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[–]ActuallyNot 3 insightful - 3 fun3 insightful - 2 fun4 insightful - 3 fun -  (8 children)

Calm down kiddies.

Inhibiting protease is a normal effect that you look for in an anti-viral medication. HIV drugs do it. Hep C drugs do it. An antiviral being a protease inhibitor doesn't mean it's horse paste. And it doesn't mean that horse paste is effective against Covid-19.

[–]jamesK_3rd 3 insightful - 2 fun3 insightful - 1 fun4 insightful - 2 fun -  (7 children)

I don't think you understand what's going on here

[–]ActuallyNot 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 2 fun -  (6 children)

What do you think it going on here, and how does it differ from what you think I understand?

[–]slushpilot 3 insightful - 1 fun3 insightful - 0 fun4 insightful - 1 fun -  (1 child)

I'd actually like to know what is going on here. On the one hand there are hypotheses about a mechanism of action and studies about potential effectiveness for ivermectin:

A reasonable person would expect that a mature discussion & further investigation would follow, and we could finally know if it was those home treatment kits that really knocked out covid in northern India, or if it's true the drug only works in vitro but the required dose would kill you, or if it's actually incredibly safe but not effective to any meaningful degree.

What we see instead are jokes about "horse dewormer", positioning a potential treatment as "anti-vax" (when it's meant for if you do get sick), and then over-the-top fake/retracted articles about how it's the most dangerous new drug and rural hospitals are unable to treat gunshot victims due to the surge in overdoses...

Then, throw in all the overt censorship when trying to even ask questions about any of the studies in public, and what's a reasonably intelligent lay person supposed to think? I don't know what it is, but something about the whole story stinks.

[–]ActuallyNot 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 2 fun -  (0 children)

A reasonable person would expect that a mature discussion & further investigation would follow, and we could finally know if it was those home treatment kits that really knocked out covid in northern India, or if it's true the drug only works in vitro but the required dose would kill you, or if it's actually incredibly safe but not effective to any meaningful degree.

The effect of Ivermectin in COVID-19 isn't strong enough for the cochrain collaboration to identify if the effect is positive or negative.

As more larger and better controlled studies come through the margins of error will come down. But it certainly doesn't help much, if at all.

What we see instead are jokes about "horse dewormer"

This is because people are so keen on taking it, despite the unknown effectiveness, that some of them are taking a vetinary formulation, and without medical advice, which is killing some of them.

This, of itself, wouldn't necessarily be the subject of jokes, but these dipsticks were pushing hydroxychloroquine which did nothing. Before that they were pushing lopinavir which did nothing. Before that they were pushing azithromycin which did nothing. At some point they need to rent a clue.

Then, throw in all the overt censorship when trying to even ask questions about any of the studies in public, and what's a reasonably intelligent lay person supposed to think?

Take the expert advice. Read the well-cited papers if you need to. Spot the bullshit because it is from the usual bullshit sources, and doesn't line up with the science.

[–]Questionable[S] 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (3 children)

They are patenting a more expensive version of a treatment they denied people, while allowing them to die. That is what's going on here. And he does not believe you understand this.

Ĥ̅͛ǝ̮̺͕̲̰llo ʍoɹlp' I,m Qnǝsʇᴉouɐqlǝ.̬̘̟ͅ

[–]ActuallyNot 2 insightful - 2 fun2 insightful - 1 fun3 insightful - 2 fun -  (2 children)

Nope.

This is not a version of another treatment. And horse paste is not effective against COVID-19. Pfizer doesn't "allow people to die".That's not within their power. They manufacture pharmaceuticals. So do other companies.

[–]Questionable[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (1 child)

[–]ActuallyNot 2 insightful - 1 fun2 insightful - 0 fun3 insightful - 1 fun -  (0 children)

Yes, it was a great step forward in medicine by being effective against parasitic worms. Notably River Blindness and Lymphatic Filariasis.

What it doesn't do is be effective against COVID-19. This is not surprising because COVID-19 isn't a parasitic worm.