you are viewing a single comment's thread.

view the rest of the comments →

[–]Tovasshi[S] 4 insightful - 1 fun4 insightful - 0 fun5 insightful - 1 fun -  (5 children)

The study doesn't mention autism, no. But the genes varients mentioned are. They are in the links. It's one of those things though wouldn't pick up on unless you were familiar with ASD research.

The point is non of the test subjects were screened for ASD but had gene varients associated with ASD.

There has lots of research regarding the connection between gender dysphoria and ASD. This genetic study just demonstrated that a handful of the test subjects had similar gene varients as thine with ASD.

[–]anonymale 3 insightful - 1 fun3 insightful - 0 fun4 insightful - 1 fun -  (4 children)

It's one of those things though wouldn't pick up on unless you were familiar with ASD research.

Could you please spell it out for those of us less familiar with the research than yourself?

[–]Tovasshi[S] 5 insightful - 1 fun5 insightful - 0 fun6 insightful - 1 fun -  (3 children)

Autism spectrum disorder, schizophrenia, bipolar disorder, etc are related disorders. There is no single gene associated with the disorder, but a few genes are associated with them. Most people with ASD or related disorders have a combination of these gene varients. Most of the genes are really close to eachother on the same chromosome.

The severity of the disorders or which features one has seems to be predicted by different combinations of these gene variants.

The genes themselves are important in brain development, they're not necessarily associated with sex development despite being on sex chromosomes.

The genes themselves (at least some of them) are used in pruning branches of neurons as they develop, so they don't have too many, or not enough connections in the brain. In layman's terms, they control how the brain is wired.

No two austic, schizophrenic or bipolar person is going to have the exact same varients in these genes, but a group of schizophrenic people will be more similar to eachother than they would be to autistic people.

In this study all the varients they found in transgender individuals are of the same genes associated with ASD, schizophrenia, etc and other neurological developmental disorders. But the researchers came to a different conclusion because the genes are on an sex chromosome.

[–]anonymale 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (2 children)

Thank you but this is the part I was hoping you could expand on:

The study doesn't mention autism, no. But the genes varients mentioned are. They are in the links.

Which of the other papers you provided links for mention the gene variants referred to in the exome sequencing paper?

[–]Tovasshi[S] 5 insightful - 1 fun5 insightful - 0 fun6 insightful - 1 fun -  (1 child)

[–]anonymale 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

Great, thanks.