The people I know buy estradiol raws from China, the precursor to the oil-suspended estradiol that is usually prescribed to trans women. It's not really practical to manufacture raws on our own, it's a synthesization process that starts with purple yams or other phytoestrogens.

But you said the hormone formulations TW rely on don't come from Big Pharma. China is Big Pharma. China is the world's single largest supplier of basic chemicals and active pharmaceutical ingredients (APIs) that provide the raw materials for the global pharmaceutical industry. From big industrial factories owned and operated by companies like J & J, Roche, AbbVie, Sanofi, Pfizer, Bristol Meyer, etc to licensed compounding pharmacies to individuals with a chem lab in their garage or a meth lab in their RV - most everyone in the drugs trade nowadays gets their raw materials from China, a country with more than 6000 pharmaceutical companies.

Now China is increasingly focusing on the development and production of finished pharmaceutical products (FPPs), primarily to serve the domestic market - which is the second largest drugs market in the world after the USA - but also with an eye to making FPPs for export. But the new focus on FPPs isn't to supplant China's role as the largest producer of the raw materials for all the makers of FPPs outside of China, it's to supplement it. China wants to keep its position as the main source of APIs and other pharma ingredients as it also produces more and more FPPs.

Today, all of the world's major estrogen products - whether you buy them already in finished form, or as raw materials are made or derived from plants - soybeans or yams - except for Premarin, which still is made from horse urine.

I have a hunch you think that estradiol is the only estrogen women's bodies produce and that "bioidentical estradiol" means the same thing as "natural estradiol." Neither is true. Estradiol is the major estrogen women produce from the ovaries, but it's not the only estrogen we produce.

Also bioidentical estradiol doesn't mean natural; it simply means it has the same molecular structure as the estradiol made by human ovaries. Another name is17β-estradiol.

Everyone produces a bit of estradiol unless they have a condition otherwise.

Yes, this is true. And unless it's coming from ovaries, the most common way that estradiol is made in the human body is by aromatizing either androstenedione into estrone and then converting the estrone into estradiol, or by converting the androstenedione into testosterone and then converting the testosterone into estradiol. The testicles and other sites in the male reproductive tract are a main source of estradiol in males.

Estradiol is produced especially within the follicles of the ovaries, but also in other tissues including the testicles, the adrenal glands, fat, liver, the breasts, and the brain. Estradiol is produced in the body from cholesterol through a series of reactions and intermediates.[10] The major pathway involves the formation of androstenedione, which is then converted by aromatase into estrone and is subsequently converted into estradiol. Alternatively, androstenedione can be converted into testosterone, which can then be converted into estradiol.

The effect of estradiol (and estrogens in general) upon male reproduction is complex.

Estrogens have traditionally been considered female hormones. Nevertheless, the presence of estrogen in males has been known for over 90 years. Initial studies suggested that estrogen was deleterious to male reproduction because exogenous treatments induced developmental abnormalities.

However, demonstrations of estrogen synthesis in the testis and high concentrations of 17β-estradiol in rete testis fluid suggested that the female hormone might have a function in normal male reproduction. Identification of estrogen receptors and development of biological radioisotope methods to assess estradiol binding revealed that the male reproductive tract expresses estrogen receptor extensively from the neonatal period to adulthood.

This indicated a role for estrogens in normal development, especially in efferent ductules, whose epithelium is the first in the male reproductive tract to express estrogen receptor during development and a site of exceedingly high expression. In the 1990s, a paradigm shift occurred in our understanding of estrogen function in the male, ushered in by knockout mouse models where estrogen production or expression of its receptors was not present. These knockout animals revealed that estrogen's main receptor (estrogen receptor 1 [ESR1]) is essential for male fertility and development of efferent ductules, epididymis, and prostate, and that loss of only the membrane fraction of ESR1 was sufficient to induce extensive male reproductive abnormalities and infertility.

This review provides perspectives on the major discoveries and developments that led to our current knowledge of estrogen's importance in the male reproductive tract and shaped our evolving concept of estrogen's physiological role in the male.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044326/

The only time I have ever heard Q angles used in the context of trans people is by this infamous Twitter user bevvie112,

But the fact that you have never heard about Q angles anywhere else is a reflection on you, not on anyone else. Matters like Q angles come up in many discussions entirely separately to discussions about trans. Not everything is about you and the trans lobby.

Women and our bodies existed and we had issues in sports and other situations due our Q angles long before the current-day trans movement got going and long before males started using gender identity claims to horn in on women's and girls' sports. You seem to think the only reason GC women or anyone else would know about biology, human sex differences and female physiology in particular is so we can refute the claims made by QT and TRAs. Again, not everything is about TW or in reference to TW.