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[–]Nombre27 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

The original 95% efficacy nonsense was based on intentionally misleading statistics and poor data collection.

Pfizer and Moderna each did a non-random follow-up based on participant self-reporting of 0.4% and 0.9% of their trial participants, respectively, and both their vaccines were found to have a 95% efficacy.

The Chinese and Indian whole inactivated viral vaccines did a pre-determined follow-up of 6.5% and 31% of trial participants and found an efficacy of about 75%.

Based on the track record of whole inactivated vaccines (literally every other vaccine in existence, have you ever heard of a widespread outbreak of mumps, measles, rubella or other pathogens amongst adults?) and the much better follow-up, I'm more inclined to believe that a 75% efficacy is the upper limit and that the efficacy calculated by Pfizer and Moderna is from poorly designed science. Intuitively, the difference in efficacies don't make sense either. A whole inactivated virus (Covid is ~30k basepairs) would result in far more greater epitopes (signatures or targets that our immune system recognizes to deal with a pathogen) and thus a more comprehensive immune response than the smaller spike protein target that only incorporated about 5k basepairs worth of material for our immune systems to be trained from. Viruses typically dump their contents within a cell in order to reproduce, so it is possible for all 30k basepairs to be utilized by the immune system.

Not Pfizer but CDC misinforming people.

This CDC report counts people as unvaccinated within 14 days after their first shot. No reason for that kind of conflation.

https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7034e5-H.pdf

s. Persons were considered fully vaccinated ≥14 days after receipt of the second dose in a 2-dose series (Pfizer-BioNTech or Moderna COVID-19 vaccines) or after 1 dose of the single dose Janssen (Johnson & Johnson) COVID-19 vaccine¶; partially vaccinated ≥14 days after receipt of the first dose and <14 days after the second dose in a 2-dose series; and unvaccinated <14 days after receipt of the first dose of a 2-dose series or 1 dose of the single-dose vaccine or if no CAIR2 vaccination data were available.