Spike Proteins

Poor Antibody Responses

• Boosting of Cross-Reactive Antibodies to Endemic Coronaviruses by SARS-CoV-2 Infection but not Vaccination with Stabilized Spike - medRxiv (Preprint)

• Anti-nucleocapsid antibodies following SARS-CoV-2 infection in the blinded phase of the mRNA-1273 Covid-19 vaccine efficacy clinical trial - medRxiv (Preprint)

• Cleavage and Presence in Bloodstream

• Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients - Clinical Infectious Diseases

Coagulopathy

• Clinical Characteristics and Pharmacological Management of COVID-19 Vaccine–Induced Immune Thrombotic Thrombocytopenia With Cerebral Venous Sinus Thrombosis - JAMA

• Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways - MDPI

• A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications - Portland Press Biochem Journal

• Evidence of SARS-CoV-2 Spike protein on retrieved thrombi from COVID-19 patients - Research Square (Preprint)

• Covid-19: European countries suspend use of Oxford-AstraZeneca vaccine after reports of blood clots - BMJ

Amyloidogenesis

• SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration - Elsevier

• Amyloidogenesis of SARS-CoV-2 Spike Protein - ACS

Autoimmune Attack

• Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model - Clinical Infectious Diseases

• Role of the antigen presentation process in the immunization mechanism of the genetic vaccines against COVID-19 and the need for biodistribution evaluations - Wiley

• New-onset autoimmune phenomena post-COVID-19 vaccination - Wiley

• Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs - Elsevier

• Auto-immune hepatitis following COVID vaccination - Elsevier

• Autoimmune hepatitis after COVID-19 vaccine – more than a coincidence - Elsevier

• SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis - Journal of Hepatology00234-3/fulltext)

Integrin Binding

• A potential role for integrins in host cell entry by SARS-CoV-2 - Elsevier

• Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2 - JBC

• ACE2-independent infection of T lymphocytes by SARS-CoV-2 - Signal Transduction and Targeted Therapy

Blood Brain Barrier Effects

• SARS-CoV-2 Spike Protein Disrupts Blood–Brain Barrier Integrity via RhoA Activation - Springer

• The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier - Elsevier

• The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice - Nature

Consequences

From the available data, our conclusions regarding the mRNA vaccines are as follows:

• The PEGylated LNPs are capable of occasionally causing severe allergic reactions. The LNPs do not remain at the injection site, but travel all over the body and accumulate in key organs.

• Unlike the virus, which only infects cells that express the host factors, LNPs can be endocytosed by practically any cell.

  Synthetically-capped, pseudouridylated mRNA:

• Resists breakdown by nucleases and may accumulate and persist over a long period of time.

• May act as a TLR7/8 inhibitor.

• May encourage stop codon readthrough and translate normally untranslated regions of the mRNA strand, resulting in an unknown product with unknown properties.

• Pfizer’s vaccine, which contains mtRNR1 in its UTR, may promote mitochondrial toxicity and mitochondrial deafness if this UTR is translated, though this has never been confirmed.

• May be taken up by LINE-1 retrotransposon activity and reverse-transcribed into DNA.

• If this DNA expresses Spike, then the afflicted cell may express Spike continuously.

• SARS-CoV-2 Spike produced by the vaccine can be cleaved by endogenous proteases, resulting in loose S1 entering the bloodstream.

• This implies that proline substitution does not render the Spike inert.

  SARS-CoV-2 Spike is:

• Incredibly pro-coagulant and harmful to endothelial integrity.

• Highly inflammatory, with a Superantigenic region.

  • Capable of penetrating the blood-brain barrier.
  • Has a heparin-binding domain, is amyloidogenic, and can aggregate Aβ, α-synuclein, tau, prion, and TDP-43 RRM, potentially generating amyloid fibrils and plaques as well as Lewy bodies. In the bloodstream, it may also generate amyloid fibrin clots.
  • Can potentially bind to LFA-1 Integrins in an ACE2-independent manner, much like HIV gp120.

  The expression of Spike by healthy cells may provoke autoimmune attack. Any cell that expresses SARS-CoV-2 Spike after being transfected with mRNA may be destroyed by the immune system.

• Inadvertent intravenous injection is very harmful and can cause myocarditis and profound heart scarring.

• The vaccines may trigger autoimmune attacks on nervous tissue, leading to Bell’s Palsy or Guillain-Barré.

• The vaccines may trigger autoimmune hepatitis.

• The vaccines may affect fertility or fetus viability if they trigger autoimmune attack against germ cells or fetal tissues.