2005. China uses their SARS-CoV vaccine: "Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease caused by SARS-associated coronavirus (SARS-CoV)"

submitted by fizzyj from medscape.com

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“This virus may use the packing mechanisms of other viruses such as HIV.”

According to the study, the mutation can generate a structure known as a cleavage site in the new coronavirus’ spike protein.

The virus uses the outreaching spike protein to hook on to the host cell, but normally this protein is inactive. The cleavage site structure’s job is to cheat the human furin protein, so it will cut and activate the spike protein and cause a “direct fusion” of the viral and cellular membranes.

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Chinese researchers said drugs targeting the furin enzyme could have the potential to hinder the virus’ replication in the human body. These include “a series of HIV-1 therapeutic drugs such as Indinavir, Tenofovir Alafenamide, Tenofovir Disoproxil and Dolutegravir and hepatitis C therapeutic drugs including Boceprevir and Telaprevir”, according to Li’s study.

This suggestion is in line with reports by some Chinese doctors who self-administered HIV drugs after testing positive for the new coronavirus, but there is as yet no clinical evidence to support the theory.