's Pharmacy Classroom



&nbsp;


Merck 2002 study conclusion that ivermectin was safe at 10x doses:


https://old.reddit.com/r/ivermectin/comments/mxw8go
Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects. J Clin Pharmacol (2002)


&nbsp;


We have the data from ivermectin use for leukemia in children - they used very high doses of ivermectin - they used 1mg/kg (compared to the typical 0.2mg/kg) for 14 days to 6 months continuously (!) (compared to the typical 1 day to 5 days with refresher doses usually used for covid19):

https://old.reddit.com/r/ivermectin/comments/mrhctp/regular_dosing_of_ivermectin_for_prophylactic/gup3hd4
Regular dosing of ivermectin for prophylactic purposes - was this done in the past?



&nbsp;



* * *


## **Ivermectin drug shelf life**


&nbsp;


See comment by u/Haitchpeasauce: https://old.reddit.com/r/ivermectin/comments/ogonhi/what_happens_to_ivermectin_after_its_expiration/h4kbn41


&nbsp;


* * *



## **Ivermectin manufacturings costs**


&nbsp;


Dr Andrew Hill, who earlier did the meta-analysis for Ivermectin for Unitaid (in support of WHO decisionmaking), has argued in interviews that countries need to stockpile Ivermectin.

At the time of that interview he said the UK did not have a stockpile of the drug.

He has argued that if countries delay approval of Ivermectin too long, then other countries will secure strategic reserves, and later mover countries may not be able to secure supply.

In this report, he examines the manufacturing costs for various generic drugs that may have utility for covid19, including Ivermectin:


&nbsp;


See this reddit post:

https://old.reddit.com/r/ivermectin/comments/nt64zb/dr_andrew_hill_author_of_unitaid_paper_that/
Dr Andrew Hill (author of Unitaid paper informed the WHO decision on Ivermectin) pre-print on costs mass production of Ivermectin and repurposed drugs (June 3, 2021)-paper in line with concerns he raised earlier UK lacked strategic stockpiles of Ivermectin


&nbsp;


Paper by Dr Andrew Hill:

https://www.medrxiv.org/content/10.1101/2021.06.01.21258147v1
Minimum manufacturing costs, national prices and estimated global availability of new repurposed therapies for COVID-19
Junzheng Wang, Jacob Levi, Leah Ellis, Andrew Hill
June 03, 2021


&nbsp;


* * *




## **Early Treatment guide for physicians - Ivermectin**


&nbsp;



### **Ivermectin - interactions with other drugs**


&nbsp;


Ivermectin is contraindicated in patients using Warfarin (Coumadin) (Coumarin family that includes Warfarin).

Low dose heparin is ok - and is part of the FLCCC protocol for treatment of covid19.

Calcineurin inhibitors - used by transplant patients - because of interactions.  However transplant patients undergoing covid19 treatment are often switched in favor of steroids (instead of calcineurin inhibitors), precisely because steroids also interact with calcineurin inhibitors.  And steroids can be used instead for a short while - to prevent rejection.

Please correct any inaccuracy in above paragraph.


&nbsp;


**Added Feb 22, 2022:**

The FLCCC MATH+ extended protocol document PDF includes a section on Ivermectin drug interactions - see "Table 5. Drug Interactions With Ivermectin".

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf



&nbsp;



**Reference:**


https://www.youtube.com/watch?v=OY8QV7lnFFo

Dr. Paul Marik Discusses Ivermectin and Vitamin D

Feb 17, 2021

Drbeen Medical Lectures 


&nbsp;


**at 5:00 minute mark:**

Dr Paul Marik starts presentation for 30 minutes


**at the 25:20 minute mark:**

drug-drug interactions

caution with calcineurin inhibitors used for transplant patients




&nbsp;


There may be some interaction with cholera and dengue vaccines:

https://old.reddit.com/r/ivermectin/comments/kfw7de/ivermectin_and_covid_19_dr_john_campbell_reviews/ggb1k0x

>(although Dr. Pierre Kory has said in a video interview with Dr Been and Dr Paul Marik - that Ivermectin has no known side-effects or drug interactions - except for some mention of possible interaction with cholera and dengue vaccines)



&nbsp;



### **Ivermectin - few side effects**


&nbsp;


Ivermectin in general has almost no side-effects (see caveats below) at the **0.2mg/kg bodyweight dosage** (FLCCC-recommended for prophylaxis), even when taken over many days.

Many people have taken ivermectin now over 8 months or more, weekly at the **0.2mg/kg bodyweight dosing**, without any visible issues.


&nbsp;


### **Ivermectin - Dizziness, visual disturbances**


&nbsp;


**High sensitivity - dizziness, low blood pressure - 1 in 20 people**

About 1 in 20 people seem to show signs of dizziness right from the first dose.  These people will generally not feel like taking more of the drug.

For this reason it is important that those planning on using Ivermectin later - first do a test with a small dose (Ivermectin 6mg for instance) - so that they can be comfortable that they will be able to use Ivermectin when the time comes - for prophylaxis, for when they get covid19 or for long haulers.

Those who have Ivermectin available, can "pre-qualify" themselves ahead of time.  They can do this by taking Ivermectin once and seeing if they have any issue with the drug at that dose.

If they are not feeling any issue, then they can be sure that they will have ability to use Ivermectin in a moment of crisis i.e. when they get covid19.


&nbsp;


**Sensitivity after prolonged exposure - visual disturbances - dazed feeling**

At the **0.4mg/kg bodyweight dosage over 5 days or more** (FLCCC recommendation for covid19 treatment) can lead to some side-effects in some people.

These side-effects can be mild dizziness, or visual disturbances (which is similar to the daze one may feel when one has been sleep deficient for a few days).


&nbsp;


Those encountering signs of dizziness or visual disturbance - for these patients the dosage can be halved and often the issues go away.

If issues remain, then consider discontinuing Ivermectin - or switching to a spread out dosing strategy.  For example for weekly prophylaxis - instead of 12mg every Sunday, you may consider giving 3mg morning + 3mg evening on Sunday, and then 3mg morning + 3mg on Thursday.


&nbsp;


Usually Ivermectin at the 0.2mg/kg bodyweight every Sunday (pre-exposure prophylaxis) dosing - does not give any side effects.

However at the 0.4mg/kg bodyweight every day for 3 days (for example when used for post-exposure prophylaxis) or for 5 days or longer (for covid19 treatment or long haulers) - some patients may experience dizziness or visual disturbance (sensation is similar to when you are sleep deprived and start seeing visual artifacts).

In some people, Ivermectin (esp at the 0.4mg/kg dose) may be causing lower blood pressure (which may lead to dizziness).


&nbsp;


**EDIT: Sept 16, 2022** - another attempt by me (u/stereomatch) to describe what visual disturbances look like: "starting to feel the eye daze ie as if white or brightness button been jacked up so contrast is less but bright more"


&nbsp;


**EDIT: Feb 7, 2023** - another description by u/RestingLogo on reddit:

https://old.reddit.com/r/ivermectin/comments/10vnrkx/hard_to_balance_benefits_of_ivermectin_against/

or

https://archive.md/847X0

**RestingLogo**

>The day after I took the ivermectin I did experience some side effects. Everything looked "bright" and sometimes I could see blue flashes. This went away however and I noticed no long term effects.


&nbsp;


**NOTE:** this user took 0.5mg/kg bodyweight dose - and then reported the visual disturbance the next day.  This is not typical - usually at the 0.4m/g/kg dose it takes about 5 days for such symptoms to appear.  However it is possible this user took the higher 0.5mg/kg dose, and maybe took it all at once (instead of splitting it into morning/evening doses).  Or they may have had sensitivity to Ivermectin (which usually occurs in 1 in 20 users - though there usually they have dizziness due to low blood pressure - or just generally don't want to take additional dose).  In this case, the user didn't have those side effects and just the visual disturbance - maybe they are not sensitive - but the 0.5mg/kg dose was just too much for them.  Note that 0.6mg/kg doses are also given (I have used it on two or more occasions - one a 74 year old severe case and another vaccinated person who was asymptomatic but showed sharp declines at day7-8 with oximeter declines etc. - so higher dose was used to gain some leverage over the declines).  This dose of 0.6mg/kg doesn't always give this side effect - so results/responses can vary from person to person.


&nbsp;


More details from u/RestingLogo:

https://old.reddit.com/r/ivermectin/comments/10vnrkx/comment/j7n7khf/

or

https://web.archive.org/web/20230208012438/https://old.reddit.com/r/ivermectin/comments/10vnrkx/hard_to_balance_benefits_of_ivermectin_against/j7n7khf/

**RestingLogo**

>Everything seemed "bright" like I had night vision. It wasn't hard to see. Just felt weird.
>
>When I closed my eyes I would occasionally see instantaneous blue flashes at the sides of my vision.



&nbsp;


**EDIT: Feb 23, 2023** - Dr Jackie Stone (Zimbabwe) suggests the dazed feeling during the visual disturbances seen with prolonged use (without a break) of Ivermectin - is due to dilated pupils (similar to the feeling you get after an ophthalmologist appointment when they diluate your pupils using eyedrops):

https://twitter.com/DrJackieStone/status/1628459199490412549

or

https://web.archive.org/web/20230223115943/https://twitter.com/DrJackieStone/status/1628459199490412549

**Dr. Jackie Stone**

>We warn all patients that the pupil may dilate with higher doses of IVM so they may have the sensation of too much light coming in - and colours being brighter. This is always transient, and if they skip a dose it will go away. (1/2 life is >72hrs so safe to miss a dose)


&nbsp;


Here she gives her estimate - that about 16-20% of patients should show visual disturbances/artifacts after 6 days of 0.6mg/kg bodyweight dose of IVM (the discussion centers around how the ACTIV-6 trial which was negative for "mortality benefit" for IVM - that had a treatment arm with much less visual side-effect than would be expected at that dose - suggesting perhaps pure Ivermectin was not used or there was an issue with the trial conduct):

https://twitter.com/DrJackieStone/status/1628458361124450305

or

https://archive.ph/3FypD

**Dr. Jackie Stone**

>I would expect 16-20% at that dose. But once the critical phase is over - we recommend to give IVM at night - as visual side effects peak at 4 hours - so if the patient is asleep - they are not aware that their vision is abnormal if their eyes are closed.



&nbsp;



**EDIT: Apr 22, 2023** - another description by u/SchlauFuchs on reddit (about an accidental overdose and it's impact):

https://old.reddit.com/r/ivermectin/comments/10vnrkx/hard_to_balance_benefits_of_ivermectin_against/

or

https://archive.ph/SBr2t

**SchlauFuchs**

>The FLCCC protocol recommends Ivermectin *amongst other substances*. They have multiple protocols for prophylaxis, early treatment and serious treatments.
>
>Ivermectin at the dosage they suggest has nearly no side effects. If you double the amount they recommend, you might get light sensitivity and visual effects.
>
>**I took a tenfold amount once, a comma slipped in the calculation.**
>
>**I had strong visual interference for about half a day, light was far too bright, moving felt like walking in stroboscopic light. Definitely not in a state to drive any vehicle or heavy machinery.**
>
>But that was it.
>
>Yes, it builds up in your fatty tissue, that is why you take more at the beginning and then only one every fortnight for prophylaxis. But it does not accumulate forever, it wears off when you stop taking it.



&nbsp;





### **Ivermectin - Reducing dose**


&nbsp;



If such side-effects are experienced, the dosage should be halved, and usually the dizziness etc. will go away in most people.  The patient can then be continued on that lower doze.

If side-effects continue, the dosage should be halved again, or should be stopped.

And an alternative treatment strategy - using Fluvoxamine, or perhaps easier for many patients the over-the-counter Bromhexine (or other such candidates) may be considered.

Generally 1 in 20 patients have been observed who may have some sort of reaction the first time they use Ivermectin.


&nbsp;



### **Ivermectin - Genetic variation**


&nbsp;


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929173

Rarely, some people may have a genetic variation which weakens the blood-brain barrier.  In these folks, Ivermectin may trigger the dizziness etc. side-effects mentioned above.

The 1 in 20 people mentioned above who have side-effects, may have these issues, or may be suffering from parasites.


&nbsp;


**One possible strategy**

For those who are concerned, start with a minor dose instead, and see if patient starts to have dizziness or visual disturbances within half a day perhaps.

If so avoid it.

Or if taking full dose dose, if feel above symptoms, halve the dose or stop entirely.



&nbsp;





### **Ivermectin - Parasites**


&nbsp;


Occasionally patients can experience a **one-time soft stool or mild diarrhea** the day after - this is often because of worms being ejected (traditional anti-parasitic action of the drug)

But in such cases, for example the first time they take their prophylaxis weekly dose of ivermectin, they may get mild diarrhea the next day.  But this should not happen the next time, or in the weeks thereafter.

Patients with **Lyme disease or Multiple Sclerosis (MS)** may have a reaction to Ivermectin.  This can be due to a herxheimer reaction (as parasites die off), or due to demyelinated nerves (in MS).  For these patients, the use of Ivermectin may not be ideal, and the physician should consider using some of the other promising early treatment drugs like Bromhexine (which is also over-the-counter).


&nbsp;



### **Ivermectin - Lyme disease and Multiple Sclerosis**


&nbsp;


Regarding **Ivermectin for treating Lyme disease or Multiple Sclerosis (MS)**, Dr Steven Phillips author of the best-selling book "Chronic" (in a Dr Been interview) has mentioned that for Lyme or MS, the dosing of Ivermectin should be done very carefully - i.e. start off with very low doses, and then build up the dose over time.  He also refers to emerging evidence that Ivermectin may help with nerve remyelination (so may be beneficial for MS in the long run). (TODO: add references to Dr Steven Phillips' interview by Dr Been).


&nbsp;



### **Ivermectin - Kidney disease and Ivermectin**


&nbsp;



Dr Been addressed this in a Q&A session video recently - someone asked about any precautions for ivermectin and kidney disease.

He suggested there should be no special caution for kidney disease, although there might be some caution for liver disease, since ivermectin is metabolized in the liver.


&nbsp;




### **Ivermectin - Kidney transplant patients with covid19**


&nbsp;


Here is a review of things to watch for a kidney transplant patient who has covid19:



https://www.tandfonline.com/doi/full/10.1080/0886022X.2021.1876730

State-of-the-Art Review

Immunosuppression in kidney transplant recipients with COVID-19 infection – where do we stand and where are we heading?

Ahmed Daoud, Ahmad Alqassieh, Duaa Alkhader, Maria Aurora Posadas Salas, Vinaya Rao, Tibor Fülöp & show all

24 Jan 2021


&nbsp;


>**Ivermectin**
>
>
>Despite not FDA approved, to date, there are more than 15 peer-reviewed published articles showing high efficacy of the anti-parasitic agent ivermectin in prophylaxis and treatment of all stages of COVID-19 infection [47].
>
>In vitro, ivermectin administered to Vero-hSLAM cells 2 h after SARS-CoV-2 infection showed ∼5000-fold reduction of viral RNA after 48 h [48].
>
>Its anti-viral effect is thought to be mediated through the inhibition of importin α/β-mediated nuclear transport of SARS-CoV-2 proteins [48].
>
>Proposed dose is 0.2 mg/kg for 4–5 days.
>
>Caution is advised when using ivermectin with CNIs, the former being a known cytochrome P450 inducer, potentially altering CNI drug levels.


NOTE: CNIs (Calcineurin inhibitors) are often used as immunosuppressive agents for kidney transplant patients, to reduce risk of rejection.



&nbsp;



### **Ivermectin - Liver disease**


&nbsp;


Ivermectin has been given to liver transplant patients on occasion, with care.


&nbsp;



Dr Pierre Kory addresses ivermectin and impact on liver here:


https://www.youtube.com/watch?v=0S8IOttV-Ew

Vanakkam Tamil Nadu: Not Banning Ivermectin Could Have Saved More Lives: US FLCCC Dr. Pierre Kory

India Ahead News

Jun 11, 2021


&nbsp;


**at the 21:40 minute mark:**

https://youtu.be/0S8IOttV-Ew&t=1300

**Dr Pierre Kory:**

The idea that it (ivermectin) hurts the liver is a joke.

There are 3 cases reported in the literature of a hepatitis (ie in 40 years and 3.7 billion doses) with ivermectin.


Again today that report out of Argentina (La Pampa province) - they reported that in 3000 patients that they treated, not one serious side effect was reported - none.  In 3000.

But we already know that from the billions of doses.

As so, a French toxicologist that just finished a review about a month ago.

And in his report, the famous toxicologist, 350 different articles and studies done on ivermectin and he wrote, in his executive summary, that severe adverse events of ivermectin are unequivocally and exceedingly rare - unequivocally and exceedingly rare.


&nbsp;



* * *




## **Early Treatment guide for physicians - Steroids**


&nbsp;


### **Steroids - Usage**


&nbsp;


Prior to starting steroids, one should check for pre-existing conditions that sometimes are present in severe covid19 patients (diabetes predisposes to severe disease, so you may find many patients have uncontrolled blood sugar levels).


&nbsp;



### **Steroids - Bacterial infection**


&nbsp;


If the patient has **yellow/green phlegm** then it is an indicator they may have a bacterial infection.  NOTE: viral infections (like covid19) typical have **clear (transparent) phlegm** (the output from lungs).

In such a case, priority should given to reduce the bacterial infection before the start of steroids for covid19 (which are usually needed at day7-8 from first symptoms when hyperinflammatory stage starts appearing).

Antibiotic treatment (and if they are diabetic, their blood sugar level normalization) will help recover from bacterial infection within a few days.

Given the risk of bacterial infection, or the return of a bacterial infectionafter treatment with antibiotics, one may evaluate whether it is wise to start steroids at day7-8 or later.

If hyperinflammation sets in, treating it at day 10 will require a higher steroids dose.

So it could be argued that it is preferable to start on time i.e. at day7-8 but at low dose steroids, i.e. to arrest early, so that the possibility of needing high dose steroids later is avoided.

You cannot start steroids much earlier than day7-8 (unless obvious oximeter levels/pulse rate are suggesting hyperinflammation has started - in which case perhaps day1 was not judged correctly because of very mild early symptoms).

But if you start steroids much later, i.e. allow oximeter readings to fall too much, then more aggressive steroids therapy is required to stop daily decline.

So timing of steroids, and needing to ensure bacterial infection is eliminated - all these considerations have to be balanced.


&nbsp;


Please send your criticism or insights into how to deal with bacterial infection at a time when you want to give steroids - by posting a comment to:

**https://old.reddit.com/r/ivermectin/comments/oh7xfw/added_a_wiki_for_rivermectin_for_organizing_the**



&nbsp;



### **Steroids - unrelated dehydration**


&nbsp;


In hot/humid climates patients can sometimes lose a lot of water and have electrolyte imbalances.  This can be corrected with ORS (oral rehydration salts) and increasing water intake.  But may require rehydration with saline IV in severe dehydration cases.

Sometimes patients who have high pulse rate (which increases on standing up or going to the bathroom) may feel they need to reduce the need for urination, and they may wind up reducing their water intake severely - leading to dehydration.

Some patients may not be taking enough water to compensate for fluid loss via sweating and urination.

Common symptoms of dehydration can be:

- listlessness

- high blood pressure

- high pulse rate (100+)

If a patient seems to be dehydrated, saline IV - or lacking that ORS (oral rehydration salts) and water should be increased.

If patient has high pulse rate, and is stressed by getting out of bed, then a pot should be provided for urination while on bed.



&nbsp;




### **Steroids - DKA (diabetic ketoacidosis)**


&nbsp;


Steroids usually raise the blood sugar level of patients.  Some mild increase in sugar levels are ok, but in some patients this can lead to issues.

Paradoxically, in some patients, once they start steroids, their blood sugar levels can remain unchanged, or in some cases may even become better - it is possible such patients had ongoing inflammation issues pre-covid19, and the steroids fixed those issues (?)

During covid19, a lot of patients have not been visiting their doctors for their diabetes and other conditions.

As a result, many may have uncontrolled blood sugar levels in the 250-300 range, despite taking their old diabetes medicines.

Patients who are used to taking insulin using insulin pen, may be in better shape generally, since they have learned a procedure to check sugar on glucometer, and dose according to need.  Their blood sugar may be the best managed among diabetes patients.  These patients are generally also adept at adjusting their insulin pen doses to deal with rising blood sugar levels (due to starting steroids)(.


&nbsp;


Diabetic ketoacidosis can happen in patients with blood sugar levels around 300 for extended periods of time.  This can lead to electrolyte imbalances and insulin exhaustion (body unable to provide sufficient insulin).

This is a dangerous condition, and can be remedied in 2-3 days with electrolyte supplementation via saline IV, and administration of solubilized insulin via IV, while monitoring with glucometer every hour - in order to bring down blood sugar levels to 200-250 range or lower.

Common symptoms of DKA can be:

- excessive thirst

- frequent urination

- low blood pressure (though in some cases high blood pressure has been observed)

- high pulse rate (100+)

Source: https://www.mayoclinic.org/diseases-conditions/diabetic-ketoacidosis/symptoms-causes/syc-20371551


&nbsp;



Blood tests can reveal:

- lowered bicarbonate levels

- somewhat higher potassium levels (as it leaches out of cells)

- high ketone levels in urine



&nbsp;



Some more info on diagnosing DKA (adding March 25, 2023)

These symptoms are often reported for DKA:

- frequent urination

- dry mouth

- high blood sugar levels

- high ketones in urine


&nbsp;


https://www.aafp.org/pubs/afp/issues/2005/0501/p1705.html#:~:text=A%20diagnosis%20of%20diabetic%20ketoacidosis,mEq%20per%20L%20or%20less.

>A diagnosis of diabetic ketoacidosis requires the patient’s plasma glucose concentration to be above 250 mg per dL (although it usually is much higher), the pH level to be less than 7.30, and the bicarbonate level to be 18 mEq per L or less.
>
>Beta-hydroxybutyrate is a better measurement of the degree of ketosis than serum ketones.
>
>Intravenous insulin and fluid replacement are the mainstays of therapy, with careful monitoring of potassium levels.
>
>Phosphorous and magnesium also may need to be replaced.
>
>Bicarbonate therapy rarely is needed
>
>Infection, insulin omission, and other problems that may have precipitated ketoacidosis should be treated.
>
>Myocardial infarction is a precipitating cause of diabetic ketoacidosis that is especially important to look for in older patients with diabetes.
>
>Cerebral edema is a major complication that occurs primarily in children.


&nbsp;


More from it's impact on kidneys:

https://www.kidney.org/atoz/content/metabolic-acidosis#:~:text=Healthy%20kidneys%20help%20keep%20your,kidney%20disease%20from%20getting%20worse.

>Healthy kidneys help keep your bicarbonate levels in balance.
>
>Low bicarbonate levels (less than 22 mmol/l) can also cause your kidney disease to get worse.
>
>A small group of studies have shown that treatment with sodium bicarbonate or sodium citrate pills can help keep kidney disease from getting worse.  However, you should not take sodium bicarbonate or sodium citrate pills unless your healthcare provider recommends it.
>
>Diet: Increasing fruit and vegetable intake may decrease acid load in the body. This is because fruits and vegetables produce alkali, whereas foods such as meats, eggs, cheese, and cereal grains cause the body to make acid. Your kidney dietitian can show you how to safely increase the right type and amounts of fruits and vegetables in your diet based on your stage of kidney disease.



&nbsp;




### **Steroids - high dose steroids in the ICU - pulse dosing for "organizing pneumonia" - part 1**


&nbsp;



Dr Been interviews Dr Pierre Kory on the need for steroids.

Capped-to-6mg Dexamethasone and Remdesiriv are still (as of Dec 31, 2021) the standard of care at many large Us hospitals.

If patients require more than 6mg Dexamethasone, they stagnate and wind up on ventilator.


Dr Pierre Kory outlines why high dose steroids are needed to turn some patients around, and pulse dosing for "organizing pneumonia".


Here Dr Pierre Kory highlights the need for early high dose steroids - **"250mg methylprednisolone for 1st 3 days in ICU"**:



&nbsp;


https://youtu.be/3UTuT9TSRFQ

Dr. Pierre Kory Talks About Human Rights and The Big Science Disinformation

May 6, 2021

Dr Been Medical Lectures


&nbsp;


**Rough transcript:**

(for each of the timestamps below, a direct link to the section in the video is provided below)


&nbsp;


**at the 4:30 minute mark:**

https://youtu.be/3UTuT9TSRFQ&t=270

Discusses steroids - how Dr Umberto Meduri suggested steroids do have benefit when regulators saying no.

And his US Senate testimony.



**at the 5:30 minute mark:**

https://youtu.be/3UTuT9TSRFQ&t=330

6 weeks later were validated when Oxford RECOVERY UK trial results came out


**at the 6:00 minute mark:**

https://youtu.be/3UTuT9TSRFQ&t=360

Mentions his paper on "organizing pneumonia"

(at 6:50 minute mark says - it took him 6 journals to get it published)


**Pulse dosing - high dose steroids**

**And need to adjust to conditions, state of patient - not a rigid protocol of 6mg prednisolone for 10 days.**



**at the 7:00 minute mark:**

https://youtu.be/3UTuT9TSRFQ&t=420

6mg dexamethasone

**1 year into pandemic - and gods of science still saying Remdesivir and 6mg dexamethasone**


**Higher dose and methylprednisolone lead to more benefit**


**250mg methylprednisolone for 1st 3 days in ICU**



**at the 8:00 minute mark:**

https://youtu.be/3UTuT9TSRFQ&t=480

We are undertreating patients on a global scale and it is really hard to watch

We are using **anemic doses of a corticosteroid** that doesnt work very well


But is hard to watch the level of doctoring occuring globally


We put this thing (MATH+) back in March - there is such a thing as expertise




&nbsp;




### **Steroids - high dose steroids in the ICU - pulse dosing for "organizing pneumonia" - part 2**




&nbsp;


Dr John Campbell (YouTuber who appears on Deutsche Welle German TV) interviews Dr Pierre Kory for a more extensive discussion on the uphill task to convince the world to use steroids (in opposition to WHO/CDC/NIH comments against steroids).

See the interview and rough transcript of the steroids-related section below.


&nbsp;



The role of RECOVERY UK trial on steroids - how it finally removed obstacles and opposition to steroids.

However, it also led to some unfortunate bad practices - large US hospitals taking the RECOVERY UK trial outcomes literally - as is the practice of placing RCTs on a pedestal without employing common sense and real world observation.

Large US hospitals instituted policies based on their reading of the RECOVERY UK trial:

- capping the doses to 6mg Dexamethasone - but primarily not tailoring it to the patient

- giving Dexamethasone even though Prednisolone is faster to lungs and better tolerated at high doses (Dr Paul Marik in Dr Been interview)

- erroneous conclusion drawn from RECOVERY UK trial on steroids - that there is a signal of harm if steroids given before intubation (!) - a result probably due to lumping of very early and day8 patients in the study.  As a result they lose the window of opportunity to give steroids-at-day8 - because they are waiting for oximter levels to decline below 95 or 90 or for intubation (day10-14 time period).  And are allowing hyperinflammation to graduate to hypercoagulability.


&nbsp;


This strategy means the subset of patients who need more steroids, will stagnate and go to ventilator.

And by denying early treatment, an opportunity is lost for timely intervention.  Patient will go home and will usually come to hospital only when gasping for air.

Since patients are not sent home with steroids, they are unable to arrest hyperinflammation at home.

A vicious cycle is created which generates more serious cases, more ICUs, more ventilator beds.


&nbsp;


Large US hospitals turned away early patients - asking them to wait for hypoxia and then come back.

These people should have been given a medicine packet in the parking lot (by another team dedicated to this task) - the medicine packet would have included Ivermectin, Famotidine, Zinc, Vitamins, NAC, Aspirin - and Prednisolone (with a strong caution to take it on day8 or after consultation over phone).

An opportunity was lost to arrest early disease.

Ostensibly the reason for this hospital behavior was to do triage in hostile working conditions.

But this lack of treatment itself created more severe patients.

The mild cases of this week became the severe cases of next week.

An opportunity to add extra staff (from the National Guard etc.) in hospital parking lots was lost.



&nbsp;


Large US hospitals are still (as of Dec 31, 2021) using Remdesivir in post-day8 patients as standard of care.

The obfuscation of viral timeline and treatment in the public eye has created an opportunity for is the prescription of Remdesivir.

Even now (as of Dec 31, 2021) large US hospital protocols still have Remdesivir as standard of care for post-day8 treatment.

If viral timeline was clear to everyone - how would hospitals be able to justify giving Remdesivir at day8?



&nbsp;




**Video:**

https://youtu.be/JMeP66gdc4o

Dr Pierre Kory, Part 1, Steroids and anticoagulants

Dr. John Campbell

Apr 26, 2021


&nbsp;




**Rough transcript:**

(for each of the timestamps below, a direct link to the section in the video is provided below)


&nbsp;


**at the 2:28 minute mark:**

https://youtu.be/JMeP66gdc4o&t=148

**Dr John Campbell:**

So I know you are the early proponents of thinking about treatments for covid19.

And you are one of the first people in the world to suggest using steroids.

Now what are steroids and why are they important in covid19.



**at the 3:19 minute mark:**

https://youtu.be/JMeP66gdc4o&t=199

**Dr Pierre Kory:**

Live virus is not present generally after about 6-7 days - so these fears of using steroids ..


**at the 4:10 minute mark:**

https://youtu.be/JMeP66gdc4o&t=250

So I testified back in May 2020, back when every national and international health agency had statements we recommend against ..

all were against steroids - all of them

And so when I testified that it was critical to use steroids, I was roundly attacked and criticized for irresponsible recommendations, even though they were based on my expertise.

And let me answer your question - so why did we know it worked?

...

**at the 7:15 minute mark:**

https://youtu.be/JMeP66gdc4o&t=435

I told him (a doctor friend) - almost screamed at him on the phone - you have to start steroids.

A bit later he said he is a little bit of a hero in his hospital because of what he tried.

...

**at the 8:15 minute mark:**

https://youtu.be/JMeP66gdc4o&t=495

I recognized that this disease is actually what's called "organizing pneumonia" ...

It used to be called BOOP (Bronchiolitis obliterans with organizing pneumonia) or COP (Cryptogenic organizing pneumonia)

It's a pretty rare disease and is not well recognized even by lung specialists.


&nbsp;


Paper describing Organizing Pneumonia (September 2014):

>https://www.sciencedirect.com/science/article/pii/S2211568414000059
>Organizing pneumonia: What is it? A conceptual approach and pictorial review
>September 2014


&nbsp;


Paper by Dr Pierre Kory (December 2020):

>https://bmjopenrespres.bmj.com/content/7/1/e000724
>SARS-CoV-2 organising pneumonia: ‘Has there been a widespread failure to identify and treat this prevalent condition in COVID-19?’
>Pierre Kory and Jeffrey P Kanne
>December 2020


&nbsp;


**at the 8:35 minute mark:**

https://youtu.be/JMeP66gdc4o&t=515

But I noticed that the covid19 patients reminded me so much of organizing pneumonia patients.

And when I talked to one of my colleagues, he's one of the top chest radiologists in the world, I called him up one day and I said Jeff, what would you say if I told you that everybody with covid19 has Organizing Pneumonia ?

And he said of course they do - we published that back in March 2020 - this was like in April 2020.

I said what do you mean.

And he came up - him and a lot of national experts, they reviews all of the CT scans from Wuhan, China - and in their position paper in the Journal of Radiology, the top journal of Radiology in the world, they wrote the predominant form of lung injury in the CAT scans is of Organizing Pneumonia.


&nbsp;


**at the 9:15 minute mark:**

https://youtu.be/JMeP66gdc4o&t=555

Just so you know John, THE gold standard therapy for Organizing Pneumonia - corticosteroids.

...

I tried to publish my paper, saying that why is there a widespread misdiagnosis of this disease and no one is considering that this is Organizing Pneumonia.

It got published by 6 rejections.

One of the rejections by a top pulmonary journal.

**The reviewer told me, that to prove my hypothesis I would need to do a randomized control trial of corticosteroids.**

So this was before the RECOVERY trial.

And so are the reasons we thought that corticosteroids would work - it is a pandemic of Organizing Pneumonia.


&nbsp;


**at the 10:10 minute mark:**

https://youtu.be/JMeP66gdc4o&t=495

**Dr John Campbell:**

And this is to do with the idea that covid19 is a phased disease, and again you were one of the first people to identify that.

What is a phased disease and why is it important to know about.


&nbsp;


**Dr Pierre Kory:**

Dr Paul Marik really tried to codify the best way early on, but I will tell you ..

People knew on the ground that it starts to hit around day 5-7.

So one of my former mentors, he got covid19 very early on, before N95s were used widely in hospitals.

And we were really worried about him - and we were watching the data - everyone was really scared, it was like the clock, every day am I going to have trouble breathing.

And he started to develop a little problem breathing, but luckily he didn't advance to the severe phase.

And so we knew that if someone went into the pulmonary phase a little bit later on, and if arrested you went into like late phase pulmonary - which is basically kind of an ARDS pattern - really damaged lung.


&nbsp;


**at the 11:33 minute mark:**

https://youtu.be/JMeP66gdc4o&t=693


**Dr John Campbell:**

What about anti-coagulants - you were very early proponents of anti-coagulants.


&nbsp;

**Dr Pierre Kory:**

I want to mention one other really important .. about corticosteroids.

So the RECOVERY trial from Oxford - when they came up with showing they tried to save the world that steroids are saving ..

I got texts from all over the world .. we should have listened to Pierre ..

But here's the deal, John I got to tell you, **the dose they used in the RECOVERY trial is an absolute farce**.

6mg of dexamethasone is about 32mg of methylprednisolone (40mg prednisolone/Deltacortril).

I will give 82 year old COPD patients 40mg prednisolone.

**And so to give patients in severe lung disease on ventilators 6mg dexamethasone is a joke.**


&nbsp;


*(NOTE: basically these studies were killing people by being miserly with steroids doses - and these studies have inspired many doctors and hospitals to also use low doses - just as these studies have lamentably according to Dr Paul Marik unnecessarily pushed dexamethasone as the steroid of choice, when prednisolone is better tolerated at high doses and is faster to lungs - according to early Dr Paul Marik interview with Dr Been)*


&nbsp;


**at the 12:25 minute mark:**

https://youtu.be/JMeP66gdc4o&t=745

But fulminant cases need pulse dose steroids - look at our protocol - we have been calling for high doses and pulse doses from the beginning.

**Yet the entire world is being treated with Remdesivir and 6mg dexamethasone**.

It gives me chest pains - and the entire world has this idiotic protocol which is ineffective in most patients.

**I call 6mg dexamethasone - "it helps the few, and fails the many".**


**at the 13:00 minute mark:**

https://youtu.be/JMeP66gdc4o&t=780

The second thing about corticosteroids and Organizing Pneumonia - is that **you do not prescribe steroids for a defined time.**

There is not 5 days or 10 days - we are not built with calendars.

You know we follow disease - **secondly, you need to do prolonged durations - number three Organizing Pneumonia it relapses.**


&nbsp;


**at the 13:20 minute mark:**

https://youtu.be/JMeP66gdc4o&t=800

And you know .. I admitted patients back in September 2020 who were discharged, off oxygen, and they came back 5-6 days later - the lungs were whited out again (ground glass opacities and infiltrates).

And some of them died.

And it was because of widespread failure to realize **you need to treat for long durations with slow tapers.**


&nbsp;


*(NOTE: this is a common mistake by many doctors working from habit - many do a 1 week course of steroids for mild cases, and do a cold stop - instead of tapering off over another week - given that there is a risk of viral debris not having being fully cleared, there exists a risk of renewed irritation and immune excitement again if steroids are stopped too early)*


&nbsp;


&nbsp;



**at the 13:40 minute mark:**

https://youtu.be/JMeP66gdc4o&t=820

And so I have been trying to communicate that.

And lastly, so many of my trainees are finding my paper, they are recognizing a lot of Organizing Pneumonia in the patients that are discharged - the pulmonologists are able to say hey (Pierre) this is Organizing Pneumonia.


&nbsp;


**at the 14:00 minute mark:**

https://youtu.be/JMeP66gdc4o&t=840

But you asked about anti-coagulation.

You know the first 4 patients we had - we had been doing something called a TEG - you know what a TEG is - it's one of the newer and fancier coagulation assays you can do.  In the past it was PP, APTT ..

And now we have in hospitals something called a TEG - and you can get it very quickly.

And it gives you this wealth of information.

And it tells you where in the coagulation cascade you have a deficit - is it platelets, is it clotting factors, and you can also diagnose hypercoagulation states.

We were doing .. because we had heard there was a lot of clotting coming out of China and New York.

So we started doing these TEGs - and they were all what's called hypercoagulable - with zero what's called fibrin lysis.

Fibrin lysis is normally active in the body - (it was) zero.

**Once the clots were forming they were not breaking down.**

So we knew we had to use anti-coagulation.

So we saw these clots - and we knew these terribly hypercoagulable ..

And we were working with actually the top haematologists, very well published.

And he said this is extremely high risk for clotting.

So we put together a protocol and the anti-coagulation committee did - **but we had a chair of medicine who decided to overrule the anti-coagulation**.

**It was crazy stuff going on in hospitals.**

There is like "leaders" telling us what to do what they never did before - covid19's made everyone crazy.

**So this chair of medicine said no, I do not want to hear an anti-coagulation protocol, I disagree, you need to wait for the trials.**

...

So it is really hard to watch what is going on ..

There is massive widespread "oh we must wait for trials".

People forget how to doctor.

Would you just doctor.

You don't need a trial to tell you wipe your nose after you sneeze.



&nbsp;

&nbsp;



**References:**

Source (split into two comments because was 10,000 characters):


https://old.reddit.com/r/ivermectin/comments/mygb2b/dr_pierre_kory_part_1_steroids_and_anticoagulants/gw3i2ng

https://old.reddit.com/r/ivermectin/comments/mygb2b/dr_pierre_kory_part_1_steroids_and_anticoagulants/gw3i493







&nbsp;





### **Steroids - the good and bad impact of RECOVERY UK trial on steroids**


&nbsp;


Physicians around the world had seen inflammation in their patients.  And had used steroids.

Some in the developing world had used steroids very early as well.

Usually by day5 things still work out well.

But much earlier can lead to complications - as you don't want to give steroids too early in the live viral stage.


&nbsp;



The FLCCC (authors of MATH+ protocol) had from mid-2020 been clear about the use of steroids at day8.

This is in my (u/stereomatch) opinion their most significant impact on worldwide treatment of covid19.

They clarified the viral timeline in their MATH+ extended PDF - and backed it up by experimental reports (preliminary) that the live virus was near zero by day5 for many patients, and was near zero by day8 for nearly all patients.

This was the foundation of their rationale for prescribing steroids-at-day8 - no earlier (would impair immune response against live virus), and not much later (would allow hyperinflammation to take hold).

They also clarified it was the viral debris (or the processes set in motion) which led to the post-day8 hyperinflammation (which killed the patient).


&nbsp;


Yet this crucial information was absent from public visibility.

Why?

Because it was being actively censored - see section a few paragraphs below.



&nbsp;



The WHO/CDC/NIH went against steroids - and for a period of months steroids were dissuaged from being used worldwide.

Dr Pierre Kory appeared before the US Senate (having been invited by Senator Ron Johnson).

This appearance was widely seen, and at the same time censored by YouTube.  Fox News removed it from their channel.

However this appearance created pressure for steroids to be reexamined.


&nbsp;


Months later, the results of RECOVERY UK trial on steroids appeared.

It brought with it the good - the cloud that had been created over steroids, had now been lifted.

However, the RECOVERY UK trial results were also misinterpreted (literal reading of RCTs) - leading to some bad practices.


&nbsp;



**RECOVERY UK - 6mg Dexamethasone as canonical dose**

The RECOVERY UK trial on steroids also led to some unfortunate bad practices - large US hospitals taking the outcomes literally - and capping the doses to 6mg Dexamethasone.

This strategy means the subset of patients who need more tend to stagnate for a few days and then wind up on ventilator.



&nbsp;


**RECOVERY UK - Dexamethasone use vs Prednisolone**

The other unfortunate outcome from RECOVERY UK trial on steroids - is that large US hospitals have remained stuck to Dexamethasone, even though Prednisolone/Methyprednisolone are faster to lungs, and better tolerated at large doses (as Dr Paul Marik of FLCCC often takes pains to point out).

As of Dec 31, 2021, large US hospitals are still capping steroids dose to 6mg Dexamethasone and giving Remdesivir.



&nbsp;


**RECOVERY UK - erroneous finding that steroids harmful prior to intubation**

Another unfortunate reading has been taken from RECOVERY UK trial on steroids.  That there is a slight signal that steroids prior to intubation are harmful.

This is the worst misread - as RECOVERY UK probably lumping very early steroids with day7-10 (prior to intubation).

This simple misreading has resulted in US hospitals still (as of Dec 31, 2021) refusing to give steroids when dailiy oximeter declines are happening (post-day7-8).

The patient is on their way down to oximeter 95 and lower, but they will not move - because they are reading RECOVERY UK trial results to mean that steroids should only be given once intubated (i.e. patient is well below oximeter 90 and when hyperinflammation has transitioned to hypercoagulability).

This is the state of affairs.

This is because the majority of folks were until a few months ago (from Dec 31, 2021 - the time of this writing) still clueless about viral timeline.



&nbsp;



**A concerted effort to obfuscate viral timeline awareness in public?**

This viral timeline was elucidated mid-2020 by FLCCC MATH+ and by Dr Paul Marik in his interviews - that the live virus is near zero by day5 or so for some, and by day8 is near zero for nearly all.

This crucial data was behind the FLCCC insistence that steroids can be used post-day8.

Yet, there is still widespread unawareness of this crucial information.  Why?

Because there has been systematic censorship of the FLCCC and MATH+ protocol.


&nbsp;


**Censorship of FLCCC MATH+ - viral timeline - and steroids strategies**

On the r/covid19 and r/coronavirus sub-reddits on Reddit, the mere mention of FLCCC or MATH+ protocol could get you a perma-ban.  The FLCCC links to MATH+ were blacklisted on these subreddits.

Once a junior moderator re-allowed posting of MATH+ link on my insistence.

He came back apologetic a bit later - saying the full moderator panel of r/covid19 had voted and insisted that the ban on FLCCC links should remain.

This is thanks to the Trusted News Initiative (TNI) (see elsewhere her for more information).









&nbsp;





### **Steroids - Dr Pierre Kory (FLCCC) explains why anemic doses of steroids as standard of care are damaging**


&nbsp;



**Part 1:**

https://pierrekory.substack.com/p/hospitalized-covid-19-patients-are

Hospitalized COVID-19 Patients are Systematically Dying from Under-Treatment with Corticosteroids - PART I

US hospitals and their doctors almost never deviate far from the standard, anemic NIH recommended dose of 6mg of dexamethasone daily. Numerous studies support far higher doses far earlier in disease.

Pierre Kory

Dec 30, 2021



&nbsp;




**Part 2:**

https://pierrekory.substack.com/p/hospitalized-covid-19-patients-are-539

Hospitalized COVID-19 Patients are Systematically Dying from Under-Treatment with Corticosteroids - PART 2

US hospitals and their doctors almost never deviate far from the standard, anemic NIH recommended dose of 6mg of dexamethasone daily. Numerous studies support far higher doses far earlier in disease.
	
Pierre Kory

Dec 31, 2021




&nbsp;





&nbsp;



### **Steroids - Dr Pierre Kory (FLCCC) historic May 6, 2020 testimony in front of US Senate**



&nbsp;


In my (u/stereomatch) view, the greatest contribution of the FLCCC has been in the outlining of the viral timeline, and the implication for steroids use - and the legitimacy of steroids at day8 and beyond.

The work of the FLCCC that was publicized vis Dr Pierre Kory's US Senate testimony (before it was removed from YouTube) and then explained by Dr Paul Marik in his Dr Been interviews - was crucial for the wider dissemination of this understanding.  And has saved many patients.  Who would otherwise have been mismanaged, steroids stopped too soon, or steroids given too early.  Or steroids given in "homeopathic" doses (anemic) as phrased by members of the FLCCC - including Dr Paul Marik in his Dr Been interviews.

**Dr Pierre Kory (FLCCC) historic May 6, 2020 testimony in front of US Senate - at a time when steroids were being actively discouraged by WHO/NIH/CDC**


https://www.hsgac.senate.gov/covid-19-how-new-information-should-drive-policy
Roundtable - COVID-19: How New Information Should Drive Policy
Full Committee Hearing
May 06, 2020 02:00 PM

Text of testimony:

https://www.hsgac.senate.gov/imo/media/doc/Testimony-Kory-2020-05-06-REVISED.pdf
Pierre Kory, MD, MPA
Medical Director, Trauma and Life Support Center
Critical Care Service Chief
Associate Professor of Medicine
University of Wisconsin School of Medicine and Public Health


&nbsp;


Dr Pierre Kory appeared a second time in front of the US Senate for his testimony on Ivermectin for prophylaxis and early treatment.

Dr Pierre Kory first appeared in front of the US Senate for his testimony in favor of steroids use.

At that time doctors around the world - esp. in the developing world - were widely aware of the hyperinflammatory nature of the later stages of covid19, and were treating with steroids and other drugs.  And seeing success.

All that came to an end when the WHO/NIH/CDC put a stop to that with their caution against use of steroids.

This put the brakes on legitimacy of steroids for covid19 - and probably resulted in under treatment and death.

Dr Pierre Kory's testimony in front of the US Senate was aimed to reignite interest in steroids (that had been waning following the WHO/NIH/CDC actions).

The brakes on steroids were lifted when the RECOVERY UK trial results were released - which showed benefit from steroids.


**Context**

At that time, doctors around the world already had recognized they hyperinflammatory nature of the disease - and were using steroids and other drugs and seeing benefit.  Many though (esp. those not aware of the FLCCC MATH+ protocol) were not aware of the viral timeline in such detail as the MATH+ protocol elucidated.  As a result some doctors in developing countries were giving steroids very early - giving steroids at day1-3 is usually not advisable and has risk of suppressing immune response at a time when the live virus is still present in large numbers.

What is surprising is how only the folks familiar with MATH+ protocol were generally aware of the day8 timeline, and the need for steroids not earlier and not much later.

Until late 2021, understanding of viral timeline was absent from the public discourse, and among most US doctors.

Only by late 2021 did one start to see acknowledgement of viral timeline - that the live virus was mostly zero by day 5 in some, and mostly zero by day8 in nearly all patients.

This was acknowledged by Dr Fauci in a web conference.

Why this crucial bit of information - which was listed on the MATH+ protocol by mid-2020 was not widely disseminate and publicize is a mystery.

It could be conjectured that if this viral timeline was more widely acknowledged, the motivation for prescribing Remdesivir well past day8 would be absent.

And most US hospitals would not have been able to justify use of Remdesivir.

Thus obfuscation or confusion of the information around viral timeline may have played a role in allowing the continued practice of Remdesivir use in the US and other countries - well after the WHO stated that it was not effective when given late.



&nbsp;



### **Steroids - undesirable impact of RECOVERY UK trial (RCT)**


&nbsp;


The brakes on steroids were lifted when the RECOVERY UK trial results were released - which showed benefit from steroids.

However RECOVERY UK trial brought with it's own impact.  Just because Dexamethasone 6mg was used in the trial, thus 6mg Dexamethasone became the fixed steroid dose in many hospital protocols.  Often hospitals would not go above this dose - regardless of the hyperinflammatory state of the patient.

Secondly, Dexamethasone became standard of care at large US hospitals - even though Prednisolone is faster to lungs, and better tolerated at high doses (i.e. if high doses are needed).

The FLCCC MATH+ protocol recommends Methylprednisolone at higher doses.  And Dr Paul Marik has lamented the unfortunate choice of Dexamethasone by US hospitals, and the capping of steroids doses to 6mg Dexamethasone - which is an anemic dose for patients that need more aggressive treatment.  In the words of the FLCCC's Dr Paul Marik hospitals are using "homeopathic" doses of steroids for patients whose hyperinflammatory state demands more aggressive treatment.

Capping of doses by hospital protocols therefore leads to a subset of patients who slip through and wind up on ventilator.


&nbsp;


In addition RECOVERY UK trial made special note of a small signal for harm when steroids taken before intubation.

I (u/stereomatch) suspect this is an erroneous reading - an outcome of bad lumping of very early steroids use in the RECOVERY UK trial.

Real world observation makes it clear that hyperinflammation is apparent on day7-8, and failure to arrest leads to oximeter readings falling to low 90s and thus the need for oxygen.  Failure to arrest at this point leads to further declines and eventually ventilator.


&nbsp;


Unfortunately many hospitals and commentators have amplified this supposed signal in the RECOVERY UK trial - and hospitals have taken this interpretation to heart.

Resulting in failure to arrest hyperinflammation.  Hospitals are starting steroids only when intubated, or when the situation is so dire that oxygen is required (usually when "max achievable" oximeter readings fall below 90 or so).

This treatment algorithm essentially winds up creating severe cases out of mild ones - since the patient's hyperinflammatory state is not arrested earlier, before it has a chance to get out of hand and cause hypoxia etc.



&nbsp;



**Obfuscation of viral timeline - continued opportunity for Remdesivir**


&nbsp;


While many doctors were using steroids prior to the WHO/NIH/CDC caution against steroids, many were not aware of the finely tuned explanation of viral timeline that the FLCCC MATH+ protocol had provided.

Which clearly explained the rationale for use of steroids, and the timing of steroids.

In many parts of the developing world, doctors were seeing benefit from steroids, but in their enthusiasm to extend that to newer patients, were sometimes starting steroids earlier (ilke day5 from first symptoms - which can still be ok) - but some were starting them on day1-3 (reason was lack of awareness of viral timeline, and secondly the very real risk that patient may not return later on time and thus lose precious time for steroids administration, so start them on steroids while patient is present in the clinic.

Starting on steroids while patient from a village is available to the doctor - is a strategy which usually works out ok because most patients take some time before appearing at a doctor's clinic.

But some patients can appear in front of doctor at day1 or day2 if they are very observant and aware of the need to get medical attention early.

The problem for these patients then becomes that the doctor may prescribe his blanket protocol without interrogating on timeline (i.e. doctor may not spend time to establish which day the patient is from first symptoms).

For these patients, steroids may be administered earlier than is ideal.


&nbsp;


I (u/stereomatch) am aware of cases where a doctor has initiated steroids earlier than day7-8 - for example at day5 - and usually there has been no issue.

However, I am also aware of cases where a doctor has initiated steroids earlier i.e. day1-3 - and things have not turned out that well.  That is patient had hypoxia and needed additional steroids at day8.

These cases happened because the doctor was not familiar with viral timeline, and did not interrogate the patient to establish day1 of first symptoms.

Some doctors have a habit of not querying - but applying the same protocol that (usually) works for all others.

This stems from the traditional way to practice medicine - medicate for a disease as if it is one phase (covid19 is biphasic).

This strategy of uniform protocol for all can fail when a patient arrives very early i.e. right after first symptoms i.e. day1-3.


&nbsp;


There have been studies earlier which suggested that steroids initiation even very early does not affect outcomes that negatively.

But still from an abundance of caution steroids should probably be delayed until day7-8.

They could be initiated immediately if there is day8-like behavior apparent from the symptoms - daily declining oximeter readings, elevated pulse rate or anomalous fever returning.  Or if there is evidence of accelerated decline - in such a case one can assume that day8-like situation is happening and to initiate steroids.



&nbsp;


* * *






## **Famotidine - covid19, long haulers and post-vax standard of care**


&nbsp;


Famotidine (H2 blocker anti-histamine):

- can be helpful during covid19 treatment (reduces symptoms within 1 day - 2 days for newer variants)

- and can be useful for a subset of long haulers

- and is very effective for post-vaccine side-effects - possibly due to it's action against Mast Cell Activation Syndrome (MCAS) - and should be the standard of care for post-vax side effects (instead of Paracetamol/Tylenol which is less effective - and potentially a depleter of Glutathione - the body's natural antioxidant)


&nbsp;



### **FLCCC MATH+ protocol includes Famotidine (optional)**


FLCCC MATH+ extended protocol:

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf



&nbsp;



### **Famotidine - proposed mechanisms of action**

Dr Robert Malone paper on Famotidine:

https://www.frontiersin.org/articles/10.3389/fphar.2021.633680/full
COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
23 March 2021


&nbsp;


**Added April 26, 2022:** thanks to u/bvw

https://www.frontiersin.org/articles/10.3389/fphar.2022.872736/full

Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells

25 April 2022

>Although famotidine, the commonly used histamine H2 receptor (H2R) blocker, was shown to have no antiviral activity, recent reports indicate that it could prevent adverse outcomes in COVID-19 patients. Histamine is a classic proinflammatory mediator, the levels of which increase along with other cytokines during COVID-19 infection. Histamine activates H2R signaling, while famotidine specifically blocks H2R activation.
>
>Investigating the effects of recombinant SARS-CoV-2 spike protein S1 Receptor-Binding Domain (Spike) on ACE2 expression in cultured human coronary artery endothelial cells, we found that the presence of histamine potentiated spike-mediated ACE2 internalization into endothelial cells.
>
>This effect was blocked by famotidine, protein kinase A inhibition, or by H2 receptor protein knockdown. Together, these results indicate that histamine and histamine receptor signaling is likely essential for spike protein to induce ACE2 internalization in endothelial cells and cause endothelial dysfunction and that this effect can be blocked by the H2R blocker, famotidine.


&nbsp;


**NOTE:** there has been some criticism that the levels used in this study may not achievable with Famotidine 20mg+20mg per day for 5 days - as is often used for day1-7 covid19 early treatment:

https://old.reddit.com/r/ivermectin/comments/u46w57/comment/i68t4uh/

SaltZookeepergame691

>They used a 10 uM dose of famotidine, and a 1 uM dose of histamine. The dose of famotidine alone is an order of magnitude higher than you get from a high clinical dose.


https://old.reddit.com/r/ivermectin/comments/u46w57/comment/i68xyeu/

SaltZookeepergame691

>80 mg three times per day (an enormous dose) gives max 1.69 uM.
>
>Disagree the impact is very obvious.


&nbsp;


My (u/stereomatch) counter to that is that Famotidine:

- has very obvious benefit in reducing symptoms to tolerable levels during day1-7

- is effective for a subset of long haulers

- is very effective for post-vax side effects across the spectrum of inactivated/adenovirus/mRNA vaccines (from observation) - and should be in my view the standard of care (instead of the currently recommended Paracetamol/Tylenol)

 

&nbsp;




### **Famotidine and kidney disease**

Famotidine is advised at lower dose for those with kidney disease in the FLCCC MATH+ extended protocol:

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf


pg 14:

>Optional: Famotidine 40 mg BID (reduce dose in patients with renal dysfunction) [109-115].



&nbsp;



### **Famotidine and vagus nerve inflammation in long haulers**


&nbsp;


Famotidine is very effective in reducing symptoms during covid19 day1-7, for a subset of long haulers, and is very effective as treatment for post-vaccine side effects).

Meanwhile treatment to reduce inflammation of the vagus nerve has been reported to benefit long haulers.

Some long haulers suggest the vagus nerve may have a central role in describing the variety of issues long haules have - POTS etc.


&nbsp;


This study suggests that Famotidine also may have impact on the vagus nerve - beyond impact on Mast Cells or Mast Cell Activation Syndrome (MCAS).

They however injected Famotidine in a way to bypass the blood-brain barrier - it is not clear if oral Famotidine also has direct effect on the vagus nerve area.


&nbsp;


**Paper:**

https://molmed.biomedcentral.com/articles/10.1186/s10020-022-00483-8

Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm

16 May 2022

>Because evidence is lacking for a direct antiviral activity of famotidine, a proposed mechanism of action is blocking the effects of histamine released by mast cells. Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor (α7nAChR) signal transduction, to prevent cytokine storm.
>
>As the inflammatory reflex is integrated and can be stimulated in the brain, and H2R antagonists penetrate the blood brain barrier poorly, famotidine was administered by intracerebroventricular (ICV) or intraperitoneal (IP) routes.
>
>Mice lacking mast cells by genetic deletion also responded to famotidine, indicating the anti-inflammatory effects are not mast cell-dependent. Either bilateral sub-diaphragmatic vagotomy or genetic knock-out of α7nAChR abolished the anti-inflammatory effects of famotidine, indicating the inflammatory reflex as famotidine’s mechanism of action. While the structurally similar H2R antagonist tiotidine displayed equivalent anti-inflammatory activity, the H2R antagonists cimetidine or ranitidine were ineffective even at very high dosages.
>
>Conclusions
>
>These observations reveal a previously unidentified vagus nerve-dependent anti-inflammatory effect of famotidine in the setting of cytokine storm which is not replicated by high dosages of other H2R antagonists in clinical use. Because famotidine is more potent when administered intrathecally, these findings are also consistent with a primarily central nervous system mechanism of action.



&nbsp;



**References:**

Also see discussion of this paper at:

https://www.reddit.com/r/COVID19/comments/usc8et/famotidine_activates_the_vagus_nerve_inflammatory/
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm



&nbsp;



Vagus nerve inflammation as possible factor in long haulers symptoms like POTS:


https://www.reddit.com/r/covidlonghaulers/comments/ushr47/recovery_after_2_years_with_stellate_ganglion/
Recovery after 2 years with stellate ganglion block

Archive of above webpage:

https://archive.ph/012Nv




&nbsp;




* * *




## **Vitamin D3 - anti-inflammatory/immuno-modulator**


Vitamin D is thought to behave like a vitamin, and also has steroid hormone-like capabilities.


https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.311585
Steroid Hormone Vitamin D
Implications for Cardiovascular Disease
25 May 2018


https://pubmed.ncbi.nlm.nih.gov/24739090/
Vitamin D, steroid hormones, and autoimmunity
May 2014


https://www.pharmacytimes.com/view/vitamin-d-is-the-new-hormone
Vitamin D Is the New Hormone
July 20, 2019


Here is a video featuring Dr Roger Seheult (MedCram on YouTube):

https://www.youtube.com/watch?v=8pXuJSxILrQ
Is Vitamin D Actually a Steroid? - Roger Seheult
Mar 24, 2021



&nbsp;



And has impact on immune health, and acts as an immuno-modulator.

It is now believed that low vitamin D levels are a risk factor when it comes to severe covid19.

Most severe patients have low levels of Vitamin D in their blood.  There is a question whether this happens because vitamin D levels fall because of the hyperinflammation that has already started in such patients.  Or whether they had pre-existing levels of vitamin D which placed them at risk of severe covid19.

Obese patients, and those not getting sufficient sunlight (to make Vitamin D) has long been associated with more severe outcomes for flu - and also for covid19.

The use of the more direct form (calcifediol) of Vitamin D supplementation for severe covid19 patients has been shown to improve outcomes.  Since Vitamin D3 takes longer to show effects on Vitamin D blood levels, the use of the direct form was chosen for this study:


https://pubmed.ncbi.nlm.nih.gov/34097036/
Calcifediol Treatment and COVID-19-Related Outcomes 
Sept 27, 2021

>Results: ICU assistance was required by 102 (12.2%) participants. Out of 447 patients treated with calcifediol at admission, 20 (4.5%) required the ICU, compared to 82 (21%) out of 391 nontreated (P < .001).


&nbsp;


https://pubmed.ncbi.nlm.nih.gov/34064175/
Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study 
May 21, 2021

>Results: A total of 537 patients were hospitalized with COVID-19 (317 males (59%), median age, 70 years), and 79 (14.7%) received calcifediol treatment. Overall, in-hospital mortality during the first 30 days was 17.5%. The OR of death for patients receiving calcifediol (mortality rate of 5%) was 0.22 (95% CI, 0.08 to 0.61) compared to patients not receiving such treatment (mortality rate of 20%; p < 0.01). 


&nbsp;


https://www.nature.com/articles/s41598-021-02701-5
Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients
03 December 2021



&nbsp;




### **Vitamin D3 - dosing**


&nbsp;


In preparing for covid19 infection in the future, one needs to start Vitamin D3 supplementation ahead of time.

This is because after starting Vitamin D3 supplementation, it can take many weeks before Vitamin D levels start to become high.

Maintain a Vitamin D level above 30ng/mL (Vitamin D levels closer to 40ng/mL may be desirable for protective effect against covid19) - such a level is achievable if Vitamin D3 5000 IU is taken daily for an adult - test after 2-3 months if a level above 30ng/mL is achieved - reduce dosage slightly if needed.



&nbsp;


See this Dr John Campbell video on dosing:


https://www.youtube.com/watch?v=V5g9AVqRsjo

Vitamin D levels advised

Nov 18, 2021

Dr. John Campbell 


&nbsp;


>Without calcium supplementation, even very high vitamin D3 supplementation does not cause vascular calcification
>
Vitamin D3 supplementation in the range of 4000 to 10,000 units (100 to 250 µg) needed to generate an optimal 40–60 ng/mL (100 to 150 nmol/L)
>
>has been shown to be completely safe when combined with approximately 200 µg vitamin K2




&nbsp;





### **Vitamin D3 - Magnesium helps bioavailability of Vitamin D3**


&nbsp;


For those who are unable to raise levels of the bioavailable form of Vitamin D in their blood (even though they may be taking Vitamin D3 5000 IU per day supplementation), consider adding Magnesium supplements (a multi-vitamin that includes Magnesium), or improving your diet to include natural source of Magnesium (nuts, whole grains, green leafy vegetables).

Magnesium is known to be useful for the metabolism of Vitamin D3:


&nbsp;


https://www.imaware.health/blog/vitamin-d-and-magnesium
Vitamin D and Magnesium - Benefits, Dosages, and Why They Should Go Together
Nov 5, 2021

>Recent studies have shown that if a person is deficient in magnesium, no amount of Vitamin D3 supplementation will allow a patient to realize the health benefits of adequate Vitamin D. Magnesium is a critical factor in making Vitamin D bioavailable. Without magnesium present, Vitamin D is stored in the body and not used.
>
>The body depends on magnesium to convert Vitamin D into its active form within the body. Magnesium also helps Vitamin D bind to its target proteins, as well as helping the liver and the kidneys to metabolize Vitamin D.
>
>This research shows that supplementing with Vitamin D is pointless if a patient is deficient in magnesium - in fact, as the next section will explain, it may actually have harmful side effects to overload your system with Vitamin D without banking the magnesium needed to use it.
>
>
>Remember, magnesium deficiency prevents the body from using the Vitamin D you are supplementing it with. Additionally, the Journal of the American Osteopathic Association points out that people with low magnesium levels who supplement with Vitamin D show markedly higher levels of calcium and phosphorus. This is probably due to the role that activated Vitamin D plays in the absorption of calcium into the bones and other tissues.
>
>Excess calcium in the bloodstream can lead to calcification of the inside of the arteries, resulting in poor cardiovascular health. Unabsorbed calcium can also cause nausea, frequent urination, fatigue, and kidney problems like kidney stones.
>
>Before starting a Vitamin D and magnesium supplementation regimen, it is worth discovering whether or not your magnesium levels are deficient first. People considering starting a Vitamin D3 regimen without the advice of a doctor should consider supplementing with magnesium as well to prevent the adverse effects of unabsorbed calcium.



&nbsp;


Paper mentioned above:

https://pubmed.ncbi.nlm.nih.gov/29480918/

or

https://www.degruyter.com/document/doi/10.7556/jaoa.2018.037/html
Role of Magnesium in Vitamin D Activation and Function 
March 1, 2018

>All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys. Deficiency in either of these nutrients is reported to be associated with various disorders, such as skeletal deformities, cardiovascular diseases, and metabolic syndrome. It is therefore essential to ensure that the recommended amount of magnesium is consumed to obtain the optimal benefits of vitamin D. 
>
>Vitamin D needs to be converted from its storage or inactive form (25[OH]D) to an active form (1,25[OH]2D) before exerting its biological functions. These various stages of vitamin D conversions are actively dependent on the bioavailability of magnesium



&nbsp;




### **Vitamin D3 - Magnesium dosing**


&nbsp;


Moderate amounts of Magnesium supplementation (taking a multi-vitamin that includes Magnesium for example) may be useful for those taking Vitamin D3 supplementation:


https://www.imaware.health/blog/vitamin-d-and-magnesium
Vitamin D and Magnesium - Benefits, Dosages, and Why They Should Go Together
Nov 5, 2021

>As far as magnesium goes, doctors recommend the following doses of magnesium, with variations between the sexes at older ages:
>
> 1–3 years: 65 mg
>
> 4–8 years: 110 mg
>
> 9 years and older: 350 mg


&nbsp;


Lack of magnesium may lead to excess unabsorbed calcium:

>Humans absorb and replenish their body’s supply of magnesium by eating foods rich in magnesium, like almonds, cashew nuts, and spinach. 
>
>Excess calcium in the bloodstream can lead to calcification of the inside of the arteries, resulting in poor cardiovascular health. Unabsorbed calcium can also cause nausea, frequent urination, fatigue, and kidney problems like kidney stones.



&nbsp;


As with any supplementation, watch out for excess dosing - here is some information on magnesium overdosing (from article above):

>Over-supplementation with magnesium can lead to hypermagnesemia. Early symptoms of hypermagnesemia include nausea, vomiting, hypotension (excessively low blood pressure), flushing, urine retention, ileus, depression, and lethargy. 
>
>Symptoms of advanced hypermagnesemia include breathing trouble, extreme hypotension, muscle weakness, irregular heartbeat, and cardiac arrest. Fatal hypermagnesemia has been observed in very young or very old subjects.




&nbsp;


Also see this list of recommended doses for Magnesium, and the foods that contain it (nuts, whole grains, green leafy vegetables):

https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/?ref=NIVvlgXeP3oGR
Magnesium

>Recommended Intakes
>
>19-30 year olds
>
>400mg for males
>
>310mg for females



&nbsp;



Dr. Jin W. Sung videos on Magnesium dosing for Vitamin D3:


https://www.youtube.com/watch?v=PhN6cYDWJ-0
MAGNESIUM the Forgotten Mineral
Sep 30, 2021
Dr. Jin W. Sung


https://www.youtube.com/watch?v=I5rcDkYthUY
Vitamin D and Magnesium
Dec 21, 2021
Dr. Jin W. Sung





&nbsp;





### **Vitamin D3 - Safety**


&nbsp;


Vitamin D3 maximum recommended doses are usually around 4000 IU per day.

However, if you are deficient, it can take 2-3 months to get Vitamin D levels above 30ng/mL with Vitamin D3 5000 IU per day.


&nbsp;


See this paper:

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5402701/
Evaluation of vitamin D3 intakes up to 15,000 international units/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on calcium metabolism in a community setting
April 13, 2017


&nbsp;


Check out this Dr John Campbell interview of Dr Michael Cohen (Israel):


&nbsp;


https://www.youtube.com/watch?v=w9h-XQm2qEY

Vitamin D in Israel

Dec 11, 2021

Dr. John Campbell


&nbsp;


**at the 10:15 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=615

Dr Michael Cohen:

But as a first line of defence we should be dealing with people's immune systems.


We know 25mg of Zinc (can take up to 40mg per day - going above that can reduce the absorption of Copper so not good taking for too long at that dose).

Vitamin D3 - 4000 IU - overweight may need 8000 or 10,000 IU per day.

Other thing I tell them to take is Vitamin K2 - 200mcg (0.2mg) per day every day.

Vitamin D3 does cause the release of Calcium from the bones into the blood and you do want to try to avoid the deposition of that into the wrong places.

And obviously the other things getting enough sleep etc.


&nbsp;


**at the 11:50 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=710

My concern is that all the focus has gone into putting the burden on the hospitals and even outpatient care.

And we need to be doing everything to prevent becoming a severe illness.



&nbsp;


**at the 12:05 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=725

Dr John Campbell:

And a lot of the focus has been on these very clever high tech - like these vaccines.

And expensive.

These vaccines are completely brilliant.

But why have expensive clever things - if can use simple things as well as.


Dr Michael Cohen:

Half the world is not vaccinated - what are we doing for them?

Why wait?



&nbsp;



**at the 12:50 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=770

Dr John Campbell:

If levels are low in Israel - which is sunny and hot - imagine what the levels must be elsewhere.



&nbsp;


**at the 13:15 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=795

Dr Michael Cohen:

Someone's supposed to have above 32ng/mL - but it seems from what seen you would want to have above 50.

Even to get to 32 it may help.

But is a cheap vitamin - pretty much no side effects - and it can do a lot.


&nbsp;



**at the 14:10 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=850

Dr John Campbell:

It is interesting how a modest dose of vitamin d3 is enough to reverse Rickets (vitamin d deficiency).

And then a little more does some more.

And at each level are interacting with more genes.



Dr Michael Cohen:

As every cell has a vitamin d receptor.

And a lot of it is immuno-modulatory.



&nbsp;



**at the 14:40 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=880

Dr Michael Cohen:

If combine with zinc - which has significant effect on viral infections - there is little to say don't take this concoction.



&nbsp;



**at the 17:10 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=1030

Dr Michael Cohen:

Important to keep at good levels.

Have seen many people get covid19 twice.

It's important to be taking it throughout.

It takes time for Vitamin D3 to kick in - so better to be taking ahead of time.



&nbsp;


**at the 18:45 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=1125

Dr Michael Cohen:

It is switching genes off and switching genes off.

For immunomodulatory it takes time.

For some of the effects need to see turnover in the cells i.e. new ones - so can take some time.


Dr John Campbell:

It's like with Iron - if give Iron - it is the new generation of cells which get benefit from that - in slides see half RBCs round and half small i.e. newer ones gotten doses of Iron.



&nbsp;



**at the 20:11 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=1211

Dr John Campbell:

Why do obese people need more Vitamin D3?


Dr Michael Cohen:

It seems they store vitamin d in the fat cells but not use it.

They don't reach the same level in plasma.

Some patients at 12,000 IU per day - and that's what get to 40-50ng/mL range bracket.



&nbsp;





### **Vitamin D3 - high dose and toxicity**


&nbsp;




https://www.youtube.com/watch?v=gFYMs94mx4E

Vitamin D Toxicity

Dec 23, 2021

Dr. Jin W. Sung

>16 year retrospective study of 73,000 people
>
>most of whom supplementing with Vitamin D3 tablet at home
>
>most people had Vitamin D levels below 80ng/mL
>
>among those with Vitamin D levels above 120ng/mL - only 4 people had symptoms of Vitamin D toxicity (nausea, abdominal pain, constipation)
>
>so is pretty rare to get it from self-supplementation
>
>in his experience, overdoses more common with liquid Vitamin D3 - where doctor may advise 1 drop a day (2000 IU) but patient may think the full dropper
>
>so people may come in with Vitamin D levels at 150-175ng/mL
>
>and still do not show Vitamin D toxicity symptoms


&nbsp;


Description section has suggestions for levels that should be targeted:

- Vitamin D levels of 60-80ng/mL

His recommendations:

- Vitamin D3 - 2000 IU to 5000 IU

- Magnesium 200-400 mg

Additional: Vitamin K2, Vitamin E and Vitamin A   https://youtu.be/pR9KN7xjxMY


&nbsp;


Considerations:

Take vitamin with a fatty meal.

Gallbladder function: ox bile, choline   https://youtu.be/ddyx2Z2mbik

Vitamin D target level on testing is 60-80 ng/mL



&nbsp;



Additional video:

https://www.youtube.com/watch?v=6E9xfwyX6mQ
The Truth About VITAMIN D
May 22, 2021
Dr. Jin W. Sung


&nbsp;


Vitamin D supplement types:

- D2 - ergocalciferol

- D3 - cholecalciferol - better absorbed (preferred)


&nbsp;


**at the 7:20 minute mark:**

https://www.youtube.com/watch?v=6E9xfwyX6mQ&t=440

Vitamin D levels can be low due to some factors:

- gastrointerstinal issues preventing 

- age - kidney function may not be as good

- skin type - darker skin absorbs less UV-B light

- where you live - sun exposure

- bile - gall bladder removed or if have liver dysfunction - lower bile - reduces absorption of Vitamin D

- insulin resistance

- auto-immune issues will suck up your Vitamin D

- genetic issues





&nbsp;





### **Vitamin D3 - taking Vitamin K2 and avoiding Calcium supplementation when doing high dose Vitamin D3 supplementation**


&nbsp;


Taking high dose Vitamin D3 can expose to risk of hypercalcemia, and deposition of Calcium in blood vessels and in calcification of heart valves (also happens with age).

When doing higher dose Vitamin D3 supplementation, a dose of Vitamin K2 will help reduce risk of hypercalcemia.

Avoid excessive Calcium supplementation while on high dose Vitamin D3 - to reduce risk of hypercalcemia.

This is not a big issue during covid19 - since the treatment period is 2-3 weeks usually with early treatment - so if you give Vitamin D3 (but not Vitamin K2 i.e. don't have it available etc.) - that may be ok.


&nbsp;


Vitamin K2 maybe more of a factor when doing longer term Vitamin D3 supplementation.

Vitamin K2 supplementation over many months (along with your Vitamin D3 supplementation) - may be beneficial for:

- reducing osteoporosis

- reducing calcification of soft tissues

- reducing plaques in blood vessels



&nbsp;



See this Dr John Campbell video on dosing Vitamin K2 to accompany Vitamin D3 supplements:


&nbsp;


https://www.youtube.com/watch?v=V5g9AVqRsjo

Vitamin D levels advised

Nov 18, 2021

Dr. John Campbell


&nbsp;



Talking about Vitamin D levels in blood:

>Preferable, 40–60 ng/mL (100 to 150 nmol/L)
>
>Without calcium supplementation, even very high vitamin D3 supplementation does not cause vascular calcification
>
>Vitamin D3 supplementation in the range of 4000 to 10,000 units (100 to 250 µg) needed to generate an optimal 40–60 ng/mL (100 to 150 nmol/L)
>
>has been shown to be completely safe when combined with approximately 200 µg vitamin K2
>
>However, this knowledge is still not widespread in the medical community, and obsolete warnings about the risks of vitamin D3 overdoses unfortunately are still commonly circulating.
>
>
>
>Conclusions
>
>we recommend raising serum 25(OH)D levels to above 50 ng/mL (100 to 150 nmol/L)
>
>to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.
>
>At a time when vaccination was not yet available,
>
>patients with sufficiently high D3 serum levels preceding the infection were highly unlikely to suffer a fatal outcome. 
>
>This correlation should have been good news when vaccination was not available but instead was widely ignored. 
>
>the lower threshold for healthy vitamin D levels should lie at approximately 125 nmol/L or 50 ng/mL 25(OH)D3,
>
>which would save most lives, reducing the impact even for patients with various comorbidities.
>
>This is—to our knowledge—the first study that aimed to determine an optimum D3 level to minimize COVID-19 mortality
>
>
>
>natural vitamin D3 levels seen among traditional hunter/gatherer lifestyles,
>
>in a highly infectious environment, 
>
>were 110–125 nmol/L (45–50 ng/mL)
>
>WHO advice may not be correct
>
>30 ng/mL D3 value considered by the WHO as the threshold for sufficiency




&nbsp;



See also Dr John Campbell discussing Vitamin K2 for those on Vitamin D3:



&nbsp;



https://www.youtube.com/watch?v=LfZpLllgd5Q

Vitamins D and K2

Mar 4, 2021

Dr. John Campbell


&nbsp;


>For 2000 IU to 4000 IU per day - usually not need to take Vitamin K2.
>
>(NOTE: Vitamin K2 helps reduce risk of calcification in blood vessels and heart valves.)
>
>(NOTE: Vitamin K1 does not - also Vitamin K1 may be contraindicated since it encourages clotting - which want to avoid during covid19)
>
>Official guidelines in UK from NICE - are potentially not helpful.
>
>
>
>**at the 10:35 minute mark:**
>
>https://www.youtube.com/watch?v=LfZpLllgd5Q&t=635
>
>starts talking about Vitamin K2




&nbsp;



Check out this Dr John Campbell interview of Dr Michael Cohen (Israel):


&nbsp;


https://www.youtube.com/watch?v=w9h-XQm2qEY

Vitamin D in Israel

Dec 11, 2021

Dr. John Campbell


&nbsp;


**at the 10:15 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=615

Dr Michael Cohen:

...

Vitamin D3 - 4000 IU - overweight may need 8000 or 10,000 IU per day.

Other thing I tell them to take is Vitamin K2 - 200mcg (0.2mg) per day every day.

Vitamin D3 does cause the release of Calcium from the bones into the blood and you do want to try to avoid the deposition of that into the wrong places.

...


&nbsp;


**at the 20:54 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=1254

**Dr John Campbell:**

>I am very interested that you are advising Vitamin K2 as well - which makes perfect sense.  My understanding is the K2 would really only be necessary if you are taking quite high Vitamin D3 - because you'd need quite high doses of Vitamin D3 to release enough Calcium into the blood to even be a risk of hypercalcemia


**Dr Michael Cohen:**

>I think your thinking is correct.  But from what I can tell from what I have read, you need at least 100mcg (micrograms) a day of Vitamin K2 if you are taking 4000 IU of Vitamin D3.

>And seeing as many people don't get levels of 50ng/mL even with 4000 IU Vitamin D3 - they often need 6000, 7000, or 8000 IU a day - I tell people to take 200mcg (i.e. 0.2mg) once they are above 4000 IU Vitamin D3.

>But 100mcg is supposed to be enough if you are taking 4000 IU Vitamin D3.

>If you are only taking 1000 or 2000 IU Vitamin D3, you probably don't need Vitamin K2.





&nbsp;




**Vitamin K1 - increases clotting risk**


For completeness I am adding this section on Vitamin K1.

Vitamin K1 enhances blood coagulation or clotting.

So may want to avoid during post-day8 covid19.  Although not a lot of people will be doing Vitamin K1 supplementation (not common).


&nbsp;


Vitamin K1 dosing is known to interfere with or enhance clotting.

Although people don't usually take Vitamin K1 supplements, still it may be advisable to taper down or reduce use of supplements that increase clotting risk, especially during the post-day8 hyperinflammatory stage.

Discuss this with your doctor.

Since in covid19, there can be hyperinflammation visible at day7-8 onwards.

Which can lead eventually to hypercoagulability (if the hyperinflammation is not arrested with sufficient steroids etc.).



&nbsp;





**Vitamin K2 - may not increase clotting risk**


&nbsp;


Vitamin K2 helps osteoporosis sufferers - reduces calcification in blood vessels and soft tissue.

Should one take Vitamin K2 during covid19 - does it also worsen clotting?

Since Vitamin K1 increases clotting risk, there may be some questions on whether Vitamin K2 may do the same.

However, Vitamin K2 does not seem to impact clotting or coagulation too much.

This suggests Vitamin K2 does not directly impact coagulation (clotting) - while Vitamin K1 does:


&nbsp;


https://pubmed.ncbi.nlm.nih.gov/34115006/

Vitamin K2 (Menaquinone-7) supplementation does not affect vitamin K-dependent coagulation factors activity in healthy individuals 

>Conclusions:
>
>MK-7 supplementation at recommended dosage does not affect vitamin K-dependent coagulation factors' coagulation activity, and does not enhance the carboxylation of prothrombin in healthy individuals. This indicated that MK-7 administration does not alter hemostatic balance in healthy populations without anticoagulation treatment. 



&nbsp;



Vitamin K2 is beneficial for avoiding calcification of soft tissue - avoiding heart valve calcification in old age - avoiding calcification/plaques in blood vessels.

And ensuring calcium is deposited in the bones (so Vitamin K2 may help reduce osteoporosis).

For this reason, if you are taking Vitamin D3 over the long term, you could add Vitamin K2 supplementation for that (to avoid hypercalcification from taking high dose Vitamin D3 - and especially so if you are also using calcium supplements).



&nbsp;




https://www.healthline.com/nutrition/vitamin-k1-vs-k2

Vitamin K1 vs K2: What’s the Difference?

>Vitamin K1, also called phylloquinone, is mostly found in plant foods like leafy green vegetables. It makes up about 75–90% of all vitamin K consumed by humans (2Trusted Source).
>
>Vitamin K2 is found in fermented foods and animal products, and is also produced by gut bacteria. It has several subtypes called menaquinones (MKs) that are named by the length of their side chain. They range from MK-4 to MK-13.
>
>Vitamin K activates a protein that helps prevent calcium from depositing in your arteries. These calcium deposits contribute to the development of plaque, so it’s not surprising that they are a strong predictor of heart disease (16Trusted Source, 17Trusted Source).


&nbsp;



Vitamin K1 and K2 helpful for reducing hypercalcemia and deposition of calcium in blood vessels and calcification of heart valves:


>Several observational studies have suggested that vitamin K2 is better than K1 at reducing these calcium deposits and lowering your risk of heart disease (18Trusted Source, 19Trusted Source, 20Trusted Source).
>
>However, higher quality controlled studies have shown that both vitamin K1 and vitamin K2 (specifically MK-7) supplements improve various measures of heart health





&nbsp;








* * *


&nbsp;




## **Zinc as antiviral**


&nbsp;



### **Zinc dosage**


&nbsp;


The typical dosage of Zinc during treatment is around 40mg "elemental zinc".

The entry of zinc into cells tends to hinder viral replication.  This is why many lozenges for flu include zinc.  Some children's syrups for flu include zinc - the syrup is to be given on an age or weight adjusted basis (described on the bottle).

Hydroxychloroquine (HCQ) is a zinc ionophone - i.e. it helps zinc get into cells.

And Quercetin is also a zinc ionophone.



&nbsp;


Check out this Dr John Campbell interview of Dr Michael Cohen (Israel):


https://www.youtube.com/watch?v=w9h-XQm2qEY

Vitamin D in Israel

Dec 11, 2021

Dr. John Campbell


&nbsp;


**at the 10:15 minute mark:**

https://www.youtube.com/watch?v=w9h-XQm2qEY&t=615

Dr Michael Cohen:

>We know 25mg of Zinc (can take up to 40mg per day - going above that can reduce the absorption of Copper so not good taking for too long at that dose).


&nbsp;


**Reference:**

FLCCC MATH+ extended protocol:

https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-%E2%80%93-A-Guide-to-the-Management-of-COVID-19.pdf

>Zinc 30–50 mg/day (elemental zinc).
>
>Zinc is essential for innate and adaptive immunity.  In addition, Zinc inhibits RNA dependent RNA polymerase in vitro against SARS-CoV-2 virus.  Due to competitive binding with the same gut transporter, prolonged high dose zinc (> 50mg day) should be avoided as this is associated with copper deficiency.
>
>Commercial zinc supplements contain 7 to 80 mg of elemental zinc, and are commonly formulated as zinc oxide or salts with acetate, gluconate, and sulfate. 220 mg zinc sulfate contains 50 mg elemental zinc. 


&nbsp;



### **Zinc - elemental zinc**


&nbsp;


Different zinc compounds will have different amounts of actual zinc - since it depends on the compound's molecule - how much actual zinc there is.

Then there maybe bioavailability - for example zinc gluconate supposedly makes it more bioavailable.  But most HCQ+zinc studies are using Zinc Sulphate.

Here is the elemental zinc in different zinc compounds:

- zinc sulfate 220mg - 50mg elemental zinc

- zinc gluconate 50mg - 7mg elemental zinc

So if the zinc sulphate 220mg (50mg elemental zinc) is the benchmark, one would match that.

I think the multivitamins which list the zinc in milligrams etc. are referring to the elemental zinc.

Some phrase it like "22mg elemental zinc (as zinc sulphate)".

Other phrasings can be confusing - whether they are referring to the zinc sulphate or elemental.


**Reference:**

https://old.reddit.com/r/covid19/comments/hs015m/_/fy8c6fa



&nbsp;



* * *



## **N-acetyl cysteine (NAC) as anti-oxidant**


&nbsp;




### **NAC usage**


&nbsp;


NAC has been found to be beneficial for a range of respiratory diseases.

NAC helps reverse the depletion of glutathione levels (the body's main antioxidant), and also breaks disulphide bonds that may be beneficial against clotting.  NAC action on disulphide bonds is useful for breaking up phlegm as well (which is why it is mainly known for it's mucolytic usage).  But it has strong anti-oxidant value as well.


NAC seems to be a useful addition to treatment measures to reduce or reverse organ damage in (see sections for these below):

- Heat stroke (heat stress related illness)

- Fatty Liver Disease

- Tylenol overdose (is used in emergency rooms to counter the effects of Tylenol overdose - and can protect the liver and kidneys from damage)

- MRI contrast agents - NAC is used to counter the effects of radioactive dyes used as contrast agents for MRI scans


&nbsp;



### **NAC impact on stomach "spare tire" and systemic inflammation**


&nbsp;


I have observed also that daily use of NAC 200mg+200mg for a month may reduce stomach "spare tire" to some degree.

I mentioned this to someone - he later reported his brother had used NAC for this and had similar effect.

If inflammation is implicated in accumulation of body fat or weight gain, there may be a possible link there.

But this could also have been coincidental.



&nbsp;



### **NAC explanatory videos**


&nbsp;


MedCram (Dr Seheult) and Dr Been (Dr Mobeen Syed) have a number of videos covering potential usability of NAC for covid19 - primarily as an anti-oxidant (to counter glutathione depletion during oxidative stress during the hyperinflammatory phase post-day8 of covid19).


**MedCram:**

https://www.youtube.com/watch?v=Dr_6w-WPr0w
Coronavirus Pandemic Update 69: "NAC" Supplementation and COVID-19 (N-Acetylcysteine)
May 11, 2020

https://www.youtube.com/watch?v=eQO1PB8-xtg
Coronavirus Update 114: COVID 19 Death Rate Drops; NAC (N acetylcysteine) Data
Oct 23, 2020

https://www.youtube.com/watch?v=NM2A2xNLWR4
Coronavirus Update 59: Dr. Roger Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)
Apr 21, 2020

https://www.youtube.com/watch?v=kK-DNyKnb5c
Coronavirus Pandemic Update 92: Blood Clots & COVID-19 - New Research & Potential Role of NAC
Jul 3, 2020

**Dr Been:**

https://www.youtube.com/watch?v=K8kKWgsGIU8
NAC N-Acetylcysteine
May 15, 2020

**Whiteboard Doctor:**

https://www.youtube.com/watch?v=PjDNzhS-mc0
N-Acetylcysteine (NAC) And COVID-19: Does This Medication Help Prevent And/Or Treat COVID-19?
Oct 30, 2020




&nbsp;



### **NAC and covid19**


&nbsp;



NAC may have direct activity against covid19:

https://chemrxiv.org/articles/preprint/Conformational_Perturbation_of_SARS-CoV-2_Spike_Protein_Using_N-Acetyl_Cysteine_a_Molecular_Scissor_A_Probable_Strategy_to_Combat_COVID-19/12687923
N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation


NAC (and L-glutathione) can be beneficial during covid19.

There is a small study that showed L-glutathione reduced hypoxia within hours:

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32322478/ Efficacy of Glutathione Therapy in Relieving Dyspnea Associated With COVID-19 Pneumonia: A Report of 2 Cases Richard I Horowitz et al. Respir Med Case Rep. 2020.


&nbsp;


Also see this review:

https://www.dovepress.com/n-acetylcysteine-as-adjuvant-therapy-for-covid-19--a-perspective-on-th-peer-reviewed-fulltext-article-JIR
N-Acetylcysteine as Adjuvant Therapy for COVID-19 – A Perspective on the Current State of the Evidence
6 July 2021

>In vitro data have depicted that N-acetylcysteine increases antioxidant capacity, interferes with virus replication, and suppresses expression of pro-inflammatory cytokines in cells infected with influenza viruses or respiratory syncytial virus. Furthermore, findings from in vivo studies have displayed that, by virtue of immune modulation and anti-inflammatory mechanism, N-acetylcysteine reduces the mortality rate in influenza-infected mice animal models.


&nbsp;



### **NAC for long haulers and post-vax**


&nbsp;



See this case and my (u/stereomatch) comments there too - for relief of neurological symptoms post-vax:

https://old.reddit.com/r/ivermectin/comments/o5g09s IVR After Pfizer Vaccine [Neurological Side Effects].

 
&nbsp;


Update:

https://old.reddit.com/r/ivermectin/comments/osx45y/ivermectin_pepcid_liposomal_glutathione_cured_me Ivermectin + Pepcid + Liposomal Glutathione Cured Me. 90% Better After Vaccine Nerve Problems.




&nbsp;



### **NAC dosage**


&nbsp;


NAC is typically given at 400mg+400mg per day (or 800mg-1200mg) per day for covid19 patients - until recovery (i.e. until steroids-at-day8 have been tapered off to zero).

After that NAC may be continued for a month or more after recovery at 200mg+200mg per day levels.

After that NAC at 200mg per day can be continued - though long term issues should be considered (see below).


&nbsp;



### **NAC dosing and safety**


&nbsp;



See this review of dosing and safety for NAC:

https://link.springer.com/article/10.1007/s40264-020-01026-y
Safety of N-Acetylcysteine at High Doses in Chronic Respiratory Diseases: A Review
16 December 2020

>When treatment requires chronic use, as in COPD and cystic fibrosis, the maximum licensed dose is 600 mg/day, but doses > 600 mg daily have been studied in some clinical trials. 
>
>Studies of high doses of NAC (up to 3000 mg/day) in respiratory diseases with explicit reports on safety found that NAC was safe and well tolerated. In general, the safety profile is similar at both the high and standard doses. 


&nbsp;



### **NAC can be found in chicken soup:**


&nbsp;



https://www.hamilton.edu/news/story/mom-was-right-chicken-soup-is-the-cure
Mom was Right ... Chicken Soup is the Cure
November 3, 2003

>.. suggests that an amino acid released from chicken during cooking chemically resembles the drug acetylcysteine, prescribed for bronchitis and other respiratory problems.



https://www.researchgate.net/publication/261983964_Saha_et_al_2012_SFN_and_Erucin_from_Fresh_Frozen_broccoli_MNFR_PUBLISHED
Saha et al (2012) SFN and Erucin from Fresh Frozen broccoli (MNFR) (PUBLISHED)
April 2014

https://www.researchgate.net/figure/Sulforaphane-N-acetyl-cysteine-and-erucin-N-acetyl-cysteine-urinary-excretion-after_tbl2_261983964

>Table 2
>
>Sulforaphane N-acetyl cysteine and erucin N-acetyl-cysteine urinary excretion after consumption of soups made with lightly cooked fresh and frozen broccoli


&nbsp;


### **NAC concerns - interactions**


&nbsp;



https://www.pharmacytimes.com/view/nac-a-natural-product-so-powerful-it-is-used-in-hospitals
NAC: A Natural Product So Powerful It Is Used in Hospitals
January 11, 2017
Gunda Siska, PharmD

>People who take nitroglycerine should not take NAC unless supervised by a physician since it can cause the nitroglycerine to work more intensely and cause an unsafe drop in blood pressure.


&nbsp;


### **NAC and alcohol**


&nbsp;



One may want to avoid consuming alcohol (ethanol) with NAC:

https://pubmed.ncbi.nlm.nih.gov/16439183/
A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice 
March 2006

>Pretreatment with NAC prevent from acute ethanol-induced liver damage via counteracting ethanol-induced oxidative stress. When administered after ethanol, NAC might behave as a pro-oxidant and aggravate acute ethanol-induced liver damage. 

This study suggests pre-treatment with NAC protected the liver from alcohol injury, but post-treatment with NAC may exacerbate i.e. worsen liver injury.


&nbsp;



### **NAC concerns - cancer**

&nbsp;


Some studies have raised concern that since NAC is an antioxidant, and for ongoing elimination of cancer cells etc., reactive oxygen species are used, that it can hinder ongoing cancer removal.

However other studies have suggested NAC may help against cancer.

Here is a comment on newer FDA restrictions on availability of NAC - also discusses the criticism of the pro-cancer potential, and anti-cancer potential:

https://old.reddit.com/r/ivermectin/comments/ncz95h/_/gy7tqpj


&nbsp;


**July 24, 2022:** also see the section **NAC for COVID-19 patients with cancer**



&nbsp;




### **NAC for COVID-19 patients with cancer**


&nbsp;

This small study suggests that NAC use for covid19 patients (who are also cancer patients) gives positive results:


Paper:

https://www.researchsquare.com/article/rs-1836295/v1

A phase II study of N-acetylcysteine in cancer patients with severe COVID-19: clinical outcomes and biological correlates

18 Jul, 2022



&nbsp;




### **NAC and copper chelation**


&nbsp;


There is some concern that NAC use long term may reduce copper availability.

NAC does seem to be useful as a chelating agent to remove heavy metals:

https://link.springer.com/chapter/10.1007/978-981-10-5311-5_10
The Use of N-Acetylcysteine as a Chelator for Metal Toxicity
Daniel A. Rossignol
21 September 2018



&nbsp;




### **NAC for Tylenol (Acetaminophen, Paracetamol) overdose - preventing and reversing organ damage (liver, kidneys)**


&nbsp;


NAC is used to prevent organ damage in liver and kidneys in the case of Tylenol overdose.


&nbsp;


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637612/

Acetylcysteine for Acetaminophen Poisoning

Kennon J. Heard, M.D.

Feb 9, 2009


&nbsp;



https://journals.lww.com/em-news/fulltext/2004/03000/n_acetylcysteine_and_acetaminophen_toxicity__two.22.aspx

N-Acetylcysteine and Acetaminophen Toxicity Two Common Misconceptions

Gussow, Leon MD

2004



&nbsp;


https://www.mdcalc.com/acetaminophen-overdose-nac-dosing

Acetaminophen Overdose and NAC Dosing

Calculates PO/IV NAC dosing for acetaminophen overdose (and nomogram to determine toxic 4 hour level).

Dr. Barry H. Rumack



&nbsp;


https://www.tylenolprofessional.com/sites/tylenol_hcp_us/files/acetaminphen_overdose_treatment_info.pdf

Guidelines for the Management of Acetaminophen Overdose



&nbsp;


https://www.nejm.org/doi/full/10.1056/NEJM198812153192401

Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose

December 15, 1988


&nbsp;


https://www.uptodate.com/contents/acetaminophen-paracetamol-poisoning-in-adults-treatment

Acetaminophen (paracetamol) poisoning in adults: Treatment

May 2022



&nbsp;


https://ubccriticalcaremedicine.ca/academic/jc_article/Acetaminophen%20Poisoning%20(Jan-30-14).pdf

A Review of Acetaminophen Poisoning

2012


&nbsp;



https://www.hindawi.com/journals/cricc/2021/6695967/

Case Report

Massive Acetaminophen Overdose Treated Successfully with N-Acetylcysteine, Fomepizole, and Hemodialysis

12 Jul 2021



&nbsp;




### **NAC for MRI Contrast Agent Injury - reversing organ damage**


NAC is used to prevent MRI contrast agent injury to liver (Contrast Induced Nephropathy)


&nbsp;


https://pubmed.ncbi.nlm.nih.gov/28934030/

Metabolomic Analysis of N-acetylcysteine Protection of Injury from Gadolinium-DTPA Contrast Agent in Rats with Chronic Renal Failure

Sept 2017



&nbsp;


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769030/

N-acetylcysteine for prevention of radiocontrast induced nephrotoxicity: the importance of dose and route of administration

August 2005



&nbsp;


**Push towards neutral trend for NAC in MRI Contrast Injury**

There has been some argument in the literature against the perceived benefit of NAC for MRI Contrast Injury.

However since some studies suggest great benefit, while others are neutral, one wonders if this is another example of RCTs giving erroneous negative signals (when the studies are not timed correctly for instance).

This type of phenomenon has been seen with other protocols:

- anosmia signal in Ivermectin trials (if you don't account for fact it is more effective in post-day8 period then may not get good signal for efficacy)

- Dr Paul Marik's sepsis protocol


Because of which RCTs taken literally are used to set religious stances in the practice of medicine (for example some set of doctors hate Dr Paul Marik for his sepsis protocol).

And it could be argued that if a subset of practitioners are seeing benefit - while others are not - it could be due to some other factor which smears out the signal for those who are not timing dosing or duration correctly or some such factor.

More importantly if a treatment does not show harm (and occasionally great benefit), then it could be considered standard of care - until contrary evidence emerges.



&nbsp;



https://cjasn.asnjournals.org/content/3/1/281

N-Acetylcysteine in the Prevention of Contrast-Induced Nephropathy
Steven Fishbane

January 2008



&nbsp;


https://rhochistj.org/RhoChiPost/role-n-acetylcysteine-contrast-induced-nephropathy/

Clinical:
The Role of N-Acetylcysteine in Contrast Induced Nephropathy

Neal Shah, Co-Editor-In-Chief

August 1, 2012



&nbsp;





### **NAC for Heat Stroke - reversing organ damage in heatstroke**


&nbsp;


NAC seems to be effective as part of a treatment plan to prevent and reverse organ damage from heat stroke.

Heat Stroke - other names:

- Exertional Heat Illness



&nbsp;


https://pubmed.ncbi.nlm.nih.gov/30811527/

N-Acetylcysteine (NAC) for the Prevention of Liver Failure in Heat Injury-Mediated Ischemic Hepatitis

Oct 1, 2019


&nbsp;


https://www.ajemjournal.com/article/S0735-6757(19)30768-5/fulltext

Case Report

A knack for “NAC”: Treatment for heat stroke induced acute liver injury

November 28, 2019



&nbsp;




### **NAC for Fatty Liver Disease - reversing organ damage**


&nbsp;

NAC seems to be effective as part of a treatment plan to reverse fatty liver disease - esp. non-alcoholic fatty liver disease (NAFLD).


&nbsp;


https://pubmed.ncbi.nlm.nih.gov/22308119/

N-acetylcysteine improves liver function in patients with non-alcoholic Fatty liver disease

March 1, 2010


&nbsp;


https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01274-y

Long term N-acetylcysteine administration rescues liver steatosis via endoplasmic reticulum stress with unfolded protein response in mice

25 May 2020



&nbsp;


https://www.frontiersin.org/articles/10.3389/fphar.2021.636204/full

N-Acetyl Cysteine Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Intracellular Triglyceride Accumulation by Preserving Mitochondrial Function

13 September 2021



&nbsp;


https://mdpi-res.com/d_attachment/antioxidants/antioxidants-09-01283/article_deploy/antioxidants-09-01283-v2.pdf?version=1608167628

Review

N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature

16 December 2020



&nbsp;





* * *






## **Inhaled Budesonide (steroids)**

Inhaled Budesonide (steroids) - usually available as Rota-caps (capsules which contain steroid powder designed to be inhaled from a plastic container - as you breathe in, the powder gets drawn into your lungs).

These consist of a plastic device - and rota-caps or capsules which you insert into the plastic device.

You then rotate the plastic device, so the capsule gets opened up inside, and it's powder gets dumped inside the device.

Then you suck (breathe in) from the plastic device, in such a way that the air rushing into your lungs brings the powder along with it.

Here is a YouTube video explaining how to use a Rota-caps-based inhaled budesonide device:

https://youtu.be/fVPKNl2tNu4
Learn how to use a Rotahaler Inhaler
Sep 16, 2010


&nbsp;


Inhaled budesonide rota-caps typically have a very low steroids dose - usually less than 1mg.

So do not have much effect systemically - i.e. your other steroids (oral or intravenous) dosing doesn't need to be changed.

That is, if you are already taking steroids orally or intravenously, the inhaled budesonide can safely be added on top of it.


&nbsp;


If a patient has been started on steroids, then it is safe to also start on Inhaled Budesonide.

Usually steroids will be started if sufficient time has passed so the live virus is near zero - i.e. usually by day7-8 from first symptoms.

Sometimes day1 counting is unclear (patient is not sure or there is some confusion when symptoms started, or as with Delta and the already-vaccinated patient, the day1-7 period may be asymptomatic).

In such cases one should watch for oximeter SpO2 daily declines (or alternatively pulse rate going high in 90s or 100+ while at rest and while there is no fever) - usually this is a good indication that "day7-8" has arrived and the hyperinflammatory stage is in full swing.  And so steroids can be started.


In some cases, where you are wary of starting steroids (oral, intravenous) - it may be possible to start the Inhaled Budesonide first to start to give some relief in breathing.

However, usually the signal to use Inhaled Budesonide will be similar to that for oral or intravenous steroids.


&nbsp;


From studies, and from practical observation, Inhaled Budesonide give very strong and immediate relief to the patient.

So for example you have started the patient on steroids, but their breathing capacity is diminished due to inflammation, or oximeter levels are around 95 and only slowly improving.

Then in such situations, adding inhaled budesonide - 4-5 times a day i.e. every 4 hours or so - will give very visible relief to the patient - both in breathing capacity (i.e. breathing will become less shallower) and in terms of oximeter SpO2 levels also.

However for such a patient, systemic steroids (oral or intravenous) are essential - since in covid19, the hyperinflammatory stage can have impact all over the body i.e. in the blood vessels - so systemic steroids are essential.

But Inhaled Budesonide can be a valuable addition on top of that - in order to give additional relief to the patient.


&nbsp;


Just as a patient in this situation - oximeter at 95 and at home - would be told to do prone positioning (lying face down in bed).

Similarly Inhaled Budesonide should be added as well.

NOTE: as with all steroids use - patient should be told to keep a watch on phlegm color - if it changes from white/clear (normal during viral infection) - to yellow/green - that may then be an indication of bacterial infection.

Viral fevers generally go up to 101 Fahrenheit - however bacterial fevers can go higher i.e. to 102-103 or higher.  And so a fever that is higher than 101 should always put you on alert to watch for any signs of bacterial infection (phlegm color changing from white/clear to more yellow/green is an indication of bacterial infection).

In such a case, pre-emptive Doxycycline should be started:

- Doxycycline 100mg - 1+1 per day - for 5 days

This will keep the bacterial infection in check and in 1-2 days the yellow/green phlegm will turn back to white/clear.



&nbsp;


* * *



## **Steroids (Prednisolone or Dexamethasone)**

Usually at day7-8 from first symptoms, the first signs of oximeter declines will start to become obvious in most patients.

Even the mild patients (or who would have recovered on their own) seem to show some decline at day7-8 as well.

So in order to prevent long haulers, and since you don't know which patient will have a serious downturn in the next few days, it is wise to start steroids for all patients at day7-8.

Of course care should be exercised for those patients who are immuno-compromised, or who have potential for viral persistence (in such cases a higher dose of Ivermectin 0.6mg/kg bodyweight could be tried, or if you are comfortable with Remdesivir, it could be used - to provide a safety net for preventing viral persistence).

And care should be exercised for those likely to get bacterial infections - one should watch for signs of bacterial infection starting (sputum or phlegm color changing from white/clear to yellow/green).


&nbsp;


Prednisolone is the steroid of choice for the MATH+ protocols, and it's author Dr Paul Marik - who advises that Prednisolone is faster to the lungs, and is better tolerated by humans at higher doses (since in covid19 high steroids doses are sometimes required to achieve turnaround in the patient - the assurance of better tolerability at high dose is welcome).

Dexamethasone is often preferred by hospitals and physicians - primarily because it was chosen as the steroid for the RECOVERY UK trial on steroids use for covid19.

Because of that RECOVERY UK trial, a number of bad behaviors have become common as well in hospitals:

- Dexamethasone is not escalated beyond 6mg dose (the dose that RECOVERY UK trial used)

- Beyond this, generally prior attitudes wind up informing current behavior and hospitals often wind up giving much less doses than are needed for patients - something Dr Paul Marik calls "homeopathic" doses of steroids.  If a patient is at day10 and declining - you may need to give Prednisolone 120mg per day even or higher to start to show daily improvement.  While a patient at day7 may only require 40mg Prednisolone to show reversal.

- RECOVERY UK trial also has another negative impact - many hospitals are under the impression that steroids should not be used unless patient is intubated or in extremely dire straits.  This is an incorrect reading from RECoVERY UK trial.  In practice it is best to give steroids not much earlier than day7-8, and not much later than day7-8.  And if patient oximeter SpO2 are falling daily, then that should be seen as a sign that "day7-8" has arrived or already happened, and that aggressive steroids therapy is needed.


&nbsp;


NOTE: as described above for Inhaled Budesonide, once steroids are given to the patient, they should be watched for signs of bacterial infection, and if phlegm turns from white/clear to yellow/green then should start antibiotics to prevent bacterial infection from taking hold:

- Doxycycline 100mg - 1+1 per day - for 5 days

Once this is started, usually the yellow/green phlegm will start to turn back to white/clear.

Since viral infections typically don't go over 101 Fahrenheit, while bacterial infections can lead to fever that is higher i.e. 101-103 Fahrenheit - for this reason, if a patient is showing fever above 101 Fahrenheit, then you will need to watch for any signs of bacterial infection (like phlegm color changing from white/clear to yellow/green).


&nbsp;


* * *




## **Fluvoxamine**


&nbsp;


### **Fluvoxamine - may simplify protocols if reduces need for time sensitive steroids-at-day8**


If Fluvoxamine is given early, there is potential that you may not need steroids-at-day8.

This is the implication of the Fluvoxamine studies since they show efficacy (in reducing deaths) when Fluvoxamine is given during disease (preferably earlier one would think).

&nbsp;


The Serotonin Syndrome preventing action of Fluvoxamine also suggests it should be given earlier in the day1-8 period before hyperinflammatory stage appears at day7-8.

 
&nbsp;


Dr Syed Haider is one of the early users of Fluvoxamine - he uses it as Ivermectin + Fluvoxamine - and has confirmed on Twitter in replies that if given early, there may be no need for steroids-at-day8.

If this remains true - that would remove a complication from outpatient treatment practices for doctors - as it removes dependence on the (time sensitive) administration of steroids-at-day8.


&nbsp;


### **Fluvoxamine - issues with patient compliance**


There remains an issue of patient compliance - as SSRIs can have side effects, which some patients may not tolerate well.

Dr Syed Haider also has said from the earliest use, that some patients do have issues with Fluvoxamine and for them one can then fall back to other treatments.

For instance, if Fluvoxamine is not given, then the safety net of steroids-at-day8 should be ensured.  So patient is caught if hyperinflammatory stage appears, and that they survive it without long haulers syndrome or organ damage from hyperinflammation.

However, lately Dr Syed Haider has suggested in twitter messages, that he resorts to reducing the Fluvoxamine dose to half or to whatever level is tolerable by the user.


&nbsp;


### **Fluvoxamine - side effects**


**EDIT: November 13, 2021** - taken from: [https://saidit.net/s/Ivermectin2/comments/8imo/here_is_an_account_of_the_early_history_of_how/vulq](https://saidit.net/s/Ivermectin2/comments/8imo/here_is_an_account_of_the_early_history_of_how/vulq)

There is a concern that some patients may have issues with Fluvoxamine from the start.

So it adds an extra layer of logistics to handle for an outpatient doctor - more monitoring and more abrupt change of medications (if patient cannot tolerate Fluvoxamine then have to fall back to steroids-by-day8).


&nbsp;


However, I (u/stereomatch) asked this of Dr Angela Reiersen on twitter - and she said that a one week course should not make dependent.

However, we have direct feedback from Dr Syed Haider who is using it as his main line of defence i.e. ivermectin + fluvoxamine - and the idea being that this avoids need for steroids-at-day8 (I (u/stereomatch) pressed him on this).

Though I am not sure of the edge cases - i.e. if start Fluvoxamine late or later patient arrives.

Dr Syed Haider also addressed the dependence issue on Fluvoxamine in a tweet response - and he also is less concerned about that.

But he has said from the start that some proportion of patients do have issue with Fluvoxamine i.e. cannot continue with it etc.


&nbsp;


Fluvoxamine has been reported by some on reddit as does have impact on libido and ejaculation.

(in fact it is used by urologists to treat premature ejaculation in men it seems - private communication by a urologist from South Africa where it is commonly prescribed for this purpose)


&nbsp;


Here are some comments about difficulty weaning off SSRIs:

https://old.reddit.com/r/askscience/comments/qhexf7/_/hiea9zy




&nbsp;



### **Fluvoxamine - treatment for covid19 - early history**


&nbsp;


**EDIT: October 5, 2022** - taken from: [https://saidit.net/s/Ivermectin2/comments/8imo/here_is_an_account_of_the_early_history_of_how/](https://saidit.net/s/Ivermectin2/comments/8imo/here_is_an_account_of_the_early_history_of_how/)





&nbsp;



* * *




## **Cyproheptadine (SSRI)**


&nbsp;


At day7-8 onwards, Cyproheptadine (also an H1 blocker anti-histamine) can be started to counter the possibility of serotonin syndrome.

Dr Farid Jalali has been highlighting the potential role of serotonin syndrome for months on Twitter and elsewhere to his fellow physicians.  Cyproheptadine is now considered an essential addition to the FLCCC MATH+ protocol for hospitals:

**Reference:**

MATH+ protocol for hospitals:

https://covid19criticalcare.com/covid-19-protocols/math-plus-protocol/

- Cyproheptadine 8mg - 3 times a day


&nbsp;


**Conjecture: A possible sign serotonin syndrome has started**

u/stereomatch conjecture: If a patient takes this dosage and still does not feel sleepy, it may be a sign of ongoing serotonin syndrome.  The drug takes about 36 hours to take effect (according to Dr Farid Jalali in an interview with Dr Been), and after 2-3 days the patient can start to feel sleepy again. (TODO: add confirmation of this conjecture)

If this is potentially a good way to diagnose ongoing serotonin syndrome, then it may be possible to use this test to decide whether a patient already on steroids needs to be put on additional Cyproheptadine or not.


&nbsp;


**Evidence for Cyproheptadine reversing lung damage within 1-2 days**

Dr Farid Jalali reports on twitter about cases where Cyproheptadine has reversed lung injury in cases where there was serotonin syndrome (platelets hold 90+ percentage of serotonin - when platelets deaggregate they can release their serotonin, which can lead to clotting).

**Reference:**

https://www.youtube.com/watch?v=Wetdq9vX__c

Dr. Farid Jalali Discusses COVID Management

May 3, 2021

Drbeen Medical Lectures





&nbsp;




### **Cyproheptadine - do not stop suddenly but taper off**


&nbsp;


Cyproheptadine should not be stopped suddenly (can make matters worse), but should be tapered off over a few days.





&nbsp;




### **Cyproheptadine - side effects**


&nbsp;


Cyproheptadine 8mg - 3 times a day (FLCCC protocol) for post-day7-8 use in severe cases - dosage will make patient sleepy.

So that they only get up for meals.

Patients who are severe or have oximeter near 90 etc. will usually not mind this sleepiness that much.

But mild patients or those who are wanting to be active may complain that they are not able to do their daily chores at home - if they are on Cyproheptadine.




&nbsp;


* * *




## **Organizations and individuals supporting Early Treatment**


&nbsp;


### **BIRD Group UK (Dr Tess Lawrie)**


&nbsp;

Dr Tess Lawrie has also had her videos on YouTube removed - the Trusted News Initiative (TNI) at work.


&nbsp;


The BIRD Group UK is the UK version of the FLCCC in the US.

Website: https://www.bird-group.org

Telegram: t.me/birdgroupuk

Reddit: https://www.reddit.com/u/EbMCsquared


&nbsp;


Video channel:

https://odysee.com/@The_BiRD_Group:3
The BiRD Group

**Jan 11, 2023** - Dr Tess Lawrie had her account blocked by Twitter (restored after Elon Musk acquisition of Twitter)

Twitter: https://twitter.com/lawrie_dr




&nbsp;




### **Canadian Covid Care Alliance**


&nbsp;


Twitter: https://www.twitter.com/CCCAlliance

Website: https://www.canadiancovidcarealliance.org/


Canadian Covid Care Alliance (CCCA) is affiliated with the BIRD Group UK (Dr Tess Lawrie):

https://bird-group.org/bird-affiliates/



&nbsp;


Since the censorship situation in Canada is worse than the UK or USA - with physicians licenses being under threat for having prescribed or advocated for Ivermectin - the CCCA has had to take the unusual step of not publicizing it's membership list:


&nbsp;



https://www.canadiancovidcarealliance.org/faq/

>Why won't the Canadian Covid Care Alliance (CCCA) publish a list of its members and their professional credentials?
>
>We regret that the state of affairs, censorship of free speech, and rampant tyranny and coercion is such now in Canada that CCCA must protect the identity of its scientific, MD, academic and other health care professional (HCP) members.
>
>This serves to shield them from career-impacting reactions by their universities, professional colleges and healthcare system employers.
>
>Sadly, some of our MDs have had their medical licenses to practice suspended or restricted because they are not on board with the mainstream narrative.
>
>Likewise, some of our university professors have had their contracts terminated. These are dark times, and while we appreciate that some people want to know identities, frankly it would be hazardous to the careers of many of our members for us to reveal them.
>
>While there are publicly identified directors of CCCA, it should be apparent from the quantity and quality of the work published on our website that our scientists, HCPs, ethicists, lawyers and other professionals in CCCA have broad and deep scientific, medical, and professional expertise.
>
>A representative listing of a number of these credentials of our more than 500 scientists, medical doctors and health care and other professional members are listed on our website.
>
>If people are willing to think critically, they will appreciate the quality of our work; if they are not, no amount of personal disclosures will convince them in this cancel culture era.



&nbsp;


**References:**

https://old.reddit.com/r/ivermectin/comments/out7zw/hey_canadians_i_just_found_out_about_this/
Hey Canadians - I just found out about this Canadian Covid Care Alliance


https://covexit.com/canadian-group-calls-for-off-label-use-of-early-treatment-drugs-with-informed-consent/
Canadian Group Calls for Off-Label Use of Early Treatment Drugs with Informed Consent
June 19, 2021



&nbsp;




### **FLCCC - Front Line COVID-19 Critical Care Alliance**


&nbsp;


https://www.flccc.net

or

https://covid19criticalcare.com/



&nbsp;


The FLCCC has also had videos removed by YouTube - the Trusted News Initiative (TNI) at work.

Dr Pierre Kory of the FLCCC even had his **US Senate testimony removed** from YouTube.  His appearance there was a matter of **public record.**


&nbsp;


FLCCC YouTube channel:

https://www.youtube.com/c/FLCCCWeeklyUpdate
FLCCC Weekly Update


&nbsp;


Because YouTube has removed many FLCCC videos, they started using Odysee instead.

FLCCC Odysee channel:

https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c



&nbsp;




### **Dr Bret Weinstein - Dark Horse Podcast**


&nbsp;


Dr Bret Weinstein and Dr Heather Heying - who are evolutionary biologists and run the Dark Horse Podcast - have had their videos removed from YouTube, and **YouTube channel demonetized** - which is an example of how the Trusted News Initiative (TNI) impacts flow of information.


&nbsp;



He has decided to switch to Odysee (open video platform).

Dr Bret Weinstein (evolutionary biologist) video channel:

https://odysee.com/@BretWeinstein:f



&nbsp;




### **Robert Malone MD - pioneer of mRNA vaccine technology**


&nbsp;


Dr Robert Malone is a pioneer in the development of mRNA vaccine technology.  He was the originator of the idea that Lipid Nano Particles (LNPs) could be used to ensure mRNA gets entry into cells.

His Twitter account was removed for suggesting mRNA vaccines may have issues.

He then moved to gettr: https://gettr.com/user/rwmalonemd


&nbsp;


Website: https://www.rwmalonemd.com/

Substack: https://rwmalonemd.substack.com/



&nbsp;



### **Alexandros Marinos - critiques of TOGETHER trial**


&nbsp;


Alexandros is the Founder/CEO of baleno.io


Video of Alexandros Marinos with Dr Bret Weinstein:

https://www.youtube.com/watch?v=kLXiQEihg8s

or

https://odysee.com/@BretWeinstein:f/cold-confusion-alexandros-marinos:7

Cold Confusion: Alexandros Marinos unpacks the TOGETHER Trial with Bret

May 2nd, 2022

Bret Weinstein



&nbsp;



Twitter: https://twitter.com/alexandrosm

Substack: https://doyourownresearch.substack.com/



&nbsp;



### **Ivory Hecker - whistleblower - formerly at Fox News**


&nbsp;


Ivory Hecker has had her videos removed from YouTube - the Trusted News Initiative (TNI) at work.

She has created a channel on bitchute:

https://www dot bitchute dot com/channel/nJZpoljWM26e/

or

https://tinyurl.com/w7c9r8uh

(reddit does not allow bitchute links)




&nbsp;


* * *



## **Experts who post on r/ivermectin**


&nbsp;



* * *



## **Frequently Asked Questions (FAQ)**


&nbsp;


### **The FLCCC authors of MATH+ protocol are quacks and no one takes them seriously**

Answered here:

https://old.reddit.com/r/ivermectin/comments/p03pvh/lesson_learned/h84a1ta


&nbsp;


As well as here:

https://old.reddit.com/r/ivermectin/comments/o9th7b/meet_the_quacks_kooky_covid_doctors_who_use/

Meet the Quacks: Kooky COVID Doctors Who Use Dangerous Animal Drugs - Censor Them! (June 28, 2021) - article provides a resume of the FLCCC doctors and their prior contributions to medicine


&nbsp;

Article:

https://degraw.substack.com/p/meet-the-quacks-kooky-covid-doctors
Meet the Quacks: Kooky COVID Doctors Who Use Dangerous Animal Drugs - Censor Them!

Courageous COVID Doctors With the Lowest Death Rates #TeamLifeSaving

David DeGraw

June 28, 2021



&nbsp;




* * *



## **Books**


&nbsp;



### **Chronic - Dr Steven Phillips, Dana Parish**


&nbsp;


Dr Steven Phillips has suffered through a chronic illness, and his book is highly recommended by Dr Been (should be on everyone's bookshelf) because of it's insights into chronic diseases - especially Lyme disease, and now long haulers syndrome due to covid19:


&nbsp;


https://www.amazon.com/Chronic-Hidden-Autoimmune-Pandemic-Healthy/dp/0358064716/ref=tmm_hrd_swatch_0?_encoding=UTF8&qid=1639185296&sr=8-2

Chronic: The Hidden Cause of the Autoimmune Pandemic and How to Get Healthy Again Hardcover – February 2, 2021

by Steven Phillips (Author), Dana Parish (Author)


&nbsp;


Dr Steven Phillips also had an online chapter for his book that addresses covid19 as well - not clear if it is available on the website, or will appear in next version of the book:

https://stevenphillipsmd.com


&nbsp;



Dr Been interviews with Dr Steven Phillips:


&nbsp;


https://youtu.be/FqVlOfzZJH0

Dr. Steven Phillips Discusses Chronic Diseases (Lyme and COVID)

Drbeen Medical Lectures 

Jan 30, 2021


&nbsp;


https://www.youtube.com/watch?v=xwMwR6IJC3o

Chronic Diseases Talk with Dr. Steven Phillips (Lyme, COVID Long Haul and More)

March 19, 2021

Drbeen Medical Lectures


&nbsp;


https://www.youtube.com/watch?v=CzIrtvjNY2M

Long COVID, Lyme - Dr. Steven Phillips, Dana Parish (Authors of The Book Chronic)

Dec 11, 2021

Drbeen Medical Lectures



&nbsp;



### **The Real Anthony Fauci - Robert F. Kennedy Jr.**


&nbsp;


Robert F. Kennedy Jr. on Dr Fauci, and the role of Bill Gates and Big Pharma:

https://www.amazon.com/Real-Anthony-Fauci-Democracy-Childrens/dp/1510766804
The Real Anthony Fauci: Bill Gates, Big Pharma, and the Global War on Democracy and Public Health (Children’s Health Defense) Hardcover – November 16, 2021
by Robert F. Kennedy Jr. (Author)


&nbsp;


### **Overcoming the COVID-19 Darkness - Dr George Fareed, Dr Brian Tyson**


&nbsp;


https://www.amazon.com/dp/B09PVNF24K/ref=cm_sw_r_tw_api_glt_fabc_8ZZCA61Z034CJH3PQF1F
Overcoming the COVID-19 Darkness: How Two Doctors Successfully Treated 7000 Patients
Paperback – January 7, 2022 

by Brian Tyson (Author), George Fareed (Author), Mathew Crawford (Author)


&nbsp;


Dr George Fareed & Dr Brian Tyson (AAPS affiliated) have also reported great success with early treatment (reduced mortality, and lower incidence of long haulers syndrome).

https://www.thedesertreview.com/news/dr-george-fareed-and-dr-brian-tyson-share-early-treatment-protocol/article_7728815e-3ca2-11eb-8a08-7b4b0156c181.html
Dr. George Fareed and Dr. Brian Tyson share early treatment protocol
Dec 12, 2020
Updated Apr 16, 2021

Their protocol includes moderate amounts of Ivermectin, Hydroxychloroquine (HCQ) and other supplements.



&nbsp;



### **COVID-19 and the Global Predators - Peter Roger Breggin**


&nbsp;


https://www.amazon.com/COVID-19-Global-Predators-are-Prey/dp/0982456069
COVID-19 and the Global Predators: We Are the Prey Paperback – September 30, 2021
by Peter Roger Breggin (Author), Ginger Ross Breggin (Author)

Foreword by:

Dr Peter McCullough

Dr Elizabeth E. Vliet

Dr Vladimir "Zev" Zelenko





&nbsp;


### **Pandemic Blunder - Peter Roger Breggin**


&nbsp;


https://www.amazon.com/Pandemic-Blunder-Public-Blocked-Treatment/dp/197723822X/ref=nav_signin?dchild=1&keywords=Pandemic+Blunder&qid=1612289098&sr=8-1&&

Pandemic Blunder - Fauci and Public Health Blocked Early Home COVID Treatment

Joel S Hirschhorn



&nbsp;


Dr Peter McCullough tweet about the book:


&nbsp;


https://twitter.com/P_McCulloughMD/status/1489287815334707202?t=HzIyD9top4oYPw5RlkXXZQ&s=19

>Rogan asked "who is behind all of this?" I did not give opinions or make claims, I referred him to this book by Dr. Peter and Ginger Breggin which lays out the field of stakeholders and their connections and how it was put together.  Not my opinion but in published nonfiction. 



&nbsp;












[Return to Ivermectin](http://reddit.com/r/Ivermectin)

revision by stereomatch— 1 month agoview source

Ivermectin2

MODERATORS

WIKI TOOLS

index

Ivermectin Table of Contents

About this Wiki

Changes

Links to Wiki

Corrections and Feedback

Instructions for Moderators

History of pinned (stickied) posts on r/ivermectin

About r/Ivermectin and r/gettingIvermectin

Archives of r/Ivermectin

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Alternative to Reddit - start posting on Saidit

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COVID-19 - Timeline of Events (Mika Turkia)

Caution - Veterinary Ivermectin

Ivermectin - availability in various countries

Ivermectin - assessing the quality of tablets ordered online from other countries

Ivermectin - Guides, Methods of Action

FLCCC FAQ

u/iResistDe4iAm guide to Ivermectin

u/albenstein has a guide as well

Dr Been

Whiteboard Doctor

Some other sources

Guidelines for Companies

Guidelines for Companies - risk management

Guidelines for Companies - Diabetes, Vitamin D3

Guidelines for Companies - Prevent Household Spread

Guidelines for Companies - Critical Employees

Understanding COVID-19 Timelines - for physicians

What is Inflammation?

PCR testing

PCR testing - understanding positive and negative results

PCR testing - should one wait for PCR testing before starting Ivermectin for suspected covid19 case?

PCR testing - for airline travel and at work

PCR testing - Dr Michael Mina (Harvard) comments on PCR testing

Early Treatment

Early Treatment - ivermectin is one part of the wider need for Early Treatment

Early Treatment - denial of early treatment

Early Treatment - understanding early treatment denial

Early Treatment - is early treatment denial heartfelt or feigned?

Early Treatment - labelling of early treatments as "Right Wing"

Early treatment - understanding Trusted News Initiative (TNI) and regulatory capture

Early Treatment Protocols

Early Treatment Protocols - my simplified protocol for early treatment and preventing long haulers

FLCCC Prophylaxis and Treatment protocols (MATH+, I-MASK+, I-MASS, I-RECOVER)

Mika Turkia - review of FLCCC MATH+ protocol

Dr George Fareed & Dr Brian Tyson - protocol

Dr Dirk Koekemoer (South Africa) protocol

Dr Peter McCullough protocol

Steven Kirsch protocol

AIMMS, New Delhi, India protocol

Early Treatment Deniers

Early Treatment cases

Long Haulers Syndrome (long COVID-19)

Long Haulers Treatment cases

Long Haulers Treatment protocols

Long Haulers Treatment Deniers

Long Haulers Treatments - React19 survey of treatments for long haulers and vaccine long haulers

Long Haulers Treatments - LongCovidPharmD (organichemusic on Twitter) survey of treatments for long haulers

Long Haulers Treatments - Nattokinase, Serrapeptase, Lumbrokinase

Long Haulers Treatments - Survey of Anosmia treatments - on Reddit

Long haulers and anosmia, olfactory bulb entry route to brain and brain shrinkage on MRIs

Long haulers and vagus nerve inflammation

Post-vax - pre-vaccine protocols for reducing vaccine injury

Post-vax - side-effects or injury and treatments

Post-vax - treatment cases