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Why mRNA vaccines have not been used until recently
submitted 3 years ago by trident765 from self.nonmorons
Up until 2020, these mRNA biotech companies had poor results testing mRNA drugs for cardiovascular, metabolic and renal diseases; selected targets for cancer; and rare diseases like Crigler–Najjar syndrome, with most finding that the side-effects of the mRNA delivery methods were too serious.[24][25] mRNA vaccines for human use have been developed and tested for the diseases rabies, Zika, cytomegalovirus, and influenza, although these mRNA vaccines have not been licensed.[26] Many large pharmaceutical companies abandoned the technology,[24] while some biotechs re-focused on the less profitable area of vaccines, where the doses would be at lower levels and side-effects reduced.[24][27] At the onset of the COVID-19 pandemic, no mRNA drug or vaccine had been licensed for use in humans. In December 2020, both Moderna and Pfizer–BioNTech obtained emergency use authorization for their mRNA-based COVID-19 vaccines, which had been funded by Operation Warp Speed (directly in the case of Moderna and indirectly for Pfizer–BioNTech).[23] On 2 December 2020, seven days after its final eight-week trial, the UK's Medicines and Healthcare products Regulatory Agency (MHRA), became the first global medicines regulator in history to approve an mRNA vaccine, granting "emergency authorization" for Pfizer–BioNTech's BNT162b2 COVID-19 vaccine for widespread use.[7][8][28] MHRA CEO June Raine said "no corners have been cut in approving it",[29] and that, "the benefits outweigh any risk".[30][31] On 11 December 2020 the FDA gave emergency use authorization for the Pfizer–BioNTech COVID-19 vaccine.[32]
Up until 2020, these mRNA biotech companies had poor results testing mRNA drugs for cardiovascular, metabolic and renal diseases; selected targets for cancer; and rare diseases like Crigler–Najjar syndrome, with most finding that the side-effects of the mRNA delivery methods were too serious.[24][25] mRNA vaccines for human use have been developed and tested for the diseases rabies, Zika, cytomegalovirus, and influenza, although these mRNA vaccines have not been licensed.[26] Many large pharmaceutical companies abandoned the technology,[24] while some biotechs re-focused on the less profitable area of vaccines, where the doses would be at lower levels and side-effects reduced.[24][27]
At the onset of the COVID-19 pandemic, no mRNA drug or vaccine had been licensed for use in humans. In December 2020, both Moderna and Pfizer–BioNTech obtained emergency use authorization for their mRNA-based COVID-19 vaccines, which had been funded by Operation Warp Speed (directly in the case of Moderna and indirectly for Pfizer–BioNTech).[23] On 2 December 2020, seven days after its final eight-week trial, the UK's Medicines and Healthcare products Regulatory Agency (MHRA), became the first global medicines regulator in history to approve an mRNA vaccine, granting "emergency authorization" for Pfizer–BioNTech's BNT162b2 COVID-19 vaccine for widespread use.[7][8][28] MHRA CEO June Raine said "no corners have been cut in approving it",[29] and that, "the benefits outweigh any risk".[30][31] On 11 December 2020 the FDA gave emergency use authorization for the Pfizer–BioNTech COVID-19 vaccine.[32]
https://en.wikipedia.org/wiki/RNA_vaccine#History
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