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Among 11,000 COVID patients who came to Columbia University Irving Medical Center with suspected COVID-19, the researchers found that over 25% of those with age-related macular degeneration died, compared to the average mortality rate of 8.5%, and roughly 20% required intubation. The greater mortality and intubation rates could not be explained by differences in the age or sex of the patients.

This is actually quite a very large increase in mortality and complications. I think the largest one I've seen discovered yet. Certainly something to be aware of. The gene is of course most active in people with obesity which, among everything ELSE obesity screws up, makes this screwup compoundingly bad.