I don't think it's just "man up", it's more about "Toughen Up". Doesn't matter what your gender is. A lot of people nowadays are just mentally and emotionally weak. They get hurt too easily and despair too fast.

Yes, it is important to toughen up. The world isn't a place where everyone will be nice to you just because you're nice to them. It's a world where good people get victimized often by the strong or the bully types. In order to not become a victim, you have to be able to stand up on your own and fight back when necessary. Of course, this doesn't mean that you're not allowed to find help. That's just ridiculous.

Another thing that doesn't help when it comes to suicide or depression is the inability of people to accept their failures or faults. Life isn't a fairy tale where if you work hard, you'll succeed. The only thing we're guaranteed in life is that we'll die someday. Don't let failures and your faults become things that you need to "correct" in your life. If no matter how many times you've tried, you still failed, then you have to let go. You have to give up and move on. There are things you cannot have in life and that's normal.