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[–]EddieC[S] 1 insightful - 1 fun1 insightful - 0 fun2 insightful - 1 fun -  (0 children)

Niacin @ Nicotonic Acid (NA)

Anti-inflammatory effects of nicotinic acid in adipocytes (aka fat cells) demonstrated by

  • suppression of fractalkine, RANTES, and MCP-1 and
  • upregulation of adiponectin (a protein hormone and adipokine involved in regulating glucose levels & fatty acid breakdown)

Link: https://www.atherosclerosis-journal.com/article/S0021-9150(09)00707-2/fulltext
 

"NA suppresses pro-atherogenic chemokines and upregulates the atheroprotective adiponectin through a G-protein-coupled pathway. Since adipose tissue has the potential to contribute to both systemic and local (perivascular) inflammation associated with atherosclerosis our results suggest a new “pleiotropic” role for NA."