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[–]spelllingchamp[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (2 children)

Hot take: I feel like everybody should just call a spade a spade. Marinos doesn't need to be so charitable. It's clear what Edward Mills is doing - he is manipulating the data to reach the desired conclusion. The trial design is janky and Mills goes out of his way to hide how janky it is. The platform trial was not randomized, pre-registered, or controlled. Perhaps there is salvageable data here, but the chances of that being published are... very low.

[–]stereomatch 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (1 child)

I appreciate the effort Steve Kirsch and Alexandros Marinos have spent sifting through what I called a "turd of a trial" on twitter.

Once you have a trial where the researchers are not interested in showing a signal, then you have a serious problem - since for a trial to show a signal it has to be structured to find that signal.

If researchers are not interested in phrasing the trial to show a signal - then it is a crap trial - unlikely to be of much use in terms of finding a signal (and finding the conditions - dosing/timing - under which a signal can appear).

[–]spelllingchamp[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

Well they're not even interested in doing science- that's a big problem. They're just injecting politics and fabricated conclusions into the scientific system.

They did find a signal for fluvoxamine.