AntibioticsTestosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline (Jan 2019) "Early-life exposure to doxycycline shows negative outcomes of testis health in later-life. Early-life exposure to low-dose of doxycycline associates with increased risk of obesity."

submitted by MaximilianKohlerreads microbiomedigest.com daily from (sciencedirect.com)

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[–]MaximilianKohlerreads microbiomedigest.com daily[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (16 children)

EDC = endocrine disrupting chemical. https://www.who.int/ceh/risks/cehemerging2/en/

Highlights

• Doxycycline may be EDCs through mitochondrial dysfunction mechanism cause endocrine disruption.

• Early-life exposure to doxycycline shows negative outcomes of testis health in later-life.

• Early-life exposure to low-dose of doxycycline associates with increased risk of obesity.

Abstract

Veterinary tetracyclines drugs are emerging organic pollutants detected at high concentrations in the urine of school children and a potential public health risk. However, the implications of early-life exposure to tetracyclines on testosterone production, being new endocrine disruptors, remain unknown. We investigated whether the early-life exposure to low-doxycycline, a widely used tetracycline, on mitochondria dysfunction and testosterone disruption in Leydig cells in vitro and in vivo. Next, we determined the mRNA levels of testis cells markers for early-life exposure to low-doxycycline outcomes of testis health in later-life. Finally, we compared the weight gain performance exposed to low- and therapeutic-doses through 15 weeks and examined the role of the microbiota during development. Our results showed doxycycline disturbed steroidogenesis process by mitochondrial dysfunction in mouse Leydig tumor cell line (MLTC-1) cells in vitro. Leydig cells mitochondrial function was disrupted by early-life exposure to low-doxycycline from birth to 49 days, causing testosterone deficiency and decreased quality of the sperm in mice. Early-life exposure to low-doxycycline significantly altered the mRNA levels of key genes in Leydig cells (Cyp11a1, Cyp17a1 and 17β-HSD) and spermatogenic cells (Grfal, Plzf, and Stra8) in later-life in mice. Subchronic low- and therapeutic-doses doxycycline changed gut microbiota differences in diversity reduction and compositional alteration. Moreover, the weight gain effects of doxycycline were only observed in low-dose in male mice. Overall, these results provide insight into the effects of doxycycline on both testis and gut microbiota health. The results provide insight that environmental antibiotics are needed additional research to classify as ECDs.

[–]Tom_Bombadil 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (15 children)

This would be a great tool for any group that was interested in clandestine eugenics.

[–]MaximilianKohlerreads microbiomedigest.com daily[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (14 children)

Well the "great tool for eugenics" is an antibiotic that is extremely common, and often for trivial things like acne.

In my opinion the situation is quite dire: https://old.reddit.com/r/worldpolitics/comments/a4yeq0/since_there_are_no_rules_here_i_might_as_well_use/

[–]Tom_Bombadil 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (12 children)

It's possible. There are definitely harmful affects associated with antibiotics.

Vaccinations are far worse in my opinion. Newborns receive the hepatitis B vaccine at birth.

I've never known anyone with hepatitis b, so it seems inconceivable to me that a new born would need to immediately receive this. That's just scratching the surface of the vaccine risks.

[–]MaximilianKohlerreads microbiomedigest.com daily[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (11 children)

You're misinformed about vaccines. You have a tremendous amount of information at your fingertips via a simple web search. Use that instead of making ignorant guesses.

There are some knowledge resources in these comments: https://archive.fo/MpwmK#selection-2331.8-2335.0

[–]Tom_Bombadil 1 insightful - 2 fun1 insightful - 1 fun2 insightful - 2 fun -  (2 children)

$4 Billion and Growing: U.S. Payouts for Vaccine Injuries and Deaths Keep Climbing • Using the government’s own conclusion that only 1% of all vaccine injuries are reported, the $4 billion is the tip of the iceberg. CDC and our Federal agencies that all vaccines are safe, the payouts say otherwise.

$4,000,000,000 in payouts strongly suggest that there is a serious problem that is being covered up.
I wouldn't blame you for being unaware of this figure.

Do you have any educated guesses about possible reasons that this info is being suppressed???

[–]MaximilianKohlerreads microbiomedigest.com daily[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (1 child)

I'm not sure. I'm not knowledgeable enough on that to comment.

But I am very knowledgeable on antibiotics and the microbiome, and to me antibiotics seem like a much bigger threat/harm.

[–]Tom_Bombadil 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

I'd like to preface my comments with the fact that I take great interest in this subject matter.
The microbiome will likely be considered the largest organ in the body, and the scientific community is only beginning to scratch the surface of the severely understated and even more underappreciated contrabution of the intestinal microbiome "gut".

Having said that, the indiscriminate destruction that antibiotics wreak on the microbiome is universally understated. This should be obvious to the medical industry, and I find it suspicious that it is not more fully investigated.

[–]Tom_Bombadil 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (2 children)

Would you be surprised to learn that in 2016 the US Supreme Court ruled that vaccines are unavoidably unsafe?

[–]MaximilianKohlerreads microbiomedigest.com daily[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (1 child)

That's a misleading statement on your part.

You have to look at the rates of vaccine injury vs rates of injury from the diseases the vaccines protect against. You also have to look at the severity of the injuries.

I think the science backing the gut microbiome as the causative factor is the strongest: https://old.reddit.com/r/HumanMicrobiome/wiki/intro#wiki_autism.3A

Though the gut microbiome also impacts vaccine efficacy & immune system: https://old.reddit.com/r/HumanMicrobiome/wiki/immunesystem

[–]Tom_Bombadil 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

It is not a misleading statement.

Well, in the previous link the govt admitted that that estimated that 1% of vaccine injured families reported the injury.

By that account, the actual damages awarded should be closer to $400,000,000,000. Almost half a trillion dollars.

A silent epidemic of unreported damage.

A multi billion dollar industry is keeping the lid on the facts. Most people implicitly trust doctors. It would take overwhelming evidence to change that belief. Half a trillion worth of unrecognized damages would probably have many families outraged.

That is why Facebook and other media are desperately suppressing this information movement.

Big money is spent on advertising in spite of shrinking audiences...

The media is effectively paid off.

[–]Tom_Bombadil 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

Would you also accuse the Supreme Court of making ignorant guesses?

Any possibility that you are misinformed about vaccines?

[–]Tom_Bombadil 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (2 children)

CDC whistleblower's sworn testimony stating that the MEASLES MUMPS AND RUBELLA VACCINE causes a STATISTICALLY SIGNIFICANT INCREASE OF AUTISM in African American populations. Testimony asserts that this doctor, his boss, and co-workers at the CDC destroyed the documented evidence.

[–]MaximilianKohlerreads microbiomedigest.com daily[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (1 child)

A web search gives me these responses:

https://www.snopes.com/fact-check/bad-medicine/

https://leftbrainrightbrain.co.uk/2017/02/10/a-look-back-at-the-so-called-cdc-whistleblower-story-and-how-vaxxed-is-misleading/

[–]Tom_Bombadil 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

Snopes needs advertising dollars too.

Did they debunk the $4 billion dollars paid out in damages?

How about the govts 1% reporting estimate?

Is the corporatists Supreme Court lying, and Snopes is telling the truth?

Does that seem probable??

You have knowledge of the medical Indusrty.... What do you think is more probable?

Edit:. By the way. I am very interested in your feild, and look forward to reading your posts. :-)