Someone posted this link to try to prove that gender identity was inate, but all the genes they found associated with transgenderism just so happen to be the same ones associated with Autism Spectrum Disorder.

submitted by Tovasshi from nature.com

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[–]BEB 47 insightful - 1 fun47 insightful - 0 fun48 insightful - 1 fun -  (10 children)

Dr. Lisa Littman's ground-breaking study on children being swept up in the transgender craze also found very high rates of autism in these kids.

[–]greenish 54 insightful - 1 fun54 insightful - 0 fun55 insightful - 1 fun -  (8 children)

So they've basically found a way to sterilize autistic and gay kids, that is labelled "progressive" and supported by institutions of power, so it can't be opposed. And they call us fascists for criticising this.

[–]BEB 33 insightful - 1 fun33 insightful - 0 fun34 insightful - 1 fun -  (2 children)

Yes. Trans, Inc., push for kids to embrace transgenderism is basically "spaying away the gay" and the autistic, as well as kids withdepression, ADHD, kids who've suffered mental, sexual and physical abuse and kids who just don't feel like they fit in.

Here is Dr. Lisa Littman talking about her Brown Univeristy study on how youngsters are being sucked into the "social contagion" of transgenderism.

BTW:this publication, Quillette.com , publishes a lot of gender critical pieces:

https://quillette.com/2019/03/19/an-interview-with-lisa-littman-who-coined-the-term-rapid-onset-gender-dysphoria/

[–]MurkyMilk 8 insightful - 1 fun8 insightful - 0 fun9 insightful - 1 fun -  (1 child)

Jesus. It just hit me -- transgenderism is the public face of a eugenics program!

[–]BEB 8 insightful - 1 fun8 insightful - 0 fun9 insightful - 1 fun -  (0 children)

I think that sterilization of "undesirables" is one part of Trans, Inc.'s goals.

I think another is just confusing kids so much about biological sex and sexuality that they stop having it as much, which has actually happened - kids are having much less sex. Which brings done the birth rate.

Jennifer Bilek, a GC feminist who has done a lot of investigative work on Trans, Inc., including the financing behind it, thinks the end goal is to disassociate ourselves from our sexed bodies in order to prepare us for trans-humanism. She makes a convincing case.

Her blog (which is very informative) is : The11thHourBlog.com

and on twitter she's @bjportraits - lots of info on her twitter too, plus a lot of other GC women

[–]SaidOverRed 13 insightful - 1 fun13 insightful - 0 fun14 insightful - 1 fun -  (4 children)

Standard leftist playbook. If you don't build an oppressed class, how else do you get more political power?

[–]spicyramen 9 insightful - 1 fun9 insightful - 0 fun10 insightful - 1 fun -  (0 children)

you are aware most people here are some form of leftist/progressive, right? that we're gender critical because it ignores women's the sex-based oppression women face?

[–]denverkris 7 insightful - 2 fun7 insightful - 1 fun8 insightful - 2 fun -  (0 children)

this.

[–]whateverneverpine 3 insightful - 2 fun3 insightful - 1 fun4 insightful - 2 fun -  (1 child)

Standard right-wing playbook, as well.

[–]SaidOverRed 1 insightful - 2 fun1 insightful - 1 fun2 insightful - 2 fun -  (0 children)

I find your lack of faith examples disturbing.

[–]Revision10 21 insightful - 2 fun21 insightful - 1 fun22 insightful - 2 fun -  (10 children)

That reddit crossover site also showed a lot of posters in trans subs were in the autism subs as well

[–]ArthnoldManacatsaman 23 insightful - 3 fun23 insightful - 2 fun24 insightful - 3 fun -  (9 children)

Are you referring to this? Fascinating little tool that I've enjoyed playing around with. Some of my favourite discoveries are:

  • Posters on /r/actuallesbians are 54 times more likely to post to /r/mtf and 7 times more likely to post to /r/autism.

  • Posters on /r/mtf are 30 times more likely to post on /r/crossdressing and 5 times more likely to post on /r/aspergers.

  • Posters in /r/askgaybros are more likely to post in /r/applehelp, /r/taylorswift, or /r/philadelphia than they are in any trans-related sub (provided we assume /r/LGBT isn't a 'trans-related sub').

  • Posters in /r/lgbt are more likely to post in a trans subreddit than they are a gay / lesbian subreddit. Also a lot of Tumblr / teen / furry / fanfiction / Sherlocked inside the Tardis bullshit in that list too.

[–]GConly 14 insightful - 1 fun14 insightful - 0 fun15 insightful - 1 fun -  (6 children)

The cross posting habits of the mtf posters are mind boggling.

Explains the attitude of witches Vs patriarchy and twox.

[–]ArthnoldManacatsaman 3 insightful - 1 fun3 insightful - 0 fun4 insightful - 1 fun -  (1 child)

Never got the WitchesVPatriarchy thing. Is it a parody sub?

[–]jet199 7 insightful - 7 fun7 insightful - 6 fun8 insightful - 7 fun -  (0 children)

Not intentionally

[–]Cass 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (3 children)

I'm unfamiliar with that sub, but I'm interested in wicca, so I'm curious what's the attitude, if you don't mind getting me up to speed?

[–]GConly 9 insightful - 1 fun9 insightful - 0 fun10 insightful - 1 fun -  (2 children)

Supposedly wiccan, actually a hangout for TIMs.

[–]TurkishCoffee 4 insightful - 1 fun4 insightful - 0 fun5 insightful - 1 fun -  (0 children)

this

ugh. so i ran across that subreddit the other day. i'm pagan and trying to y'know, maybe find more of a community. Read about 30 seconds into that sub and was like "...well. can't read for a minute without someone talking about trans something....nope".

[–]Cass 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

Thanks.

[–]BEB 4 insightful - 1 fun4 insightful - 0 fun5 insightful - 1 fun -  (0 children)

Great digging - thanks! I'm going to save your research.

[–]Revision10 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

Yes, exactly. I noticed the autism link not long ago, including self harm

[–]hermiona52 19 insightful - 1 fun19 insightful - 0 fun20 insightful - 1 fun -  (1 child)

It was an interesting interview for sure, but one part I found just... eh. Not surprising but just plain stupid and sad.

Unlike children typically diagnosed with gender dysphoria, these kids did not, prior to puberty, exhibit any (or only exhibited very few) of the readily observable, hard-to-miss indicators that would need to be present to meet criteria for a diagnosis. For example, it would be hard not to notice if a child had a strong preference or strong rejection of specific toys, games and activities, or a strong preference for playmates of the other gender.

In Poland at the end of each of the first three years at elementary school you didn't get normal report cards with grades, but overall descriptive performance. So after second or third year I basically was praised by my teacher, but at the very bottom she found it important to add that I usually spend most of my time with male friends, socializing and playing with them, mostly ignoring my female friends. I mentioned it to my mother a few years back (I'm 26 now) and she said my teacher once hailed mother to school to show her this 'different behavior' of mine. During play time I of course was having fun with guys, teacher brought me to a corner where gals were playing... and after a few minutes I naturally navigated to guys.

I grew up with only male friends in my area, I have a brother 4 years older than me, and guys always had so much fun ways to play - of course I preferred their company. It was that simple.

To think that it could be considered a sign of gender dysphoria now is just ridiculous. I am a woman (although also a lesbian but I don't think it matters - it would be just a stereotype) and everything I do is womanly because of that. Even when I scraped my knees climbing roofs or playing soccer.

[–]jet199 8 insightful - 1 fun8 insightful - 0 fun9 insightful - 1 fun -  (0 children)

I don't think it's ridiculous.

I act think people have an instinct to have friends of their own sex, that is the case in the vast majority of friendship groups. I've seen many people who have the opposite instinct often have a hard time of it and think people need to be tolerant of a behaviour they can't help.

You think your preference is just normal because it's normal for you. That teacher had probably seen hundreds of little girls so was in a far better position to see it wasn't. There's nothing wrong with with being different, you shouldn't feel the need to attack people who point it out in a neutral way. Gender non conforming behaviour is far more common in children who grow up to be homosexual so that is relevant, where you like it or not.

When you think about it wanting to play with boys or other girls is a far less regressive measure of gender non conformity than what clothes or toys kids prefer.

[–]Tovasshi[S] 16 insightful - 1 fun16 insightful - 0 fun17 insightful - 1 fun -  (0 children)

Genes associated with ASD: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334288/ https://pubmed.ncbi.nlm.nih.gov/31177578/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612093/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341098/ https://molecularautism.biomedcentral.com/articles/10.1186/s13229-018-0244-2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633421/

[–]endless_assfluff 14 insightful - 1 fun14 insightful - 0 fun15 insightful - 1 fun -  (2 children)

Okay, wow, your analysis is far more interesting than the paper itself, but I'm going to add my $0.02 in case anyone wants it.

Right off the bat, WES studies and GWAS are currently next-to-useless, in terms of predictive power and mechanistic insight, for complex conditions. But the last time I looked at WES and GWAS in the context of complex diseases was years ago and that's just my opinion.

A primary limitation of this study was that it included only 30 subjects...

You think?

And a control cohort of 88, with the same number of TIMs and Ms who aren't TI.

... though this does constitute a larger sample size than the majority of prior studies utilizing WES to study gender dysphoria.

I can't figure out which prior WES studies they're referring to, since this paragraph doesn't cite anything. [24] does seem to be a WES project with... 9 TIFs and 4 TIMs. LMAO. Let's see---the next one I can't access from home, the next is a review, and [27] has a pretty sweet cohort of 380 TIMs, and they chose their 12 genes based on a lit review rather than WES.

The authors don't mention whether their findings are consistent with previous genetic studies. They're posing new candidate genes rather than looking to confirm existing results, so it's not a huge issue. They do filter out results that appear in dbSNP. I'm just curious.

I can't get that one review paper they keep citing that suggests gender dysphoria has a genetic component ([22]), but will download it the next time I'm on campus.

K, so how widespread are these mutations?

With the exception of a variant of DIAPH2, which is localized to the X chromosome, each variant was observed in only a single subject, and all were heterozygous.

In general, all frameshift variants were heterozygous, including a variant of PPP2R3B, c.356dupC (p.P119fs), located on chromosome X, in one transgender male. One exception to this was noted in a single transgender male, who was homozygous for a variant of PRAMEF13, c.1291_1292insA (p.A431fs).

All splice-region variants were heterozygous and noted in only a single subject.

Variants in this group were heterozygous and only observed in a single individual, unless otherwise noted below.

Okay, so with nine exceptions, most of the variants in Tables 1--4 were observed in only one person out of 30 (and not observed in any of the 88 controls). And because the method the authors chose is just to find new genes that might be related to gender dysphoria, they can't confirm whether these variants do anything, and instead speculate on why these genes might be related to gender dysphoria in the mini review paper that dominates the discussion section. So these long tables are mostly variants that they found in a single person, out of 30, and they don't know which ones are important, or even if any of these are important at all.

We have a lot of genes. I'd guess every single one of us has variants that don't appear in dbSNP and might also not appear in 88 randomly selected people. It's not surprising that they were able to find such variants in their cohort of 30, even restricted to genes that might affect sexual development.

I'm also not seeing anyone's race mentioned anywhere. Sad to say, but WES studies and GWAS have to be super racist by design. People whose ancestry is constrained to a certain region are genetically similar to each other and genetically different from people whose ancestors lived in a different region, in ways that are unrelated to the goal of the study. This does often confound results.

Ooh, and now I'm thinking of how hormone therapy would affect epigenetics. Unfortunately,

In addition, we are unable to characterize the extent of the majority of subjects’ transition processes, as this information was not collected as part of the enrollment process.

And:

However, we did make certain that each subject met the clinical criteria for gender dysphoria before enrollment.

Are they saying only people with gender dysphoria can be trans? TERF TERF TERF TERF TERF

I'm scrolling through Tables 1--4 and recognize a few of these genes. I don't know if this is useful for anyone to hear, but the genes they identify as contributing to sexual dimorphism aren't exclusively developmental. Many of these genes have specific roles that don't neatly relate to sex or gender, and sexual dimorphism is kind of a side gig for them. And:

In contrast to the limited knowledge regarding the development of human gender identity, there has been significant progress, over the last twenty years, using animal models to demonstrate the neurodevelopmental pathways leading to sexually dimorphic brain regions and resultant sex-specific behavior patterns. In rodents, four key areas of the brain have been identified with developmental pathways leading to sexual dimorphism...

The key phrase here is 'in rodents.' Do the authors know of any studies on sexual dimorphism in humans?

Lastly, in addition to the two paragraphs in the intro about how bad trans kids have it (not related to the content of the study), the subsection in Discussion titled 'Special considerations...' suggests that the authors want their work to lend legitimacy to gender dysphoria claims, meaning that they are not addressing the question "is there a genetic component to gender dysphoria?" but rather "there's probably a genetic component to gender dysphoria, what is it?" These claims don't have anything to do with the study and suggest the authors are biased towards one hypothesis over another (that gender dysphoria has a genetic component), but this study says so little that this bias wouldn't affect their results. It's only dangerous here because laypeople like the one in OP's title don't realize that this paper does nothing to confirm or support this hypothesis.

Is it the case that every single gene in Tables 1--4 is associated with ASD? That's what I interpreted your title to mean. I don't see any mention of CNTNAP2/CASPR2, in particular, and I see DIAPH2 but not DIAPH3.

So, what this paper is saying is "we think gender dysphoria has a genetic link. If it does have one, it's complicated. We tried to find some genes that are different in trans and non-trans people. We have an idea of how these genes are linked to gender and are telling other scientists about these genes because we think they might be interesting." In particular, these authors start out by assuming gender dysphoria has a genetic component, so they can't prove that gender dysphoria has a genetic component. Link to ASD or not, this paper does not prove that gender identity is innate, as whoever posted this study claims.

(Edit: typo)

[–]Tovasshi[S] 10 insightful - 1 fun10 insightful - 0 fun11 insightful - 1 fun -  (0 children)

"transgender females there were seven hemizygous variants noted in six genes located on the X chromosome: ASMT, CXORF57 , GTPBP6, P2RY8, PLCXD1, and RGAG1. "

ASMT - autism https://pubmed.ncbi.nlm.nih.gov/23995775/ CXORF57 - https://www.alliancegenome.org/gene/HGNC:25486

RGAG1 - Autism and Schizophrenia https://www.semanticscholar.org/topic/RGAG1-gene/2162946

PLCXD1 - schizophrenia.

"four variants were noted in genes on the X chromosome: ATRX, GTPBP6, PPP2R3B, and ZXDA."

ATRX - autism like symptoms https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315487/

ZXDA - https://www.morressier.com/article/03--proteomic-research-psychiatry-schizophrenia/5c642be19ae8fb00131ceb17?

[–]InvisibleWoman 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

Very interesting, thank you for the explanation!

[–][deleted] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (1 child)

I dropped science high school so I can't really get through a paper like this. Could someone explain though, does correlation here equal causation? Like, is the high crossover due to some genetic component or are people with ASD more likely to be taken advantage of by the trans communities (esp the online ones) and therefore will show up in higher numbers in studies? Is it possible that transwomen (males) who have AGP will be more likely to have ASD because men with ASD will be more likely that their non-ASD counterparts to develop paraphilias?

[–]Tovasshi[S] 4 insightful - 1 fun4 insightful - 0 fun5 insightful - 1 fun -  (0 children)

Overall, no one knows the full answer. But as an autistic person I do understand the body- brain issue. Many austic people don't feel their bodies in space. I myself feel extreme discomfort if my arms are dangling by my sides. It's hard to explain, but often time my arms feel alien to me eviden i look at them because my brain isn't registering that they're mine. A similar phenomenon is experienced by schizophrenics, they're able to tickle themselves because their brain doesn't register that it's them that's touching themself.

A lot of what trans people say about their experiences sound word for word what austic and schizophrenic people say about how they perceive themselves.