Placeholder for Vaccine Discussion Points
Note: Work-In-Progress - To be updated as necessary based on comments below
(I)At the individual level, a vaccine maybe considered IF
A. Immunological protection is required i.e.
i. there is a deadly disease caused by a pathogen
ii. the individual is at risk due to a lack of immunity to the pathogen and the disease
iii. the individual's immune system stand to gain protection from the pathogen/disease upon vaccination (Note: Some people that are undergoing chemotherapy or have severely compromised immune systems cannot receive vaccines -- any vaccines, they don't have a functioning immune system able to respond. Also, people that have had a prior anaphylactic reaction to any the vaccine components cannot be vaccinated.)
B. All information pertaining to the safety & efficacy of the vaccine in providing the immunological protection is made known to the individual to weigh the potential gains against potential risks
i. How the vaccine
a. works in providing the immunological protection
b. is able to prevent/reduce infection, morbidity & mortality
c. has been tested for safety & efficacy, including its approval status (ie full FDA approval) etc
ii. How the individual's immune system would likely react (positively and/or adversely) to the vaccine given the individual's genetic predisposition, health condition, age, pregnancy status (as applicable) etc
C. There are no other alternatives offering protection against the disease - be they immunological or otherwise
(II) At the Population level, mass vaccination maybe considered IF
(on top of the above individual level considerations)
a. the pathogen for the disease is (easily?) transmissible
b. the vaccine is able to prevent/significantly reduce transmission in the population
c. the vaccine has been given Full FDA approval or otherwise granted Emergency Use Authorization (EUA)
d. the vaccine is a complete (sterilizing) vaccine
e. the pathogen causing the disease is not actively spreading e.g. in a pandemic
[Note: mass vaccination with
- a non-sterilizing/"leaky" vaccine which prevents symptoms but prevents neither infection nor transmission, and
- an actively spreading pathogen
(i.e. the opposite of (d) & (e))
would create evolutionary pressure towards vaccine escape variants that are potentially more virulent]
(III)Mandatory mass vaccination should only be considered IF
(on top of the above individual & population level considerations)
a. the pathogen for the disease is highly transmissible
b. the disease is deadly to a significant proportion of the population
c. there is no other effective protection (immunological or otherwise) against the pathogen nor the disease for those at risk
d. the vaccine has been given full FDA approval i.e. including assessment of long term safety & efficacy.
Factors against mandatory mass vaccination
For a biphasic disease:
Phase 1: Viral infection
Phase 2: Hypersensitivity reaction i.e. Severe Phase - that <20% experience
1) Which is (more) deadly: the virus or the over-reaction by the immune system
2) If only 20% of the population are expected to get the severe disease (from an immune system hypersensitivity reaction - possibly to viral debris), is it justifiable for the 80% to be vaccinated as well?
3) Immunologically, recent studies suggest that even prior to vaccination, a significant proportion of the population already have cross reactive immunity to the virus
Link
4) Mandatory mass vaccination with a non-sterilizing/"leaky" vaccine which prevents symptoms but not infection nor transmission, whilst the virus is known to be actively spreading and mutating would accelerate evolutionary pressure towards potentially more virulent vaccine escape variants - see also #8 below.
5) There are other protection against the pathogen / the disease
Consider these
6) Vaccines are still under EUA and not FDA approved i.e. long term consequences are still under study.
7) Vaccine Adverse Events point to (at a minimum) adverse reaction to the vaccines in a not insignificant proportion of the population.
8) Vaccine Efficacy against the Wuhan Strain: The Absolute Risk Reduction (ARR) of the vaccines were only between 0.84% to 1.3% in preventing symptoms (not preventing morbidity nor mortality).
Link: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(21)00069-0/fulltext?s=09
Since then there have been many variants, Alpha, Beta, Gamma, Epsilon and Delta and even Lambda has been reported. Meanwhile, the vaccines (2 shots & possibly the third shot i.e. "Booster") is for the Wuhan strain.
Domestic Vaccine Passports have been pushed by Governments despite strong protests against the programs. The foregoing factors show that mass vaccination programs will lead to a worsening of the crisis and are unjustifiable. The insistence on Domestic Vaccine Passport despite the data & science should lead us all to question the Agenda behind the push.
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