IMO when it comes to friends it’s easier to stick to less controversial topics:

-trans women don’t belong in womens sports

-queer is a slur for a lot of people and it’s offensive when it’s used as an umbrella term

-non-binary is more of a fashion statement than anything real

-transing children is based on sexist stereotypes and medicalizing trans children is causing irreparable harm to many children who would otherwise grow up LGB or GNC

^{^} I think all of the above can and should be argued without rocking the boat too much. No one will want to be your friend if you’re an extremist, keep it to the arguments that support your views but aren’t too extreme and you should be ok.